Showing entry for Serine protease HTRA2, mitochondrial


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004595
Protein NameSerine protease HTRA2, mitochondrial
Uniport IdO43464
GeneHTRA2
Gene Id27429
DomainPDZ_6; Trypsin_2
Pfam PF17820  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.2 Cell growth and death hsa04210 Apoptosis
4. Cellular Processes 4.2 Cell growth and death hsa04215 Apoptosis - multiple species
6. Human Diseases 6.4 Neurodegenerative diseases hsa05012 Parkinson disease
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007628 adult walking behavior
Biological Process GO:0007568 aging
Biological Process GO:0044257 cellular protein catabolic process
Biological Process GO:0071363 cellular response to growth factor stimulus
Biological Process GO:0034605 cellular response to heat
Biological Process GO:0035458 cellular response to interferon-beta
Biological Process GO:0034599 cellular response to oxidative stress
Biological Process GO:0071300 cellular response to retinoic acid
Biological Process GO:0006672 ceramide metabolic process
Biological Process GO:0097194 execution phase of apoptosis
Biological Process GO:0030900 forebrain development
Biological Process GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
Biological Process GO:0007005 mitochondrion organization
Biological Process GO:0045786 negative regulation of cell cycle
Biological Process GO:1904924 negative regulation of mitophagy in response to mitochondrial depolarization
Biological Process GO:1901215 negative regulation of neuron death
Biological Process GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
Biological Process GO:0048666 neuron development
Biological Process GO:0019742 pentacyclic triterpenoid metabolic process
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Process GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Biological Process GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Biological Process GO:0010822 positive regulation of mitochondrion organization
Biological Process GO:1903955 positive regulation of protein targeting to mitochondrion
Biological Process GO:0012501 programmed cell death
Biological Process GO:0016540 protein autoprocessing
Biological Process GO:0006508 proteolysis
Biological Process GO:1903146 regulation of autophagy of mitochondrion
Biological Process GO:0040014 regulation of multicellular organism growth
Biological Process GO:0009635 response to herbicide
molecular function GO:0042802 identical protein binding
molecular function GO:0008233 peptidase activity
molecular function GO:0004252 serine-type endopeptidase activity
molecular function GO:0008236 serine-type peptidase activity
molecular function GO:0051082 unfolded protein binding
cellular component GO:0035631 CD40 receptor complex
cellular component GO:0000785 chromatin
cellular component GO:0009898 cytoplasmic side of plasma membrane
cellular component GO:0005856 cytoskeleton
cellular component GO:0005829 cytosol
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0016020 membrane
cellular component GO:0005758 mitochondrial intermembrane space
cellular component GO:0031966 mitochondrial membrane
cellular component GO:0005739 mitochondrion
cellular component GO:0005634 nucleus
cellular component GO:1905370 serine-type endopeptidase complex
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003578 BXGD000211 Apnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0004045 BXGD000249 Asphyxia Neonatorum Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0007787 BXGD000487 Transient Ischemic Attack Nervous System Diseases; Cardiovascular Diseases
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0009398 BXGD000604 Color vision defect Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0012236 BXGD000772 DiGeorge Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0012569 BXGD000777 Diplopia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0013363 BXGD000818 Dysautonomia Nervous System Diseases
C0013384 BXGD000826 Dyskinetic syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0018524 BXGD001200 Hallucinations Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0021125 BXGD001483 Impulsive Behavior Behavior and Behavior Mechanisms
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0025521 BXGD001876 Inborn Errors of Metabolism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0026650 BXGD001913 Movement Disorders Nervous System Diseases
C0026826 BXGD001935 Muscle Hypertonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026837 BXGD001937 Muscle Rigidity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0026847 BXGD001940 Spinal Muscular Atrophy Nervous System Diseases
C0027497 BXGD001993 Nausea Pathological Conditions, Signs and Symptoms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027708 BXGD002025 Nephroblastoma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0027868 BXGD002053 Neuromuscular Diseases Nervous System Diseases
C0027947 BXGD002061 Neutropenia Hemic and Lymphatic Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0033300 BXGD002403 Progeria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0033581 BXGD002410 prostatitis Male Urogenital Diseases
C0035258 BXGD002523 Restless Legs Syndrome Nervous System Diseases; Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037763 BXGD002699 Spasm Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085631 BXGD003214 Agitation Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0085632 BXGD003215 Apathy Behavior and Behavior Mechanisms
C0086543 BXGD003294 Cataract Eye Diseases
C0086692 BXGD003306 Benign Neoplasm Neoplasms
C0086769 BXGD003310 Panic Attacks Mental Disorders
C0150080 BXGD003402 Social Communication Disorder Mental Disorders
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152020 BXGD003519 Gastroparesis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0231341 BXGD004492 Premature aging syndrome Pathological Conditions, Signs and Symptoms
C0233565 BXGD004590 Bradykinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235946 BXGD004789 Cerebral atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0242422 BXGD005163 Parkinsonian Disorders Nervous System Diseases
C0242423 BXGD005164 Ramsay Hunt Paralysis Syndrome Nervous System Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0262630 BXGD005262 Reduced concentration span Behavior and Behavior Mechanisms
C0270736 BXGD006096 Essential Tremor Nervous System Diseases
C0278097 BXGD006496 Abnormal male sexual function
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0338455 BXGD007177 Dementia of frontal lobe type Nervous System Diseases; Mental Disorders
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0344482 BXGD007678 Hypoplasia of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0393615 BXGD008108 Familial Tremor Nervous System Diseases
C0393642 BXGD008111 Sepsis-Associated Encephalopathy Nervous System Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0428977 BXGD008644 Bradycardia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0456070 BXGD008863 Growth delay
C0472381 BXGD008910 Posterior Circulation Transient Ischemic Attack Nervous System Diseases; Cardiovascular Diseases
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0740392 BXGD009988 Infarction, Middle Cerebral Artery Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0751019 BXGD010293 Carotid Circulation Transient Ischemic Attack Nervous System Diseases; Cardiovascular Diseases
C0751020 BXGD010294 Transient Ischemic Attack, Vertebrobasilar Circulation Nervous System Diseases; Cardiovascular Diseases
C0751021 BXGD010295 Crescendo Transient Ischemic Attacks Nervous System Diseases; Cardiovascular Diseases
C0751022 BXGD010296 Brain Stem Ischemia, Transient Nervous System Diseases; Cardiovascular Diseases
C0752097 BXGD010659 Autosomal Dominant Juvenile Parkinson Disease Nervous System Diseases
C0752098 BXGD010660 Autosomal Dominant Parkinsonism Nervous System Diseases
C0752100 BXGD010661 Autosomal Recessive Parkinsonism Nervous System Diseases
C0752101 BXGD010662 Parkinsonism, Experimental Nervous System Diseases
C0752104 BXGD010663 Familial Juvenile Parkinsonism Nervous System Diseases
C0752105 BXGD010664 Parkinsonism, Juvenile Nervous System Diseases
C0752347 BXGD010721 Lewy Body Disease Nervous System Diseases; Mental Disorders
C0917801 BXGD011412 Sleeplessness Nervous System Diseases; Mental Disorders
C0917805 BXGD011414 Transient Cerebral Ischemia Nervous System Diseases; Cardiovascular Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1112442 BXGD011668 Female sexual dysfunction
C1112443 BXGD011669 Male sexual dysfunction
C1136033 BXGD011703 Cutaneous Mastocytosis Neoplasms; Skin and Connective Tissue Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1145670 BXGD011764 Respiratory Failure Respiratory Tract Diseases
C1167918 BXGD011779 Increased CSF lactate
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1335177 BXGD012771 Ovarian Serous Adenocarcinoma Neoplasms
C1527335 BXGD013270 Transient Ischemic Attack, Anterior Circulation Nervous System Diseases; Cardiovascular Diseases
C1531647 BXGD013301 Cerebral ventriculomegaly Nervous System Diseases
C1536220 BXGD013341 ST segment elevation myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1611743 BXGD013456 Familial (FPAH)
C1704272 BXGD013537 Benign Prostatic Hyperplasia Male Urogenital Diseases
C1836150 BXGD014082 Gait imbalance
C1836440 BXGD014115 Increased serum lactate Nutritional and Metabolic Diseases
C1837142 BXGD014201 Poor suck
C1843921 BXGD014620 Postural instability Nervous System Diseases
C1846868 BXGD014846 Parkinsonism with favorable response to dopaminergic medication Nervous System Diseases
C1847514 BXGD014868 Postnatal microcephaly
C1853202 BXGD015315 PARKINSON DISEASE 13, AUTOSOMAL DOMINANT, SUSCEPTIBILITY TO
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1858430 BXGD015792 Death in infancy
C1868675 BXGD016520 PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE Nervous System Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1963060 BXGD016679 Agitation, CTCAE 3.0
C2004489 BXGD016873 Regurgitation
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2364082 BXGD017123 Sense of smell impaired Nervous System Diseases
C2986665 BXGD018237 Early-Stage Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C3160718 BXGD018468 PARKINSON DISEASE, LATE-ONSET
C3278923 BXGD018748 Dilated ventricles (finding)
C3696376 BXGD019346 3-Methylglutaconic Aciduria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C4024896 BXGD021461 Motor neuron atrophy
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4255010 BXGD022310 Non-ST Elevated Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C4274355 BXGD022352 Autosomal dominant late onset Parkinson disease Nervous System Diseases
C4310650 BXGD022611 3-METHYLGLUTACONIC ACIDURIA, TYPE VIII
C4511452 BXGD023002 Sporadic Parkinson disease Nervous System Diseases
C4552855 BXGD023528 Agitation, CTCAE 5.0
C4553743 BXGD023548 Spasticity, CTCAE
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002591 Potassium 39.1
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein