Showing entry for Hydroxycarboxylic acid receptor 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT018812
Protein NameHydroxycarboxylic acid receptor 2
Uniport IdQ8TDS4
GeneHCAR2
Gene Id338442
Domain7tm_1
Pfam PF00001  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04024 cAMP signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0050995 negative regulation of lipid catabolic process
Biological Process GO:0001781 neutrophil apoptotic process
Biological Process GO:0070165 positive regulation of adiponectin secretion
Biological Process GO:0033031 positive regulation of neutrophil apoptotic process
molecular function GO:0070553 nicotinic acid receptor activity
cellular component GO:0030054 cell junction
cellular component GO:0016021 integral component of membrane
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-3296197 Hydroxycarboxylic acid-binding receptors
R-HSA-372790 Signaling by GPCR
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-418594 G alpha (i) signalling events
R-HSA-500792 GPCR ligand binding
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001430 BXGD000054 Adenoma Neoplasms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0005944 BXGD000355 Metabolic Bone Disorder Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007114 BXGD000431 Malignant neoplasm of skin Neoplasms; Skin and Connective Tissue Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011603 BXGD000734 Dermatitis Skin and Connective Tissue Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011884 BXGD000762 Diabetic Retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0016382 BXGD001054 Flushing Pathological Conditions, Signs and Symptoms
C0017601 BXGD001125 Glaucoma Eye Diseases
C0019187 BXGD001296 Hepatitis, Alcoholic Digestive System Diseases; Chemically-Induced Disorders
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0021670 BXGD001509 insulinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023267 BXGD001626 Fibroid Tumor Neoplasms
C0023896 BXGD001718 Alcoholic Liver Diseases Digestive System Diseases; Chemically-Induced Disorders
C0026269 BXGD001897 Mitral Valve Stenosis Cardiovascular Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030246 BXGD002198 Pustulosis of Palms and Soles Skin and Connective Tissue Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0037286 BXGD002681 Skin Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C0042133 BXGD002960 Uterine Fibroids Neoplasms
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0162871 BXGD003996 Aortic Aneurysm, Abdominal Cardiovascular Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0235272 BXGD004737 Retinal damage Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases; Wounds and Injuries
C0242339 BXGD005150 Dyslipidemias Nutritional and Metabolic Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0345407 BXGD007736 OSTEOPETROSIS, AUTOSOMAL RECESSIVE 3 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases; Male Urogenital Diseases; Nervous System Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0424790 BXGD008543 Rigor - Temperature-associated observation Pathological Conditions, Signs and Symptoms
C0598608 BXGD009668 Hyperhomocysteinemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0751213 BXGD010352 Tactile Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1167791 BXGD011776 Skin toxicity
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1512981 BXGD013196 Mammary Tumorigenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3875321 BXGD019874 Inflammatory dermatosis Skin and Connective Tissue Diseases
C4048158 BXGD021890 Convulsions Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4272578 BXGD022330 Autosomal Recessive Osteopetrosis Musculoskeletal Diseases
C4531013 BXGD023180 Light induced retinopathy
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000506 3,5-Dihydroxybenzoic acid 154.12
BXGC0000622 Nicotinic acid 123.11
BXGC0001857 Caffeic acid 180.16
BXGC0001886 trans-o-Coumaric acid 164.16
BXGC0001887 m-Coumaric acid 164.16
BXGC0001889 p-Coumaric acid 164.16
BXGC0001954 trans-p-Methoxycinnamic acid 178.18
BXGC0004588 trans-Cinnamic acid 148.16
BXGC0004710 3-Hydroxybenzoic acid 138.12
BXGC0006366 trans-Ferulic acid 194.18
BXGC0029784 Fumaric Acid 116.01
BXGC0039819 Crotonic Acid 86.04
BXGC0041433 senecioic acid 100.05
BXGC0043816 Ethyl Fumarate 144.04
BXGC0046878 4-Methylcinnamic acid 162.07
BXGC0047856 (E)-3-(1,3-Benzodioxol-5-Yl)Prop-2-Enoic Acid 192.04
BXGC0051446 pent-2-enoic acid 100.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein