Showing entry for Integrin beta-3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006315
Protein NameIntegrin beta-3
Uniport IdP05106
GeneITGB3
Gene Id3690
DomainEGF_2; I-EGF_1; Integrin_beta; Integrin_b_cyt; Integrin_B_tail; PSI_integrin
Pfam PF07974   PF18372   PF08725   PF07965   PF00362   PF17205  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04015 Rap1 signaling pathway
4. Cellular Processes 4.1 Transport and catabolism hsa04145 Phagosome
3. Environmental Information Processing 3.2 Signal transduction hsa04151 PI3K-Akt signaling pathway
5. Organismal Systems 5.8 Development hsa04380 Osteoclast differentiation
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04510 Focal adhesion
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04512 ECM-receptor interaction
5. Organismal Systems 5.1 Immune system hsa04611 Platelet activation
5. Organismal Systems 5.1 Immune system hsa04640 Hematopoietic cell lineage
4. Cellular Processes 4.5 Cell motility hsa04810 Regulation of actin cytoskeleton
5. Organismal Systems 5.2 Endocrine system hsa04919 Thyroid hormone signaling pathway
6. Human Diseases 6.9 Infectious diseases: Viral hsa05163 Human cytomegalovirus infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05165 Human papillomavirus infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05168 Herpes simplex virus 1 infection
6. Human Diseases 6.1 Cancers: Overview hsa05205 Proteoglycans in cancer
6. Human Diseases 6.1 Cancers: Overview hsa05206 MicroRNAs in cancer
6. Human Diseases 6.6 Cardiovascular diseases hsa05410 Hypertrophic cardiomyopathy (HCM)
6. Human Diseases 6.6 Cardiovascular diseases hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
6. Human Diseases 6.6 Cardiovascular diseases hsa05414 Dilated cardiomyopathy (DCM)
6. Human Diseases 6.6 Cardiovascular diseases hsa05418 Fluid shear stress and atherosclerosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0032147 activation of protein kinase activity
Biological Process GO:0060055 angiogenesis involved in wound healing
Biological Process GO:0038027 apolipoprotein A-I-mediated signaling pathway
Biological Process GO:0043277 apoptotic cell clearance
Biological Process GO:0007596 blood coagulation
Biological Process GO:0007155 cell adhesion
Biological Process GO:0033627 cell adhesion mediated by integrin
Biological Process GO:0007160 cell-matrix adhesion
Biological Process GO:0016477 cell migration
Biological Process GO:0031589 cell-substrate adhesion
Biological Process GO:0030198 extracellular matrix organization
Biological Process GO:0034113 heterotypic cell-cell adhesion
Biological Process GO:0007229 integrin-mediated signaling pathway
Biological Process GO:0050900 leukocyte migration
Biological Process GO:0048333 mesodermal cell differentiation
Biological Process GO:0050919 negative chemotaxis
Biological Process GO:0010888 negative regulation of lipid storage
Biological Process GO:0032369 negative regulation of lipid transport
Biological Process GO:0050748 negative regulation of lipoprotein metabolic process
Biological Process GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process
Biological Process GO:0010745 negative regulation of macrophage derived foam cell differentiation
Biological Process GO:0030168 platelet activation
Biological Process GO:0070527 platelet aggregation
Biological Process GO:0002576 platelet degranulation
Biological Process GO:0010595 positive regulation of endothelial cell migration
Biological Process GO:0001938 positive regulation of endothelial cell proliferation
Biological Process GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
Biological Process GO:0001934 positive regulation of protein phosphorylation
Biological Process GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
Biological Process GO:0045124 regulation of bone resorption
Biological Process GO:0032880 regulation of protein localization
Biological Process GO:0051611 regulation of serotonin uptake
Biological Process GO:0014909 smooth muscle cell migration
Biological Process GO:0034446 substrate adhesion-dependent cell spreading
Biological Process GO:0035295 tube development
Biological Process GO:0048010 vascular endothelial growth factor receptor signaling pathway
Biological Process GO:0046718 viral entry into host cell
Biological Process GO:0042060 wound healing
molecular function GO:0050839 cell adhesion molecule binding
molecular function GO:0015026 coreceptor activity
molecular function GO:0019899 enzyme binding
molecular function GO:0050840 extracellular matrix binding
molecular function GO:0001968 fibronectin binding
molecular function GO:0042802 identical protein binding
molecular function GO:0005178 integrin binding
molecular function GO:0005161 platelet-derived growth factor receptor binding
molecular function GO:0002020 protease binding
molecular function GO:0003756 protein disulfide isomerase activity
molecular function GO:0043184 vascular endothelial growth factor receptor 2 binding
molecular function GO:0001618 virus receptor activity
cellular component GO:0035868 alphav-beta3 integrin-HMGB1 complex
cellular component GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex
cellular component GO:0035866 alphav-beta3 integrin-PKCalpha complex
cellular component GO:0071062 alphav-beta3 integrin-vitronectin complex
cellular component GO:0005911 cell-cell junction
cellular component GO:0009986 cell surface
cellular component GO:0070062 extracellular exosome
cellular component GO:0031527 filopodium membrane
cellular component GO:0005925 focal adhesion
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0034683 integrin alphav-beta3 complex
cellular component GO:0008305 integrin complex
cellular component GO:0031258 lamellipodium membrane
cellular component GO:0042470 melanosome
cellular component GO:0031528 microvillus membrane
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
cellular component GO:0031092 platelet alpha granule membrane
cellular component GO:0045211 postsynaptic membrane
cellular component GO:0032991 protein-containing complex
cellular component GO:0043235 receptor complex
cellular component GO:0032587 ruffle membrane
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-114608 Platelet degranulation
R-HSA-1266738 Developmental Biology
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1474244 Extracellular matrix organization
R-HSA-1474244 Extracellular matrix organization
R-HSA-1566948 Elastic fibre formation
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-168256 Immune System
R-HSA-194138 Signaling by VEGF
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-210990 PECAM1 interactions
R-HSA-2129379 Molecules associated with elastic fibres
R-HSA-216083 Integrin cell surface interactions
R-HSA-216083 Integrin cell surface interactions
R-HSA-3000170 Syndecan interactions
R-HSA-3000170 Syndecan interactions
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-3000178 ECM proteoglycans
R-HSA-354192 Integrin signaling
R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-HSA-372708 p130Cas linkage to MAPK signaling for integrins
R-HSA-373760 L1CAM interactions
R-HSA-422475 Axon guidance
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-445144 Signal transduction by L1
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5674135 MAP2K and MAPK activation
R-HSA-5683057 MAPK family signaling cascades
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants
R-HSA-6802949 Signaling by RAS mutants
R-HSA-6802952 Signaling by BRAF and RAF fusions
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF
R-HSA-6802957 Oncogenic MAPK signaling
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-76005 Response to elevated platelet cytosolic Ca2+
R-HSA-76009 Platelet Aggregation (Plug Formation)
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9607240 FLT3 Signaling
R-HSA-9649948 Signaling downstream of RAS mutants
R-HSA-9656223 Signaling by RAF1 mutants
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000786 BXGD000010 Spontaneous abortion Female Urogenital Diseases and Pregnancy Complications
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0002874 BXGD000134 Aplastic Anemia Hemic and Lymphatic Diseases
C0002965 BXGD000162 Angina, Unstable Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003130 BXGD000183 Anoxia Pathological Conditions, Signs and Symptoms
C0003499 BXGD000201 Supravalvular aortic stenosis Cardiovascular Diseases
C0003507 BXGD000203 Aortic Valve Stenosis Cardiovascular Diseases
C0003838 BXGD000224 Arterial Occlusive Diseases Cardiovascular Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0004626 BXGD000283 Pneumonia, Bacterial Infections; Respiratory Tract Diseases
C0004936 BXGD000295 Mental disorders Mental Disorders
C0004943 BXGD000297 Behcet Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Skin and Connective Tissue Diseases; Stomatognathic Diseases; Cardiovascular Diseases
C0005129 BXGD000304 Bernard-Soulier Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005779 BXGD000336 Blood Coagulation Disorders Hemic and Lymphatic Diseases
C0005818 BXGD000338 Blood Platelet Disorders Hemic and Lymphatic Diseases
C0005859 BXGD000342 Bloom Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007274 BXGD000456 Carotid Artery Thrombosis Nervous System Diseases; Cardiovascular Diseases
C0007282 BXGD000458 Carotid Stenosis Nervous System Diseases; Cardiovascular Diseases
C0007722 BXGD000474 Cephalhematoma due to birth trauma Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Wounds and Injuries
C0007772 BXGD000480 Intracranial Arteriovenous Malformation Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Cardiovascular Diseases
C0007787 BXGD000487 Transient Ischemic Attack Nervous System Diseases; Cardiovascular Diseases
C0007789 BXGD000488 Cerebral Palsy Nervous System Diseases
C0008479 BXGD000544 Chondrosarcoma Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010072 BXGD000649 Coronary Thrombosis Cardiovascular Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011644 BXGD000744 Scleroderma Skin and Connective Tissue Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0011884 BXGD000762 Diabetic Retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0013366 BXGD000820 Dyschondroplasias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0013491 BXGD000847 Ecchymosis Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0013528 BXGD000851 Echolalia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014057 BXGD000880 Japanese Encephalitis Infections; Nervous System Diseases
C0014084 BXGD000891 Enchondromatosis Musculoskeletal Diseases
C0014121 BXGD000895 Bacterial Endocarditis Infections; Cardiovascular Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0014591 BXGD000938 Epistaxis Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0014743 BXGD000946 Erythema Nodosum Skin and Connective Tissue Diseases; Immune System Diseases; Chemically-Induced Disorders
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0016057 BXGD001042 Fibrosarcoma Neoplasms
C0017181 BXGD001103 Gastrointestinal Hemorrhage Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0017565 BXGD001118 Gingival Hemorrhage Pathological Conditions, Signs and Symptoms; Stomatognathic Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0017639 BXGD001133 Gliosis Pathological Conditions, Signs and Symptoms
C0017658 BXGD001138 Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0018915 BXGD001244 Hemangioendothelioma Neoplasms
C0018965 BXGD001258 Hematuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0019080 BXGD001279 Hemorrhage Pathological Conditions, Signs and Symptoms
C0019101 BXGD001284 Hemorrhagic Fever with Renal Syndrome Infections
C0019829 BXGD001350 Hodgkin Disease Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021308 BXGD001494 Infarction Pathological Conditions, Signs and Symptoms
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024305 BXGD001763 Lymphoma, Non-Hodgkin Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0024668 BXGD001795 Mammary Neoplasms, Experimental Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0025222 BXGD001838 Melena Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0025323 BXGD001864 Menorrhagia Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0025500 BXGD001874 Mesothelioma Neoplasms
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026837 BXGD001937 Muscle Rigidity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029134 BXGD002118 Optic Neuritis Eye Diseases; Nervous System Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0030805 BXGD002256 Bullous pemphigoid Skin and Connective Tissue Diseases; Immune System Diseases
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0032463 BXGD002357 Polycythemia Vera Neoplasms; Hemic and Lymphatic Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0034150 BXGD002466 Purpura Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0035126 BXGD002509 Reperfusion Injury Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0036220 BXGD002587 Kaposi Sarcoma Neoplasms; Infections
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0038525 BXGD002768 Subarachnoid Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0039263 BXGD002805 Takayasu Arteritis Skin and Connective Tissue Diseases; Cardiovascular Diseases
C0039483 BXGD002813 Giant Cell Arteritis Skin and Connective Tissue Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C0040015 BXGD002833 Thrombasthenia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0040028 BXGD002835 Thrombocythemia, Essential Hemic and Lymphatic Diseases
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0040053 BXGD002839 Thrombosis Cardiovascular Diseases
C0042345 BXGD002977 Varicosity Cardiovascular Diseases
C0042571 BXGD002991 Vertigo Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0043194 BXGD003036 Wiskott-Aldrich Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085110 BXGD003126 Severe Combined Immunodeficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0085129 BXGD003128 Bronchial Hyperreactivity Respiratory Tract Diseases
C0149871 BXGD003375 Deep Vein Thrombosis Cardiovascular Diseases
C0151529 BXGD003433 Prolonged bleeding time
C0151699 BXGD003461 Intracranial Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0153633 BXGD003674 Malignant neoplasm of brain Neoplasms; Nervous System Diseases
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0155626 BXGD003806 Acute myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0202236 BXGD004086 Triglycerides measurement
C0220613 BXGD004297 Adult Soft Tissue Sarcoma
C0220645 BXGD004307 Childhood Soft Tissue Sarcoma
C0220650 BXGD004310 Metastatic malignant neoplasm to brain Pathological Conditions, Signs and Symptoms; Neoplasms; Nervous System Diseases
C0232943 BXGD004570 Intermenstrual heavy bleeding Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0238790 BXGD004956 bone destruction
C0241144 BXGD005080 Petechiae of skin Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242584 BXGD005179 Autoimmune thrombocytopenia Immune System Diseases; Hemic and Lymphatic Diseases
C0242594 BXGD005180 Residual Cancer Pathological Conditions, Signs and Symptoms; Neoplasms
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0265808 BXGD005578 Cyanotic congenital heart disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Respiratory Tract Diseases; Cardiovascular Diseases
C0268731 BXGD006029 Renal glomerular disease Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0272278 BXGD006335 Congenital thrombocytopenia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C0272285 BXGD006336 Heparin-induced thrombocytopenia Hemic and Lymphatic Diseases
C0272286 BXGD006337 Thrombocytopenia due to platelet alloimmunization Hemic and Lymphatic Diseases
C0278595 BXGD006545 Adult Fibrosarcoma Neoplasms
C0280141 BXGD006716 Acute Undifferentiated Leukemia
C0333209 BXGD006934 Platelet thrombus Cardiovascular Diseases
C0333864 BXGD006970 Giant platelet (morphologic abnormality)
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0345905 BXGD007746 Intrahepatic Cholangiocarcinoma Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376618 BXGD008003 Endotoxemia Pathological Conditions, Signs and Symptoms; Infections
C0398356 BXGD008185 Abdominal aortic atherosclerosis
C0398623 BXGD008202 Thrombophilia Hemic and Lymphatic Diseases
C0398648 BXGD008211 Posttransfusion purpura Immune System Diseases; Hemic and Lymphatic Diseases
C0398650 BXGD008212 Immune thrombocytopenic purpura Pathological Conditions, Signs and Symptoms; Immune System Diseases; Hemic and Lymphatic Diseases
C0423798 BXGD008510 Increased tendency to bruise Wounds and Injuries
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0428474 BXGD008631 Serum LDL cholesterol measurement
C0452138 BXGD008831 Sensorineural hearing loss, bilateral Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0456909 BXGD008883 Blindness Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0473237 BXGD008936 Frank hematuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0477317 BXGD008998 Other primary thrombocytopenia Hemic and Lymphatic Diseases
C0524528 BXGD009229 Pervasive Development Disorder Mental Disorders
C0555198 BXGD009432 Malignant Glioma Neoplasms
C0557874 BXGD009444 Global developmental delay
C0577631 BXGD009535 Carotid Atherosclerosis Nervous System Diseases; Cardiovascular Diseases
C0577698 BXGD009540 Exercise-induced angina Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0584960 BXGD009579 Factor V Leiden mutation Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598935 BXGD009674 Tumor Initiation Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0750145 BXGD010227 Occlusive vascular disease
C0750988 BXGD010275 Common Carotid Artery Thrombosis Nervous System Diseases; Cardiovascular Diseases
C0750989 BXGD010276 External Carotid Artery Thrombosis Nervous System Diseases; Cardiovascular Diseases
C0750990 BXGD010277 Internal Carotid Artery Thrombosis Nervous System Diseases; Cardiovascular Diseases
C0751633 BXGD010529 Carotid Artery Plaque Nervous System Diseases; Cardiovascular Diseases
C0751711 BXGD010563 Anterior Ischemic Optic Neuropathy Eye Diseases; Nervous System Diseases; Cardiovascular Diseases
C0751956 BXGD010653 Acute Cerebrovascular Accidents Nervous System Diseases; Cardiovascular Diseases
C0796154 BXGD010805 SIMPSON-GOLABI-BEHMEL SYNDROME, TYPE 1 Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Endocrine System Diseases; Mental Disorders; Behavior and Behavior Mechanisms; Cardiovascular Diseases
C0853879 BXGD010982 Invasive carcinoma of breast Neoplasms; Skin and Connective Tissue Diseases
C0858252 BXGD011172 Breast adenocarcinoma Neoplasms; Skin and Connective Tissue Diseases
C0860207 BXGD011220 Drug-Induced Liver Disease Digestive System Diseases; Chemically-Induced Disorders
C0877015 BXGD011327 Pelvic Organ Prolapse Pathological Conditions, Signs and Symptoms
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C0948089 BXGD011504 Acute Coronary Syndrome Cardiovascular Diseases
C0948201 BXGD011515 Alloimmunisation
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1261473 BXGD011855 Sarcoma Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1334815 BXGD012743 Multi-centric Castleman's Disease Immune System Diseases; Hemic and Lymphatic Diseases
C1378511 BXGD012932 Undifferentiated leukemia
C1458140 BXGD013134 Bleeding tendency Hemic and Lymphatic Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1519666 BXGD013240 Tumor-Associated Vasculature
C1519670 BXGD013241 Tumor Angiogenesis Pathological Conditions, Signs and Symptoms
C1541923 BXGD013355 Infective endocarditis Cardiovascular Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1697453 BXGD013507 Spontaneous hematomas
C1739105 BXGD013729 Platelet anisocytosis
C1832662 BXGD013867 MYOCARDIAL INFARCTION, SUSCEPTIBILITY TO
C1854520 BXGD015412 SEBASTIAN SYNDROME Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases; Hemic and Lymphatic Diseases
C1855853 BXGD015555 Impaired platelet aggregation
C1861172 BXGD016016 Venous Thromboembolism Cardiovascular Diseases
C1861185 BXGD016017 THROMBOCYTOPENIA 2 (disorder) Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C1861195 BXGD016018 Glanzmann Thrombasthenia, Autosomal Dominant Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C1861305 BXGD016027 TARSAL-CARPAL COALITION SYNDROME Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1868251 BXGD016494 Neonatal alloimmune thrombocytopenia (NAIT)
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2237512 BXGD016961 cephalohematoma
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2347761 BXGD017049 Childhood Myelodysplastic Syndrome Hemic and Lymphatic Diseases
C2363741 BXGD017100 HIV-1 infection
C2584409 BXGD017126 Prothrombin G20210A mutation Hemic and Lymphatic Diseases
C2697501 BXGD017427 Giant Platelet Count (procedure)
C2751260 BXGD017694 Macrothrombocytopenia Hemic and Lymphatic Diseases
C2937358 BXGD018159 Cerebral Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3179396 BXGD018551 Glanzmann Thrombasthenia, Type A Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3662483 BXGD019270 Allergic sensitization
C3714948 BXGD019440 PACHYONYCHIA CONGENITA 3
C3809715 BXGD019607 Spontaneous, recurrent epistaxis Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C3853779 BXGD019822 Neonatal Alloimmune Thrombocytopenia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C3854603 BXGD019839 FNAITP
C3887640 BXGD019908 Astrocytosis Pathological Conditions, Signs and Symptoms
C3898127 BXGD020061 Non-Metastatic Childhood Soft Tissue Sarcoma
C3900098 BXGD020106 Adult Myelodysplastic Syndrome Hemic and Lymphatic Diseases
C4021646 BXGD020717 Prolonged bleeding after surgery
C4021767 BXGD020765 Decreased platelet glycoprotein IIb-IIIa
C4022611 BXGD020938 Prolonged bleeding following circumcision
C4023154 BXGD021126 Impaired ristocetin-induced platelet aggregation
C4284013 BXGD022428 Primary cholangiocarcinoma of intrahepatic biliary tract Neoplasms
C4304021 BXGD022570 Autosomal dominant macrothrombocytopenia Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C4476985 BXGD022899 Impaired clot retraction
C4551687 BXGD023392 Sarcoma of soft tissue Neoplasms
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C4733092 BXGD023907 estrogen receptor-negative breast cancer
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000537 Acetylsalicylic acid 180.16
BXGC0001767 (E)-Resveratrol 228.25
BXGC0002586 Calcium 40.08
BXGC0002588 Magnesium 24.31
BXGC0003705 Chloride 35.45
BXGC0018397 beta-1,4-mannan 180.06
BXGC0018709 Melilotoside 326.1
BXGC0025862 Levothyroxine 776.69
BXGC0027421 Paclitaxel 853.33
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein