Showing entry for Protein kinase C eta type


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008989
Protein NameProtein kinase C eta type
Uniport IdP24723
GenePRKCH
Gene Id5583
DomainC1_1; C2; Pkinase; Pkinase_C
Pfam PF00130   PF00168   PF00069   PF00433  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.3 Circulatory system hsa04270 Vascular smooth muscle contraction
5. Organismal Systems 5.7 Sensory system hsa04750 Inflammatory mediator regulation of TRP channels
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0034351 negative regulation of glial cell apoptotic process
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:0030168 platelet activation
Biological Process GO:0050861 positive regulation of B cell receptor signaling pathway
Biological Process GO:0060252 positive regulation of glial cell proliferation
Biological Process GO:0045618 positive regulation of keratinocyte differentiation
Biological Process GO:0010744 positive regulation of macrophage derived foam cell differentiation
Biological Process GO:0051092 positive regulation of NF-kappaB transcription factor activity
Biological Process GO:1903078 positive regulation of protein localization to plasma membrane
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:2000810 regulation of bicellular tight junction assembly
Biological Process GO:0007165 signal transduction
molecular function GO:0005524 ATP binding
molecular function GO:0004698 calcium-dependent protein kinase C activity
molecular function GO:0019899 enzyme binding
molecular function GO:0046872 metal ion binding
molecular function GO:0004697 protein kinase C activity
molecular function GO:0004674 protein serine/threonine kinase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-114508 Effects of PIP2 hydrolysis
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-372790 Signaling by GPCR
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-388396 GPCR downstream signalling
R-HSA-416476 G alpha (q) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-76002 Platelet activation, signaling and aggregation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0013146 BXGD000801 Drug abuse Chemically-Induced Disorders; Mental Disorders
C0013170 BXGD000802 Drug habituation Chemically-Induced Disorders; Mental Disorders
C0013222 BXGD000805 Drug Use Disorders Chemically-Induced Disorders; Mental Disorders
C0017154 BXGD001097 Gastritis, Atrophic Digestive System Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029231 BXGD002125 Organic Mental Disorders, Substance-Induced Chemically-Induced Disorders; Mental Disorders
C0035227 BXGD002514 Respiratory Function Tests
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0038580 BXGD002771 Substance Dependence Chemically-Induced Disorders; Mental Disorders
C0038586 BXGD002772 Substance Use Disorders Chemically-Induced Disorders; Mental Disorders
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0236969 BXGD004842 Substance-Related Disorders Chemically-Induced Disorders; Mental Disorders
C0280141 BXGD006716 Acute Undifferentiated Leukemia
C0333559 BXGD006960 Infarction, Lacunar Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0410702 BXGD008447 Adolescent idiopathic scoliosis Musculoskeletal Diseases
C0522631 BXGD009205 Acute myeloid leukemia, minimal differentiation Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0740858 BXGD010012 Substance abuse problem Chemically-Induced Disorders; Mental Disorders
C0751010 BXGD010289 Cerebral Infarction, Left Hemisphere Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0751011 BXGD010290 Cerebral Infarction, Right Hemisphere Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0751012 BXGD010291 Anterior Choroidal Artery Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0751014 BXGD010292 Subcortical Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0751955 BXGD010652 Brain Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0887799 BXGD011396 Posterior Choroidal Artery Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1319315 BXGD012415 Adenocarcinoma of large intestine Digestive System Diseases; Neoplasms
C1378511 BXGD012932 Undifferentiated leukemia
C1445957 BXGD013081 Serum total cholesterol measurement
C1510472 BXGD013170 Drug Dependence Chemically-Induced Disorders; Mental Disorders
C1837461 BXGD014234 SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
C1861172 BXGD016016 Venous Thromboembolism Cardiovascular Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C4016929 BXGD020391 CEREBRAL INFARCTION, SUSCEPTIBILITY TO
C4275242 BXGD022371 Sudden sensorineural hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C4316881 BXGD022709 Prescription Drug Abuse Chemically-Induced Disorders; Mental Disorders
C4551472 BXGD023303 Hypertrophic obstructive cardiomyopathy Cardiovascular Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000063 Galloyl glucose 332.26
BXGC0001545 Harmine 212.25
BXGC0002029 Taxifolin 304.25
BXGC0003403 Phasin 523.73
BXGC0003772 Corilagin 634.45
BXGC0003789 1,6-di-O-Galloylglucose 484.37
BXGC0004115 Norharman 168.19
BXGC0008707 Isoliquiritigenin 256.25
BXGC0009230 Proanthocyanidin B2 3,3'-digallate 882.73
BXGC0009557 Procyanidin C1 866.78
BXGC0011627 Glycyrrhetic acid 470.69
BXGC0012352 Chelerythrine 348.12
BXGC0012913 Pentagalloyl Glucose 940.12
BXGC0013881 Cucurbitacin I 514.29
BXGC0014303 n.a 344.07
BXGC0015010 Chebulagic Acid 954.1
BXGC0018192 vescalagin 934.07
BXGC0019625 Prostratin 390.2
BXGC0022307 Phorbol 12,13-Dibutyrate 504.27
BXGC0029271 Cucurbitacin E 556.3
BXGC0031878 3-O-Galloylshikimic Acid 326.06
BXGC0033667 n.a 648.1
BXGC0034873 n.a 802.09
BXGC0042191 vescalagin 934.07
BXGC0042352 procyanidin A2 576.13
BXGC0043221 1-O,4-O,6-O-Trigalloyl-alpha-D-glucopyranose 636.1
BXGC0043892 E181 1120.09
BXGC0044194 Punicafolin 938.1
BXGC0044244 1,2,6-Tri-O-Galloyl-Beta-D-Glucose 636.1
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047024 Aplysiatoxin 670.24
BXGC0047692 Gefitinib 446.15
BXGC0048159 Phorbol Myristate Acetate 616.4
BXGC0048578 Rediocide A 794.39
BXGC0048581 Debromoaplysiatoxin 592.32
BXGC0050483 Hamamelitannin 484.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein