protein

Showing entry for Alkaline phosphatase, tissue-nonspecific isozyme

General Target Information
BXGT Id	BXGT006338
Protein Name	Alkaline phosphatase, tissue-nonspecific isozyme
Uniport Id	P05186
Gene	ALPL
Gene Id	249
Domain	Alk_phosphatase
Pfam	PF00245
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
1. Metabolism	1.8 Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism
1. Metabolism	1.8 Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis
1. Metabolism	1.0 Global and overview maps	hsa01100	Metabolic pathways

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0071407	cellular response to organic cyclic compound
Biological Process	GO:0071529	cementum mineralization
Biological Process	GO:0016311	dephosphorylation
Biological Process	GO:0003006	developmental process involved in reproduction
Biological Process	GO:0001958	endochondral ossification
Biological Process	GO:0001649	osteoblast differentiation
Biological Process	GO:0046677	response to antibiotic
Biological Process	GO:0051384	response to glucocorticoid
Biological Process	GO:0032496	response to lipopolysaccharide
Biological Process	GO:0033280	response to vitamin D
Biological Process	GO:0001501	skeletal system development
molecular function	GO:0004035	alkaline phosphatase activity
molecular function	GO:0046872	metal ion binding
molecular function	GO:0016462	pyrophosphatase activity
cellular component	GO:0031225	anchored component of membrane
cellular component	GO:0070062	extracellular exosome
cellular component	GO:0031012	extracellular matrix
cellular component	GO:0065010	extracellular membrane-bounded organelle
cellular component	GO:0005576	extracellular region
cellular component	GO:0016020	membrane
cellular component	GO:0005886	plasma membrane

Reactome

Pathway Id	Pathway Name
R-HSA-163125	Post-translational modification: synthesis of GPI-anchored proteins
R-HSA-392499	Metabolism of proteins
R-HSA-597592	Post-translational protein modification

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0000768	BXGD000007	Congenital Abnormality	Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0000846	BXGD000015	Agenesis
C0001787	BXGD000076	Osteoporosis, Age-Related	Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0002382	BXGD000109	Alveolar Bone Loss	Musculoskeletal Diseases; Stomatognathic Diseases
C0002871	BXGD000132	Anemia	Hemic and Lymphatic Diseases
C0003123	BXGD000178	Anorexia	Pathological Conditions, Signs and Symptoms
C0003467	BXGD000194	Anxiety	Behavior and Behavior Mechanisms
C0003469	BXGD000195	Anxiety Disorders	Mental Disorders
C0003578	BXGD000211	Apnea	Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0003850	BXGD000225	Arteriosclerosis	Cardiovascular Diseases
C0004096	BXGD000252	Asthma	Respiratory Tract Diseases; Immune System Diseases
C0004153	BXGD000260	Atherosclerosis	Cardiovascular Diseases
C0005940	BXGD000352	Bone Diseases	Musculoskeletal Diseases
C0005944	BXGD000355	Metabolic Bone Disorder	Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0006142	BXGD000374	Malignant neoplasm of breast	Neoplasms; Skin and Connective Tissue Diseases
C0006663	BXGD000403	Calcinosis	Nutritional and Metabolic Diseases
C0006826	BXGD000408	Malignant Neoplasms	Neoplasms
C0007222	BXGD000454	Cardiovascular Diseases	Cardiovascular Diseases
C0009207	BXGD000593	Cockayne Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0009319	BXGD000596	Colitis	Digestive System Diseases
C0009806	BXGD000633	Constipation	Pathological Conditions, Signs and Symptoms
C0010054	BXGD000647	Coronary Arteriosclerosis	Cardiovascular Diseases
C0010068	BXGD000648	Coronary heart disease	Cardiovascular Diseases
C0010278	BXGD000660	Craniosynostosis	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0011334	BXGD000716	Dental caries	Stomatognathic Diseases
C0011430	BXGD000723	Dentin Dysplasia	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0011570	BXGD000729	Mental Depression	Behavior and Behavior Mechanisms
C0011581	BXGD000733	Depressive disorder	Mental Disorders
C0011860	BXGD000755	Diabetes Mellitus, Non-Insulin-Dependent	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013336	BXGD000815	Dwarfism	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0014544	BXGD000926	Epilepsy	Nervous System Diseases
C0015300	BXGD000973	Exophthalmos	Eye Diseases
C0015544	BXGD001003	Failure to Thrive	Pathological Conditions, Signs and Symptoms
C0015967	BXGD001030	Fever	Pathological Conditions, Signs and Symptoms
C0016506	BXGD001062	Foot Deformities	Musculoskeletal Diseases
C0016663	BXGD001071	Pathological fracture	Wounds and Injuries
C0020224	BXGD001366	Polyhydramnios	Female Urogenital Diseases and Pregnancy Complications
C0020437	BXGD001381	Hypercalcemia	Nutritional and Metabolic Diseases
C0020438	BXGD001382	Hypercalciuria	Pathological Conditions, Signs and Symptoms
C0020443	BXGD001385	Hypercholesterolemia	Nutritional and Metabolic Diseases
C0020492	BXGD001404	Hyperostosis	Musculoskeletal Diseases
C0020503	BXGD001411	Hyperparathyroidism, Secondary	Endocrine System Diseases
C0020630	BXGD001454	Hypophosphatasia	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0021368	BXGD001502	Inflammation	Pathological Conditions, Signs and Symptoms
C0022107	BXGD001530	Irritable Mood	Behavior and Behavior Mechanisms
C0022333	BXGD001534	Jacksonian Seizure	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0022408	BXGD001544	Arthropathy	Musculoskeletal Diseases
C0022650	BXGD001568	Kidney Calculi	Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022658	BXGD001570	Kidney Diseases	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023895	BXGD001717	Liver diseases	Digestive System Diseases
C0025286	BXGD001850	Meningioma	Neoplasms; Nervous System Diseases
C0025517	BXGD001875	Metabolic Diseases	Nutritional and Metabolic Diseases
C0025521	BXGD001876	Inborn Errors of Metabolism	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0025995	BXGD001885	Micromelia	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0026827	BXGD001936	Muscle hypotonia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026848	BXGD001941	Myopathy	Musculoskeletal Diseases; Nervous System Diseases
C0027627	BXGD002006	Neoplasm Metastasis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651	BXGD002009	Neoplasms	Neoplasms
C0027709	BXGD002026	Nephrocalcinosis	Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027765	BXGD002033	nervous system disorder	Nervous System Diseases
C0028259	BXGD002073	Nodule
C0028754	BXGD002082	Obesity	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029408	BXGD002137	Degenerative polyarthritis	Musculoskeletal Diseases
C0029410	BXGD002138	Osteoarthritis of hip	Musculoskeletal Diseases
C0029422	BXGD002142	Osteochondrodysplasias	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0029434	BXGD002146	Osteogenesis Imperfecta	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0029453	BXGD002154	Osteopenia	Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029456	BXGD002157	Osteoporosis	Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029463	BXGD002160	Osteosarcoma	Neoplasms
C0029464	BXGD002161	Osteosclerosis	Musculoskeletal Diseases
C0031090	BXGD002280	Periodontal Diseases	Stomatognathic Diseases
C0033300	BXGD002403	Progeria	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0033578	BXGD002408	Prostatic Neoplasms	Neoplasms; Male Urogenital Diseases
C0033802	BXGD002425	Pseudogout	Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0033847	BXGD002437	Pseudoxanthoma Elasticum	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0034068	BXGD002457	Pulmonary Eosinophilia	Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C0035579	BXGD002560	Rickets	Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0036117	BXGD002577	Salmonella infections	Infections
C0036572	BXGD002625	Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036690	BXGD002632	Septicemia	Pathological Conditions, Signs and Symptoms; Infections
C0038013	BXGD002725	Ankylosing spondylitis	Musculoskeletal Diseases
C0041948	BXGD002939	Uremia	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0042963	BXGD003018	Vomiting	Pathological Conditions, Signs and Symptoms
C0085584	BXGD003195	Encephalopathies	Nervous System Diseases
C0086565	BXGD003295	Liver Dysfunction	Digestive System Diseases
C0149958	BXGD003395	Complex partial seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151699	BXGD003461	Intracranial Hemorrhage	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0201850	BXGD004053	Alkaline phosphatase measurement
C0202178	BXGD004080	Phosphorus measurement
C0202251	BXGD004088	Vitamin B6 measurement
C0202252	BXGD004089	VITAMIN B12 MEASUREMENT
C0206659	BXGD004222	Embryonal Carcinoma	Neoplasms
C0220743	BXGD004334	Childhood hypophosphatasia (disorder)	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0221354	BXGD004446	Frontal bossing	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0221358	BXGD004450	Long narrow head
C0231712	BXGD004519	Waddling gait	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234533	BXGD004687	Generalized seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234535	BXGD004688	Clonic Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0243026	BXGD005210	Sepsis	Pathological Conditions, Signs and Symptoms; Infections
C0262444	BXGD005244	Abnormality of the dentition	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0263628	BXGD005334	Tumoral calcinosis	Nutritional and Metabolic Diseases
C0266039	BXGD005612	Taurodontism	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0266052	BXGD005614	Precocious exfoliation of primary tooth	Stomatognathic Diseases
C0268412	BXGD005937	Infantile hypophosphatasia	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0268413	BXGD005938	Adult hypophosphatasia (disorder)	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0270824	BXGD006113	Visual seizure	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270844	BXGD006115	Tonic Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270846	BXGD006116	Epileptic drop attack	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0340076	BXGD007302	Asthmatic pulmonary eosinophilia	Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C0342649	BXGD007522	Vascular calcification	Nutritional and Metabolic Diseases
C0344315	BXGD007666	Depressed mood	Behavior and Behavior Mechanisms
C0344911	BXGD007707	Left ventricular dilatation
C0349588	BXGD007933	Short stature
C0376358	BXGD007992	Malignant neoplasm of prostate	Neoplasms; Male Urogenital Diseases
C0392525	BXGD008052	Nephrolithiasis	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0409860	BXGD008397	Rotator cuff tear arthropathy	Musculoskeletal Diseases
C0410528	BXGD008430	Skeletal dysplasia	Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0410529	BXGD008431	Hypochondroplasia (disorder)	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0410719	BXGD008448	Deformity of bone	Musculoskeletal Diseases
C0422850	BXGD008457	Seizures, Somatosensory	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422852	BXGD008458	Seizures, Auditory	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422853	BXGD008459	Olfactory seizure	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422854	BXGD008460	Gustatory seizure	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422855	BXGD008461	Vertiginous seizure	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0426817	BXGD008585	Short ribs
C0426901	BXGD008597	Short leg
C0494475	BXGD009030	Tonic - clonic seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0520739	BXGD009106	Hereditary pyropoikilocytosis	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0521174	BXGD009133	Microcalcification	Nutritional and Metabolic Diseases
C0523827	BXGD009220	Inorganic phosphate measurement
C0542514	BXGD009277	Blue sclera	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0543918	BXGD009302	SCHIZOPHRENIA 10
C0544755	BXGD009310	Genu varum	Musculoskeletal Diseases
C0549567	BXGD009387	Pigmentation Disorders	Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0553730	BXGD009417	Calcium pyrophosphate deposition disease	Musculoskeletal Diseases
C0585442	BXGD009593	Osteosarcoma of bone	Neoplasms
C0595939	BXGD009629	Stillbirth	Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0600139	BXGD009695	Prostate carcinoma	Neoplasms; Male Urogenital Diseases
C0678222	BXGD009749	Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases
C0751056	BXGD010306	Non-epileptic convulsion	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751110	BXGD010318	Single Seizure	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751123	BXGD010326	Atonic Absence Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751494	BXGD010472	Convulsive Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751495	BXGD010473	Seizures, Focal	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751496	BXGD010474	Seizures, Sensory	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0795796	BXGD010732	Chromosome 1, monosomy 1p	Pathological Conditions, Signs and Symptoms
C0877009	BXGD011326	Muscle fibrosis
C1269955	BXGD012005	Tumor Cell Invasion
C1306459	BXGD012361	Primary malignant neoplasm	Neoplasms
C1332986	BXGD012574	Childhood Osteosarcoma	Neoplasms
C1390474	BXGD012969	Increased susceptibility to fractures
C1704328	BXGD013547	Osteoblastic Osteosarcoma	Neoplasms
C1704330	BXGD013548	Dental Diseases	Stomatognathic Diseases
C1704421	BXGD013558	Skin Pigmentation Disorder	Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C1833762	BXGD013945	Decreased calvarial ossification
C1837082	BXGD014194	Metaphyseal cupping
C1840322	BXGD014448	ODONTOHYPOPHOSPHATASIA (disorder)	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Stomatognathic Diseases
C1844704	BXGD014665	Platyspondyly
C1849300	BXGD015032	Widely patent fontanelles and sutures
C1849937	BXGD015091	Disproportionate short-limb short stature
C1855815	BXGD015548	Skin dimple over apex of long bone angulation
C1855828	BXGD015549	Vertebral clefting
C1858120	BXGD015774	Generalized hypotonia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1858430	BXGD015792	Death in infancy
C1859722	BXGD015925	Arthrogryposis, renal dysfunction, and cholestasis 1	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases; Male Urogenital Diseases
C1860130	BXGD015958	Low alkaline phosphatase
C1860202	BXGD015966	Unossified vertebral bodies
C1861922	BXGD016094	CAMPOMELIC DYSPLASIA	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1956346	BXGD016627	Coronary Artery Disease	Cardiovascular Diseases
C1969738	BXGD016792	Premature loss of permanent teeth
C2363774	BXGD017105	Neutrophilic asthma
C2363819	BXGD017108	Paucigranulocytic asthma
C2673477	BXGD017206	Hypophosphatasia, Perinatal Lethal	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C2700617	BXGD017474	Irritation - emotion	Behavior and Behavior Mechanisms
C2919142	BXGD017867	Short Stature, CTCAE
C2919414	BXGD017873	Low density lipoprotein receptor mutation
C3495874	BXGD019008	Nonepileptic Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3805574	BXGD019481	Increased fracture rate
C3806482	BXGD019514	Recurrent respiratory infections	Infections; Respiratory Tract Diseases
C3887650	BXGD019911	Adult Rickets	Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C4021776	BXGD020772	Abnormality of the voice
C4023157	BXGD021127	Elevated plasma pyrophosphate
C4025607	BXGD021690	Elevated urine pyrophosphate
C4048158	BXGD021890	Convulsions	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4316903	BXGD022711	Absence Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4317109	BXGD022725	Epileptic Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4317123	BXGD022727	Myoclonic Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4505436	BXGD022962	Generalized Absence Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4551565	BXGD023353	Rachitic rosary	Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C4552810	BXGD023525	Irritability, CTCAE

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0000099	3,4-Dihydroxyphenylacetic acid		168.15
BXGC0000204	Theophylline		180.16
BXGC0000392	Eriodictyol		288.26
BXGC0001623	L-Tryptophan		204.23
BXGC0001691	Questiomycin A		212.2
BXGC0001868	Catechin		290.27
BXGC0002061	Aloeemodin		270.24
BXGC0002690	alpha-Catechin		290.27
BXGC0003214	L-(-)-Phenylalanine		165.19
BXGC0003534	Mangiferol		422.34
BXGC0004322	xi-3-Hydroxy-5-phenylpentanoic acid O-beta-D-Glucopyranoside		356.37
BXGC0005982	Curcumin		368.38
BXGC0006306	Myricetin		318.24
BXGC0006367	Mangiferin		422.34
BXGC0008753	Isoquercitrin		464.38
BXGC0008962	Gancaonin U		380.48
BXGC0009194	Quercetin 3-glucuronide		478.36
BXGC0011390	Dihydroroseoside		388.45
BXGC0011421	3-Hydroxy-1-(4-hydroxyphenyl)-1-propanone		166.17
BXGC0013582	Curcumin		368.13
BXGC0017933	Sulfuretin		270.05
BXGC0024261	Adenosine Phosphate		347.06
BXGC0024810	curcumin		368.13
BXGC0024813	Demethoxycurcumin		338.12
BXGC0028589	5,6,7,8-Tetrahydroxy-2-(4-Hydroxyphenyl)Chromen-4-One		302.04
BXGC0032575	Leucine		131.09
BXGC0037242	Homoarginine		188.13
BXGC0044285	Hematoxylin		302.08
BXGC0050877	(2R,3S)-2-(3,4-Dihydroxyphenyl)-3,4-Dihydro-2H-Chromene-3,5,7-Triol;Hydrate		290.08

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}