protein

Showing entry for Histidine--tRNA ligase, cytoplasmic

General Target Information
BXGT Id	BXGT007772
Protein Name	Histidine--tRNA ligase, cytoplasmic
Uniport Id	P12081
Gene	HARS1
Gene Id	3035
Domain	HGTP_anticodon; tRNA-synt_His; WHEP-TRS
Pfam	PF03129 PF13393 PF00458
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
2. Genetic Information Processing	2.2 Translation	hsa00970	Aminoacyl-tRNA biosynthesis

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0006427	histidyl-tRNA aminoacylation
Biological Process	GO:0032543	mitochondrial translation
Biological Process	GO:0006412	translation
Biological Process	GO:0006418	tRNA aminoacylation for protein translation
molecular function	GO:0005524	ATP binding
molecular function	GO:0004821	histidine-tRNA ligase activity
molecular function	GO:0042802	identical protein binding
molecular function	GO:0042803	protein homodimerization activity
cellular component	GO:0005737	cytoplasm
cellular component	GO:0005829	cytosol
cellular component	GO:0005739	mitochondrion

Reactome

Pathway Id	Pathway Name
R-HSA-379716	Cytosolic tRNA aminoacylation
R-HSA-379724	tRNA Aminoacylation
R-HSA-392499	Metabolism of proteins
R-HSA-72766	Translation

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0001973	BXGD000095	Alcoholic Intoxication, Chronic	Chemically-Induced Disorders; Mental Disorders
C0002395	BXGD000111	Alzheimer's Disease	Nervous System Diseases; Mental Disorders
C0003431	BXGD000190	Antisocial Personality Disorder	Mental Disorders
C0003467	BXGD000194	Anxiety	Behavior and Behavior Mechanisms
C0003811	BXGD000222	Cardiac Arrhythmia	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003873	BXGD000236	Rheumatoid Arthritis	Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004106	BXGD000254	Astigmatism	Eye Diseases
C0004134	BXGD000256	Ataxia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004238	BXGD000262	Atrial Fibrillation	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004364	BXGD000270	Autoimmune Diseases	Immune System Diseases
C0004936	BXGD000295	Mental disorders	Mental Disorders
C0006142	BXGD000374	Malignant neoplasm of breast	Neoplasms; Skin and Connective Tissue Diseases
C0006826	BXGD000408	Malignant Neoplasms	Neoplasms
C0007134	BXGD000443	Renal Cell Carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007959	BXGD000507	Charcot-Marie-Tooth Disease	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0009241	BXGD000595	Cognition Disorders	Mental Disorders
C0011265	BXGD000708	Presenile dementia	Nervous System Diseases; Mental Disorders
C0011570	BXGD000729	Mental Depression	Behavior and Behavior Mechanisms
C0011581	BXGD000733	Depressive disorder	Mental Disorders
C0011849	BXGD000751	Diabetes Mellitus	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854	BXGD000753	Diabetes Mellitus, Insulin-Dependent	Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860	BXGD000755	Diabetes Mellitus, Non-Insulin-Dependent	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0015397	BXGD000983	Disorder of eye	Eye Diseases
C0018524	BXGD001200	Hallucinations	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0018784	BXGD001220	Sensorineural Hearing Loss (disorder)	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018979	BXGD001260	Hemianopsia	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0019196	BXGD001301	Hepatitis C	Digestive System Diseases; Infections
C0019212	BXGD001306	Hepatorenal Syndrome	Digestive System Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0019829	BXGD001350	Hodgkin Disease	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0022660	BXGD001571	Kidney Failure, Acute	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022672	BXGD001574	Acute Kidney Tubular Necrosis	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023890	BXGD001713	Liver Cirrhosis	Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023895	BXGD001717	Liver diseases	Digestive System Diseases
C0024115	BXGD001732	Lung diseases	Respiratory Tract Diseases
C0026650	BXGD001913	Movement Disorders	Nervous System Diseases
C0026827	BXGD001936	Muscle hypotonia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026848	BXGD001941	Myopathy	Musculoskeletal Diseases; Nervous System Diseases
C0027121	BXGD001973	Myositis	Musculoskeletal Diseases; Nervous System Diseases
C0027651	BXGD002009	Neoplasms	Neoplasms
C0027765	BXGD002033	nervous system disorder	Nervous System Diseases
C0027809	BXGD002040	Neurilemmoma	Neoplasms
C0027832	BXGD002048	Neurofibromatosis 2	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0028077	BXGD002069	Nyctalopia	Eye Diseases
C0029408	BXGD002137	Degenerative polyarthritis	Musculoskeletal Diseases
C0030193	BXGD002191	Pain	Pathological Conditions, Signs and Symptoms
C0031117	BXGD002285	Peripheral Neuropathy	Nervous System Diseases
C0035436	BXGD002550	Rheumatic Fever	Infections; Musculoskeletal Diseases
C0036341	BXGD002600	Schizophrenia	Mental Disorders
C0036454	BXGD002616	Scotoma	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0039273	BXGD002806	Talipes cavus	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0085636	BXGD003218	Photophobia	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0085655	BXGD003226	Polymyositis	Musculoskeletal Diseases; Nervous System Diseases
C0086543	BXGD003294	Cataract	Eye Diseases
C0154920	BXGD003755	Pigmentary iris degeneration	Eye Diseases; Skin and Connective Tissue Diseases
C0206062	BXGD004148	Lung Diseases, Interstitial	Respiratory Tract Diseases
C0220597	BXGD004292	Adult Hodgkin Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0220644	BXGD004306	Childhood Hodgkin Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0239831	BXGD004999	Hand muscle weakness	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0242966	BXGD005201	Systemic Inflammatory Response Syndrome	Pathological Conditions, Signs and Symptoms
C0270549	BXGD006079	Generalized Anxiety Disorder	Mental Disorders
C0270922	BXGD006134	Peripheral demyelinating neuropathy	Immune System Diseases; Nervous System Diseases
C0271097	BXGD006163	Usher Syndrome	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C0271385	BXGD006193	Horizontal Nystagmus	Eye Diseases; Nervous System Diseases
C0279702	BXGD006685	Conventional (Clear Cell) Renal Cell Carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0338656	BXGD007211	Impaired cognition	Mental Disorders
C0338908	BXGD007218	Mixed anxiety and depressive disorder	Mental Disorders
C0344315	BXGD007666	Depressed mood	Behavior and Behavior Mechanisms
C0376358	BXGD007992	Malignant neoplasm of prostate	Neoplasms; Male Urogenital Diseases
C0427149	BXGD008608	Gait, Drop Foot	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0427190	BXGD008611	Ataxia, Truncal	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0476397	BXGD008991	Electroretinogram abnormal
C0497169	BXGD009054	hiv-infection/aids	Infections
C0497327	BXGD009061	Dementia	Nervous System Diseases; Mental Disorders
C0554970	BXGD009428	Pallor of optic disc
C0558845	BXGD009459	Reflex, Ankle, Absent	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0678222	BXGD009749	Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases
C0685838	BXGD009820	Gonadal dysgenesis XX type deafness	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Nervous System Diseases; Endocrine System Diseases; Otorhinolaryngologic Diseases
C0699790	BXGD009866	Colon Carcinoma	Digestive System Diseases; Neoplasms
C0730285	BXGD009943	Diabetic macular edema	Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0740279	BXGD009973	Cerebellar atrophy
C0743073	BXGD010074	depression anxiety disorder
C0751356	BXGD010406	Idiopathic Inflammatory Myopathies	Musculoskeletal Diseases; Nervous System Diseases
C0878544	BXGD011368	Cardiomyopathies	Cardiovascular Diseases
C0919267	BXGD011426	ovarian neoplasm	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1136179	BXGD011712	Hammer Toe	Musculoskeletal Diseases
C1140680	BXGD011718	Malignant neoplasm of ovary	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1141890	BXGD011721	Congenital long QT syndrome	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1142166	BXGD011736	Brugada Syndrome (disorder)	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1263857	BXGD011900	Peripheral axonal neuropathy	Nervous System Diseases
C1266042	BXGD011938	Chromophobe Renal Cell Carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1266043	BXGD011939	Sarcomatoid Renal Cell Carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1266044	BXGD011940	Collecting Duct Carcinoma of the Kidney	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1269955	BXGD012005	Tumor Cell Invasion
C1306837	BXGD012377	Papillary Renal Cell Carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1318485	BXGD012394	Liver regeneration disorder	Digestive System Diseases
C1333064	BXGD012587	Classical Hodgkin's Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1384666	BXGD012948	hearing impairment	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1565489	BXGD013401	Renal Insufficiency	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1568248	BXGD013419	Usher Syndrome, Type III	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C1704436	BXGD013564	Peripheral Arterial Diseases	Cardiovascular Diseases
C1833144	BXGD013898	Slender long bone
C1836450	BXGD014117	Distal lower limb muscle weakness
C1837522	BXGD014244	Impaired pain sensation
C1837658	BXGD014257	Gross motor development delay	Mental Disorders
C1843570	BXGD014595	Tip-toe gait
C1847584	BXGD014876	Distal sensory impairment	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1848606	BXGD014950	Vestibular hypofunction
C1849134	BXGD015010	Impaired vibration sensation in the lower limbs
C1855925	BXGD015561	Hyperopia, High	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1861403	BXGD016045	Variable expressivity
C1864716	BXGD016245	Intrinsic hand muscle atrophy
C1955603	BXGD016603	Deaf-Blind Disorders	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C2347747	BXGD017040	Adult Classical Hodgkin Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2607914	BXGD017148	Allergic rhinitis (disorder)	Respiratory Tract Diseases; Immune System Diseases; Otorhinolaryngologic Diseases
C2609059	BXGD017162	Antisynthetase syndrome	Musculoskeletal Diseases; Nervous System Diseases
C2673700	BXGD017223	Brisk reflexes	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2749625	BXGD017629	Motor axonal neuropathy
C3150620	BXGD018314	Distal upper limb muscle weakness
C3281066	BXGD018879	USHER SYNDROME, TYPE IIIB
C3665346	BXGD019278	Unspecified visual loss	Pathological Conditions, Signs and Symptoms; Eye Diseases
C3665347	BXGD019279	Visual Impairment	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3665386	BXGD019284	Abnormal vision	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C4021583	BXGD020685	Impaired distal tactile sensation
C4025858	BXGD021832	Abnormal cochlea morphology
C4225265	BXGD022199	CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2W
C4721453	BXGD023744	Peripheral Nervous System Diseases	Nervous System Diseases
C4721610	BXGD023760	Carcinoma, Ovarian Epithelial	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0000436	Glycerol		92.09
BXGC0003705	Chloride		35.45
BXGC0031608	Histidine		155.07

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}