protein

Showing entry for Splicing factor U2AF 35 kDa subunit

General Target Information
BXGT Id	BXGT012566
Protein Name	Splicing factor U2AF 35 kDa subunit
Uniport Id	Q01081
Gene	U2AF1
Gene Id	102724594;7307
Domain	RRM_1; zf-CCCH
Pfam	PF00076 PF00642
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
2. Genetic Information Processing	2.1 Transcription	hsa03040	Spliceosome
2. Genetic Information Processing	2.1 Transcription	hsa03040	Spliceosome
6. Human Diseases	6.8 Infectious diseases: Bacterial	hsa05131	Shigellosis
6. Human Diseases	6.8 Infectious diseases: Bacterial	hsa05131	Shigellosis

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0031124	mRNA 3'-end processing
Biological Process	GO:0006406	mRNA export from nucleus
Biological Process	GO:0006397	mRNA processing
Biological Process	GO:0000398	mRNA splicing, via spliceosome
Biological Process	GO:0006405	RNA export from nucleus
Biological Process	GO:0008380	RNA splicing
molecular function	GO:0046872	metal ion binding
molecular function	GO:0030628	pre-mRNA 3'-splice site binding
molecular function	GO:0003723	RNA binding
cellular component	GO:0015030	Cajal body
cellular component	GO:0071013	catalytic step 2 spliceosome
cellular component	GO:0016607	nuclear speck
cellular component	GO:0005654	nucleoplasm
cellular component	GO:0005681	spliceosomal complex
cellular component	GO:0089701	U2AF complex

Reactome

Pathway Id	Pathway Name
R-HSA-159236	Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72163	mRNA Splicing - Major Pathway
R-HSA-72172	mRNA Splicing
R-HSA-72187	mRNA 3'-end processing
R-HSA-72202	Transport of Mature Transcript to Cytoplasm
R-HSA-72203	Processing of Capped Intron-Containing Pre-mRNA
R-HSA-73856	RNA Polymerase II Transcription Termination
R-HSA-73857	RNA Polymerase II Transcription
R-HSA-74160	Gene expression (Transcription)
R-HSA-8953854	Metabolism of RNA

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0001418	BXGD000050	Adenocarcinoma	Neoplasms
C0001787	BXGD000076	Osteoporosis, Age-Related	Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0001815	BXGD000078	Primary Myelofibrosis	Hemic and Lymphatic Diseases
C0002894	BXGD000151	Refractory anaemia with excess blasts	Hemic and Lymphatic Diseases
C0004135	BXGD000257	Ataxia Telangiectasia	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C0006826	BXGD000408	Malignant Neoplasms	Neoplasms
C0007137	BXGD000445	Squamous cell carcinoma	Neoplasms
C0007873	BXGD000500	Uterine Cervical Neoplasm	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0008626	BXGD000559	Congenital chromosomal disease	Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0011854	BXGD000753	Diabetes Mellitus, Insulin-Dependent	Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0013080	BXGD000797	Down Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0017638	BXGD001132	Glioma	Neoplasms
C0018939	BXGD001253	Hematological Disease	Hemic and Lymphatic Diseases
C0019621	BXGD001340	Histiocytosis, Langerhans-Cell	Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C0019693	BXGD001346	HIV Infections	Infections; Immune System Diseases
C0023418	BXGD001642	leukemia	Neoplasms
C0023434	BXGD001643	Chronic Lymphocytic Leukemia	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467	BXGD001658	Leukemia, Myelocytic, Acute	Neoplasms
C0023480	BXGD001664	Leukemia, Myelomonocytic, Chronic	Neoplasms; Hemic and Lymphatic Diseases
C0026985	BXGD001956	Myelodysplasia
C0027022	BXGD001962	Myeloproliferative disease	Hemic and Lymphatic Diseases
C0027651	BXGD002009	Neoplasms	Neoplasms
C0029456	BXGD002157	Osteoporosis	Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029459	BXGD002159	Osteoporosis, Senile	Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030312	BXGD002207	Pancytopenia	Hemic and Lymphatic Diseases
C0032463	BXGD002357	Polycythemia Vera	Neoplasms; Hemic and Lymphatic Diseases
C0033578	BXGD002408	Prostatic Neoplasms	Neoplasms; Male Urogenital Diseases
C0040028	BXGD002835	Thrombocythemia, Essential	Hemic and Lymphatic Diseases
C0152013	BXGD003516	Adenocarcinoma of lung (disorder)	Neoplasms
C0153574	BXGD003667	Malignant Uterine Corpus Neoplasm	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0178874	BXGD004037	Tumor Progression	Pathological Conditions, Signs and Symptoms
C0220621	BXGD004300	Childhood Acute Myeloid Leukemia	Neoplasms
C0221013	BXGD004363	Mastocytosis, Systemic	Neoplasms; Immune System Diseases
C0235974	BXGD004796	Pancreatic carcinoma	Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0242379	BXGD005157	Malignant neoplasm of lung	Neoplasms; Respiratory Tract Diseases
C0265219	BXGD005468	Miller Dieker syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0279680	BXGD006680	Transitional cell carcinoma of bladder	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0280449	BXGD006746	secondary acute myeloid leukemia	Neoplasms
C0280451	BXGD006747	de novo myelodysplastic syndromes	Hemic and Lymphatic Diseases
C0280630	BXGD006751	Uterine Carcinosarcoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0281361	BXGD006774	Adenocarcinoma of pancreas	Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0349639	BXGD007943	Juvenile Myelomonocytic Leukemia	Neoplasms; Hemic and Lymphatic Diseases
C0376358	BXGD007992	Malignant neoplasm of prostate	Neoplasms; Male Urogenital Diseases
C0376545	BXGD008002	Hematologic Neoplasms	Neoplasms; Hemic and Lymphatic Diseases
C0596263	BXGD009639	Carcinogenesis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0598766	BXGD009669	Leukemogenesis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0684249	BXGD009790	Carcinoma of lung	Neoplasms; Respiratory Tract Diseases
C0751406	BXGD010428	Post-Traumatic Osteoporosis	Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0751778	BXGD010587	Myoclonic Epilepsies, Progressive	Nervous System Diseases
C0751785	BXGD010594	Unverricht-Lundborg Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1168401	BXGD011792	Squamous cell carcinoma of the head and neck	Neoplasms
C1269955	BXGD012005	Tumor Cell Invasion
C1292772	BXGD012232	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	Neoplasms; Hemic and Lymphatic Diseases
C1306459	BXGD012361	Primary malignant neoplasm	Neoplasms
C1306460	BXGD012362	Primary malignant neoplasm of lung	Neoplasms; Respiratory Tract Diseases
C1961099	BXGD016672	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2347761	BXGD017049	Childhood Myelodysplastic Syndrome	Hemic and Lymphatic Diseases
C2713368	BXGD017496	Hematopoetic Myelodysplasia	Hemic and Lymphatic Diseases
C2825139	BXGD017770	Acute Myeloid Leukemia with Myelodysplasia-Related Changes	Neoplasms
C2939461	BXGD018180	Myeloid neoplasm	Neoplasms; Hemic and Lymphatic Diseases
C3463824	BXGD018899	MYELODYSPLASTIC SYNDROME	Hemic and Lymphatic Diseases
C3544204	BXGD019108	Borderline mucinous tumour of ovary
C3899655	BXGD020091	Childhood Langerhans Cell Histiocytosis	Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C3900098	BXGD020106	Adult Myelodysplastic Syndrome	Hemic and Lymphatic Diseases
C3900100	BXGD020108	Adult Langerhans Cell Histiocytosis	Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C4505456	BXGD022964	HIV Coinfection	Infections; Immune System Diseases
C4521042	BXGD023055	Complete Trisomy 21 Syndrome	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0028206	hexamethylene glycol		118.1

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}