adisease

Showing entry for Pterygium

General Disease Information
BXGD Id	BXGD002448
Disease Name	Pterygium
Disease CUI Id	C0033999
MeSH Codes	C11
Disease Class Name	Eye Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0001574 HP:0000924
Human Phenotype Ontology Term	Abnormality of the integument; Abnormality of the skeletal system
Disease Ontology Id	DOID:7
Disease Ontology Class Name	disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O00469	BXGT003926	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	5352	reviewed	Enzyme
O14746	BXGT004091	Telomerase reverse transcriptase	7015	reviewed	Enzyme
O15146	BXGT004131	Muscle, skeletal receptor tyrosine-protein kinase	4593	reviewed	Kinase
O15527	BXGT004176	N-glycosylase/DNA lyase	4968	reviewed
O43175	BXGT004575	D-3-phosphoglycerate dehydrogenase	26227	reviewed	Enzyme
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P00749	BXGT005641	Urokinase-type plasminogen activator	5328	reviewed	Enzyme
P01100	BXGT005727	Proto-oncogene c-Fos	2353	reviewed	Transcription factor
P01106	BXGT005730	Myc proto-oncogene protein	4609	reviewed	Transcription factor
P01130	BXGT005735	Low-density lipoprotein receptor	3949	reviewed
P01133	BXGT005736	Pro-epidermal growth factor	1950	reviewed
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01215	BXGT005743	Glycoprotein hormones alpha chain	1081	reviewed
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P02461	BXGT005880	Collagen alpha-1(III) chain	1281	reviewed
P02462	BXGT005881	Collagen alpha-1(IV) chain	1282	reviewed
P02751	BXGT005943	Fibronectin	2335	reviewed	Signaling
P03950	BXGT006116	Angiogenin	283	reviewed
P03956	BXGT006120	Interstitial collagenase	4312	reviewed	Enzyme
P04271	BXGT006177	Protein S100-B	6285	reviewed	Calcium-binding protein
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P04798	BXGT006265	Cytochrome P450 1A1	1543	reviewed	Enzyme
P05109	BXGT006318	Protein S100-A8	6279	reviewed	Calcium-binding protein
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05412	BXGT006354	Transcription factor AP-1	3725	reviewed	Transcription factor
P06702	BXGT006476	Protein S100-A9	6280	reviewed	Calcium-binding protein
P06703	BXGT006477	Protein S100-A6	6277	reviewed	Calcium-binding protein
P07510	BXGT006631	Acetylcholine receptor subunit gamma	1146	reviewed	Ion channel
P08253	BXGT006757	72 kDa type IV collagenase	4313	reviewed	Enzyme
P08254	BXGT006758	Stromelysin-1	4314	reviewed	Enzyme
P08670	BXGT006810	Vimentin	7431	reviewed
P09038	BXGT006851	Fibroblast growth factor 2	2247	reviewed	Signaling
P09238	BXGT006875	Stromelysin-2	4319	reviewed	Enzyme
P09486	BXGT006897	SPARC	6678	reviewed	Signaling
P09488	BXGT006899	Glutathione S-transferase Mu 1	2944	reviewed
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10909	BXGT007630	Clusterin	1191	reviewed
P11413	BXGT007701	Glucose-6-phosphate 1-dehydrogenase	2539	reviewed	Enzyme
P11473	BXGT007709	Vitamin D3 receptor	7421	reviewed	Nuclear receptor
P12004	BXGT007766	Proliferating cell nuclear antigen	5111	reviewed	Nucleic acid binding
P12821	BXGT007849	Angiotensin-converting enzyme	1636	reviewed	Enzyme
P12830	BXGT007852	Cadherin-1	999	reviewed
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P15884	BXGT008166	Transcription factor 4	6925	reviewed	Transcription factor
P16144	BXGT008200	Integrin beta-4	3691	reviewed	Receptor
P16234	BXGT008209	Platelet-derived growth factor receptor alpha	5156	reviewed	Kinase
P16410	BXGT008224	Cytotoxic T-lymphocyte protein 4	1493	reviewed
P17936	BXGT008357	Insulin-like growth factor-binding protein 3	3486	reviewed	Enzyme modulator
P17948	BXGT008358	Vascular endothelial growth factor receptor 1	2321	reviewed	Kinase
P18074	BXGT008374	General transcription and DNA repair factor IIH helicase subunit XPD	2068	reviewed	Enzyme
P18887	BXGT008437	DNA repair protein XRCC1	7515	reviewed
P19438	BXGT008480	Tumor necrosis factor receptor superfamily member 1A	7132	reviewed
P21673	BXGT008676	Diamine acetyltransferase 1	6303	reviewed
P21817	BXGT008693	Ryanodine receptor 1	6261	reviewed	Ion channel
P22607	BXGT008784	Fibroblast growth factor receptor 3	2261	reviewed	Kinase
P22894	BXGT008815	Neutrophil collagenase	4317	reviewed	Enzyme
P23297	BXGT008848	Protein S100-A1	6271	reviewed	Calcium-binding protein
P27695	BXGT009199	DNA-(apurinic or apyrimidinic site) lyase	328	reviewed
P28074	BXGT009232	Proteasome subunit beta type-5	5693	reviewed
P28161	BXGT009234	Glutathione S-transferase Mu 2	2946	reviewed
P28300	BXGT009243	Protein-lysine 6-oxidase	4015	reviewed
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P29323	BXGT009334	Ephrin type-B receptor 2	2048	reviewed	Kinase
P30711	BXGT009460	Glutathione S-transferase theta-1	2952	reviewed
P30838	BXGT009471	Aldehyde dehydrogenase, dimeric NADP-preferring	218	reviewed
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P32119	BXGT009600	Peroxiredoxin-2	7001	reviewed	Enzyme
P35221	BXGT009798	Catenin alpha-1	1495	reviewed	Cellular structure
P35222	BXGT009799	Catenin beta-1	1499	reviewed
P35354	BXGT009816	Prostaglandin G/H synthase 2	5743	reviewed	Enzyme
P35555	BXGT009845	Fibrillin-1	2200	reviewed	Calcium-binding protein
P35968	BXGT009887	Vascular endothelial growth factor receptor 2	3791	reviewed	Kinase
P36222	BXGT009914	Chitinase-3-like protein 1	1116	reviewed
P40692	BXGT010195	DNA mismatch repair protein Mlh1	4292	reviewed	Nucleic acid binding
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P42574	BXGT010317	Caspase-3	836	reviewed	Enzyme
P43246	BXGT010371	DNA mismatch repair protein Msh2	4436	reviewed	Nucleic acid binding
P46100	BXGT010508	Transcriptional regulator ATRX	546	reviewed
P46108	BXGT010509	Adapter molecule crk	1398	reviewed
P46527	BXGT010525	Cyclin-dependent kinase inhibitor 1B	1027	reviewed
P48061	BXGT010616	Stromal cell-derived factor 1	6387	reviewed
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P49585	BXGT010712	Choline-phosphate cytidylyltransferase A	5130	reviewed
P49767	BXGT010739	Vascular endothelial growth factor C	7424	reviewed	Signaling
P50281	BXGT010788	Matrix metalloproteinase-14	4323	reviewed	Enzyme
P53350	BXGT010984	Serine/threonine-protein kinase PLK1	5347	reviewed	Kinase
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
P60709	BXGT011322	Actin, cytoplasmic 1	60	reviewed	Cellular structure
P61073	BXGT011352	C-X-C chemokine receptor type 4	7852	reviewed	G-protein coupled receptor
Q00987	BXGT012559	E3 ubiquitin-protein ligase Mdm2	4193	reviewed	Nucleic acid binding
Q01831	BXGT012621	DNA repair protein complementing XP-C cells	7508	reviewed	Nucleic acid binding
Q02643	BXGT012660	Growth hormone-releasing hormone receptor	2692	reviewed	G-protein coupled receptor
Q06124	BXGT012856	Tyrosine-protein phosphatase non-receptor type 11	5781	reviewed
Q06609	BXGT012884	DNA repair protein RAD51 homolog 1	5888	reviewed
Q06830	BXGT012894	Peroxiredoxin-1	5052	reviewed	Enzyme
Q07954	BXGT012950	Prolow-density lipoprotein receptor-related protein 1	4035	reviewed
Q11203	BXGT013218	CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase	6487	reviewed
Q13155	BXGT013320	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2	7965	reviewed
Q13393	BXGT013346	Phospholipase D1	5337	reviewed
Q15063	BXGT013531	Periostin	10631	reviewed	Signaling
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q16539	BXGT013634	Mitogen-activated protein kinase 14	1432	reviewed	Kinase
Q16637	BXGT013646	Survival motor neuron protein	6607	reviewed	Epigenetic regulator
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	3091	reviewed	Transcription factor
Q8NER1	BXGT018556	Transient receptor potential cation channel subfamily V member 1	7442	reviewed	Ion channel
Q8NET8	BXGT018557	Transient receptor potential cation channel subfamily V member 3	162514	reviewed	Ion channel
Q92843	BXGT019384	Bcl-2-like protein 2	599	reviewed	Signaling
Q9HBA0	BXGT020516	Transient receptor potential cation channel subfamily V member 4	59341	reviewed	Ion channel
Q9UBC3	BXGT021650	DNA (cytosine-5)-methyltransferase 3B	1789	reviewed
Q9Y617	BXGT022314	Phosphoserine aminotransferase	29968	reviewed
P16284	BXGT022972	Platelet endothelial cell adhesion molecule	5175	reviewed	Cell adhesion
Q92878	BXGT023071	DNA repair protein RAD50	10111	reviewed
P17535	BXGT023437	Transcription factor jun-D	3727	reviewed	Transcription factor
P53539	BXGT023438	Protein fosB	2354	reviewed	Transcription factor
P08123	BXGT024477	Collagen alpha-2(I) chain	1278	reviewed
P28715	BXGT025675	DNA repair protein complementing XP-G cells	2073	reviewed
Q9BY76	BXGT025687	Angiopoietin-related protein 4	51129	reviewed	Signaling
P00403	BXGT026137	Cytochrome c oxidase subunit 2	4513	reviewed	Enzyme

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}