Showing entry for Phorbol Myristate Acetate


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0048159
Compound NamePhorbol Myristate Acetate
Structure
FormulaC36H56O8
InchiKeyPHEDXBVPIONUQT-RGYGYFBISA-N
SMILESCCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)[C@H]([C@H]3[C@]1(OC(=O)C)C3(C)C)C=C(C[C@]1([C@H]2C=C(C1=O)C)O)CO
InchiInChI=1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34-,35-,36-/m1/s1
IUPAC
Molecular Weight616.4
Pubchem Id27924
Chembl IdCHEMBL279115
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
CHEMBL CHEMBL279115
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA Activity '=' 100 %
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA Activity '=' 85 %
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA Activity '=' 62 %
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency '=' 63095 nM
Q05655 BXGT012832 Protein kinase C delta type reviewed Kinase PRKCD EC50 '=' 5170 nM
Q04759 BXGT012781 Protein kinase C theta type reviewed Kinase PRKCQ EC50 '=' 3190 nM
Q8IV61 BXGT018340 Ras guanyl-releasing protein 3 reviewed Enzyme modulator RASGRP3 Activity - - -
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 19952 nM
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA Ki '=' 6 nM
Q04759 BXGT012781 Protein kinase C theta type reviewed Kinase PRKCQ Activity '=' 899 pM min-1 (mg of protein)-1
Q15139 BXGT013546 Serine/threonine-protein kinase D1 reviewed Kinase PRKD1 Activity '=' 899 pM min-1 (mg of protein)-1
P24723 BXGT008989 Protein kinase C eta type reviewed Kinase PRKCH Activity '=' 899 pM min-1 (mg of protein)-1
Q02156 BXGT012639 Protein kinase C epsilon type reviewed Kinase PRKCE Activity '=' 899 pM min-1 (mg of protein)-1
Q05513 BXGT012820 Protein kinase C zeta type reviewed Kinase PRKCZ Activity '=' 899 pM min-1 (mg of protein)-1
P05771 BXGT006384 Protein kinase C beta type reviewed Kinase PRKCB Activity '=' 899 pM min-1 (mg of protein)-1
Q05655 BXGT012832 Protein kinase C delta type reviewed Kinase PRKCD Activity '=' 899 pM min-1 (mg of protein)-1
P05129 BXGT006322 Protein kinase C gamma type reviewed Kinase PRKCG Activity '=' 899 pM min-1 (mg of protein)-1
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA Activity '=' 899 pM min-1 (mg of protein)-1
P41743 BXGT010270 Protein kinase C iota type reviewed Kinase PRKCI Activity '=' 899 pM min-1 (mg of protein)-1
O94806 BXGT005335 Serine/threonine-protein kinase D3 reviewed Kinase PRKD3 Activity '=' 899 pM min-1 (mg of protein)-1
O95267 BXGT005368 RAS guanyl-releasing protein 1 reviewed Enzyme modulator RASGRP1 Activity - - -
Q13951 BXGT013407 Core-binding factor subunit beta reviewed - CBFB Potency - 3162 nM
Q01196 BXGT012575 Runt-related transcription factor 1 reviewed Transcription factor RUNX1 Potency - 3162 nM
P05771 BXGT006384 Protein kinase C beta type reviewed Kinase PRKCB Ki '=' 1 nM
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA Activity '=' 11 %
Q02156 BXGT012639 Protein kinase C epsilon type reviewed Kinase PRKCE Ki '=' 0 nM
P05129 BXGT006322 Protein kinase C gamma type reviewed Kinase PRKCG Ki '=' 4 nM
Q02156 BXGT012639 Protein kinase C epsilon type reviewed Kinase PRKCE EC50 '=' 5560 nM
Q05655 BXGT012832 Protein kinase C delta type reviewed Kinase PRKCD Ki '=' 0 nM
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA Activity '=' 108 %
P05771 BXGT006384 Protein kinase C beta type reviewed Kinase PRKCB Activity - - -
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' 19 %
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA Activity '=' 0 %
Q02156 BXGT012639 Protein kinase C epsilon type reviewed Kinase PRKCE Activity - - -
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA Ki '=' 2 nM
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA Activity - - -
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 10000 nM
P11021 BXGT007644 Endoplasmic reticulum chaperone BiP reviewed - HSPA5 Potency - 10000 nM
Q04759 BXGT012781 Protein kinase C theta type reviewed Kinase PRKCQ Activity - - -
Q15139 BXGT013546 Serine/threonine-protein kinase D1 reviewed Kinase PRKD1 Activity - - -
P24723 BXGT008989 Protein kinase C eta type reviewed Kinase PRKCH Activity - - -
Q02156 BXGT012639 Protein kinase C epsilon type reviewed Kinase PRKCE Activity - - -
Q05513 BXGT012820 Protein kinase C zeta type reviewed Kinase PRKCZ Activity - - -
P05771 BXGT006384 Protein kinase C beta type reviewed Kinase PRKCB Activity - - -
Q05655 BXGT012832 Protein kinase C delta type reviewed Kinase PRKCD Activity - - -
P05129 BXGT006322 Protein kinase C gamma type reviewed Kinase PRKCG Activity - - -
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA Activity - - -
P41743 BXGT010270 Protein kinase C iota type reviewed Kinase PRKCI Activity - - -
O94806 BXGT005335 Serine/threonine-protein kinase D3 reviewed Kinase PRKD3 Activity - - -
Q04759 BXGT012781 Protein kinase C theta type reviewed Kinase PRKCQ EC50 '=' 9 nM
Q15139 BXGT013546 Serine/threonine-protein kinase D1 reviewed Kinase PRKD1 EC50 '=' 9 nM
P24723 BXGT008989 Protein kinase C eta type reviewed Kinase PRKCH EC50 '=' 9 nM
Q02156 BXGT012639 Protein kinase C epsilon type reviewed Kinase PRKCE EC50 '=' 9 nM
Q05513 BXGT012820 Protein kinase C zeta type reviewed Kinase PRKCZ EC50 '=' 9 nM
P05771 BXGT006384 Protein kinase C beta type reviewed Kinase PRKCB EC50 '=' 9 nM
Q05655 BXGT012832 Protein kinase C delta type reviewed Kinase PRKCD EC50 '=' 9 nM
P05129 BXGT006322 Protein kinase C gamma type reviewed Kinase PRKCG EC50 '=' 9 nM
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA EC50 '=' 9 nM
P41743 BXGT010270 Protein kinase C iota type reviewed Kinase PRKCI EC50 '=' 9 nM
O94806 BXGT005335 Serine/threonine-protein kinase D3 reviewed Kinase PRKD3 EC50 '=' 9 nM
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA Activity '=' 80 %
Q05655 BXGT012832 Protein kinase C delta type reviewed Kinase PRKCD Activity - - -
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA EC50 '=' 1700000 nM
Q04759 BXGT012781 Protein kinase C theta type reviewed Kinase PRKCQ Activity - - -
P81908 BXGT011959 Cholinesterase reviewed - BCHE Inhibition '=' -6 %
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 39810 nM
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 891 nM
Q05655 BXGT012832 Protein kinase C delta type reviewed Kinase PRKCD EC50 '=' 290 nM
Q8IV61 BXGT018340 Ras guanyl-releasing protein 3 reviewed Enzyme modulator RASGRP3 EC50 '=' 82 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF02356 Elsholtzia bodinieri Elsholtzia bodinieri Medicinal Plant
BXGF02883 Trigonostemon howii Trigonostemon howii Others
BXGF03163 Wisteria brachybotrys Wisteria brachybotrys Human Edible Plant
BXGF04209 Chaenomeles sinensis Chaenomeles sinensis Medicinal Plant
BXGF04915 Croton tiglium Croton tiglium Medicinal Plant
BXGF05504 Silybum marianum Silybum marianum Medicinal Plant
BXGF05796 Tylophora ovata Tylophora ovata Medicinal Plant
BXGF06086 Euphorbia wallichii Euphorbia wallichii Others
BXGF06323 Euphorbia turczaninowii Euphorbia turczaninowii Others
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease