Showing entry for Thrombocythemia, Essential


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD002835
Disease NameThrombocythemia, Essential
Disease CUI IdC0040028
MeSH Codes C15  
Disease Class NameHemic and Lymphatic Diseases
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id DOID:7   DOID:14566  
Disease Ontology Class Namedisease of anatomical entity; disease of cellular proliferation
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O00206 BXGT003894 Toll-like receptor 4 7099 reviewed
O14746 BXGT004091 Telomerase reverse transcriptase 7015 reviewed Enzyme
O60674 BXGT004892 Tyrosine-protein kinase JAK2 3717 reviewed Kinase
O75874 BXGT005157 Isocitrate dehydrogenase [NADP] cytoplasmic 3417 reviewed
O94907 BXGT005340 Dickkopf-related protein 1 22943 reviewed
O96017 BXGT005415 Serine/threonine-protein kinase Chk2 11200 reviewed Kinase
P00338 BXGT005504 L-lactate dehydrogenase A chain 3939 reviewed Enzyme
P00519 BXGT005570 Tyrosine-protein kinase ABL1 25 reviewed Kinase
P00734 BXGT005630 Prothrombin 2147 reviewed Enzyme
P00797 BXGT005658 Renin 5972 reviewed Enzyme
P01106 BXGT005730 Myc proto-oncogene protein 4609 reviewed Transcription factor
P01111 BXGT005731 GTPase NRas 4893 reviewed Enzyme modulator
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P01579 BXGT005770 Interferon gamma 3458 reviewed
P01889 BXGT005809 HLA class I histocompatibility antigen, B-7 alpha chain 3106 reviewed
P02647 BXGT005908 Apolipoprotein A-I 335 reviewed
P02741 BXGT005936 C-reactive protein 1401 reviewed
P04070 BXGT006143 Vitamin K-dependent protein C 5624 reviewed Enzyme
P04150 BXGT006154 Glucocorticoid receptor 2908 reviewed Nuclear receptor
P04629 BXGT006239 High affinity nerve growth factor receptor 4914 reviewed Kinase
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P05106 BXGT006315 Integrin beta-3 3690 reviewed Receptor
P05107 BXGT006316 Integrin beta-2 3689 reviewed Receptor
P05109 BXGT006318 Protein S100-A8 6279 reviewed Calcium-binding protein
P05121 BXGT006320 Plasminogen activator inhibitor 1 5054 reviewed Enzyme modulator
P05231 BXGT006345 Interleukin-6 3569 reviewed
P05546 BXGT006367 Heparin cofactor 2 3053 reviewed Enzyme modulator
P06702 BXGT006476 Protein S100-A9 6280 reviewed Calcium-binding protein
P07225 BXGT006572 Vitamin K-dependent protein S 5627 reviewed
P07996 BXGT006710 Thrombospondin-1 7057 reviewed
P08253 BXGT006757 72 kDa type IV collagenase 4313 reviewed Enzyme
P08514 BXGT006781 Integrin alpha-IIb 3674 reviewed
P08700 BXGT006816 Interleukin-3 3562 reviewed
P08758 BXGT006821 Annexin A5 308 reviewed
P09038 BXGT006851 Fibroblast growth factor 2 2247 reviewed Signaling
P09466 BXGT006892 Glycodelin 5047 reviewed Enzyme
P10145 BXGT007542 Interleukin-8 3576 reviewed Signaling
P10275 BXGT007552 Androgen receptor 367 reviewed Nuclear receptor
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P10646 BXGT007598 Tissue factor pathway inhibitor 7035 reviewed Enzyme modulator
P10721 BXGT007605 Mast/stem cell growth factor receptor Kit 3815 reviewed Kinase
P11215 BXGT007672 Integrin alpha-M 3684 reviewed
P11274 BXGT007681 Breakpoint cluster region protein 613 reviewed Enzyme modulator
P11413 BXGT007701 Glucose-6-phosphate 1-dehydrogenase 2539 reviewed Enzyme
P12004 BXGT007766 Proliferating cell nuclear antigen 5111 reviewed Nucleic acid binding
P12318 BXGT007799 Low affinity immunoglobulin gamma Fc region receptor II-a 2212 reviewed Cell adhesion
P12821 BXGT007849 Angiotensin-converting enzyme 1636 reviewed Enzyme
P13726 BXGT007950 Tissue factor 2152 reviewed Receptor
P14780 BXGT008053 Matrix metalloproteinase-9 4318 reviewed Enzyme
P15086 BXGT008078 Carboxypeptidase B 1360 reviewed Enzyme
P15289 BXGT008102 Arylsulfatase A 410 reviewed Enzyme
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P16109 BXGT008194 P-selectin 6403 reviewed
P16234 BXGT008209 Platelet-derived growth factor receptor alpha 5156 reviewed Kinase
P16581 BXGT008245 E-selectin 6401 reviewed
P17516 BXGT008313 Aldo-keto reductase family 1 member C4 1109 reviewed Enzyme
P17931 BXGT008356 Galectin-3 3958 reviewed Signaling
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 2321 reviewed Kinase
P18074 BXGT008374 General transcription and DNA repair factor IIH helicase subunit XPD 2068 reviewed Enzyme
P19440 BXGT008481 Glutathione hydrolase 1 proenzyme 2678 reviewed Enzyme
P22681 BXGT008795 E3 ubiquitin-protein ligase CBL 867 reviewed Enzyme
P23219 BXGT008837 Prostaglandin G/H synthase 1 5742 reviewed Enzyme
P23458 BXGT008868 Tyrosine-protein kinase JAK1 3716 reviewed Kinase
P23560 BXGT008883 Brain-derived neurotrophic factor 627 reviewed Signaling
P24385 BXGT008965 G1/S-specific cyclin-D1 595 reviewed Enzyme modulator
P25024 BXGT009005 C-X-C chemokine receptor type 1 3577 reviewed G-protein coupled receptor
P25025 BXGT009006 C-X-C chemokine receptor type 2 3579 reviewed G-protein coupled receptor
P27797 BXGT009206 Calreticulin 811 reviewed Calcium-binding protein
P29474 BXGT009352 Nitric oxide synthase, endothelial 4846 reviewed
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase 207 reviewed Kinase
P34932 BXGT009772 Heat shock 70 kDa protein 4 3308 reviewed
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P35610 BXGT009855 Sterol O-acyltransferase 1 6646 reviewed Enzyme
P36222 BXGT009914 Chitinase-3-like protein 1 1116 reviewed
P40189 BXGT010164 Interleukin-6 receptor subunit beta 3572 reviewed Signaling
P40225 BXGT010168 Thrombopoietin 7066 reviewed
P40763 BXGT010202 Signal transducer and activator of transcription 3 6774 reviewed Nucleic acid binding
P42224 BXGT010286 Signal transducer and activator of transcription 1-alpha/beta 6772 reviewed Nucleic acid binding
P42898 BXGT010344 Methylenetetrahydrofolate reductase 4524 reviewed
P48023 BXGT010604 Tumor necrosis factor ligand superfamily member 6 356 reviewed Signaling
P48061 BXGT010616 Stromal cell-derived factor 1 6387 reviewed
P48735 BXGT010657 Isocitrate dehydrogenase [NADP], mitochondrial 3418 reviewed
P49763 BXGT010737 Placenta growth factor 5228 reviewed Signaling
P49908 BXGT010760 Selenoprotein P 6414 reviewed Extracellular structure
P49916 BXGT010764 DNA ligase 3 3980 reviewed Enzyme
P51692 BXGT010885 Signal transducer and activator of transcription 5B 6777 reviewed Nucleic acid binding
P54136 BXGT011033 Arginine--tRNA ligase, cytoplasmic 5917 reviewed
P54578 BXGT011056 Ubiquitin carboxyl-terminal hydrolase 14 9097 reviewed Enzyme
P55211 BXGT011111 Caspase-9 842 reviewed Enzyme
P55957 BXGT011137 BH3-interacting domain death agonist 637 reviewed
P58004 BXGT011222 Sestrin-2 83667 reviewed Enzyme
P61073 BXGT011352 C-X-C chemokine receptor type 4 7852 reviewed G-protein coupled receptor
P62834 BXGT011464 Ras-related protein Rap-1A 5906 reviewed Enzyme modulator
P78540 BXGT011848 Arginase-2, mitochondrial 384 reviewed Enzyme
P80188 BXGT011882 Neutrophil gelatinase-associated lipocalin 3934 reviewed Enzyme
P80511 BXGT011914 Protein S100-A12 6283 reviewed Calcium-binding protein
P81172 BXGT011935 Hepcidin 57817 reviewed
Q00987 BXGT012559 E3 ubiquitin-protein ligase Mdm2 4193 reviewed Nucleic acid binding
Q01081 BXGT012566 Splicing factor U2AF 35 kDa subunit 7307 reviewed
Q02083 BXGT012633 N-acylethanolamine-hydrolyzing acid amidase 27163 reviewed Enzyme
Q07108 BXGT012919 Early activation antigen CD69 969 reviewed
Q07812 BXGT012940 Apoptosis regulator BAX 581 reviewed Signaling
Q07817 BXGT012941 Bcl-2-like protein 1 598 reviewed Signaling
Q13231 BXGT013329 Chitotriosidase-1 1118 reviewed
Q13336 BXGT013343 Urea transporter 1 6563 reviewed Transporter
Q13485 BXGT013363 Mothers against decapentaplegic homolog 4 4089 reviewed Transcription factor
Q15910 BXGT013612 Histone-lysine N-methyltransferase EZH2 2146 reviewed Epigenetic regulator
Q16611 BXGT013644 Bcl-2 homologous antagonist/killer 578 reviewed Signaling
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha 3091 reviewed Transcription factor
Q30201 BXGT014297 Hereditary hemochromatosis protein 3077 reviewed
Q6N021 BXGT016378 Methylcytosine dioxygenase TET2 54790 reviewed
Q8TDQ0 BXGT018810 Hepatitis A virus cellular receptor 2 84868 reviewed
Q8WWM9 BXGT019001 Cytoglobin 114757 reviewed
Q92843 BXGT019384 Bcl-2-like protein 2 599 reviewed Signaling
Q96DB2 BXGT019639 Histone deacetylase 11 79885 reviewed Epigenetic regulator
Q96P20 BXGT019704 NACHT, LRR and PYD domains-containing protein 3 114548 reviewed
Q9BXR0 BXGT020173 Queuine tRNA-ribosyltransferase catalytic subunit 1 81890 reviewed
Q9BYF1 BXGT020186 Angiotensin-converting enzyme 2 59272 reviewed Enzyme
Q9BYW2 BXGT020192 Histone-lysine N-methyltransferase SETD2 29072 reviewed Epigenetic regulator
Q9GZX6 BXGT020428 Interleukin-22 50616 reviewed
Q9UBN7 BXGT021658 Histone deacetylase 6 10013 reviewed Epigenetic regulator
Q9UJ41 BXGT021723 Rab5 GDP/GTP exchange factor 27342 reviewed Enzyme modulator
Q9UKV0 BXGT021750 Histone deacetylase 9 9734 reviewed Epigenetic regulator
Q9Y251 BXGT022215 Heparanase 10855 reviewed Enzyme
Q9Y3D8 BXGT022258 Adenylate kinase isoenzyme 6 102157402 reviewed
Q9Y4D1 BXGT022273 Disheveled-associated activator of morphogenesis 1 23002 reviewed
Q9Y6X2 BXGT022343 E3 SUMO-protein ligase PIAS3 10401 reviewed
P19235 BXGT022895 Erythropoietin receptor 2057 reviewed Receptor
Q01543 BXGT023137 Friend leukemia integration 1 transcription factor 2313 reviewed Transcription factor
P00395 BXGT023596 Cytochrome c oxidase subunit 1 4512 reviewed Enzyme
P16104 BXGT024571 Histone H2AX 3014 reviewed Nucleic acid binding
V9HWB9 BXGT026149 L-lactate dehydrogenase 3939 unreviewed
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease