Showing entry for Protein kinase C theta type


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT012781
Protein NameProtein kinase C theta type
Uniport IdQ04759
GenePRKCQ
Gene Id5588
DomainC1_1; Pkinase; Pkinase_C
Pfam PF00130   PF00069   PF00433  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04064 NF-kappa B signaling pathway
4. Cellular Processes 4.1 Transport and catabolism hsa04140 Autophagy - animal
5. Organismal Systems 5.3 Circulatory system hsa04270 Vascular smooth muscle contraction
5. Organismal Systems 5.1 Immune system hsa04658 Th1 and Th2 cell differentiation
5. Organismal Systems 5.1 Immune system hsa04659 Th17 cell differentiation
5. Organismal Systems 5.1 Immune system hsa04660 T cell receptor signaling pathway
5. Organismal Systems 5.7 Sensory system hsa04750 Inflammatory mediator regulation of TRP channels
5. Organismal Systems 5.2 Endocrine system hsa04920 Adipocytokine signaling pathway
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04931 Insulin resistance
6. Human Diseases 6.1 Cancers: Overview hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007411 axon guidance
Biological Process GO:0060326 cell chemotaxis
Biological Process GO:0038095 Fc-epsilon receptor signaling pathway
Biological Process GO:0006954 inflammatory response
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0006509 membrane protein ectodomain proteolysis
Biological Process GO:0046627 negative regulation of insulin receptor signaling pathway
Biological Process GO:0070233 negative regulation of T cell apoptotic process
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:0030168 platelet activation
Biological Process GO:0032740 positive regulation of interleukin-17 production
Biological Process GO:0032743 positive regulation of interleukin-2 production
Biological Process GO:0032753 positive regulation of interleukin-4 production
Biological Process GO:0051092 positive regulation of NF-kappaB transcription factor activity
Biological Process GO:0050870 positive regulation of T cell activation
Biological Process GO:0042102 positive regulation of T cell proliferation
Biological Process GO:0051973 positive regulation of telomerase activity
Biological Process GO:1904355 positive regulation of telomere capping
Biological Process GO:0032212 positive regulation of telomere maintenance via telomerase
Biological Process GO:2000318 positive regulation of T-helper 17 type immune response
Biological Process GO:2000570 positive regulation of T-helper 2 cell activation
Biological Process GO:0001558 regulation of cell growth
Biological Process GO:0045652 regulation of megakaryocyte differentiation
Biological Process GO:0090330 regulation of platelet aggregation
Biological Process GO:0006355 regulation of transcription, DNA-templated
Biological Process GO:0050852 T cell receptor signaling pathway
molecular function GO:0005524 ATP binding
molecular function GO:0004698 calcium-dependent protein kinase C activity
molecular function GO:0046872 metal ion binding
molecular function GO:0004672 protein kinase activity
molecular function GO:0004674 protein serine/threonine kinase activity
cellular component GO:0016235 aggresome
cellular component GO:0034451 centriolar satellite
cellular component GO:0005829 cytosol
cellular component GO:0001772 immunological synapse
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-109581 Apoptosis
R-HSA-109582 Hemostasis
R-HSA-111465 Apoptotic cleavage of cellular proteins
R-HSA-114508 Effects of PIP2 hydrolysis
R-HSA-1266738 Developmental Biology
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1280218 Adaptive Immune System
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-168249 Innate Immune System
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168256 Immune System
R-HSA-202403 TCR signaling
R-HSA-202424 Downstream TCR signaling
R-HSA-212436 Generic Transcription Pathway
R-HSA-2187338 Visual phototransduction
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2514856 The phototransduction cascade
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-372790 Signaling by GPCR
R-HSA-372790 Signaling by GPCR
R-HSA-373752 Netrin-1 signaling
R-HSA-388396 GPCR downstream signalling
R-HSA-388396 GPCR downstream signalling
R-HSA-416476 G alpha (q) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-422475 Axon guidance
R-HSA-5357801 Programmed Cell Death
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5683057 MAPK family signaling cascades
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-75153 Apoptotic execution phase
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-8878171 Transcriptional regulation by RUNX1
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-HSA-9607240 FLT3 Signaling
R-HSA-9648002 RAS processing
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004943 BXGD000297 Behcet Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Skin and Connective Tissue Diseases; Stomatognathic Diseases; Cardiovascular Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007112 BXGD000429 Adenocarcinoma of prostate Neoplasms; Male Urogenital Diseases
C0007115 BXGD000432 Malignant neoplasm of thyroid Neoplasms; Endocrine System Diseases
C0007570 BXGD000467 Celiac Disease Digestive System Diseases; Nutritional and Metabolic Diseases
C0008313 BXGD000528 Cholangitis, Sclerosing Digestive System Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0013264 BXGD000808 Muscular Dystrophy, Duchenne Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0018133 BXGD001176 Graft-vs-Host Disease Immune System Diseases
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0021655 BXGD001508 Insulin Resistance Nutritional and Metabolic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0035305 BXGD002529 Retinal Detachment Eye Diseases
C0038013 BXGD002725 Ankylosing spondylitis Musculoskeletal Diseases
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0079772 BXGD003099 T-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079773 BXGD003100 Lymphoma, T-Cell, Cutaneous Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0205734 BXGD004115 Diabetes, Autoimmune Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0220994 BXGD004357 Hyperammonemia Pathological Conditions, Signs and Symptoms
C0238198 BXGD004893 Gastrointestinal Stromal Tumors Digestive System Diseases; Neoplasms
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0264408 BXGD005387 Childhood asthma Respiratory Tract Diseases; Immune System Diseases
C0268398 BXGD005933 Familial lichen amyloidosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0339546 BXGD007268 Retinal Pigment Epithelial Detachment Eye Diseases
C0342302 BXGD007458 Brittle diabetes Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0376407 BXGD007996 Granulomatous Slack Skin Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0428474 BXGD008631 Serum LDL cholesterol measurement
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0678202 BXGD009747 Regional enteritis Digestive System Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1319315 BXGD012415 Adenocarcinoma of large intestine Digestive System Diseases; Neoplasms
C1445957 BXGD013081 Serum total cholesterol measurement
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1840264 BXGD014439 IMMUNE SUPPRESSION
C1961099 BXGD016672 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2699541 BXGD017461 Cytokine Measurement
C3495559 BXGD018994 Juvenile arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3714514 BXGD019409 Infection Infections
C3837958 BXGD019756 Diabetes Mellitus, Ketosis-Prone Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C4048329 BXGD021904 Immunosuppression
C4554117 BXGD023561 Diabetes Mellitus, Sudden-Onset Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000063 Galloyl glucose 332.26
BXGC0001545 Harmine 212.25
BXGC0002029 Taxifolin 304.25
BXGC0003403 Phasin 523.73
BXGC0003772 Corilagin 634.45
BXGC0003789 1,6-di-O-Galloylglucose 484.37
BXGC0004115 Norharman 168.19
BXGC0004580 Carbanilide 212.25
BXGC0005980 Isoxanthohumol 354.4
BXGC0008707 Isoliquiritigenin 256.25
BXGC0008873 Xanthohumol 354.4
BXGC0009230 Proanthocyanidin B2 3,3'-digallate 882.73
BXGC0009557 Procyanidin C1 866.78
BXGC0012352 Chelerythrine 348.12
BXGC0012913 Pentagalloyl Glucose 940.12
BXGC0013109 4-[2-(3,5-Dihydroxyphenyl)Ethenyl]Benzene-1,2-Diol 244.07
BXGC0013582 Curcumin 368.13
BXGC0013881 Cucurbitacin I 514.29
BXGC0014303 n.a 344.07
BXGC0015010 Chebulagic Acid 954.1
BXGC0018192 vescalagin 934.07
BXGC0019625 Prostratin 390.2
BXGC0022307 Phorbol 12,13-Dibutyrate 504.27
BXGC0024810 curcumin 368.13
BXGC0029271 Cucurbitacin E 556.3
BXGC0031878 3-O-Galloylshikimic Acid 326.06
BXGC0033667 n.a 648.1
BXGC0034873 n.a 802.09
BXGC0037687 (4S)-2-methylpentane-2,4-diol 118.1
BXGC0042191 vescalagin 934.07
BXGC0042352 procyanidin A2 576.13
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0043221 1-O,4-O,6-O-Trigalloyl-alpha-D-glucopyranose 636.1
BXGC0043892 E181 1120.09
BXGC0044194 Punicafolin 938.1
BXGC0044244 1,2,6-Tri-O-Galloyl-Beta-D-Glucose 636.1
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047024 Aplysiatoxin 670.24
BXGC0047692 Gefitinib 446.15
BXGC0048159 Phorbol Myristate Acetate 616.4
BXGC0048578 Rediocide A 794.39
BXGC0048581 Debromoaplysiatoxin 592.32
BXGC0050483 Hamamelitannin 484.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein