Showing entry for Farnesyl pyrophosphate synthase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008005
Protein NameFarnesyl pyrophosphate synthase
Uniport IdP14324
GeneFDPS
Gene Id2224
Domainpolyprenyl_synt
Pfam PF00348  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.9 Metabolism of terpenoids and polyketides hsa00900 Terpenoid backbone biosynthesis
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
6. Human Diseases 6.9 Infectious diseases: Viral hsa05164 Influenza A
6. Human Diseases 6.9 Infectious diseases: Viral hsa05166 Human T-cell leukemia virus 1 infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006695 cholesterol biosynthetic process
Biological Process GO:0045337 farnesyl diphosphate biosynthetic process
Biological Process GO:0033384 geranyl diphosphate biosynthetic process
Biological Process GO:0045540 regulation of cholesterol biosynthetic process
Biological Process GO:0016032 viral process
molecular function GO:0004161 dimethylallyltranstransferase activity
molecular function GO:0004337 geranyltranstransferase activity
molecular function GO:0046872 metal ion binding
molecular function GO:0003723 RNA binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005654 nucleoplasm
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF)
R-HSA-191273 Cholesterol biosynthesis
R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
R-HSA-556833 Metabolism of lipids
R-HSA-8957322 Metabolism of steroids
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002895 BXGD000152 Anemia, Sickle Cell Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0005940 BXGD000352 Bone Diseases Musculoskeletal Diseases
C0006111 BXGD000369 Brain Diseases Nervous System Diseases
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014335 BXGD000908 Enteritis Digestive System Diseases
C0015468 BXGD000995 Facial Pain Pathological Conditions, Signs and Symptoms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0018081 BXGD001171 Gonorrhea Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0018824 BXGD001237 Heart valve disease Cardiovascular Diseases
C0023283 BXGD001629 Leishmaniasis, Cutaneous Infections; Skin and Connective Tissue Diseases
C0023448 BXGD001649 Lymphoid leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024535 BXGD001785 Malaria, Falciparum Infections
C0025202 BXGD001832 melanoma Neoplasms
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0033300 BXGD002403 Progeria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0033774 BXGD002419 Pruritus Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0034067 BXGD002456 Pulmonary Emphysema Respiratory Tract Diseases
C0038525 BXGD002768 Subarachnoid Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0040558 BXGD002873 Toxoplasmosis Infections
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0041234 BXGD002901 Chagas Disease Infections
C0086025 BXGD003262 Codependency Behavior and Behavior Mechanisms
C0151650 BXGD003454 Renal fibrosis Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0153633 BXGD003674 Malignant neoplasm of brain Neoplasms; Nervous System Diseases
C0162839 BXGD003991 Porokeratosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0184567 BXGD004039 Acute onset pain Pathological Conditions, Signs and Symptoms
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238461 BXGD004936 Anaplastic thyroid carcinoma Neoplasms
C0265970 BXGD005593 Porokeratosis, Disseminated Superficial Actinic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0266631 BXGD005703 Accessory spleen Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0334463 BXGD007076 Malignant Fibrous Histiocytoma Neoplasms
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0349506 BXGD007912 Photosensitivity of skin Skin and Connective Tissue Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0856169 BXGD011096 Endothelial dysfunction
C0877008 BXGD011325 Enzyme inhibition disorder
C0949506 BXGD011577 Porokeratosis of Mibelli Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1611743 BXGD013456 Familial (FPAH)
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C2827407 BXGD017795 Infectious Otitis Media Otorhinolaryngologic Diseases
C2936719 BXGD018130 Mechanical Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C3825414 BXGD019695 Pain in children Pathological Conditions, Signs and Symptoms
C3839507 BXGD019774 Diminished ovarian reserve Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4225262 BXGD022198 POROKERATOSIS 9, MULTIPLE TYPES
C4721773 BXGD023768 Postoperative cognitive dysfunction
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000954 Geranyl diphosphate 314.21
BXGC0002588 Magnesium 24.31
BXGC0003705 Chloride 35.45
BXGC0031847 Riboprine 335.16
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein