Showing entry for RAS guanyl-releasing protein 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005368
Protein NameRAS guanyl-releasing protein 1
Uniport IdO95267
GeneRASGRP1
Gene Id10125
DomainC1_1; RasGEF; RasGEF_N
Pfam PF00130   PF00617   PF00618  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04014 Ras signaling pathway
5. Organismal Systems 5.1 Immune system hsa04611 Platelet activation
5. Organismal Systems 5.1 Immune system hsa04660 T cell receptor signaling pathway
6. Human Diseases 6.1 Cancers: Overview hsa05200 Pathways in cancer
6. Human Diseases 6.1 Cancers: Overview hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0090630 activation of GTPase activity
Biological Process GO:0042113 B cell activation
Biological Process GO:0042100 B cell proliferation
Biological Process GO:0030154 cell differentiation
Biological Process GO:0001816 cytokine production
Biological Process GO:0002437 inflammatory response to antigenic stimulus
Biological Process GO:0000165 MAPK cascade
Biological Process GO:0043303 mast cell degranulation
Biological Process GO:0030101 natural killer cell activation
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production
Biological Process GO:0043547 positive regulation of GTPase activity
Biological Process GO:0032729 positive regulation of interferon-gamma production
Biological Process GO:0046330 positive regulation of JNK cascade
Biological Process GO:0043406 positive regulation of MAP kinase activity
Biological Process GO:0032825 positive regulation of natural killer cell differentiation
Biological Process GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
Biological Process GO:0001934 positive regulation of protein phosphorylation
Biological Process GO:0046579 positive regulation of Ras protein signal transduction
Biological Process GO:0033089 positive regulation of T cell differentiation in thymus
Biological Process GO:0032760 positive regulation of tumor necrosis factor production
Biological Process GO:0007265 Ras protein signal transduction
Biological Process GO:0070372 regulation of ERK1 and ERK2 cascade
Biological Process GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
Biological Process GO:0032252 secretory granule localization
Biological Process GO:0007165 signal transduction
Biological Process GO:0042110 T cell activation
Biological Process GO:0042098 T cell proliferation
Biological Process GO:0047496 vesicle transport along microtubule
molecular function GO:0005509 calcium ion binding
molecular function GO:0019992 diacylglycerol binding
molecular function GO:0005085 guanyl-nucleotide exchange factor activity
molecular function GO:0042802 identical protein binding
molecular function GO:0008289 lipid binding
molecular function GO:0031210 phosphatidylcholine binding
molecular function GO:0005088 Ras guanyl-nucleotide exchange factor activity
molecular function GO:0008270 zinc ion binding
cellular component GO:0005829 cytosol
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0005794 Golgi apparatus
cellular component GO:0000139 Golgi membrane
cellular component GO:0042629 mast cell granule
cellular component GO:0016020 membrane
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-109582 Hemostasis
R-HSA-114508 Effects of PIP2 hydrolysis
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR)
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR)
R-HSA-1169092 Activation of RAS in B cells
R-HSA-1169092 Activation of RAS in B cells
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1280218 Adaptive Immune System
R-HSA-1280218 Adaptive Immune System
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168256 Immune System
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-354192 Integrin signaling
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-392517 Rap1 signalling
R-HSA-416476 G alpha (q) signalling events
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5683057 MAPK family signaling cascades
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-76009 Platelet Aggregation (Plug Formation)
R-HSA-9607240 FLT3 Signaling
R-HSA-983705 Signaling by the B Cell Receptor (BCR)
R-HSA-983705 Signaling by the B Cell Receptor (BCR)
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002880 BXGD000139 Autoimmune hemolytic anemia Immune System Diseases; Hemic and Lymphatic Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0005818 BXGD000338 Blood Platelet Disorders Hemic and Lymphatic Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006413 BXGD000397 Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0014457 BXGD000915 Eosinophilia Hemic and Lymphatic Diseases
C0014522 BXGD000922 Epidermodysplasia Verruciformis Infections; Skin and Connective Tissue Diseases
C0017152 BXGD001096 Gastritis Digestive System Diseases
C0017658 BXGD001138 Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0017661 BXGD001139 IGA Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C0018681 BXGD001214 Headache Pathological Conditions, Signs and Symptoms
C0019158 BXGD001293 Hepatitis Digestive System Diseases
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0019829 BXGD001350 Hodgkin Disease Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0020305 BXGD001374 Hydrops Fetalis Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Immune System Diseases; Hemic and Lymphatic Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020532 BXGD001420 Hypersplenism Hemic and Lymphatic Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023492 BXGD001671 Leukemia, T-Cell Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024312 BXGD001766 Lymphopenia Immune System Diseases; Hemic and Lymphatic Diseases
C0024314 BXGD001767 Lymphoproliferative Disorders Immune System Diseases; Hemic and Lymphatic Diseases
C0024894 BXGD001810 Mastitis Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C0025322 BXGD001863 Premature Menopause Female Urogenital Diseases and Pregnancy Complications
C0026010 BXGD001886 Microphthalmos Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0026998 BXGD001959 Acute Myeloid Leukemia, M1 Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0030326 BXGD002209 Panniculitis Skin and Connective Tissue Diseases
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0038002 BXGD002723 Splenomegaly Pathological Conditions, Signs and Symptoms
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0040147 BXGD002847 Thyroiditis Endocrine System Diseases
C0040411 BXGD002859 Tongue Neoplasms Neoplasms; Stomatognathic Diseases
C0042109 BXGD002957 Urticaria Skin and Connective Tissue Diseases; Immune System Diseases
C0042164 BXGD002965 Uveitis Eye Diseases
C0042384 BXGD002979 Vasculitis Cardiovascular Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079772 BXGD003099 T-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0149678 BXGD003346 Epstein-Barr Virus Infections Infections
C0151379 BXGD003416 Rheumatoid factor positive (finding)
C0151468 BXGD003424 Thyroid Gland Follicular Adenoma Neoplasms; Endocrine System Diseases
C0151480 BXGD003426 Anti-nuclear factor positive Skin and Connective Tissue Diseases
C0178421 BXGD004026 Fibroadenoma of breast Neoplasms; Skin and Connective Tissue Diseases
C0206160 BXGD004166 Reticulocytosis Pathological Conditions, Signs and Symptoms
C0220597 BXGD004292 Adult Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0220644 BXGD004306 Childhood Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0235896 BXGD004785 Pulmonary Infiltrate Respiratory Tract Diseases
C0242172 BXGD005138 Pelvic Inflammatory Disease Female Urogenital Diseases and Pregnancy Complications; Infections
C0242380 BXGD005158 Libman-Sacks Disease Skin and Connective Tissue Diseases; Immune System Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0269102 BXGD006053 Endometrioma Female Urogenital Diseases and Pregnancy Complications
C0398650 BXGD008212 Immune thrombocytopenic purpura Pathological Conditions, Signs and Symptoms; Immune System Diseases; Hemic and Lymphatic Diseases
C0423798 BXGD008510 Increased tendency to bruise Wounds and Injuries
C0494261 BXGD009023 Combined immunodeficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0520736 BXGD009105 Coombs positive hemolytic anemia Hemic and Lymphatic Diseases
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0677607 BXGD009721 Hashimoto Disease Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1328840 BXGD012474 Autoimmune Lymphoproliferative Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1565489 BXGD013401 Renal Insufficiency Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1839304 BXGD014365 Decreased proportion of CD4-positive T cells Immune System Diseases; Hemic and Lymphatic Diseases
C1855710 BXGD015534 Bone marrow hypocellularity
C1858970 BXGD015835 Chronic noninfectious lymphadenopathy Hemic and Lymphatic Diseases
C1858972 BXGD015836 Increased B cell count Hemic and Lymphatic Diseases
C1858973 BXGD015837 Elevated proportion of CD4-negative, CD8-negative, alpha-beta regulatory T cells
C1858981 BXGD015839 Antineutrophil antibody positivity
C1860320 BXGD015977 Bone marrow hypercellularity
C1879321 BXGD016572 Acute Myeloid Leukemia (AML-M2) Neoplasms
C1961099 BXGD016672 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2937365 BXGD018161 Recurrent aphthous ulcer Stomatognathic Diseases
C3150797 BXGD018337 AUTOIMMUNE DISEASE, SUSCEPTIBILITY TO, 6
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C4014795 BXGD020166 AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1
C4019436 BXGD020467 Antiphospholipid antibody positivity
C4021032 BXGD020528 Abnormal vitamin B12 level
C4021747 BXGD020753 Specific anti-polysaccharide antibody deficiency
C4280772 BXGD022403 Abnormal serum interleukin level
C4310768 BXGD022658 AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 2
C4531155 BXGD023197 Abnormal proportion of CD8 T cells
C4531156 BXGD023198 Abnormal proportion of CD4 T cells
C4721806 BXGD023772 Carcinoma, Basal Cell Neoplasms
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C4743661 BXGD023935 Leukocyte Adhesion Deficiency Type 3
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0006198 Citric acid 192.12
BXGC0048159 Phorbol Myristate Acetate 616.4
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein