Showing entry for Endoplasmic reticulum aminopeptidase 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021266
Protein NameEndoplasmic reticulum aminopeptidase 1
Uniport IdQ9NZ08
GeneERAP1
Gene Id51752
DomainERAP1_C; Peptidase_M1; Peptidase_M1_N
Pfam PF11838   PF01433  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0002250 adaptive immune response
Biological Process GO:0001525 angiogenesis
Biological Process GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
Biological Process GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
Biological Process GO:0045444 fat cell differentiation
Biological Process GO:0006509 membrane protein ectodomain proteolysis
Biological Process GO:0043171 peptide catabolic process
Biological Process GO:0045766 positive regulation of angiogenesis
Biological Process GO:0006508 proteolysis
Biological Process GO:0008217 regulation of blood pressure
Biological Process GO:0045088 regulation of innate immune response
Biological Process GO:0009617 response to bacterium
molecular function GO:0004177 aminopeptidase activity
molecular function GO:0005151 interleukin-1, type II receptor binding
molecular function GO:0005138 interleukin-6 receptor binding
molecular function GO:0070006 metalloaminopeptidase activity
molecular function GO:0008235 metalloexopeptidase activity
molecular function GO:0042277 peptide binding
molecular function GO:0008270 zinc ion binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005788 endoplasmic reticulum lumen
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0016021 integral component of membrane
cellular component GO:0016020 membrane
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1280218 Adaptive Immune System
R-HSA-168256 Immune System
R-HSA-983169 Class I MHC mediated antigen processing & presentation
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000737 BXGD000005 Abdominal Pain Pathological Conditions, Signs and Symptoms
C0003123 BXGD000178 Anorexia Pathological Conditions, Signs and Symptoms
C0003504 BXGD000202 Aortic Valve Insufficiency Cardiovascular Diseases
C0003862 BXGD000230 Arthralgia Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003872 BXGD000235 Arthritis, Psoriatic Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004943 BXGD000297 Behcet Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Skin and Connective Tissue Diseases; Stomatognathic Diseases; Cardiovascular Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0008313 BXGD000528 Cholangitis, Sclerosing Digestive System Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009326 BXGD000598 Collagen Diseases Skin and Connective Tissue Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0009676 BXGD000619 Confusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011615 BXGD000738 Dermatitis, Atopic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0014038 BXGD000878 Encephalitis Nervous System Diseases
C0014118 BXGD000894 Endocarditis Cardiovascular Diseases
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0017086 BXGD001091 Gangrene Pathological Conditions, Signs and Symptoms
C0017181 BXGD001103 Gastrointestinal Hemorrhage Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0018989 BXGD001263 Hemiparesis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0019079 BXGD001278 Hemoptysis Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0022107 BXGD001530 Irritable Mood Behavior and Behavior Mechanisms
C0022575 BXGD001555 Keratoconjunctivitis Sicca Eye Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024523 BXGD001781 Malabsorption Syndrome Digestive System Diseases; Nutritional and Metabolic Diseases
C0024530 BXGD001783 Malaria Infections
C0025202 BXGD001832 melanoma Neoplasms
C0025289 BXGD001851 Meningitis Nervous System Diseases
C0026266 BXGD001895 Mitral Valve Insufficiency Cardiovascular Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027121 BXGD001973 Myositis Musculoskeletal Diseases; Nervous System Diseases
C0027498 BXGD001994 Nausea and vomiting Pathological Conditions, Signs and Symptoms
C0027543 BXGD001997 Avascular necrosis of bone Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0029191 BXGD002122 Orchitis Male Urogenital Diseases; Endocrine System Diseases
C0030246 BXGD002198 Pustulosis of Palms and Soles Skin and Connective Tissue Diseases
C0030305 BXGD002206 Pancreatitis Digestive System Diseases
C0030554 BXGD002239 Paresthesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0031046 BXGD002275 Pericarditis Cardiovascular Diseases
C0032227 BXGD002336 Pleural effusion disorder Respiratory Tract Diseases
C0032231 BXGD002339 Pleurisy Infections; Respiratory Tract Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0034065 BXGD002454 Pulmonary Embolism Respiratory Tract Diseases; Cardiovascular Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0035435 BXGD002549 Rheumatism Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038002 BXGD002723 Splenomegaly Pathological Conditions, Signs and Symptoms
C0038013 BXGD002725 Ankylosing spondylitis Musculoskeletal Diseases
C0040560 BXGD002875 Toxoplasmosis, Congenital Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Infections; Nervous System Diseases
C0042164 BXGD002965 Uveitis Eye Diseases
C0042165 BXGD002966 Anterior uveitis Eye Diseases
C0042384 BXGD002979 Vasculitis Cardiovascular Diseases
C0042487 BXGD002986 Venous Thrombosis Cardiovascular Diseases
C0042571 BXGD002991 Vertigo Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0085582 BXGD003193 Retrobulbar Neuritis Eye Diseases; Nervous System Diseases
C0085636 BXGD003218 Photophobia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0085660 BXGD003228 Aseptic necrosis Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0149721 BXGD003349 Left Ventricular Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0149745 BXGD003356 Oral Ulcer Stomatognathic Diseases
C0149931 BXGD003388 Migraine Disorders Nervous System Diseases
C0151311 BXGD003412 Cranial nerve palsies Nervous System Diseases
C0151740 BXGD003468 Intracranial Hypertension Nervous System Diseases
C0151811 BXGD003478 Subcutaneous nodule Neoplasms; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151942 BXGD003507 Arterial thrombosis Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0206708 BXGD004256 Cervical Intraepithelial Neoplasia Neoplasms
C0231528 BXGD004496 Myalgia Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0234132 BXGD004623 Pyramidal sign Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235896 BXGD004785 Pulmonary Infiltrate Respiratory Tract Diseases
C0237653 BXGD004847 Immunologic hypersensitivity
C0263361 BXGD005292 Psoriasis vulgaris Skin and Connective Tissue Diseases
C0268731 BXGD006029 Renal glomerular disease Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0268790 BXGD006039 Renal vascular disorder Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Cardiovascular Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279671 BXGD006677 Cervical Squamous Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0280100 BXGD006713 Solid Neoplasm Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0332563 BXGD006894 Papule Pathological Conditions, Signs and Symptoms
C0346629 BXGD007831 Malignant neoplasm of large intestine Digestive System Diseases; Neoplasms
C0456909 BXGD008883 Blindness Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0497156 BXGD009053 Lymphadenopathy Hemic and Lymphatic Diseases
C0542476 BXGD009276 Forgetful Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0575081 BXGD009512 Gait abnormality Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0701807 BXGD009901 Acute anterior uveitis Eye Diseases
C0702166 BXGD009912 Acne Skin and Connective Tissue Diseases
C0871470 BXGD011316 Systolic Pressure
C0917798 BXGD011409 Cerebral Ischemia Nervous System Diseases; Cardiovascular Diseases
C0949690 BXGD011584 Spondylarthritis Musculoskeletal Diseases
C0949691 BXGD011585 Spondylarthropathies Musculoskeletal Diseases
C1262477 BXGD011882 Weight decreased Pathological Conditions, Signs and Symptoms
C1269955 BXGD012005 Tumor Cell Invasion
C1290884 BXGD012198 Inflammatory disorder Pathological Conditions, Signs and Symptoms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1319315 BXGD012415 Adenocarcinoma of large intestine Digestive System Diseases; Neoplasms
C1333064 BXGD012587 Classical Hodgkin's Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1336905 BXGD012873 Endometrial Endometrioid Adenocarcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1519353 BXGD013236 Skin Papule Skin and Connective Tissue Diseases
C1565489 BXGD013401 Renal Insufficiency Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1611743 BXGD013456 Familial (FPAH)
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1836830 BXGD014165 Developmental regression Mental Disorders
C1837315 BXGD014218 COLORECTAL CANCER, SUSCEPTIBILITY TO, 1
C1853959 BXGD015372 Birdshot chorioretinopathy
C1962966 BXGD016678 Retinopathy, CTCAE
C1963165 BXGD016685 Malabsorption, CTCAE
C1963167 BXGD016686 Memory Impairment, CTCAE 3.0
C2132198 BXGD016930 Abnormal blistering of the skin
C2347747 BXGD017040 Adult Classical Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2363741 BXGD017100 HIV-1 infection
C2675481 BXGD017292 COLORECTAL CANCER, SUSCEPTIBILITY TO, 10
C2677123 BXGD017364 COLORECTAL CANCER, SUSCEPTIBILITY TO, 3
C2700617 BXGD017474 Irritation - emotion Behavior and Behavior Mechanisms
C2937365 BXGD018161 Recurrent aphthous ulcer Stomatognathic Diseases
C2985280 BXGD018223 Blood Protein Measurement
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3267073 BXGD018613 Autoinflammatory disease
C3495559 BXGD018994 Juvenile arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3495919 BXGD019013 Enthesitis-Related Arthritis Musculoskeletal Diseases
C3554460 BXGD019215 COLORECTAL CANCER, SUSCEPTIBILITY TO, 12
C3714745 BXGD019427 Malabsorption Digestive System Diseases
C3714757 BXGD019430 Juvenile rheumatoid arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3714758 BXGD019431 Juvenile psoriatic arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3840565 BXGD019797 Autoimmune thyroid disease (AITD)
C3860213 BXGD019844 Autoinflammatory disorder
C3887513 BXGD019887 Avascular necrosis Pathological Conditions, Signs and Symptoms
C4025758 BXGD021779 Abnormal myocardium morphology Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4048329 BXGD021904 Immunosuppression
C4225381 BXGD022254 PEELING SKIN WITH LEUKONYCHIA, ACRAL PUNCTATE KERATOSES, CHEILITIS, AND KNUCKLE PADS
C4521256 BXGD023058 Glomerulopathy Assessment
C4551915 BXGD023441 Gait Disturbance, CTCAE
C4552810 BXGD023525 Irritability, CTCAE
C4553018 BXGD023532 Avascular Necrosis, CTCAE
C4553765 BXGD023551 Memory Impairment, CTCAE 5.0
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000681 Umbelliferone 162.14
BXGC0002052 Aesculetin 178.14
BXGC0002591 Potassium 39.1
BXGC0004187 D-Malic acid 134.09
BXGC0004269 Propanoic acid 74.08
BXGC0006291 Scopoletin 192.17
BXGC0018397 beta-1,4-mannan 180.06
BXGC0027558 oscillaginin A 614.31
BXGC0028036 Esculin hydrate 340.08
BXGC0030612 tetraethylene glycol 194.12
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein