Showing entry for Histidine ammonia-lyase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010306
Protein NameHistidine ammonia-lyase
Uniport IdP42357
GeneHAL
Gene Id3034
DomainLyase_aromatic; Par3_HAL_N_term
Pfam PF00221   PF12053  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.5 Amino acid metabolism hsa00340 Histidine metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006548 histidine catabolic process
Biological Process GO:0019556 histidine catabolic process to glutamate and formamide
Biological Process GO:0019557 histidine catabolic process to glutamate and formate
molecular function GO:0016841 ammonia-lyase activity
molecular function GO:0004397 histidine ammonia-lyase activity
cellular component GO:0005829 cytosol
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-70921 Histidine catabolism
R-HSA-71291 Metabolism of amino acids and derivatives
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007117 BXGD000433 Basal cell carcinoma Neoplasms
C0007125 BXGD000438 Carcinoma, Ehrlich Tumor Neoplasms
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007789 BXGD000488 Cerebral Palsy Nervous System Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011253 BXGD000706 Delusions Behavior and Behavior Mechanisms
C0018524 BXGD001200 Hallucinations Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0019069 BXGD001277 Hemophilia A Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0019112 BXGD001286 Hemorrhoids Digestive System Diseases; Cardiovascular Diseases
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023493 BXGD001672 Adult T-Cell Lymphoma/Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024591 BXGD001789 Malignant hyperpyrexia due to anesthesia Pathological Conditions, Signs and Symptoms
C0025202 BXGD001832 melanoma Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0037822 BXGD002706 Speech Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038586 BXGD002772 Substance Use Disorders Chemically-Induced Disorders; Mental Disorders
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0184567 BXGD004039 Acute onset pain Pathological Conditions, Signs and Symptoms
C0206624 BXGD004190 Hepatoblastoma Neoplasms
C0206710 BXGD004258 Basal Cell Neoplasm Neoplasms
C0220992 BXGD004355 Histidinemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0268642 BXGD006020 Histidinuria renal tubular defect Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0497156 BXGD009053 Lymphadenopathy Hemic and Lymphatic Diseases
C0520679 BXGD009101 Sleep Apnea, Obstructive Respiratory Tract Diseases; Nervous System Diseases
C0523979 BXGD009227 Vitamin D3 measurement
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0684275 BXGD009792 Hemophilia, NOS Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0699893 BXGD009871 Skin carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0751606 BXGD010523 Adult Acute Lymphocytic Leukemia
C0751676 BXGD010549 Basal Cell Cancer Neoplasms
C0871189 BXGD011312 Psychotic symptom
C0919758 BXGD011440 Vitamin D measurement
C1269955 BXGD012005 Tumor Cell Invasion
C1291163 BXGD012203 Increased histidine
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C2237142 BXGD016960 Moderate global developmental delay
C3811653 BXGD019662 Experimental Organism Basal Cell Carcinoma Neoplasms
C4025790 BXGD021791 Specific learning disability
C4048329 BXGD021904 Immunosuppression
C4721806 BXGD023772 Carcinoma, Basal Cell Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0031608 Histidine 155.07
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein