Showing entry for Catenin alpha-1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009798
Protein NameCatenin alpha-1
Uniport IdP35221
GeneCTNNA1
Gene Id1495
DomainVinculin
Pfam PF01044  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04390 Hippo signaling pathway
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04520 Adherens junction
5. Organismal Systems 5.1 Immune system hsa04670 Leukocyte transendothelial migration
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05100 Bacterial invasion of epithelial cells
6. Human Diseases 6.1 Cancers: Overview hsa05200 Pathways in cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05213 Endometrial cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05226 Gastric cancer
6. Human Diseases 6.6 Cardiovascular diseases hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0034332 adherens junction organization
Biological Process GO:0007568 aging
Biological Process GO:0043297 apical junction assembly
Biological Process GO:0031103 axon regeneration
Biological Process GO:0007155 cell adhesion
Biological Process GO:0034613 cellular protein localization
Biological Process GO:0071681 cellular response to indole-3-methanol
Biological Process GO:0090136 epithelial cell-cell adhesion
Biological Process GO:0007163 establishment or maintenance of cell polarity
Biological Process GO:0016264 gap junction assembly
Biological Process GO:0008584 male gonad development
Biological Process GO:2000146 negative regulation of cell motility
Biological Process GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Biological Process GO:2001045 negative regulation of integrin-mediated signaling pathway
Biological Process GO:0007406 negative regulation of neuroblast proliferation
Biological Process GO:0042475 odontogenesis of dentin-containing tooth
Biological Process GO:0001541 ovarian follicle development
Biological Process GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Biological Process GO:0051149 positive regulation of muscle cell differentiation
Biological Process GO:0045880 positive regulation of smoothened signaling pathway
Biological Process GO:0043627 response to estrogen
molecular function GO:0051015 actin filament binding
molecular function GO:0008013 beta-catenin binding
molecular function GO:0045296 cadherin binding
molecular function GO:0045295 gamma-catenin binding
molecular function GO:0042802 identical protein binding
molecular function GO:0003723 RNA binding
molecular function GO:0005198 structural molecule activity
molecular function GO:0017166 vinculin binding
cellular component GO:0001669 acrosomal vesicle
cellular component GO:0015629 actin cytoskeleton
cellular component GO:0016342 catenin complex
cellular component GO:0005911 cell-cell junction
cellular component GO:0030054 cell junction
cellular component GO:0005829 cytosol
cellular component GO:0016600 flotillin complex
cellular component GO:0005925 focal adhesion
cellular component GO:0014704 intercalated disc
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0030027 lamellipodium
cellular component GO:0005886 plasma membrane
cellular component GO:0005915 zonula adherens
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-1266738 Developmental Biology
R-HSA-1500931 Cell-Cell communication
R-HSA-162582 Signal Transduction
R-HSA-194138 Signaling by VEGF
R-HSA-194315 Signaling by Rho GTPases
R-HSA-195258 RHO GTPase Effectors
R-HSA-418990 Adherens junctions interactions
R-HSA-421270 Cell-cell junction organization
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-446728 Cell junction organization
R-HSA-5218920 VEGFR2 mediated vascular permeability
R-HSA-525793 Myogenesis
R-HSA-525793 Myogenesis
R-HSA-5626467 RHO GTPases activate IQGAPs
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009405 BXGD000607 Hereditary Nonpolyposis Colorectal Neoplasms Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms; Nutritional and Metabolic Diseases
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0026998 BXGD001959 Acute Myeloid Leukemia, M1 Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027672 BXGD002020 Neoplastic Syndromes, Hereditary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms
C0027708 BXGD002025 Nephroblastoma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027794 BXGD002036 Neural Tube Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0027809 BXGD002040 Neurilemmoma Neoplasms
C0030297 BXGD002204 Pancreatic Neoplasm Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0033999 BXGD002448 Pterygium Eye Diseases
C0079218 BXGD003066 Fibromatosis, Aggressive Neoplasms
C0153413 BXGD003634 Malignant neoplasm of upper third of esophagus Digestive System Diseases; Neoplasms
C0153414 BXGD003635 Malignant neoplasm of middle third of esophagus Digestive System Diseases; Neoplasms
C0153415 BXGD003636 Malignant neoplasm of lower third of esophagus Digestive System Diseases; Neoplasms
C0153416 BXGD003637 Malignant neoplasm of other specified part of esophagus Digestive System Diseases; Neoplasms
C0206696 BXGD004247 Carcinoma, Signet Ring Cell Neoplasms
C0238198 BXGD004893 Gastrointestinal Stromal Tumors Digestive System Diseases; Neoplasms
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0264408 BXGD005387 Childhood asthma Respiratory Tract Diseases; Immune System Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0339508 BXGD007256 Hereditary macular dystrophy
C0376544 BXGD008001 Hematopoietic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0496775 BXGD009040 Malignant neoplasm of abdominal part of esophagus Digestive System Diseases; Neoplasms
C0553723 BXGD009416 Squamous cell carcinoma of skin Neoplasms; Skin and Connective Tissue Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0730292 BXGD009947 Macular dystrophy Eye Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1112155 BXGD011647 Hereditary non-polyposis colorectal cancer syndrome
C1260959 BXGD011846 Drusen
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332153 BXGD012490 acute myeloid leukemia with multilineage dysplasia following myelodysplastic syndrome
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1333015 BXGD012581 Childhood Kidney Wilms Tumor Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1333990 BXGD012670 Hereditary Nonpolyposis Colorectal Cancer Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms; Nutritional and Metabolic Diseases
C1333991 BXGD012671 Hereditary Non-Polyposis Colon Cancer Type 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1708349 BXGD013597 Hereditary Diffuse Gastric Cancer Digestive System Diseases; Neoplasms
C1837029 BXGD014188 Macular Dystrophy, Butterfly-Shaped Pigmentary, 2 Eye Diseases
C1859486 BXGD015901 BIETTI CRYSTALLINE CORNEORETINAL DYSTROPHY Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1868569 BXGD016507 Patterned dystrophy of retinal pigment epithelium Eye Diseases
C1879321 BXGD016572 Acute Myeloid Leukemia (AML-M2) Neoplasms
C2347761 BXGD017049 Childhood Myelodysplastic Syndrome Hemic and Lymphatic Diseases
C2713368 BXGD017496 Hematopoetic Myelodysplasia Hemic and Lymphatic Diseases
C2931258 BXGD017991 Amaurosis congenita of Leber, type 1 Eye Diseases
C2936783 BXGD018136 Colorectal cancer, hereditary nonpolyposis, type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms; Nutritional and Metabolic Diseases
C3179349 BXGD018550 Gastrointestinal Stromal Sarcoma Digestive System Diseases; Neoplasms
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3714514 BXGD019409 Infection Infections
C3809301 BXGD019581 Foveal hyperpigmentation
C3900098 BXGD020106 Adult Myelodysplastic Syndrome Hemic and Lymphatic Diseases
C4511237 BXGD022998 Butterfly-shaped pigmentary macular dystrophy
C4520821 BXGD023039 Stage 0 Breast Cancer AJCC v6 and v7 Neoplasms; Skin and Connective Tissue Diseases
C4721859 BXGD023779 Hereditary Diffuse Gastric Adenocarcinoma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0003705 Chloride 35.45
BXGC0037687 (4S)-2-methylpentane-2,4-diol 118.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein