Showing entry for Protein kinase C zeta type


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT012820
Protein NameProtein kinase C zeta type
Uniport IdQ05513
GenePRKCZ
Gene Id5590
DomainC1_1; PB1; Pkinase; Pkinase_C
Pfam PF00130   PF00564   PF00069   PF00433  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04015 Rap1 signaling pathway
5. Organismal Systems 5.1 Immune system hsa04062 Chemokine signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04071 Sphingolipid signaling pathway
4. Cellular Processes 4.1 Transport and catabolism hsa04144 Endocytosis
5. Organismal Systems 5.8 Development hsa04360 Axon guidance
3. Environmental Information Processing 3.2 Signal transduction hsa04390 Hippo signaling pathway
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04530 Tight junction
5. Organismal Systems 5.1 Immune system hsa04611 Platelet activation
5. Organismal Systems 5.2 Endocrine system hsa04910 Insulin signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04926 Relaxin signaling pathway
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04930 Type II diabetes mellitus
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04931 Insulin resistance
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04933 AGE-RAGE signaling pathway in diabetic complications
6. Human Diseases 6.9 Infectious diseases: Viral hsa05165 Human papillomavirus infection
6. Human Diseases 6.6 Cardiovascular diseases hsa05418 Fluid shear stress and atherosclerosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0031584 activation of phospholipase D activity
Biological Process GO:0032148 activation of protein kinase B activity
Biological Process GO:0016477 cell migration
Biological Process GO:0032869 cellular response to insulin stimulus
Biological Process GO:0030010 establishment of cell polarity
Biological Process GO:0006954 inflammatory response
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0007616 long-term memory
Biological Process GO:0060291 long-term synaptic potentiation
Biological Process GO:0051899 membrane depolarization
Biological Process GO:0060081 membrane hyperpolarization
Biological Process GO:0000226 microtubule cytoskeleton organization
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0051346 negative regulation of hydrolase activity
Biological Process GO:0046627 negative regulation of insulin receptor signaling pathway
Biological Process GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
Biological Process GO:0031333 negative regulation of protein-containing complex assembly
Biological Process GO:1990138 neuron projection extension
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:0001954 positive regulation of cell-matrix adhesion
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:2000463 positive regulation of excitatory postsynaptic potential
Biological Process GO:0046628 positive regulation of insulin receptor signaling pathway
Biological Process GO:0032733 positive regulation of interleukin-10 production
Biological Process GO:0032736 positive regulation of interleukin-13 production
Biological Process GO:0032753 positive regulation of interleukin-4 production
Biological Process GO:0032754 positive regulation of interleukin-5 production
Biological Process GO:0051092 positive regulation of NF-kappaB transcription factor activity
Biological Process GO:0051222 positive regulation of protein transport
Biological Process GO:2000553 positive regulation of T-helper 2 cell cytokine production
Biological Process GO:0045630 positive regulation of T-helper 2 cell differentiation
Biological Process GO:0070528 protein kinase C signaling
Biological Process GO:0072659 protein localization to plasma membrane
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0007165 signal transduction
Biological Process GO:0007179 transforming growth factor beta receptor signaling pathway
Biological Process GO:0047496 vesicle transport along microtubule
molecular function GO:0071889 14-3-3 protein binding
molecular function GO:0005524 ATP binding
molecular function GO:0004698 calcium-dependent protein kinase C activity
molecular function GO:0043560 insulin receptor substrate binding
molecular function GO:0046872 metal ion binding
molecular function GO:0043274 phospholipase binding
molecular function GO:0015459 potassium channel regulator activity
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0004672 protein kinase activity
molecular function GO:0019901 protein kinase binding
molecular function GO:0004674 protein serine/threonine kinase activity
cellular component GO:0045179 apical cortex
cellular component GO:0016324 apical plasma membrane
cellular component GO:0043203 axon hillock
cellular component GO:0005923 bicellular tight junction
cellular component GO:0005911 cell-cell junction
cellular component GO:0030054 cell junction
cellular component GO:0031252 cell leading edge
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005768 endosome
cellular component GO:0070062 extracellular exosome
cellular component GO:0016020 membrane
cellular component GO:0045121 membrane raft
cellular component GO:0005815 microtubule organizing center
cellular component GO:0035748 myelin sheath abaxonal region
cellular component GO:0005635 nuclear envelope
cellular component GO:0016363 nuclear matrix
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0005886 plasma membrane
cellular component GO:0014069 postsynaptic density
cellular component GO:0001725 stress fiber
cellular component GO:0031982 vesicle
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-114604 GPVI-mediated activation cascade
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-170834 Signaling by TGF-beta Receptor Complex
R-HSA-170834 Signaling by TGF-beta Receptor Complex
R-HSA-194138 Signaling by VEGF
R-HSA-194315 Signaling by Rho GTPases
R-HSA-195258 RHO GTPase Effectors
R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-5218921 VEGFR2 mediated cell proliferation
R-HSA-5668599 RHO GTPases Activate NADPH Oxidases
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-8939211 ESR-mediated signaling
R-HSA-8939211 ESR-mediated signaling
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9006936 Signaling by TGFB family members
R-HSA-9006936 Signaling by TGFB family members
R-HSA-9009391 Extra-nuclear estrogen signaling
R-HSA-9009391 Extra-nuclear estrogen signaling
R-HSA-9634635 Estrogen-stimulated signaling through PRKCZ
R-HSA-9634635 Estrogen-stimulated signaling through PRKCZ
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001430 BXGD000054 Adenoma Neoplasms
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011884 BXGD000762 Diabetic Retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0013371 BXGD000823 Shigella Infections Digestive System Diseases; Infections
C0014836 BXGD000954 Escherichia coli Infections Infections
C0017636 BXGD001131 Glioblastoma Neoplasms
C0018800 BXGD001225 Cardiomegaly Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0020429 BXGD001378 Hyperalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0020557 BXGD001432 Hypertriglyceridemia Nutritional and Metabolic Diseases
C0021841 BXGD001519 Intestinal Neoplasms Digestive System Diseases; Neoplasms
C0023418 BXGD001642 leukemia Neoplasms
C0023798 BXGD001702 Lipoma Neoplasms
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024232 BXGD001751 Lymphatic Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0026499 BXGD001905 Monosomy Pathological Conditions, Signs and Symptoms
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0030297 BXGD002204 Pancreatic Neoplasm Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0149721 BXGD003349 Left Ventricular Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0154251 BXGD003710 Lipid Metabolism Disorders Nutritional and Metabolic Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0271650 BXGD006227 Impaired glucose tolerance Nutritional and Metabolic Diseases
C0278601 BXGD006547 Inflammatory Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0279565 BXGD006638 Invasive Lobular Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0279628 BXGD006659 Adenocarcinoma Of Esophagus Digestive System Diseases; Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0333516 BXGD006957 Tumor necrosis Pathological Conditions, Signs and Symptoms
C0346627 BXGD007830 Intestinal Cancer Digestive System Diseases; Neoplasms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0458247 BXGD008904 Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0489786 BXGD009018 Height
C0525045 BXGD009255 Mood Disorders Mental Disorders
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0684328 BXGD009795 Reasoning
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0751211 BXGD010350 Hyperalgesia, Primary Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751212 BXGD010351 Hyperalgesia, Secondary Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751213 BXGD010352 Tactile Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751214 BXGD010353 Hyperalgesia, Thermal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751606 BXGD010523 Adult Acute Lymphocytic Leukemia
C0853879 BXGD010982 Invasive carcinoma of breast Neoplasms; Skin and Connective Tissue Diseases
C1134719 BXGD011688 Invasive Ductal Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1176475 BXGD011798 Ductal Carcinoma Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1292753 BXGD012226 Primary Effusion Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1319315 BXGD012415 Adenocarcinoma of large intestine Digestive System Diseases; Neoplasms
C1383860 BXGD012935 Cardiac Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1527349 BXGD013277 Ductal Breast Carcinoma Neoplasms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1839839 BXGD014416 MAJOR AFFECTIVE DISORDER 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Mental Disorders
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2826323 BXGD017790 Refractory Cytopenia of Childhood
C2936719 BXGD018130 Mechanical Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3828416 BXGD019740 Radiation Damage Wounds and Injuries
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000063 Galloyl glucose 332.26
BXGC0000655 Harmalol 200.24
BXGC0001544 Harmaline 214.26
BXGC0001545 Harmine 212.25
BXGC0002029 Taxifolin 304.25
BXGC0003403 Phasin 523.73
BXGC0003772 Corilagin 634.45
BXGC0003789 1,6-di-O-Galloylglucose 484.37
BXGC0004115 Norharman 168.19
BXGC0007014 Harman 182.22
BXGC0008707 Isoliquiritigenin 256.25
BXGC0009230 Proanthocyanidin B2 3,3'-digallate 882.73
BXGC0009557 Procyanidin C1 866.78
BXGC0012352 Chelerythrine 348.12
BXGC0012913 Pentagalloyl Glucose 940.12
BXGC0013881 Cucurbitacin I 514.29
BXGC0014303 n.a 344.07
BXGC0014883 Clausine E 241.07
BXGC0015010 Chebulagic Acid 954.1
BXGC0018192 vescalagin 934.07
BXGC0019625 Prostratin 390.2
BXGC0024554 D-luciferin 280
BXGC0029271 Cucurbitacin E 556.3
BXGC0031878 3-O-Galloylshikimic Acid 326.06
BXGC0033667 n.a 648.1
BXGC0034256 Rottlerin 516.18
BXGC0034873 n.a 802.09
BXGC0042191 vescalagin 934.07
BXGC0042352 procyanidin A2 576.13
BXGC0043221 1-O,4-O,6-O-Trigalloyl-alpha-D-glucopyranose 636.1
BXGC0043892 E181 1120.09
BXGC0044194 Punicafolin 938.1
BXGC0044244 1,2,6-Tri-O-Galloyl-Beta-D-Glucose 636.1
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
BXGC0048159 Phorbol Myristate Acetate 616.4
BXGC0048578 Rediocide A 794.39
BXGC0050099 (2E,5S,6S,8Z,11S)-5,6,15-Trihydroxy-17-Methoxy-11-Methyl-12-Oxabicyclo[12.4.0]Octadeca-1(14),2,8,15,17-Pentaene-7,13-Dione 362.14
BXGC0050483 Hamamelitannin 484.09
BXGC0051873 Sl-0101 516.13
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein