Showing entry for Heparin cofactor 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006367
Protein NameHeparin cofactor 2
Uniport IdP05546
GeneSERPIND1
Gene Id3053
DomainSerpin
Pfam PF00079  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04610 Complement and coagulation cascades
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007596 blood coagulation
Biological Process GO:0044267 cellular protein metabolic process
Biological Process GO:0006935 chemotaxis
Biological Process GO:0010951 negative regulation of endopeptidase activity
Biological Process GO:0043687 post-translational protein modification
molecular function GO:0004866 endopeptidase inhibitor activity
molecular function GO:0008201 heparin binding
molecular function GO:0004867 serine-type endopeptidase inhibitor activity
cellular component GO:0005788 endoplasmic reticulum lumen
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation
R-HSA-140875 Common Pathway of Fibrin Clot Formation
R-HSA-140877 Formation of Fibrin Clot (Clotting Cascade)
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-392499 Metabolism of proteins
R-HSA-597592 Post-translational protein modification
R-HSA-8957275 Post-translational protein phosphorylation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002895 BXGD000152 Anemia, Sickle Cell Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007274 BXGD000456 Carotid Artery Thrombosis Nervous System Diseases; Cardiovascular Diseases
C0007787 BXGD000487 Transient Ischemic Attack Nervous System Diseases; Cardiovascular Diseases
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0012739 BXGD000786 Disseminated Intravascular Coagulation Hemic and Lymphatic Diseases
C0018790 BXGD001221 Cardiac Arrest Cardiovascular Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019880 BXGD001351 Homocystinuria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases; Nervous System Diseases
C0020473 BXGD001396 Hyperlipidemia Nutritional and Metabolic Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024530 BXGD001783 Malaria Infections
C0025472 BXGD001872 Mesenteric Vascular Occlusion Digestive System Diseases; Cardiovascular Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0029172 BXGD002120 Oral Submucous Fibrosis Stomatognathic Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0032914 BXGD002379 Pre-Eclampsia Female Urogenital Diseases and Pregnancy Complications
C0034067 BXGD002456 Pulmonary Emphysema Respiratory Tract Diseases
C0034341 BXGD002476 Pyruvate Carboxylase Deficiency Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0040028 BXGD002835 Thrombocythemia, Essential Hemic and Lymphatic Diseases
C0085096 BXGD003123 Peripheral Vascular Diseases Cardiovascular Diseases
C0149871 BXGD003375 Deep Vein Thrombosis Cardiovascular Diseases
C0162429 BXGD003942 Malnutrition Nutritional and Metabolic Diseases
C0206708 BXGD004256 Cervical Intraepithelial Neoplasia Neoplasms
C0265101 BXGD005454 Carotid artery occlusion Nervous System Diseases; Cardiovascular Diseases
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0333873 BXGD006971 Squamous intraepithelial lesion Pathological Conditions, Signs and Symptoms; Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0333875 BXGD006972 High-Grade Squamous Intraepithelial Lesions Pathological Conditions, Signs and Symptoms; Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0343641 BXGD007636 Human papilloma virus infection Infections
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0375023 BXGD007970 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
C0398623 BXGD008202 Thrombophilia Hemic and Lymphatic Diseases
C0398625 BXGD008203 Protein C Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0398626 BXGD008204 Heparin cofactor II deficiency (disorder) Cardiovascular Diseases
C0577631 BXGD009535 Carotid Atherosclerosis Nervous System Diseases; Cardiovascular Diseases
C0584960 BXGD009579 Factor V Leiden mutation Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0750988 BXGD010275 Common Carotid Artery Thrombosis Nervous System Diseases; Cardiovascular Diseases
C0750989 BXGD010276 External Carotid Artery Thrombosis Nervous System Diseases; Cardiovascular Diseases
C0750990 BXGD010277 Internal Carotid Artery Thrombosis Nervous System Diseases; Cardiovascular Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1260903 BXGD011842 Dysfibrinogenemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C1302773 BXGD012312 Low Grade Squamous Intraepithelial Neoplasia Pathological Conditions, Signs and Symptoms; Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1512409 BXGD013188 Hepatocarcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1704436 BXGD013564 Peripheral Arterial Diseases Cardiovascular Diseases
C1735901 BXGD013718 Recurrent deep vein thrombosis Cardiovascular Diseases
C1861172 BXGD016016 Venous Thromboembolism Cardiovascular Diseases
C2676505 BXGD017335 Post-angioplasty coronary artery restenosis Cardiovascular Diseases
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4290046 BXGD022507 trachomatis
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0002616 Copper 63.55
BXGC0002682 Zinc 65.41
BXGC0018397 beta-1,4-mannan 180.06
BXGC0037687 (4S)-2-methylpentane-2,4-diol 118.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein