Showing entry for Eriodictyol


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0000392
Compound NameEriodictyol
Structure
FormulaC15H12O6
InchiKeySBHXYTNGIZCORC-UHFFFAOYSA-N
SMILESOC1=CC(O)=C2C(=O)CC(OC2=C1)C1=CC(O)=C(O)C=C1
InchiInChI=1S/C15H12O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-5,13,16-19H,6H2
IUPAC(2S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-1-benzopyran-4-one
Molecular Weight288.26
Pubchem Id11095
Chembl IdCHEMBL307893
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 69393
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT010750 Glycogen synthase kinase-3 beta reviewed Kinase GSK3B - - - >300000
reviewed BXGT008148 Intestinal-type alkaline phosphatase 1 reviewed Alpi - - - 54100
reviewed BXGT006942 Intestinal-type alkaline phosphatase reviewed Enzyme ALPI - - - 50400
reviewed BXGT007603 Alkaline phosphatase, germ cell type reviewed Enzyme ALPG - - - 60300
reviewed BXGT006338 Alkaline phosphatase, tissue-nonspecific isozyme reviewed Enzyme ALPL - - - 81800
CHEMBL CHEMBL307893
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P14618 BXGT008027 Pyruvate kinase PKM reviewed Kinase PKM Potency '=' 11220 nM
P24822 BXGT008996 Intestinal-type alkaline phosphatase reviewed - Iap EC50 - 54100 nM
Q14191 BXGT013452 Werner syndrome ATP-dependent helicase reviewed Enzyme WRN Potency - 56234 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 39810 nM
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency '=' 15848 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 31622 nM
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 Potency '=' 10000 nM
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 39810 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 15848 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 28183 nM
O15296 BXGT004148 Arachidonate 15-lipoxygenase B reviewed Enzyme ALOX15B Potency - 15848 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 35481 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 25118 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 29092 nM
P11021 BXGT007644 Endoplasmic reticulum chaperone BiP reviewed - HSPA5 Potency - 50118 nM
P09923 BXGT006942 Intestinal-type alkaline phosphatase reviewed Enzyme ALPI EC50 '=' 50400 nM
Q9Y253 BXGT022216 DNA polymerase eta reviewed - POLH Potency - 75686 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 31622 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 12589 nM
O75164 BXGT005104 Lysine-specific demethylase 4A reviewed - KDM4A Potency - 79432 nM
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency '=' 35481 nM
P10253 BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA Potency '=' 12589 nM
P10696 BXGT007603 Alkaline phosphatase, germ cell type reviewed Enzyme ALPG EC50 '=' 60300 nM
O94925 BXGT005342 Glutaminase kidney isoform, mitochondrial reviewed Enzyme GLS Potency - 35481 nM
Q962Y6 BXGT019597 Thioredoxin glutathione reductase unreviewed - TGR Potency '=' 39810 nM
P05164 BXGT006333 Myeloperoxidase reviewed Enzyme MPO Inhibition '=' 40 %
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 28183 nM
P05186 BXGT006338 Alkaline phosphatase, tissue-nonspecific isozyme reviewed Enzyme ALPL EC50 '=' 81800 nM
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 Inhibition '=' 9 %
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 50118 nM
P11021 BXGT007644 Endoplasmic reticulum chaperone BiP reviewed - HSPA5 Potency - 28183 nM
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Potency '=' 7 nM
P39748 BXGT010134 Flap endonuclease 1 reviewed Enzyme FEN1 Potency - 39810 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 12589 nM
Q9Y253 BXGT022216 DNA polymerase eta reviewed - POLH Potency - 22387 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 4610 nM
Q15118 BXGT013540 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial reviewed Kinase PDK1 Inhibition '=' 20 %
P06746 BXGT006496 DNA polymerase beta reviewed Enzyme POLB Potency '=' 35481 nM
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 7079 nM
P00747 BXGT005639 Plasminogen reviewed Enzyme PLG Inhibition '=' 20 %
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 12589 nM
P09917 BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 Inhibition '=' 53 %
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 Inhibition '=' 3 %
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00016 Peanut Arachis hypogaea Nuts
BXGF00019 Tarragon Artemisia dracunculus Herbs and Spices
BXGF00054 Lemon Citrus limon Fruits
BXGF00067 Cumin Cuminum cyminum Herbs and Spices
BXGF00102 Mexican oregano Lippia graveolens Herbs and Spices
BXGF00108 Lemon balm Melissa officinalis Herbs and Spices
BXGF00119 Sweet basil Ocimum basilicum Herbs and Spices
BXGF00122 Sweet marjoram Origanum majorana Herbs and Spices
BXGF00124 Common oregano Origanum vulgare Herbs and Spices
BXGF00131 Parsley Petroselinum crispum Herbs and Spices
BXGF00140 Pistachio Pistacia vera Nuts
BXGF00148 Almond Prunus dulcis Nuts
BXGF00159 Rosemary Rosmarinus officinalis Herbs and Spices
BXGF00183 Common thyme Thymus vulgaris Herbs and Spices
BXGF00811 Citrus Fruits
BXGF00816 Fats and oils Fats and oils
BXGF00824 Green vegetables Vegetables
BXGF02445 Onopordum acanthium Onopordum acanthium Medicinal Plant
BXGF05002 Scutellaria balcalensis Scutellaria balcalensis Others
BXGF05420 Lawsonia inermis Lawsonia inermis Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease