Showing entry for trans-Cinnamic acid


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0004588
Compound Nametrans-Cinnamic acid
Structure
FormulaC9H8O2
InchiKeyWBYWAXJHAXSJNI-VOTSOKGWSA-N
SMILESOC(=O)\C=C\C1=CC=CC=C1
InchiInChI=1S/C9H8O2/c10-9(11)7-6-8-4-2-1-3-5-8/h1-7H,(H,10,11)/b7-6+
IUPAC(2E)-3-phenylprop-2-enoic acid
Molecular Weight148.16
Pubchem Id444539
Chembl IdCHEMBL27246
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB TCA
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P00780 BXGT005652 Subtilisin Carlsberg reviewed subC - - - - -
Q3IWB0 BXGT014427 Tyrosine ammonia-lyase reviewed hutH - - - - -
O60341 BXGT004873 Lysine-specific histone demethylase 1A reviewed KDM1A Epigenetic regulator - - - -
Q6GZ04 BXGT016319 Phenylalanine aminomutase (L-beta-phenylalanine forming) reviewed pam - - - - -
Q68G84 BXGT016191 Phenylalanine aminomutase (L-beta-phenylalanine forming) reviewed pam - - - - -
A2QHE5 BXGT001087 Ferulic acid decarboxylase 1 reviewed fdc1 - - - - -
Binding DB 16430
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT008083 Aldo-keto reductase family 1 member B1 reviewed Enzyme AKR1B1 280000 - - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 9900000 - -
reviewed BXGT004563 Polyphenol oxidase 2 reviewed PPO2 - 410000 - -
reviewed BXGT004563 Polyphenol oxidase 2 reviewed PPO2 - >350000 - -
reviewed BXGT018812 Hydroxycarboxylic acid receptor 2 reviewed HCAR2 4900 - - -
CHEMBL CHEMBL27246
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P15121 BXGT008083 Aldo-keto reductase family 1 member B1 reviewed Enzyme AKR1B1 IC50 '=' 68 ug.mL-1
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Activity '=' 25 %
P07265 BXGT006583 Alpha-glucosidase MAL62 reviewed - MAL62 Inhibition '=' 4 %
Q64725 BXGT016130 Tyrosine-protein kinase SYK reviewed - Syk Inhibition - - -
Q969S8 BXGT019613 Polyamine deacetylase HDAC10 reviewed Epigenetic regulator HDAC10 Activity '=' 95 %
Q9UKV0 BXGT021750 Histone deacetylase 9 reviewed Epigenetic regulator HDAC9 Activity '=' 95 %
P56524 BXGT011176 Histone deacetylase 4 reviewed Epigenetic regulator HDAC4 Activity '=' 95 %
Q96DB2 BXGT019639 Histone deacetylase 11 reviewed Epigenetic regulator HDAC11 Activity '=' 95 %
Q9BY41 BXGT020180 Histone deacetylase 8 reviewed Epigenetic regulator HDAC8 Activity '=' 95 %
Q8WUI4 BXGT018992 Histone deacetylase 7 reviewed Epigenetic regulator HDAC7 Activity '=' 95 %
Q9UQL6 BXGT021813 Histone deacetylase 5 reviewed Epigenetic regulator HDAC5 Activity '=' 95 %
Q92769 BXGT019370 Histone deacetylase 2 reviewed Epigenetic regulator HDAC2 Activity '=' 95 %
Q9UBN7 BXGT021658 Histone deacetylase 6 reviewed Epigenetic regulator HDAC6 Activity '=' 95 %
O15379 BXGT004159 Histone deacetylase 3 reviewed Epigenetic regulator HDAC3 Activity '=' 95 %
Q13547 BXGT013373 Histone deacetylase 1 reviewed Epigenetic regulator HDAC1 Activity '=' 95 %
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 IC50 '=' 410000 nM
Q75NA5 BXGT016840 Gamma-aminobutyric acid receptor subunit beta reviewed - Rdl Activity '=' 101 %
P47989 BXGT010602 Xanthine dehydrogenase/oxidase reviewed Enzyme XDH IC50 '=' 26 ug.mL-1
P07265 BXGT006583 Alpha-glucosidase MAL62 reviewed - MAL62 IC50 '>' 300000 nM
C3TDZ2 BXGT002450 3-oxoacyl-[acyl-carrier-protein] synthase 3 unreviewed - fabH IC50 '=' 43400 nM
Q8TDS4 BXGT018812 Hydroxycarboxylic acid receptor 2 reviewed - HCAR2 Ki '=' 4900 nM
P18031 BXGT008369 Tyrosine-protein phosphatase non-receptor type 1 reviewed - PTPN1 Inhibition - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Activity '=' 12 %
P47199 BXGT010568 Quinone oxidoreductase reviewed - Cryz CD - - -
P47989 BXGT010602 Xanthine dehydrogenase/oxidase reviewed Enzyme XDH Inhibition '=' 93 %
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP IC50 '>' 100000 nM
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 IC50 '>' 350000 nM
O95271 BXGT005369 Poly [ADP-ribose] polymerase tankyrase-1 reviewed - TNKS IC50 '=' 685 nM
Q9H2K2 BXGT020454 Poly [ADP-ribose] polymerase tankyrase-2 reviewed - TNKS2 IC50 '=' 685 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition - - -
P15121 BXGT008083 Aldo-keto reductase family 1 member B1 reviewed Enzyme AKR1B1 Inhibition '=' 43 %
Q969S8 BXGT019613 Polyamine deacetylase HDAC10 reviewed Epigenetic regulator HDAC10 Ki '=' 8 nM
Q9UKV0 BXGT021750 Histone deacetylase 9 reviewed Epigenetic regulator HDAC9 Ki '=' 8 nM
P56524 BXGT011176 Histone deacetylase 4 reviewed Epigenetic regulator HDAC4 Ki '=' 8 nM
Q96DB2 BXGT019639 Histone deacetylase 11 reviewed Epigenetic regulator HDAC11 Ki '=' 8 nM
Q9BY41 BXGT020180 Histone deacetylase 8 reviewed Epigenetic regulator HDAC8 Ki '=' 8 nM
Q8WUI4 BXGT018992 Histone deacetylase 7 reviewed Epigenetic regulator HDAC7 Ki '=' 8 nM
Q9UQL6 BXGT021813 Histone deacetylase 5 reviewed Epigenetic regulator HDAC5 Ki '=' 8 nM
Q92769 BXGT019370 Histone deacetylase 2 reviewed Epigenetic regulator HDAC2 Ki '=' 8 nM
Q9UBN7 BXGT021658 Histone deacetylase 6 reviewed Epigenetic regulator HDAC6 Ki '=' 8 nM
O15379 BXGT004159 Histone deacetylase 3 reviewed Epigenetic regulator HDAC3 Ki '=' 8 nM
Q13547 BXGT013373 Histone deacetylase 1 reviewed Epigenetic regulator HDAC1 Ki '=' 8 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP IC50 - - -
A0A0C7ACN7 BXGT000141 3-oxoacyl-ACP synthase unreviewed - pqsD Inhibition '=' 33 %
P00784 BXGT005655 Papain reviewed - Inhibition - - -
Q4QEW7 BXGT014876 Dihydroorotate dehydrogenase (fumarate) unreviewed - DHODH IC50 '=' 391600 nM
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 IC50 '=' 209500 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 9900000 nM
Q4QEW7 BXGT014876 Dihydroorotate dehydrogenase (fumarate) unreviewed - DHODH IC50 '=' 398107 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00050 Chinese cinnamon Cinnamomum aromaticum Herbs and Spices
BXGF00051 Ceylon cinnamon Cinnamomum verum Herbs and Spices
BXGF00056 Mandarin orange (Clementine, Tangerine) Citrus reticulata Fruits
BXGF00072 Wild carrot Daucus carota Vegetables
BXGF00082 Fennel Foeniculum vulgare Herbs and Spices
BXGF00086 Sunflower Helianthus annuus Herbs and Spices
BXGF00092 Sweet potato Ipomoea batatas Vegetables
BXGF00111 Cornmint Mentha arvensis Herbs and Spices
BXGF00119 Sweet basil Ocimum basilicum Herbs and Spices
BXGF00141 Common pea Pisum sativum Pulses
BXGF00171 Garden tomato Solanum lycopersicum Vegetables
BXGF00206 Ginger Zingiber officinale Herbs and Spices
BXGF00230 Carrot Daucus carota ssp. sativus Vegetables
BXGF00264 Alfalfa Medicago sativa Herbs and Spices
BXGF00354 Jerusalem artichoke Helianthus tuberosus Vegetables
BXGF00369 Sacred lotus Nelumbo nucifera Vegetables
BXGF00530 Cinnamon Cinnamomum Herbs and Spices
BXGF00805 Mushrooms Vegetables
BXGF00806 Alcoholic beverages Beverages
BXGF00810 Cereals and cereal products Cereals and cereal products
BXGF00823 Fruits Fruits
BXGF00857 Mitracarpus scaber Mitracarpus scaber Others
BXGF00871 Citrus unshiu Citrus unshiu Medicinal Plant
BXGF00902 Liquidambar orientalis Liquidambar orientalis Medicinal Plant
BXGF00997 Bletilla striata Bletilla striata Medicinal Plant
BXGF01109 Styrax benzoin Styrax benzoin Medicinal Plant
BXGF01185 Aloe vera Aloe vera Medicinal Plant
BXGF01423 Sauromatum giganteum Sauromatum giganteum Others
BXGF01487 Styrax tonkinensis Styrax tonkinensis Medicinal Plant
BXGF01550 Callicarpa macrophylla Callicarpa macrophylla Medicinal Plant
BXGF01716 Mentha canadensis Mentha canadensis Medicinal Plant
BXGF01900 Aloe ferox Aloe ferox Medicinal Plant
BXGF01941 Scrophularia nodosa Scrophularia nodosa Medicinal Plant
BXGF01973 Lonicera japonica Lonicera japonica Medicinal Plant
BXGF02167 Scutellaria barbata Scutellaria barbata Medicinal Plant
BXGF02214 Morus bombycis Morus bombycis Medicinal Plant
BXGF02425 Ephedra herba Ephedra herba Others
BXGF02463 Selaginella doederleinii hieron Selaginella doederleinii hieron Others
BXGF02509 Xanthium sibiricum Xanthium sibiricum Medicinal Plant
BXGF02567 Lycium chinense Lycium chinense Medicinal Plant
BXGF02731 Saussurea involucrata Saussurea involucrata Medicinal Plant
BXGF02786 Rubus coreanus Rubus coreanus Human Edible Plant
BXGF02950 Boschniakia rossica Boschniakia rossica Medicinal Plant
BXGF03006 Styrax Styrax Medicinal Plant
BXGF03058 Gymnacranthera paniculata Gymnacranthera paniculata Others
BXGF03158 Rheum officinale Rheum officinale Medicinal Plant
BXGF03189 Rhododendron dauricum Rhododendron dauricum Medicinal Plant
BXGF03234 Plantago major Plantago major Medicinal Plant
BXGF03247 Anastatica hierochuntica Anastatica hierochuntica Medicinal Plant
BXGF03256 Platycodon grandiflorus Platycodon grandiflorus Medicinal Plant
BXGF03257 Anagallis monelli Anagallis monelli Medicinal Plant
BXGF03682 Imperata cylindrica Imperata cylindrica Medicinal Plant
BXGF03689 Jatropha curcas Jatropha curcas Medicinal Plant
BXGF03919 Xanthium strumarium Xanthium strumarium Medicinal Plant
BXGF03988 Rheum coreanum Rheum coreanum Others
BXGF04112 Euphorbia micractina Euphorbia micractina Others
BXGF04209 Chaenomeles sinensis Chaenomeles sinensis Medicinal Plant
BXGF04235 Rubus chingii Rubus chingii Food Plant
BXGF04500 Eliokarmos thyrsoides Eliokarmos thyrsoides Others
BXGF04539 Rheum palmatum Rheum palmatum Medicinal Plant
BXGF04564 Ephedra equisetina Ephedra equisetina Medicinal Plant
BXGF04607 Morus alba Morus alba Medicinal Plant
BXGF04631 Aloe spicata Aloe spicata Medicinal Plant
BXGF04659 Phyllanthus emblica Phyllanthus emblica Medicinal Plant
BXGF04660 Piper sarmentosum Piper sarmentosum Medicinal Plant
BXGF04905 Aloe Aloe Medicinal Plant
BXGF04926 Aloe africana Aloe africana Medicinal Plant
BXGF05005 Cinnamomum cassia Cinnamomum cassia Medicinal Plant
BXGF05120 Rheum maximowiczii Rheum maximowiczii Medicinal Plant
BXGF05160 Chaenomeles speciosa Chaenomeles speciosa Medicinal Plant
BXGF05341 Scrophularia ningpoensis Scrophularia ningpoensis Medicinal Plant
BXGF05444 Aconitum koreanum Aconitum koreanum Medicinal Plant
BXGF05462 Campsis flos Campsis flos Others
BXGF05491 Harpagophytum procumbens Harpagophytum procumbens Medicinal Plant
BXGF05571 Ziziphus jujuba Ziziphus jujuba Medicinal Plant
BXGF05667 Myroxylon pereirae Myroxylon pereirae Others
BXGF05670 Scrophularia buergeriana Scrophularia buergeriana Medicinal Plant
BXGF05705 Pseudostellaria heterophylla Pseudostellaria heterophylla Medicinal Plant
BXGF05790 Glycyrrhiza uralensis Glycyrrhiza uralensis Medicinal Plant
BXGF05877 Rheum tanguticum Rheum tanguticum Medicinal Plant
BXGF05962 Rehmannia glutinosa Rehmannia glutinosa Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease