Showing entry for Core-binding factor subunit beta


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013407
Protein NameCore-binding factor subunit beta
Uniport IdQ13951
GeneCBFB
Gene Id865
DomainCBF_beta
Pfam PF02312  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0048469 cell maturation
Biological Process GO:0060216 definitive hemopoiesis
Biological Process GO:0030098 lymphocyte differentiation
Biological Process GO:0030099 myeloid cell differentiation
Biological Process GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0001649 osteoblast differentiation
Biological Process GO:0043378 positive regulation of CD8-positive, alpha-beta T cell differentiation
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0000209 protein polyubiquitination
Biological Process GO:0050855 regulation of B cell receptor signaling pathway
Biological Process GO:2000810 regulation of bicellular tight junction assembly
Biological Process GO:0001959 regulation of cytokine-mediated signaling pathway
Biological Process GO:1902036 regulation of hematopoietic stem cell differentiation
Biological Process GO:0033146 regulation of intracellular estrogen receptor signaling pathway
Biological Process GO:0045616 regulation of keratinocyte differentiation
Biological Process GO:0045652 regulation of megakaryocyte differentiation
Biological Process GO:0045637 regulation of myeloid cell differentiation
Biological Process GO:0045589 regulation of regulatory T cell differentiation
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0030111 regulation of Wnt signaling pathway
Biological Process GO:0006366 transcription by RNA polymerase II
Biological Process GO:0006367 transcription initiation from RNA polymerase II promoter
molecular function GO:0003677 DNA binding
molecular function GO:0043565 sequence-specific DNA binding
molecular function GO:0003713 transcription coactivator activity
molecular function GO:0003712 transcription coregulator activity
cellular component GO:0016513 core-binding factor complex
cellular component GO:0016020 membrane
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-162582 Signal Transduction
R-HSA-212436 Generic Transcription Pathway
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-74160 Gene expression (Transcription)
R-HSA-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
R-HSA-8878159 Transcriptional regulation by RUNX3
R-HSA-8878159 Transcriptional regulation by RUNX3
R-HSA-8878166 Transcriptional regulation by RUNX2
R-HSA-8878166 Transcriptional regulation by RUNX2
R-HSA-8878171 Transcriptional regulation by RUNX1
R-HSA-8878171 Transcriptional regulation by RUNX1
R-HSA-8931987 RUNX1 regulates estrogen receptor mediated transcription
R-HSA-8934593 Regulation of RUNX1 Expression and Activity
R-HSA-8935964 RUNX1 regulates expression of components of tight junctions
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-HSA-8939211 ESR-mediated signaling
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
R-HSA-8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-HSA-8939245 RUNX1 regulates transcription of genes involved in BCR signaling
R-HSA-8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
R-HSA-8939247 RUNX1 regulates transcription of genes involved in interleukin signaling
R-HSA-8939256 RUNX1 regulates transcription of genes involved in WNT signaling
R-HSA-8939902 Regulation of RUNX2 expression and activity
R-HSA-8939902 Regulation of RUNX2 expression and activity
R-HSA-8940973 RUNX2 regulates osteoblast differentiation
R-HSA-8940973 RUNX2 regulates osteoblast differentiation
R-HSA-8941284 RUNX2 regulates chondrocyte maturation
R-HSA-8941326 RUNX2 regulates bone development
R-HSA-8941326 RUNX2 regulates bone development
R-HSA-8941332 RUNX2 regulates genes involved in cell migration
R-HSA-8941332 RUNX2 regulates genes involved in cell migration
R-HSA-8941333 RUNX2 regulates genes involved in differentiation of myeloid cells
R-HSA-8941858 Regulation of RUNX3 expression and activity
R-HSA-8949275 RUNX3 Regulates Immune Response and Cell Migration
R-HSA-8949275 RUNX3 Regulates Immune Response and Cell Migration
R-HSA-8951911 RUNX3 regulates RUNX1-mediated transcription
R-HSA-8951936 RUNX3 regulates p14-ARF
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-9018519 Estrogen-dependent gene expression
R-HSA-9616222 Transcriptional regulation of granulopoiesis
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0005941 BXGD000353 Bone Diseases, Developmental Musculoskeletal Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0008626 BXGD000559 Congenital chromosomal disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0008925 BXGD000575 Cleft Palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0014457 BXGD000915 Eosinophilia Hemic and Lymphatic Diseases
C0018798 BXGD001223 Congenital Heart Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0018939 BXGD001253 Hematological Disease Hemic and Lymphatic Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023465 BXGD001656 Acute monocytic leukemia Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023470 BXGD001659 Myeloid Leukemia Neoplasms
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023479 BXGD001663 Acute myelomonocytic leukemia Neoplasms
C0023530 BXGD001683 Leukopenia Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0026499 BXGD001905 Monosomy Pathological Conditions, Signs and Symptoms
C0026998 BXGD001959 Acute Myeloid Leukemia, M1 Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027708 BXGD002025 Nephroblastoma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0029396 BXGD002133 Heterotopic Ossification Pathological Conditions, Signs and Symptoms
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0033027 BXGD002388 Preleukemia Neoplasms; Hemic and Lymphatic Diseases
C0038356 BXGD002747 Stomach Neoplasms Digestive System Diseases; Neoplasms
C0085669 BXGD003233 Acute leukemia Pathological Conditions, Signs and Symptoms; Neoplasms
C0152276 BXGD003581 Granulocytic Sarcoma Neoplasms
C0220615 BXGD004298 Adult Acute Myeloblastic Leukemia Neoplasms
C0220621 BXGD004300 Childhood Acute Myeloid Leukemia Neoplasms
C0221013 BXGD004363 Mastocytosis, Systemic Neoplasms; Immune System Diseases
C0242596 BXGD005181 Neoplasm, Residual Pathological Conditions, Signs and Symptoms; Neoplasms
C0279563 BXGD006637 Lobular carcinoma in situ of breast Neoplasms; Skin and Connective Tissue Diseases
C0279565 BXGD006638 Invasive Lobular Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0279627 BXGD006658 Adult Acute Myelomonocytic Leukemia Neoplasms
C0279644 BXGD006668 Childhood Acute Myelomonocytic Leukemia Neoplasms
C0376545 BXGD008002 Hematologic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0427460 BXGD008616 Red cell distribution width determination
C0544886 BXGD009319 Somatic mutation
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0751606 BXGD010523 Adult Acute Lymphocytic Leukemia
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1261502 BXGD011856 Finding of Mean Corpuscular Hemoglobin
C1304746 BXGD012343 RDW - Red blood cell distribution width result
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306759 BXGD012374 Eosinophilic disorder Hemic and Lymphatic Diseases
C1332156 BXGD012491 Acute myelomonocytic leukemia with abnormal eosinophils Neoplasms
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1336735 BXGD012856 Treatment related acute myeloid leukaemia
C1533174 BXGD013312 Acute myeloid leukemia, inv(16)(p13q22)
C1837218 BXGD014207 Cleft palate, isolated Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C1879321 BXGD016572 Acute Myeloid Leukemia (AML-M2) Neoplasms
C1961099 BXGD016672 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1961102 BXGD016673 Precursor Cell Lymphoblastic Leukemia Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2825149 BXGD017771 Myeloid leukemia associated with Down Syndrome Neoplasms
C2938924 BXGD018167 Oestrogen receptor positive breast cancer
C3164096 BXGD018525 Sarcoma of mesentery
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3839741 BXGD019782 Core binding factor acute myeloid leukemia Neoplasms
C3888194 BXGD019955 MIXED LINEAGE LEUKEMIA
C4721505 BXGD023746 Sarcoma, Myeloid Neoplasms
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000194 Sanguinarine 332.33
BXGC0000244 S-Carboxymethyl-L-cysteine 179.19
BXGC0000286 L-DOPA 197.19
BXGC0000324 Isovitexin 432.38
BXGC0000430 Gossypol 518.55
BXGC0000505 Protocatechuic acid 154.12
BXGC0000623 Methyl nicotinate 137.14
BXGC0000655 Harmalol 200.24
BXGC0000759 Arabinan 243.22
BXGC0001166 Vitexin 6''-O-malonyl 2''-O-xyloside 432.38
BXGC0001167 Isoorientin 7-O-(6'''-O-(E)-feruloyl)glucoside 448.38
BXGC0001273 Hippuric acid 179.17
BXGC0001426 (S)-Isocorydine 341.4
BXGC0001498 Boldine 327.37
BXGC0001550 Ficus Latex peptide 2 244.26
BXGC0001589 Arecoline 155.19
BXGC0001725 2(3H)-Benzothiazolethione 167.25
BXGC0001747 Rosmarinic acid 360.31
BXGC0001767 (E)-Resveratrol 228.25
BXGC0001911 5,7-Dihydroxyisoflavone 254.24
BXGC0001940 Daphnetin 178.14
BXGC0001991 Juglone 174.15
BXGC0002018 Morin 302.24
BXGC0002029 Taxifolin 304.25
BXGC0002071 Apigenin 270.24
BXGC0002244 Doconexent 328.49
BXGC0002273 Avocadyne 1-acetate 326.47
BXGC0002390 Spermine 202.34
BXGC0002572 Dimethyl disulfide 94.2
BXGC0002796 Nicotine 162.23
BXGC0002906 Caffeic acid ester 284.31
BXGC0002971 alpha-Lipoic acid 206.33
BXGC0003219 Oxypeucedanin hydrate 304.29
BXGC0003364 Cerebroside 299.49
BXGC0003761 Dimethyl sulfone 94.13
BXGC0003955 Fenugrin A 350.45
BXGC0004556 1,2,3-Benzenetriol 126.11
BXGC0004574 Eugenyl benzoate 268.31
BXGC0005682 3,3',4,4'-Tetrahydroxylignan 302.36
BXGC0005702 2H-1-Benzopyran-2-one 146.15
BXGC0005703 Bergamottin 338.4
BXGC0005793 Baicalein 270.24
BXGC0005893 3-Phenyl-1-propanol 136.19
BXGC0005935 3,4',7-Trihydroxyflavone 270.24
BXGC0005989 Auraptene 298.38
BXGC0006060 1-Methoxy-4-(2-propenyl)benzene 148.2
BXGC0006107 alpha-Linolenic acid 278.43
BXGC0006165 Thiolutin 228.29
BXGC0006193 Ellagic acid 302.19
BXGC0006212 Hypericin 504.44
BXGC0006306 Myricetin 318.24
BXGC0006367 Mangiferin 422.34
BXGC0006392 Benzyl benzoate 212.24
BXGC0006635 Luteolin 286.24
BXGC0006908 Geranial 152.24
BXGC0007029 Emodin 270.24
BXGC0007528 p-Menthan-3-ol 156.27
BXGC0007533 Biotin 244.31
BXGC0008667 6-Prenylnaringenin 340.38
BXGC0008943 Kaempferol 3-robinobioside 594.52
BXGC0010427 Xanthotoxol geranyl ether 338.4
BXGC0011280 Isothymonin 360.31
BXGC0011887 (3S,5R,6S,7E,9x)-7-Megastigmene-3,6,9-triol 9-glucoside 390.47
BXGC0012236 Quercetin 3-alpha-D-galactoside 464.38
BXGC0012322 Proline 115.13
BXGC0013265 retrorsine 351.17
BXGC0013491 n.a 172.15
BXGC0013714 1,3-Dicyclohexylurea 224.19
BXGC0014934 L-Norepinephrine 169.07
BXGC0016421 punicalin 782.06
BXGC0016681 Hispidin 246.05
BXGC0016788 D-Valine 117.08
BXGC0016854 cytisine 190.11
BXGC0016886 Papaverine Hydrochloride 339.15
BXGC0016973 Guvacine Hydrochloride 127.06
BXGC0017115 Cephalexin 347.09
BXGC0017701 Altenusin 290.08
BXGC0017719 Strychnine 334.17
BXGC0018099 [(4S)-2,5-Dioxoimidazolidin-4-Yl]Urea 158.04
BXGC0019091 D-Tryptophan 204.09
BXGC0020654 Dopa 197.07
BXGC0021348 Nicotinyl Alcohol 109.05
BXGC0021931 [(1S,5R)-8-Methyl-8-Azabicyclo[3.2.1]Octan-3-Yl] (2R)-3-Hydroxy-2-Phenylpropanoate 289.17
BXGC0023948 (S)-2-Aminoadipic Acid 161.07
BXGC0024428 3-(1H-Benzimidazol-2-Yl)-7-(Diethylamino)Chromen-2-One 333.15
BXGC0024915 Dehydroglaucine 353.16
BXGC0025200 2-Anilinonaphthalene-1,4-Dione 249.08
BXGC0025323 Senecionine 335.17
BXGC0025757 Calcimycin 523.27
BXGC0026658 (E)-3-Phenyl-N-(2-Phenylethyl)Prop-2-Enamide 251.13
BXGC0028001 Beta-Lapachone 242.09
BXGC0028058 Isoboldine 327.15
BXGC0028696 Cichoric Acid 474.08
BXGC0030954 roemerine 279.13
BXGC0031384 Epinephrine 183.09
BXGC0032798 Shikonin 288.1
BXGC0034006 Fluoranthene 202.08
BXGC0034035 Capsaicin 305.2
BXGC0034208 3-Aminophenol 109.05
BXGC0034256 Rottlerin 516.18
BXGC0034778 Artemisinin 282.15
BXGC0037134 bilobalide 326.1
BXGC0037152 (Z)-1-[6-[(3-Acetyl-2,4,6-Trihydroxy-5-Methylphenyl)Methyl]-5,7-Dihydroxy-2,2-Dimethylchromen-8-Yl]-3-Phenylprop-2-En-1-One 516.18
BXGC0037599 Tanshinone Iia 294.13
BXGC0037795 Cyclopamine 411.31
BXGC0038895 Emodic Acid 300.03
BXGC0038963 Dichlorvos 219.95
BXGC0039019 Harmol 198.08
BXGC0039397 Athraquinones A 240.04
BXGC0040155 Triptolide 360.16
BXGC0040336 Pterocarpin 298.08
BXGC0040485 Benzene-1,4-Diamine 108.07
BXGC0041240 Atenolol 266.16
BXGC0041560 Thiram 239.99
BXGC0042118 beta-glycerophosphoric acid 172.01
BXGC0042143 Methyl 6,18-Dimethoxy-17-(3,4,5-Trimethoxybenzoyl)Oxy-1,3,11,12,14,15,16,17,18,19,20,21-Dodecahydroyohimban-19-Carboxylate 608.27
BXGC0042546 5-Hydroxy-2-(4-Hydroxyphenyl)-7-Methoxy-2,3-Dihydrochromen-4-One 286.08
BXGC0042870 Piceatannol 244.07
BXGC0044245 2,4-Dibromo-6-(2,4-Dibromophenoxy)Phenol 497.71
BXGC0044285 Hematoxylin 302.08
BXGC0044333 12-Phenyldodecanoic Acid 276.21
BXGC0045252 Sc-560 352.06
BXGC0045746 Diphenyleneiodonium 278.97
BXGC0046548 Seneciphyllin 333.16
BXGC0047281 Berberine 336.12
BXGC0047855 dimethyladipate 174.09
BXGC0048159 Phorbol Myristate Acetate 616.4
BXGC0048379 camptothecin 348.11
BXGC0048661 Nicardipine Hydrochloride 479.21
BXGC0049263 4-Methoxydalbergione 254.09
BXGC0049633 4-Aminophenol 109.05
BXGC0049738 Dexibuprofen 206.13
BXGC0050184 Myricitrin 464.1
BXGC0050651 Cryptotanshinone 296.14
BXGC0050823 Chebulinic acid 956.11
BXGC0051995 Wedelolactone 314.04
BXGC0052052 (2E)-2-[(3,4-Dihydroxyphenyl)Methylidene]-6-Hydroxy-1-Benzofuran-3-One 270.05
BXGC0052374 Reserpine 608.27
BXGC0053494 Quinizarin 240.04
BXGC0053768 bornyl acetate 196.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein