acompound

Showing entry for Histidine

General Compound Information
BXGC Id	BXGC0031608
Compound Name	Histidine
Structure
Formula	C6H9N3O2
InchiKey	HNDVDQJCIGZPNO-YFKPBYRVSA-N
SMILES	N[C@H](C(=O)O)Cc1cnc[nH]1
Inchi	InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1
IUPAC	(2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acid
Molecular Weight	155.07
Pubchem Id	6274
Chembl Id	CHEMBL17962

Targets of Information Source

DrugBank

DB00117

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
P19113	BXGT008458	Histidine decarboxylase	reviewed	-	HDC	investigational; nutraceutical	-
P12081	BXGT007772	Histidine--tRNA ligase, cytoplasmic	reviewed	Enzyme	HARS	investigational; nutraceutical	-
Q99624	BXGT019942	Sodium-coupled neutral amino acid transporter 3	reviewed	Transporter	SLC38A3	investigational; nutraceutical	-
P42357	BXGT010306	Histidine ammonia-lyase	reviewed	-	HAL	investigational; nutraceutical	-

PDB

n.a

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1

Binding DB

7953

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
reviewed	BXGT013665	Glutaminyl-peptide cyclotransferase	reviewed	Enzyme	QPCT	4400000	-	-	-
reviewed	BXGT006812	Cytochrome P450 3A4	reviewed	Enzyme	CYP3A4	-	>10000	-	-

CHEMBL

CHEMBL17962

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	width="10%">Type	Relation	value	Units
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Type	Relation	value	Units
Q91Y77	BXGT019323	Monocarboxylate transporter 10	reviewed	-	Slc16a10	Activity	-	-	-
P22748	BXGT008802	Carbonic anhydrase 4	reviewed	-	CA4	KA	'='	33	uM
P42357	BXGT010306	Histidine ammonia-lyase	reviewed	-	HAL	Km	'='	5200000	nM
P00915	BXGT005689	Carbonic anhydrase 1	reviewed	-	CA1	Ka	'='	0	uM
P07451	BXGT006627	Carbonic anhydrase 3	reviewed	-	CA3	Ka	'='	35	uM
P22748	BXGT008802	Carbonic anhydrase 4	reviewed	-	CA4	Kcat	'='	4	10'6/s
Q99N23	BXGT019994	Carbonic anhydrase 15	reviewed	-	Ca15	KA	'='	32	uM
P00918	BXGT005690	Carbonic anhydrase 2	reviewed	-	CA2	Kcat	'='	4	10'6/s
O43570	BXGT004601	Carbonic anhydrase 12	reviewed	-	CA12	KA	'='	37	uM
P10635	BXGT007595	Cytochrome P450 2D6	reviewed	-	CYP2D6	AC50	-	-	-
P07451	BXGT006627	Carbonic anhydrase 3	reviewed	-	CA3	Kcat	'='	1	10'4/s
P00918	BXGT005690	Carbonic anhydrase 2	reviewed	-	CA2	KA	'='	10	uM
Q16790	BXGT013670	Carbonic anhydrase 9	reviewed	-	CA9	KA	'='	9	uM
Q92830	BXGT019379	Histone acetyltransferase KAT2A	reviewed	-	KAT2A	Potency	-	39810	nM
Q9ULX7	BXGT021769	Carbonic anhydrase 14	reviewed	-	CA14	KA	'='	0	uM
P22748	BXGT008802	Carbonic anhydrase 4	reviewed	-	CA4	Ka	'='	7	uM
P35218	BXGT009796	Carbonic anhydrase 5A, mitochondrial	reviewed	-	CA5A	KA	'='	1	uM
Q50565	BXGT014936	Carbonic anhydrase	unreviewed	-	MTH_1582	Ka	'='	69	uM
P08684	BXGT006812	Cytochrome P450 3A4	reviewed	Enzyme	CYP3A4	Potency	'='	794	nM
P00915	BXGT005689	Carbonic anhydrase 1	reviewed	-	CA1	KA	'='	4	uM
P00918	BXGT005690	Carbonic anhydrase 2	reviewed	-	CA2	KA	'='	113	uM
Q9D6N1	BXGT020260	Carbonic anhydrase 13	reviewed	-	Ca13	KA	'='	0	uM
P42357	BXGT010306	Histidine ammonia-lyase	reviewed	-	HAL	Vmax	'='	25	IU mg-1
P42357	BXGT010306	Histidine ammonia-lyase	reviewed	-	HAL	Vmax	'='	0	IU mg-1
P53615	BXGT011003	Carbonic anhydrase	reviewed	-	NCE103	Ka	'='	82	uM
P19145	BXGT008463	General amino-acid permease GAP1	reviewed	-	GAP1	Activity	-	-	-
Q95323	BXGT019579	Carbonic anhydrase 4	reviewed	-	CA4	KA	'='	39	uM
P00918	BXGT005690	Carbonic anhydrase 2	reviewed	-	CA2	Ka	'='	125	uM
P23280	BXGT008844	Carbonic anhydrase 6	reviewed	-	CA6	Ka	'='	6	uM
P00915	BXGT005689	Carbonic anhydrase 1	reviewed	-	CA1	Kcat	'='	13	10'5/s
Q96KQ7	BXGT019687	Histone-lysine N-methyltransferase EHMT2	reviewed	Epigenetic regulator	EHMT2	Potency	-	5972	nM
P43166	BXGT010364	Carbonic anhydrase 7	reviewed	-	CA7	KA	'='	0	uM
P00915	BXGT005689	Carbonic anhydrase 1	reviewed	-	CA1	Activity	'='	30	nM
P40881	BXGT010205	Carbonic anhydrase	reviewed	-		KA	'='	68	uM
Q96QE3	BXGT019718	ATPase family AAA domain-containing protein 5	reviewed	-	ATAD5	Potency	-	6510	nM
Q5AJ71	BXGT015288	Carbonic anhydrase	reviewed	-	NCE103	KA	'='	24	uM
Q3I4V7	BXGT014421	Carbonic anhydrase	unreviewed	-	CAN2	KA	'='	45	uM
Q9Y2D0	BXGT022229	Carbonic anhydrase 5B, mitochondrial	reviewed	-	CA5B	KA	'='	0	uM
P00918	BXGT005690	Carbonic anhydrase 2	reviewed	-	CA2	Activity	'='	10	uM
P42357	BXGT010306	Histidine ammonia-lyase	reviewed	-	HAL	Km	'='	3100000	nM
P42357	BXGT010306	Histidine ammonia-lyase	reviewed	-	HAL	Km	'='	5300000	nM
P23280	BXGT008844	Carbonic anhydrase 6	reviewed	-	CA6	KA	'='	32	uM
Q6FTL6	BXGT016286	Carbonic anhydrase	unreviewed	-	NCE103	Ka	'='	37	uM
P42357	BXGT010306	Histidine ammonia-lyase	reviewed	-	HAL	Vmax	'='	0	IU mg-1
Q05BR4	BXGT012851	SLC16A10 protein	unreviewed	-	SLC16A10	Activity	-	-	-
P42357	BXGT010306	Histidine ammonia-lyase	reviewed	-	HAL	Km	'='	7500000	nM
P33261	BXGT009707	Cytochrome P450 2C19	reviewed	-	CYP2C19	AC50	-	-	-
P42357	BXGT010306	Histidine ammonia-lyase	reviewed	-	HAL	Vmax	'='	0	IU mg-1
P08684	BXGT006812	Cytochrome P450 3A4	reviewed	Enzyme	CYP3A4	AC50	'='	794	nM
P39748	BXGT010134	Flap endonuclease 1	reviewed	Enzyme	FEN1	Potency	-	8436	nM
P11712	BXGT007738	Cytochrome P450 2C9	reviewed	-	CYP2C9	AC50	-	-	-
P00915	BXGT005689	Carbonic anhydrase 1	reviewed	-	CA1	Ka	'='	2	uM
Q99N23	BXGT019994	Carbonic anhydrase 15	reviewed	-	Ca15	Kcat	'='	8	10'5/s
P08684	BXGT006812	Cytochrome P450 3A4	reviewed	Enzyme	CYP3A4	IC50	'>'	10000	nM
P05177	BXGT006336	Cytochrome P450 1A2	reviewed	Enzyme	CYP1A2	AC50	-	-	-
Q4CVY4	BXGT026093	Carbonic anhydrase-like protein, putative	unreviewed	-	Tc00.1047053509597.20	KA	'='	11	uM
Q01650	BXGT012603	Large neutral amino acids transporter small subunit 1	reviewed	Transporter	SLC7A5	IC50	'='	20000	nM
Q01650	BXGT012603	Large neutral amino acids transporter small subunit 1	reviewed	Transporter	SLC7A5	Inhibition	'='	92	%
Q01650	BXGT012603	Large neutral amino acids transporter small subunit 1	reviewed	Transporter	SLC7A5	Activity	'='	140	%

Foods containing the compound

Foods

BXGF Id	Food Name	Scientific Name	Food Group
BXGF Id	Food Name	Scientific Name	Food Group
BXGF00008	Garlic	Allium sativum	Herbs and Spices
BXGF00027	Chinese mustard	Brassica juncea	Vegetables
BXGF00148	Almond	Prunus dulcis	Nuts
BXGF00186	Fenugreek	Trigonella foenum-graecum	Herbs and Spices
BXGF00337	Ginkgo nuts	Ginkgo biloba	Herbs and Spices
BXGF00380	White mustard	Sinapis alba	Herbs and Spices
BXGF01426	Cornus officinalis	Cornus officinalis	Medicinal Plant
BXGF01848	Pyrus pyraster	Pyrus pyraster	Medicinal Plant
BXGF02054	Shorea uliginosa	Shorea uliginosa	Others
BXGF02094	Astragalus oxyphysus	Astragalus oxyphysus	Others
BXGF02275	Trichosanthes kirilowii maxim	Trichosanthes kirilowii maxim	Others
BXGF02290	Sonchus microcarpus	Sonchus microcarpus	Others
BXGF02330	Codonopsis pilosula	Codonopsis pilosula	Medicinal Plant
BXGF02497	Hydrodictyon reticulatum	Hydrodictyon reticulatum	Human Edible Plant
BXGF02526	Santalum album	Santalum album	Medicinal Plant
BXGF02801	Senecio candollei	Senecio candollei	Others
BXGF02815	Pinellia ternata	Pinellia ternata	Medicinal Plant
BXGF02849	Polyscias scutellaria	Polyscias scutellaria	Medicinal Plant
BXGF02871	Centaurea glastifolia	Centaurea glastifolia	Others
BXGF02902	Grindelia havardii	Grindelia havardii	Others
BXGF02918	Nephelium maingayi	Nephelium maingayi	Human Edible Plant
BXGF02934	Galanthus nivalis	Galanthus nivalis	Medicinal Plant
BXGF02954	Euphorbia armena	Euphorbia armena	Others
BXGF03490	Atractylodes macrocephala koidz	Atractylodes macrocephala koidz	Others
BXGF05178	Lilium hansonii	Lilium hansonii	Medicinal Plant
BXGF05203	Chlamydomonas reinhardtii	Chlamydomonas reinhardtii	Others
BXGF05330	Arum ternatum thunb	Arum ternatum thunb	Others
BXGF06109	Cuscuta reflexa	Cuscuta reflexa	Medicinal Plant
BXGF06113	Plantago depressa	Plantago depressa	Medicinal Plant
BXGF06126	Strychnos diplotricha	Strychnos diplotricha	Medicinal Plant

The compound-realted diseases

Diseases

BXGD Id	Disease Name	CUI Disease Id	Disease Class Name	Number of targets^{?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease}