Showing entry for TP53-binding protein 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT024878
Protein NameTP53-binding protein 1
Uniport IdQ12888
GeneTP53BP1
Gene Id7158
Domain53-BP1_Tudor; BRCT_3
Pfam PF09038  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04621 NOD-like receptor signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006974 cellular response to DNA damage stimulus
Biological Process GO:0071481 cellular response to X-ray
Biological Process GO:0000077 DNA damage checkpoint
Biological Process GO:0006303 double-strand break repair via nonhomologous end joining
Biological Process GO:2000042 negative regulation of double-strand break repair via homologous recombination
Biological Process GO:0051091 positive regulation of DNA-binding transcription factor activity
Biological Process GO:0045830 positive regulation of isotype switching
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0051260 protein homooligomerization
molecular function GO:0003684 damaged DNA binding
molecular function GO:0042393 histone binding
molecular function GO:0035064 methylated histone binding
molecular function GO:0002039 p53 binding
molecular function GO:0001102 RNA polymerase II activating transcription factor binding
molecular function GO:0042162 telomeric DNA binding
molecular function GO:0003712 transcription coregulator activity
molecular function GO:0061649 ubiquitin modification-dependent histone binding
cellular component GO:0000777 condensed chromosome kinetochore
cellular component GO:0005737 cytoplasm
cellular component GO:1990391 DNA repair complex
cellular component GO:0016604 nuclear body
cellular component GO:0000784 nuclear chromosome, telomeric region
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0005657 replication fork
cellular component GO:0035861 site of double-strand break
Reactome
Pathway Id Pathway Name
R-HSA-1640170 Cell Cycle
R-HSA-2990846 SUMOylation
R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins
R-HSA-3232118 SUMOylation of transcription factors
R-HSA-392499 Metabolism of proteins
R-HSA-5693532 DNA Double-Strand Break Repair
R-HSA-5693538 Homology Directed Repair
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
R-HSA-5693571 Nonhomologous End-Joining (NHEJ)
R-HSA-5693606 DNA Double Strand Break Response
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-597592 Post-translational protein modification
R-HSA-69473 G2/M DNA damage checkpoint
R-HSA-69481 G2/M Checkpoints
R-HSA-69620 Cell Cycle Checkpoints
R-HSA-73894 DNA Repair
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0001948 BXGD000091 Alcohol consumption Behavior and Behavior Mechanisms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002690 BXGD000124 Amputation Stumps
C0002793 BXGD000130 Anaplasia Pathological Conditions, Signs and Symptoms; Neoplasms
C0004135 BXGD000257 Ataxia Telangiectasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C0005859 BXGD000342 Bloom Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007113 BXGD000430 Rectal Carcinoma Digestive System Diseases; Neoplasms
C0007115 BXGD000432 Malignant neoplasm of thyroid Neoplasms; Endocrine System Diseases
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007138 BXGD000446 Carcinoma, Transitional Cell Neoplasms
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0008479 BXGD000544 Chondrosarcoma Neoplasms
C0008626 BXGD000559 Congenital chromosomal disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009676 BXGD000619 Confusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0014457 BXGD000915 Eosinophilia Hemic and Lymphatic Diseases
C0014772 BXGD000948 Red Blood Cell Count measurement
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0015625 BXGD001006 Fanconi Anemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0016057 BXGD001042 Fibrosarcoma Neoplasms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0018671 BXGD001211 Head and Neck Neoplasms Neoplasms
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0021841 BXGD001519 Intestinal Neoplasms Digestive System Diseases; Neoplasms
C0022602 BXGD001564 Actinic keratosis Neoplasms; Skin and Connective Tissue Diseases
C0023267 BXGD001626 Fibroid Tumor Neoplasms
C0023269 BXGD001627 leiomyosarcoma Neoplasms
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024131 BXGD001736 Lupus Vulgaris Infections; Skin and Connective Tissue Diseases
C0024138 BXGD001738 Lupus Erythematosus, Discoid Skin and Connective Tissue Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024232 BXGD001751 Lymphatic Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0032181 BXGD002332 Platelet Count measurement
C0032927 BXGD002381 Precancerous Conditions Neoplasms
C0033300 BXGD002403 Progeria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0035344 BXGD002541 Retinopathy of Prematurity Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0037286 BXGD002681 Skin Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C0038868 BXGD002781 Progressive supranuclear palsy Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0039483 BXGD002813 Giant Cell Arteritis Skin and Connective Tissue Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0040997 BXGD002894 Trigeminal Neuralgia Nervous System Diseases; Stomatognathic Diseases
C0042133 BXGD002960 Uterine Fibroids Neoplasms
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0149978 BXGD003397 Adenocarcinoma of rectum Digestive System Diseases; Neoplasms
C0151468 BXGD003424 Thyroid Gland Follicular Adenoma Neoplasms; Endocrine System Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0200638 BXGD004043 Eosinophil count procedure
C0202236 BXGD004086 Triglycerides measurement
C0205647 BXGD004099 Follicular adenoma Neoplasms
C0206139 BXGD004159 Lichen Planus, Oral Skin and Connective Tissue Diseases; Stomatognathic Diseases
C0206708 BXGD004256 Cervical Intraepithelial Neoplasia Neoplasms
C0221055 BXGD004382 Paramyotonia Congenita (disorder) Musculoskeletal Diseases; Nervous System Diseases
C0233407 BXGD004576 Disorientation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0235754 BXGD004768 Bladder papilloma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0278510 BXGD006526 Childhood Medulloblastoma Neoplasms
C0278595 BXGD006545 Adult Fibrosarcoma Neoplasms
C0278607 BXGD006548 Adult Leiomyosarcoma Neoplasms
C0278876 BXGD006607 Adult Medulloblastoma Neoplasms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0279680 BXGD006680 Transitional cell carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0279986 BXGD006705 Childhood Leiomyosarcoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0280785 BXGD006760 Diffuse Astrocytoma Neoplasms
C0302142 BXGD006831 Deformity Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0334588 BXGD007128 Giant Cell Glioblastoma Neoplasms
C0338508 BXGD007196 Optic Atrophy 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Eye Diseases; Nervous System Diseases
C0339467 BXGD007248 Proliferative retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0392885 BXGD008071 High density lipoprotein measurement
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0409974 BXGD008401 Lupus Erythematosus Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Immune System Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598935 BXGD009674 Tumor Initiation Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0948089 BXGD011504 Acute Coronary Syndrome Cardiovascular Diseases
C1136033 BXGD011703 Cutaneous Mastocytosis Neoplasms; Skin and Connective Tissue Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1257931 BXGD011815 Mammary Neoplasms, Human Neoplasms; Skin and Connective Tissue Diseases
C1266051 BXGD011946 Papillary microcarcinoma
C1269955 BXGD012005 Tumor Cell Invasion
C1292772 BXGD012232 Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative Neoplasms; Hemic and Lymphatic Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1306759 BXGD012374 Eosinophilic disorder Hemic and Lymphatic Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1333762 BXGD012639 Gastric Cardia Adenocarcinoma
C1334274 BXGD012695 Invasive Carcinoma Neoplasms
C1337013 BXGD012876 Differentiated Thyroid Gland Carcinoma
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1519346 BXGD013235 Skin Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1851710 BXGD015226 LATERAL MENINGOCELE SYNDROME Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1863753 BXGD016197 LIMB-MAMMARY SYNDROME Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C2145472 BXGD016931 Urothelial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2216702 BXGD016951 malignant neoplasm of breast staging Neoplasms; Skin and Connective Tissue Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2677792 BXGD017386 Riddle Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Immune System Diseases; Nervous System Diseases; Mental Disorders
C2921627 BXGD017886 Clinically isolated syndrome
C2986658 BXGD018234 Diffuse Intrinsic Pontine Glioma
C3160889 BXGD018491 Node-negative breast cancer
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3469521 BXGD018910 FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C3502492 BXGD019046 Microcephaly with Chorioretinopathy, Autosomal Recessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Musculoskeletal Diseases; Nervous System Diseases
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3805278 BXGD019474 Extrahepatic Cholangiocarcinoma Neoplasms
C3809768 BXGD019610 IMMUNODEFICIENCY 13
C3811653 BXGD019662 Experimental Organism Basal Cell Carcinoma Neoplasms
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4225362 BXGD022240 MICROCEPHALY AND CHORIORETINOPATHY, AUTOSOMAL RECESSIVE, 3
C4287589 BXGD022469 Serous Tubal Intraepithelial Carcinoma
C4329280 BXGD022784 Advanced Head and Neck Carcinoma
C4704874 BXGD023682 Mammary Carcinoma, Human Neoplasms; Skin and Connective Tissue Diseases
C4721579 BXGD023759 Secondary malignant neoplasm of colon and/or rectum Digestive System Diseases; Neoplasms
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4721806 BXGD023772 Carcinoma, Basal Cell Neoplasms
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722172 BXGD023791 Primary differentiated carcinoma of thyroid gland
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C4733092 BXGD023907 estrogen receptor-negative breast cancer
C4733093 BXGD023908 progesterone receptor-negative breast cancer
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0006368 Formic acid 46.03
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein