Showing entry for Serine/threonine-protein kinase D1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013546
Protein NameSerine/threonine-protein kinase D1
Uniport IdQ15139
GenePRKD1
Gene Id5587
DomainC1_1; PH; Pkinase
Pfam PF00130   PF00169   PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04015 Rap1 signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04925 Aldosterone synthesis and secretion
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0001525 angiogenesis
Biological Process GO:0006915 apoptotic process
Biological Process GO:0034198 cellular response to amino acid starvation
Biological Process GO:0071447 cellular response to hydroperoxide
Biological Process GO:0034599 cellular response to oxidative stress
Biological Process GO:0035924 cellular response to vascular endothelial growth factor stimulus
Biological Process GO:0007030 Golgi organization
Biological Process GO:0048193 Golgi vesicle transport
Biological Process GO:0006954 inflammatory response
Biological Process GO:0045087 innate immune response
Biological Process GO:0007229 integrin-mediated signaling pathway
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0060548 negative regulation of cell death
Biological Process GO:0045806 negative regulation of endocytosis
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:0018107 peptidyl-threonine phosphorylation
Biological Process GO:0045766 positive regulation of angiogenesis
Biological Process GO:0010508 positive regulation of autophagy
Biological Process GO:0043536 positive regulation of blood vessel endothelial cell migration
Biological Process GO:0032793 positive regulation of CREB transcription factor activity
Biological Process GO:2001028 positive regulation of endothelial cell chemotaxis
Biological Process GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
Biological Process GO:0010595 positive regulation of endothelial cell migration
Biological Process GO:0001938 positive regulation of endothelial cell proliferation
Biological Process GO:1901727 positive regulation of histone deacetylase activity
Biological Process GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
Biological Process GO:0010976 positive regulation of neuron projection development
Biological Process GO:0051092 positive regulation of NF-kappaB transcription factor activity
Biological Process GO:0045669 positive regulation of osteoblast differentiation
Biological Process GO:0033138 positive regulation of peptidyl-serine phosphorylation
Biological Process GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0089700 protein kinase D signaling
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0007265 Ras protein signal transduction
Biological Process GO:2001044 regulation of integrin-mediated signaling pathway
Biological Process GO:0010837 regulation of keratinocyte proliferation
Biological Process GO:0031647 regulation of protein stability
Biological Process GO:0007165 signal transduction
Biological Process GO:0030148 sphingolipid biosynthetic process
Biological Process GO:0048010 vascular endothelial growth factor receptor signaling pathway
molecular function GO:0005524 ATP binding
molecular function GO:0004698 calcium-dependent protein kinase C activity
molecular function GO:0042802 identical protein binding
molecular function GO:0016301 kinase activity
molecular function GO:0046872 metal ion binding
molecular function GO:0004697 protein kinase C activity
molecular function GO:0004674 protein serine/threonine kinase activity
cellular component GO:0000421 autophagosome membrane
cellular component GO:0005829 cytosol
cellular component GO:0005794 Golgi apparatus
cellular component GO:0005886 plasma membrane
cellular component GO:0005802 trans-Golgi network
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1660661 Sphingolipid de novo biosynthesis
R-HSA-428157 Sphingolipid metabolism
R-HSA-556833 Metabolism of lipids
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0001339 BXGD000041 Acute pancreatitis Digestive System Diseases
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0002170 BXGD000105 Alopecia Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005893 BXGD000346 Body mass index procedure
C0005910 BXGD000349 Body Weight Pathological Conditions, Signs and Symptoms
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007095 BXGD000423 Carcinoid Tumor Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007107 BXGD000428 Malignant neoplasm of larynx Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0007124 BXGD000437 Noninfiltrating Intraductal Carcinoma Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0009676 BXGD000619 Confusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0009714 BXGD000624 Hepatic Fibrosis, Congenital Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0010051 BXGD000646 Coronary Aneurysm Cardiovascular Diseases
C0010606 BXGD000677 Adenoid Cystic Carcinoma Neoplasms
C0010709 BXGD000689 Cyst Pathological Conditions, Signs and Symptoms; Neoplasms
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013384 BXGD000826 Dyskinetic syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0018378 BXGD001190 Guillain-Barre Syndrome Immune System Diseases; Nervous System Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019348 BXGD001325 Herpes Simplex Infections Infections; Skin and Connective Tissue Diseases
C0020258 BXGD001371 Hydrocephalus, Normal Pressure Nervous System Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021704 BXGD001510 Intelligence Behavior and Behavior Mechanisms
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022679 BXGD001575 Cystic kidney Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022680 BXGD001576 Polycystic Kidney Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026277 BXGD001899 Mixed Salivary Gland Tumor Neoplasms
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030305 BXGD002206 Pancreatitis Digestive System Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0036095 BXGD002576 Salivary Gland Neoplasms Neoplasms; Stomatognathic Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0039075 BXGD002788 Syndactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0041207 BXGD002898 Truncus Arteriosus, Persistent Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0041341 BXGD002918 Tuberous Sclerosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0085413 BXGD003171 Polycystic Kidney, Autosomal Dominant Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0085548 BXGD003183 Autosomal Recessive Polycystic Kidney Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0151908 BXGD003502 Dry skin Skin and Connective Tissue Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0158683 BXGD003899 Polycystic liver disease Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Neoplasms
C0175754 BXGD004015 Agenesis of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0200635 BXGD004041 Lymphocyte Count measurement
C0205641 BXGD004093 Adenocarcinoma, Basal Cell Neoplasms
C0205642 BXGD004094 Adenocarcinoma, Oxyphilic Neoplasms
C0205643 BXGD004095 Carcinoma, Cribriform Neoplasms
C0205644 BXGD004096 Carcinoma, Granular Cell Neoplasms
C0205645 BXGD004097 Adenocarcinoma, Tubular Neoplasms
C0220636 BXGD004304 Malignant neoplasm of salivary gland Neoplasms; Stomatognathic Diseases
C0232466 BXGD004543 Feeding difficulties
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0240340 BXGD005031 Microdontia (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0264423 BXGD005389 Asthma, Occupational Respiratory Tract Diseases; Immune System Diseases; Occupational Diseases
C0266052 BXGD005614 Precocious exfoliation of primary tooth Stomatognathic Diseases
C0268800 BXGD006041 Simple renal cyst Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0278883 BXGD006614 Metastatic melanoma Neoplasms
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0282160 BXGD006797 Aplasia Cutis Congenita Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0311245 BXGD006869 Congenital cystic kidney disease Pathological Conditions, Signs and Symptoms; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0334054 BXGD006984 cystic disease
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0423757 BXGD008504 Thin skin
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0426891 BXGD008595 Broad thumbs
C0427086 BXGD008605 Involuntary Movements Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0454644 BXGD008850 Delayed speech and language development Behavior and Behavior Mechanisms
C0455829 BXGD008859 Waist Circumference
C0497156 BXGD009053 Lymphadenopathy Hemic and Lymphatic Diseases
C0521158 BXGD009130 Recurrent tumor
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0549622 BXGD009392 Sexual Dysfunction Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Mental Disorders; Behavior and Behavior Mechanisms
C0557874 BXGD009444 Global developmental delay
C0562350 BXGD009476 Hip circumference
C0578022 BXGD009541 Finding of body mass index
C0585265 BXGD009590 Hypoglossal Nerve Palsy Nervous System Diseases
C0595989 BXGD009632 Carcinoma of larynx Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0740391 BXGD009987 Middle Cerebral Artery Occlusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0751815 BXGD010597 Carotid Artery, Internal, Dissection Nervous System Diseases; Cardiovascular Diseases; Wounds and Injuries
C0853879 BXGD010982 Invasive carcinoma of breast Neoplasms; Skin and Connective Tissue Diseases
C0871470 BXGD011316 Systolic Pressure
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1134719 BXGD011688 Invasive Ductal Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1266086 BXGD011952 Polymorphous low grade adenocarcinoma
C1269955 BXGD012005 Tumor Cell Invasion
C1305855 BXGD012348 Body mass index
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1314691 BXGD012388 Age at menarche Behavior and Behavior Mechanisms
C1334768 BXGD012735 Minor Salivary Gland Adenocarcinoma
C1335302 BXGD012775 Pancreatic Ductal Adenocarcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1335907 BXGD012813 Polymorphous low grade adenocarcinoma of salivary gland Neoplasms; Stomatognathic Diseases
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1519670 BXGD013241 Tumor Angiogenesis Pathological Conditions, Signs and Symptoms
C1567435 BXGD013413 Polycystic Kidney - body part Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1608408 BXGD013434 Malignant transformation
C1611743 BXGD013456 Familial (FPAH)
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1691228 BXGD013492 Cystic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1739135 BXGD013733 Progression of prostate cancer
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1836542 BXGD014129 Depressed nasal bridge
C1837260 BXGD014214 Prominent forehead
C1844813 BXGD014679 Widely spaced teeth
C1854113 BXGD015382 Prominent nasal bridge
C1855496 BXGD015502 Contiguous gene syndrome
C1856963 BXGD015662 Fragile nails Pathological Conditions, Signs and Symptoms
C1857042 BXGD015669 Sparse scalp hair
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1868682 BXGD016525 Paroxysmal kinesigenic choreoathetosis Nervous System Diseases
C1963094 BXGD016681 Dry Skin, CTCAE
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2020625 BXGD016882 Group B Streptococcal Infection Infections
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2316787 BXGD017029 Chronic kidney disease stage 3 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2316810 BXGD017030 Chronic kidney disease stage 5 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2317473 BXGD017034 Chronic kidney disease stage 4 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2936719 BXGD018130 Mechanical Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3149841 BXGD018287 POLYCYSTIC KIDNEY DISEASE 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3714744 BXGD019426 Psychosexual dysfunction Mental Disorders
C3887499 BXGD019884 Renal cyst Pathological Conditions, Signs and Symptoms; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C4048158 BXGD021890 Convulsions Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4083008 BXGD022100 Guillain-Barre Syndrome, Familial Immune System Diseases; Nervous System Diseases
C4277690 BXGD022377 Ciliopathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C4479250 BXGD022929 CONGENITAL HEART DEFECTS AND ECTODERMAL DYSPLASIA
C4552000 BXGD023473 Episodic Kinesigenic Dyskinesia 1 Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
C4721579 BXGD023759 Secondary malignant neoplasm of colon and/or rectum Digestive System Diseases; Neoplasms
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000063 Galloyl glucose 332.26
BXGC0000655 Harmalol 200.24
BXGC0001544 Harmaline 214.26
BXGC0001545 Harmine 212.25
BXGC0002029 Taxifolin 304.25
BXGC0003403 Phasin 523.73
BXGC0003772 Corilagin 634.45
BXGC0003789 1,6-di-O-Galloylglucose 484.37
BXGC0004115 Norharman 168.19
BXGC0007014 Harman 182.22
BXGC0008707 Isoliquiritigenin 256.25
BXGC0009230 Proanthocyanidin B2 3,3'-digallate 882.73
BXGC0009557 Procyanidin C1 866.78
BXGC0012352 Chelerythrine 348.12
BXGC0012913 Pentagalloyl Glucose 940.12
BXGC0013881 Cucurbitacin I 514.29
BXGC0014303 n.a 344.07
BXGC0015010 Chebulagic Acid 954.1
BXGC0018192 vescalagin 934.07
BXGC0019625 Prostratin 390.2
BXGC0024554 D-luciferin 280
BXGC0029271 Cucurbitacin E 556.3
BXGC0031878 3-O-Galloylshikimic Acid 326.06
BXGC0033667 n.a 648.1
BXGC0034256 Rottlerin 516.18
BXGC0034873 n.a 802.09
BXGC0042191 vescalagin 934.07
BXGC0042352 procyanidin A2 576.13
BXGC0043221 1-O,4-O,6-O-Trigalloyl-alpha-D-glucopyranose 636.1
BXGC0043892 E181 1120.09
BXGC0044194 Punicafolin 938.1
BXGC0044244 1,2,6-Tri-O-Galloyl-Beta-D-Glucose 636.1
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
BXGC0048159 Phorbol Myristate Acetate 616.4
BXGC0048578 Rediocide A 794.39
BXGC0050483 Hamamelitannin 484.09
BXGC0051873 Sl-0101 516.13
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein