Showing entry for 2,4-Dihydroxybenzoic acid


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0000500
Compound Name2,4-Dihydroxybenzoic acid
Structure
FormulaC7H6O4
InchiKeyUIAFKZKHHVMJGS-UHFFFAOYSA-N
SMILESOC(=O)C1=C(O)C=C(O)C=C1
InchiInChI=1S/C7H6O4/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,8-9H,(H,10,11)
IUPAC2,4-dihydroxybenzoic acid
Molecular Weight154.12
Pubchem Id1491
Chembl IdCHEMBL328910
Targets of Information Source
DrugBank DB02839
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
P20586 BXGT008584 p-hydroxybenzoate hydroxylase reviewed - pobA experimental -
P00438 BXGT005538 p-hydroxybenzoate hydroxylase reviewed - pobA experimental -
PDB DOB
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P20586 BXGT008584 p-hydroxybenzoate hydroxylase reviewed pobA - - - - -
P00438 BXGT005538 p-hydroxybenzoate hydroxylase reviewed pobA - - - - -
Binding DB 74208
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT021373 Protein LANA1 reviewed LANA1 - - - >75000
reviewed BXGT013216 Alpha-(1,3)-fucosyltransferase 7 reviewed Enzyme FUT7 - >200000 - -
reviewed BXGT008271 Prolyl 4-hydroxylase subunit alpha-1 reviewed P4HA1 530000 - - -
reviewed BXGT013670 Carbonic anhydrase 9 reviewed CA9 68000 - - -
reviewed BXGT010364 Carbonic anhydrase 7 reviewed CA7 72000 - - -
reviewed BXGT005690 Carbonic anhydrase 2 reviewed CA2 4900 - - -
reviewed BXGT005689 Carbonic anhydrase 1 reviewed CA1 5200 - - -
reviewed BXGT021769 Carbonic anhydrase 14 reviewed CA14 70000 - - -
reviewed BXGT004601 Carbonic anhydrase 12 reviewed CA12 7500 - - -
CHEMBL CHEMBL328910
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P09917 BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 Inhibition '=' -62 %
P00915 BXGT005689 Carbonic anhydrase 1 reviewed - CA1 Ki '=' 5200 nM
O75874 BXGT005157 Isocitrate dehydrogenase [NADP] cytoplasmic reviewed - IDH1 Potency - 1158 nM
P08254 BXGT006758 Stromelysin-1 reviewed Enzyme MMP3 Inhibition '=' 3 %
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 Inhibition '=' -8 %
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 Inhibition '=' 14 %
P83916 BXGT012025 Chromobox protein homolog 1 reviewed Epigenetic regulator CBX1 Potency - 63095 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 580 nM
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Ki '=' 4900 nM
P15917 BXGT008169 Lethal factor reviewed - lef Inhibition '=' 7 %
P22894 BXGT008815 Neutrophil collagenase reviewed Enzyme MMP8 Inhibition '=' -1 %
Q03181 BXGT012701 Peroxisome proliferator-activated receptor delta reviewed Nuclear receptor PPARD Potency - 125 nM
P43166 BXGT010364 Carbonic anhydrase 7 reviewed - CA7 Ki '=' 72000 nM
P08253 BXGT006757 72 kDa type IV collagenase reviewed Enzyme MMP2 Inhibition '=' -7 %
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 25118 nM
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR Potency - 39 nM
O95398 BXGT005378 Rap guanine nucleotide exchange factor 3 reviewed Enzyme modulator RAPGEF3 Potency - 79432 nM
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma reviewed Nuclear receptor PPARG Potency - 50118 nM
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 Inhibition '=' 16 %
P16473 BXGT008234 Thyrotropin receptor reviewed G-protein coupled receptor TSHR Potency '=' 7943 nM
Q16790 BXGT013670 Carbonic anhydrase 9 reviewed - CA9 Ki '=' 68000 nM
O43570 BXGT004601 Carbonic anhydrase 12 reviewed - CA12 Ki '=' 7500 nM
O94925 BXGT005342 Glutaminase kidney isoform, mitochondrial reviewed Enzyme GLS Potency - 28183 nM
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 Inhibition '=' 91 %
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 18356 nM
P16473 BXGT008234 Thyrotropin receptor reviewed G-protein coupled receptor TSHR Potency '=' 3162 nM
Q9ULX7 BXGT021769 Carbonic anhydrase 14 reviewed - CA14 Ki '=' 70000 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 66824 nM
P11511 BXGT007717 Aromatase reviewed Enzyme CYP19A1 Activity '=' 93 %
P68400 BXGT011599 Casein kinase II subunit alpha reviewed Kinase CSNK2A1 Delta Tm '=' 3 degrees C
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00107 German camomile Matricaria recutita Herbs and Spices
BXGF00121 Olive Olea europaea Vegetables
BXGF00192 American cranberry Vaccinium macrocarpon Fruits
BXGF00806 Alcoholic beverages Beverages
BXGF00813 Coffee and coffee products Coffee and coffee products
BXGF00823 Fruits Fruits
BXGF03189 Rhododendron dauricum Rhododendron dauricum Medicinal Plant
BXGF04595 Abelmoschus manihot Abelmoschus manihot Medicinal Plant
BXGF04881 Fallopia multiflora Fallopia multiflora Medicinal Plant
BXGF05367 Toxicodendron vernicifluum Toxicodendron vernicifluum Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease