Showing entry for Transient receptor potential cation channel subfamily V member 4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT020516
Protein NameTransient receptor potential cation channel subfamily V member 4
Uniport IdQ9HBA0
GeneTRPV4
Gene Id59341
DomainAnk; Ion_trans
Pfam PF00023   PF00520  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.2 Cell growth and death hsa04218 Cellular senescence
5. Organismal Systems 5.7 Sensory system hsa04750 Inflammatory mediator regulation of TRP channels
6. Human Diseases 6.6 Cardiovascular diseases hsa05418 Fluid shear stress and atherosclerosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0031532 actin cytoskeleton reorganization
Biological Process GO:0007015 actin filament organization
Biological Process GO:0097497 blood vessel endothelial cell delamination
Biological Process GO:0070509 calcium ion import
Biological Process GO:0098703 calcium ion import across plasma membrane
Biological Process GO:1902656 calcium ion import into cytosol
Biological Process GO:0070588 calcium ion transmembrane transport
Biological Process GO:0006816 calcium ion transport
Biological Process GO:0060351 cartilage development involved in endochondral bone morphogenesis
Biological Process GO:0007043 cell-cell junction assembly
Biological Process GO:0006874 cellular calcium ion homeostasis
Biological Process GO:0071476 cellular hypotonic response
Biological Process GO:0034605 cellular response to heat
Biological Process GO:0071470 cellular response to osmotic stress
Biological Process GO:0006884 cell volume homeostasis
Biological Process GO:0043622 cortical microtubule organization
Biological Process GO:0046785 microtubule polymerization
Biological Process GO:0050891 multicellular organismal water homeostasis
Biological Process GO:0010977 negative regulation of neuron projection development
Biological Process GO:0007231 osmosensory signaling pathway
Biological Process GO:0007204 positive regulation of cytosolic calcium ion concentration
Biological Process GO:0031117 positive regulation of microtubule depolymerization
Biological Process GO:0043117 positive regulation of vascular permeability
Biological Process GO:0009612 response to mechanical stimulus
molecular function GO:0003779 actin binding
molecular function GO:0051015 actin filament binding
molecular function GO:0043014 alpha-tubulin binding
molecular function GO:0005524 ATP binding
molecular function GO:0048487 beta-tubulin binding
molecular function GO:0005262 calcium channel activity
molecular function GO:0005516 calmodulin binding
molecular function GO:0005261 cation channel activity
molecular function GO:0042802 identical protein binding
molecular function GO:0005216 ion channel activity
molecular function GO:0008289 lipid binding
molecular function GO:0046872 metal ion binding
molecular function GO:0008017 microtubule binding
molecular function GO:0019901 protein kinase binding
molecular function GO:0005080 protein kinase C binding
molecular function GO:0042169 SH2 domain binding
molecular function GO:0015275 stretch-activated, cation-selective, calcium channel activity
cellular component GO:0005912 adherens junction
cellular component GO:0016324 apical plasma membrane
cellular component GO:0005929 cilium
cellular component GO:0030864 cortical actin cytoskeleton
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0030175 filopodium
cellular component GO:0005925 focal adhesion
cellular component GO:0030426 growth cone
cellular component GO:0016021 integral component of membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0030027 lamellipodium
cellular component GO:0005886 plasma membrane
cellular component GO:0032587 ruffle membrane
Reactome
Pathway Id Pathway Name
R-HSA-2672351 Stimuli-sensing channels
R-HSA-3295583 TRP channels
R-HSA-382551 Transport of small molecules
R-HSA-983712 Ion channel transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0000772 BXGD000009 Multiple congenital anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003507 BXGD000203 Aortic Valve Stenosis Cardiovascular Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003862 BXGD000230 Arthralgia Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0003886 BXGD000238 Arthrogryposis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0005940 BXGD000352 Bone Diseases Musculoskeletal Diseases
C0005941 BXGD000353 Bone Diseases, Developmental Musculoskeletal Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006625 BXGD000401 Cachexia Pathological Conditions, Signs and Symptoms
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0007786 BXGD000486 Brain Ischemia Nervous System Diseases; Cardiovascular Diseases
C0007959 BXGD000507 Charcot-Marie-Tooth Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0008373 BXGD000536 Cholesteatoma Skin and Connective Tissue Diseases
C0008925 BXGD000575 Cleft Palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0009081 BXGD000581 Congenital clubfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0009676 BXGD000619 Confusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0009917 BXGD000635 Contracture Musculoskeletal Diseases
C0010200 BXGD000653 Coughing Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0010201 BXGD000654 Chronic cough Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0010278 BXGD000660 Craniosynostosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0010692 BXGD000686 Cystitis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0011175 BXGD000701 Dehydration Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0011269 BXGD000710 Dementia, Vascular Nervous System Diseases; Mental Disorders; Cardiovascular Diseases
C0011311 BXGD000714 Dengue Fever Infections
C0011644 BXGD000744 Scleroderma Skin and Connective Tissue Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011884 BXGD000762 Diabetic Retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013366 BXGD000820 Dyschondroplasias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014547 BXGD000927 Epilepsies, Partial Nervous System Diseases
C0014556 BXGD000932 Epilepsy, Temporal Lobe Nervous System Diseases
C0015469 BXGD000996 Facial paralysis Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Stomatognathic Diseases
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0015814 BXGD001021 Femur Head Necrosis Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0016202 BXGD001050 Flatfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0016506 BXGD001062 Foot Deformities Musculoskeletal Diseases
C0017168 BXGD001101 Gastroesophageal reflux disease Digestive System Diseases
C0017638 BXGD001132 Glioma Neoplasms
C0017654 BXGD001136 Glomerular Filtration Rate
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019553 BXGD001333 Hip Contracture Musculoskeletal Diseases
C0019559 BXGD001335 Hip joint pain Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0019825 BXGD001349 Hoarseness Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C0020255 BXGD001369 Hydrocephalus Nervous System Diseases
C0020429 BXGD001378 Hyperalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020437 BXGD001381 Hypercalcemia Nutritional and Metabolic Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020490 BXGD001403 Hyperopia Eye Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020625 BXGD001451 Hyponatremia Nutritional and Metabolic Diseases
C0021167 BXGD001487 Incontinence Nervous System Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0022104 BXGD001529 Irritable Bowel Syndrome Digestive System Diseases
C0022107 BXGD001530 Irritable Mood Behavior and Behavior Mechanisms
C0022408 BXGD001544 Arthropathy Musculoskeletal Diseases
C0022680 BXGD001576 Polycystic Kidney Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022821 BXGD001590 Kyphosis deformity of spine Musculoskeletal Diseases
C0023221 BXGD001619 Leg Length Inequality Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0023234 BXGD001622 Legg-Calve-Perthes Disease Musculoskeletal Diseases
C0024003 BXGD001726 Lordosis Musculoskeletal Diseases
C0024115 BXGD001732 Lung diseases Respiratory Tract Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0025237 BXGD001841 Melnick-Needles Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0025281 BXGD001848 Meniere Disease Otorhinolaryngologic Diseases
C0025286 BXGD001850 Meningioma Neoplasms; Nervous System Diseases
C0025362 BXGD001866 Mental Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0025995 BXGD001885 Micromelia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0026707 BXGD001922 Mucopolysaccharidosis IV Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0026760 BXGD001927 Multiple Epiphyseal Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026837 BXGD001937 Muscle Rigidity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0026847 BXGD001940 Spinal Muscular Atrophy Nervous System Diseases
C0027430 BXGD001988 Nasal Polyps Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027859 BXGD002052 Acoustic Neuroma Neoplasms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0027868 BXGD002053 Neuromuscular Diseases Nervous System Diseases
C0027888 BXGD002056 Hereditary Motor and Sensory Neuropathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0028840 BXGD002089 Ocular Hypertension Eye Diseases
C0028866 BXGD002094 Oculomotor Nerve Paralysis Eye Diseases; Nervous System Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029410 BXGD002138 Osteoarthritis of hip Musculoskeletal Diseases
C0029422 BXGD002142 Osteochondrodysplasias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0031090 BXGD002280 Periodontal Diseases Stomatognathic Diseases
C0031117 BXGD002285 Peripheral Neuropathy Nervous System Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0033999 BXGD002448 Pterygium Eye Diseases
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0034933 BXGD002496 Reflex, Abnormal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0035078 BXGD002505 Kidney Failure Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0035204 BXGD002511 Respiration Disorders Respiratory Tract Diseases
C0035229 BXGD002516 Respiratory Insufficiency Respiratory Tract Diseases
C0035242 BXGD002521 Respiratory Tract Diseases Respiratory Tract Diseases
C0035305 BXGD002529 Retinal Detachment Eye Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0035854 BXGD002568 Rosacea Skin and Connective Tissue Diseases
C0036280 BXGD002591 Burn scar Pathological Conditions, Signs and Symptoms; Wounds and Injuries
C0036391 BXGD002608 Schwartz-Jampel Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0036857 BXGD002638 Severe intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0037036 BXGD002661 Sialorrhea Stomatognathic Diseases
C0037274 BXGD002676 Dermatologic disorders Skin and Connective Tissue Diseases
C0037926 BXGD002712 Compression of spinal cord Nervous System Diseases; Wounds and Injuries
C0038015 BXGD002726 Spondyloepiphyseal Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038450 BXGD002759 Stridor Pathological Conditions, Signs and Symptoms
C0039273 BXGD002806 Talipes cavus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0040485 BXGD002871 Torticollis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0040997 BXGD002894 Trigeminal Neuralgia Nervous System Diseases; Stomatognathic Diseases
C0042024 BXGD002949 Urinary Incontinence Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0042035 BXGD002952 Urination Disorders Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0042345 BXGD002977 Varicosity Cardiovascular Diseases
C0042928 BXGD003014 Vocal Cord Paralysis Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C0043144 BXGD003032 Wheezing Pathological Conditions, Signs and Symptoms
C0085413 BXGD003171 Polycystic Kidney, Autosomal Dominant Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0085606 BXGD003201 Urgency of micturition Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0085623 BXGD003210 Akinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0086743 BXGD003308 Osteoarthrosis Deformans Musculoskeletal Diseases
C0149516 BXGD003324 Chronic sinusitis Infections; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0151313 BXGD003413 Sensory neuropathy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151650 BXGD003454 Renal fibrosis Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0151888 BXGD003497 Hyporeflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151908 BXGD003502 Dry skin Skin and Connective Tissue Diseases
C0152171 BXGD003552 Idiopathic pulmonary hypertension Respiratory Tract Diseases; Cardiovascular Diseases
C0155877 BXGD003830 Allergic asthma Respiratory Tract Diseases; Immune System Diseases
C0158266 BXGD003878 Intervertebral Disc Degeneration Musculoskeletal Diseases
C0158731 BXGD003902 Congenital pectus carinatum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0162298 BXGD003933 Joint stiffness Musculoskeletal Diseases
C0162820 BXGD003985 Dermatitis, Allergic Contact Skin and Connective Tissue Diseases; Immune System Diseases
C0175754 BXGD004015 Agenesis of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0201976 BXGD004063 Creatinine measurement, serum (procedure)
C0205713 BXGD004114 Roussy-Levy Syndrome (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0220810 BXGD004346 Congenital defects
C0221357 BXGD004449 Brachydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0231557 BXGD004500 Abnormal bone formation Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0231712 BXGD004519 Waddling gait Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0233715 BXGD004605 Speech impairment
C0233754 BXGD004609 Derealization Behavior and Behavior Mechanisms
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0234146 BXGD004626 Absent reflex Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234182 BXGD004631 Gowers sign
C0234244 BXGD004640 Tissue Pain Pathological Conditions, Signs and Symptoms
C0234245 BXGD004641 Visceral Pain Pathological Conditions, Signs and Symptoms
C0234251 BXGD004645 Inflammatory pain Pathological Conditions, Signs and Symptoms
C0234252 BXGD004646 Mechanical pain Pathological Conditions, Signs and Symptoms
C0235025 BXGD004713 Peripheral motor neuropathy Nervous System Diseases
C0235031 BXGD004714 Neurologic Symptoms Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235659 BXGD004763 Reduced fetal movement Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0239138 BXGD004966 Hip joint varus deformity - observation Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0239399 BXGD004981 Short extremities
C0239594 BXGD004987 Short finger
C0239676 BXGD004989 High forehead
C0239783 BXGD004992 Inguinal pain Pathological Conditions, Signs and Symptoms
C0239830 BXGD004998 Hand muscle atrophy
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0240017 BXGD005013 Intercostal muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Respiratory Tract Diseases; Nervous System Diseases
C0240733 BXGD005051 Peroneal muscle weakness
C0240953 BXGD005067 Winged scapula
C0241005 BXGD005072 Creatine phosphokinase serum increased
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0264081 BXGD005364 Osteoarthropathy of fingers familial Musculoskeletal Diseases
C0264172 BXGD005371 Barrel chest Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0264408 BXGD005387 Childhood asthma Respiratory Tract Diseases; Immune System Diseases
C0265280 BXGD005497 Spondylometaphyseal dysplasia, Kozlowski type Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0265281 BXGD005498 Metatropic dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0265610 BXGD005555 Clinodactyly of fingers Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0270765 BXGD006101 Myelopathic Muscular Atrophy Nervous System Diseases
C0270911 BXGD006128 Charcot-Marie-Tooth Disease, Type Ia (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0270912 BXGD006129 Charcot-Marie-Tooth Disease, Type Ib Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0270914 BXGD006131 Hereditary Motor and Sensory-Neuropathy Type II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0270921 BXGD006133 Axonal neuropathy Nervous System Diseases
C0271683 BXGD006234 Polyneuropathy, Motor Nervous System Diseases
C0276289 BXGD006418 Zika Virus Infection Infections
C0278877 BXGD006608 Adult Meningioma Neoplasms; Nervous System Diseases
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0333068 BXGD006920 Flexion contracture Musculoskeletal Diseases
C0338474 BXGD007183 Central nervous system demyelination
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0343284 BXGD007613 Chondrodysplasia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0345392 BXGD007732 Congenital kyphoscoliosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0349588 BXGD007933 Short stature
C0374997 BXGD007967 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
C0376618 BXGD008003 Endotoxemia Pathological Conditions, Signs and Symptoms; Infections
C0392476 BXGD008046 Epiphyseal dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0393541 BXGD008084 Distal Spinal Muscular Atrophy Nervous System Diseases
C0393546 BXGD008085 Oculopharyngeal Spinal Muscular Atrophy Nervous System Diseases
C0393547 BXGD008086 Bulbospinal Neuronopathy Nervous System Diseases
C0393907 BXGD008154 Axonal sensorimotor neuropathy
C0398350 BXGD008184 Acute cardiac pulmonary edema
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0409338 BXGD008381 Flexion contracture - elbow
C0409348 BXGD008384 Flexion contracture of proximal interphalangeal joint
C0410480 BXGD008429 Avascular Necrosis of Femur Head Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0410528 BXGD008430 Skeletal dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0410719 BXGD008448 Deformity of bone Musculoskeletal Diseases
C0426789 BXGD008576 Short thorax
C0426790 BXGD008577 Narrow thorax
C0426817 BXGD008585 Short ribs
C0426901 BXGD008597 Short leg
C0427065 BXGD008604 Distal muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0432072 BXGD008718 Dysmorphic features
C0432185 BXGD008730 Aplasia of muscle Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0432211 BXGD008737 Spondyloepimetaphyseal disorder Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0432227 BXGD008745 Brachyolmia Type 3 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0432228 BXGD008746 Brachyolmia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0432272 BXGD008761 Van Buchem disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0442874 BXGD008814 Neuropathy Nervous System Diseases
C0452138 BXGD008831 Sensorineural hearing loss, bilateral Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0458247 BXGD008904 Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0476403 BXGD008992 Electromyogram abnormal
C0520679 BXGD009101 Sleep Apnea, Obstructive Respiratory Tract Diseases; Nervous System Diseases
C0520947 BXGD009126 Clumsiness - motor delay Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0521170 BXGD009131 Osteoporotic Fractures Wounds and Injuries
C0521525 BXGD009139 Short neck
C0521532 BXGD009141 Diaphragmatic paresis Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0524595 BXGD009233 Aseptic Necrosis of Femur Head Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0541764 BXGD009259 Delayed bone age
C0559031 BXGD009464 Functional Gastrointestinal Disorders Digestive System Diseases
C0562557 BXGD009477 Sexually disinhibited behavior
C0575081 BXGD009512 Gait abnormality Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0575158 BXGD009515 Kyphoscoliosis deformity of spine Musculoskeletal Diseases
C0575484 BXGD009517 Long thorax
C0575802 BXGD009521 Small hand
C0576093 BXGD009525 Knee joint valgus deformity Musculoskeletal Diseases
C0595921 BXGD009626 Intraocular pressure disorder Eye Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598589 BXGD009667 Inherited neuropathies Nervous System Diseases
C0600033 BXGD009682 Acquired Kyphoscoliosis Musculoskeletal Diseases
C0600041 BXGD009685 Infective cystitis Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0600467 BXGD009709 Neurogenic Inflammation Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0699893 BXGD009871 Skin carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0700635 BXGD009897 Strudwick syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0751036 BXGD010299 Hereditary Motor and Sensory Neuropathy Type I Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0751074 BXGD010313 Diabetic Neuralgia Nervous System Diseases; Endocrine System Diseases
C0751211 BXGD010350 Hyperalgesia, Primary Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751212 BXGD010351 Hyperalgesia, Secondary Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751213 BXGD010352 Tactile Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751214 BXGD010353 Hyperalgesia, Thermal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751226 BXGD010358 Hypersomnia, Recurrent Nervous System Diseases; Mental Disorders
C0751334 BXGD010390 Progressive Proximal Myelopathic Muscular Atrophy Nervous System Diseases
C0751335 BXGD010391 Scapuloperoneal Form of Spinal Muscular Atrophy Nervous System Diseases
C0751576 BXGD010508 Partial Paralysis (Paresis) Vocal Cords Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C0751956 BXGD010653 Acute Cerebrovascular Accidents Nervous System Diseases; Cardiovascular Diseases
C0752121 BXGD010669 Spinocerebellar Ataxia Type 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0856169 BXGD011096 Endothelial dysfunction
C0856863 BXGD011122 Broad-based gait
C0858599 BXGD011181 Taste sour
C0877430 BXGD011347 Asthma chronic
C0878659 BXGD011380 Disproportionate short stature Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0917981 BXGD011423 Progressive Muscular Atrophy Nervous System Diseases
C0947751 BXGD011494 Vascular inflammations Cardiovascular Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1136179 BXGD011712 Hammer Toe Musculoskeletal Diseases
C1145670 BXGD011764 Respiratory Failure Respiratory Tract Diseases
C1263857 BXGD011900 Peripheral axonal neuropathy Nervous System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1285162 BXGD012167 Degenerative disorder Pathological Conditions, Signs and Symptoms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1328407 BXGD012465 Hip Dysplasia Musculoskeletal Diseases; Wounds and Injuries
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1389118 BXGD012966 Peroneal muscle atrophy
C1442965 BXGD013064 Avascular necrosis of the capital femoral epiphysis Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C1519346 BXGD013235 Skin Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1519670 BXGD013241 Tumor Angiogenesis Pathological Conditions, Signs and Symptoms
C1527303 BXGD013265 Chronic Airflow Obstruction Respiratory Tract Diseases
C1535950 BXGD013325 Gastrointestinal inflammation
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1565489 BXGD013401 Renal Insufficiency Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1611743 BXGD013456 Familial (FPAH)
C1658953 BXGD013486 tumor vasculature
C1720983 BXGD013698 Channelopathies Pathological Conditions, Signs and Symptoms
C1762616 BXGD013753 Meningioma, benign, no ICD-O subtype Neoplasms; Nervous System Diseases
C1834975 BXGD014004 Irregular acetabular roof
C1835570 BXGD014034 Hypoplastic cervical vertebrae
C1836057 BXGD014076 Muscle fiber splitting
C1836184 BXGD014088 Short femoral neck
C1836189 BXGD014091 Radial deviation of finger
C1836296 BXGD014105 Muscle Weakness Lower Limb Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1836320 BXGD014108 Proximal femoral metaphyseal irregularity
C1836542 BXGD014129 Depressed nasal bridge
C1836609 BXGD014138 Progressive distal muscle weakness
C1836767 BXGD014159 Proximal lower limb amyotrophy
C1837485 BXGD014239 Flat acetabular roof
C1838492 BXGD014316 SPINAL MUSCULAR ATROPHY, DISTAL, CONGENITAL NONPROGRESSIVE (disorder) Nervous System Diseases
C1839326 BXGD014367 Abnormal form of the vertebral bodies
C1839829 BXGD014413 Short distal phalanx of finger
C1842083 BXGD014494 Abnormality of the ribs
C1842162 BXGD014502 Scapuloperoneal amyotrophy
C1844548 BXGD014642 Hypoplastic finger
C1844704 BXGD014665 Platyspondyly
C1846435 BXGD014815 Disproportionate short-trunk short stature
C1846439 BXGD014817 Hypoplasia of the odontoid process Musculoskeletal Diseases
C1846950 BXGD014848 Short middle phalanx of finger
C1847406 BXGD014863 Digital Arthropathy-Brachydactyly, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1847408 BXGD014864 Brachytelomesophalangy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1847584 BXGD014876 Distal sensory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1847766 BXGD014888 Shoulder girdle muscle atrophy
C1848736 BXGD014970 Distal amyotrophy
C1850049 BXGD015101 Clinodactyly of the 5th finger
C1850135 BXGD015112 Flared metaphysis
C1850383 BXGD015137 Neuropathy, Painful Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1851542 BXGD015217 Limited hip movement
C1853710 BXGD015353 HEREDITARY MOTOR AND SENSORY NEUROPATHY, TYPE IIC (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1854158 BXGD015386 DEAFNESS, AUTOSOMAL DOMINANT 25 (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1854301 BXGD015391 Motor delay Mental Disorders
C1855544 BXGD015508 Enlarged metaphyses
C1856872 BXGD015647 Down-sloping shoulders
C1857101 BXGD015676 Anisospondyly
C1857108 BXGD015677 Limitation of joint mobility
C1857486 BXGD015710 Low-set, posteriorly rotated ears
C1857665 BXGD015734 Aplastic clavicle
C1859111 BXGD015852 Enlarged joints
C1859461 BXGD015895 Femoral bowing Musculoskeletal Diseases
C1860601 BXGD015988 Flattened femoral head
C1861403 BXGD016045 Variable expressivity
C1863749 BXGD016195 Carpal bone hypoplasia
C1864853 BXGD016261 Increased vertebral height
C1866141 BXGD016379 Foot dorsiflexor weakness
C1866700 BXGD016416 Irregular, rachitic-like metaphyses
C1866703 BXGD016417 Severe carpal ossification delay
C1868616 BXGD016515 Parastremmatic dwarfism Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Endocrine System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C2079540 BXGD016915 Charcot-Marie-Tooth disease, Type 2C Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2700617 BXGD017474 Irritation - emotion Behavior and Behavior Mechanisms
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2745959 BXGD017570 Spondyloepiphyseal dysplasia, congenita Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C2919142 BXGD017867 Short Stature, CTCAE
C2936719 BXGD018130 Mechanical Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C2973725 BXGD018205 Pulmonary arterial hypertension Respiratory Tract Diseases; Cardiovascular Diseases
C3148833 BXGD018271 Childhood-onset short-trunk short stature
C3150755 BXGD018335 SODIUM SERUM LEVEL QUANTITATIVE TRAIT LOCUS 1
C3159322 BXGD018466 SPONDYLOEPIPHYSEAL DYSPLASIA, MAROTEAUX TYPE Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
C3277114 BXGD018701 Relatively short spine
C3277116 BXGD018702 Long coccyx
C3277117 BXGD018703 Caudal appendage
C3277119 BXGD018704 Halberd-shaped pelvis
C3277120 BXGD018705 Hyperplasia of the femoral trochanters
C3277123 BXGD018706 Dumbbell-shaped metaphyses
C3277126 BXGD018707 Absent primary metaphyseal spongiosa
C3277127 BXGD018708 Abnormal metaphyseal vascular invasion
C3541456 BXGD019096 Spondyloepiphyseal Dysplasia Tarda, X-Linked Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C3543005 BXGD019107 Surgical incision wound (morphologic abnormality) Wounds and Injuries
C3661519 BXGD019264 Hereditary Motor Neuronopathy Nervous System Diseases
C3665927 BXGD019312 Renal hypoperfusion
C3711162 BXGD019377 Metatropic Dysplasia Type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3805715 BXGD019484 Short stepped shuffling gait Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3805969 BXGD019495 Scapular muscle atrophy
C3839460 BXGD019773 Nonprogressive
C4020912 BXGD020496 Flared humeral metaphysis
C4020958 BXGD020508 Rough bone trabeculation
C4021605 BXGD020694 Shortening of all middle phalanges of the toes
C4021611 BXGD020697 Abnormality of epiphysis morphology
C4021723 BXGD020733 Short middle phalanx of toe
C4021741 BXGD020749 Abnormal cortical bone morphology
C4021771 BXGD020768 Short distal phalanx of toe
C4024611 BXGD021342 Nonprogressive muscular atrophy
C4024613 BXGD021344 Progressive distal muscular atrophy
C4024920 BXGD021474 Decreased distal sensory nerve action potential
C4024921 BXGD021475 Lower limb amyotrophy
C4024996 BXGD021518 Aplasia/Hypoplasia of the lungs
C4025132 BXGD021562 Shortening of all distal phalanges of the toes
C4025249 BXGD021604 Abnormality of the intervertebral disk
C4025381 BXGD021655 Osteoarthritis of the small joints of the hand Musculoskeletal Diseases
C4025628 BXGD021702 Abnormal enchondral ossification
C4025674 BXGD021725 Flared femoral metaphysis
C4025763 BXGD021783 Abnormality of the rib cage
C4025814 BXGD021806 Abnormality of the metaphysis
C4025871 BXGD021839 Abnormality of the face
C4082169 BXGD022084 Metatarsus Varus Musculoskeletal Diseases
C4086152 BXGD022123 Childhood Astrocytoma Neoplasms
C4316870 BXGD022707 Abnormality of the eye
C4476938 BXGD022892 Impairment of activities of daily living
C4479260 BXGD022930 AVASCULAR NECROSIS OF FEMORAL HEAD, PRIMARY, 2
C4551479 BXGD023309 Schwartz-Jampel Syndrome, Type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C4551485 BXGD023312 Clinodactyly
C4551516 BXGD023333 Hip pain Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C4551519 BXGD023335 Abducens Nerve Palsy Nervous System Diseases
C4551562 BXGD023350 AVASCULAR NECROSIS OF FEMORAL HEAD, PRIMARY, 1 Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C4551915 BXGD023441 Gait Disturbance, CTCAE
C4552810 BXGD023525 Irritability, CTCAE
C4553976 BXGD023554 Urinary Urgency, CTCAE 5
C4704753 BXGD023679 Urinary Bladder, Underactive Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0005620 beta-D-Glucopyranose 180.16
BXGC0040150 Cannabidiol 314.22
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein