Showing entry for Thrombopoietin


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010168
Protein NameThrombopoietin
Uniport IdP40225
GeneTHPO
Gene Id7066
DomainEPO_TPO
Pfam PF00758  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04060 Cytokine-cytokine receptor interaction
3. Environmental Information Processing 3.2 Signal transduction hsa04630 Jak-STAT signaling pathway
5. Organismal Systems 5.1 Immune system hsa04640 Hematopoietic cell lineage
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0008283 cell population proliferation
Biological Process GO:0035855 megakaryocyte development
Biological Process GO:0007275 multicellular organism development
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:1902035 positive regulation of hematopoietic stem cell proliferation
Biological Process GO:0043410 positive regulation of MAPK cascade
Biological Process GO:0045654 positive regulation of megakaryocyte differentiation
Biological Process GO:0051897 positive regulation of protein kinase B signaling
Biological Process GO:0001934 positive regulation of protein phosphorylation
Biological Process GO:0097696 receptor signaling pathway via STAT
Biological Process GO:0038163 thrombopoietin-mediated signaling pathway
molecular function GO:0005125 cytokine activity
molecular function GO:0008083 growth factor activity
molecular function GO:0005179 hormone activity
molecular function GO:0005102 signaling receptor binding
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-76009 Platelet Aggregation (Plug Formation)
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0000786 BXGD000010 Spontaneous abortion Female Urogenital Diseases and Pregnancy Complications
C0001339 BXGD000041 Acute pancreatitis Digestive System Diseases
C0001815 BXGD000078 Primary Myelofibrosis Hemic and Lymphatic Diseases
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0002874 BXGD000134 Aplastic Anemia Hemic and Lymphatic Diseases
C0002893 BXGD000150 Refractory anemias Hemic and Lymphatic Diseases
C0002894 BXGD000151 Refractory anaemia with excess blasts Hemic and Lymphatic Diseases
C0004623 BXGD000282 Bacterial Infections Infections
C0005129 BXGD000304 Bernard-Soulier Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0005779 BXGD000336 Blood Coagulation Disorders Hemic and Lymphatic Diseases
C0005818 BXGD000338 Blood Platelet Disorders Hemic and Lymphatic Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0007787 BXGD000487 Transient Ischemic Attack Nervous System Diseases; Cardiovascular Diseases
C0008031 BXGD000511 Chest Pain Pathological Conditions, Signs and Symptoms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011311 BXGD000714 Dengue Fever Infections
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014038 BXGD000878 Encephalitis Nervous System Diseases
C0018681 BXGD001214 Headache Pathological Conditions, Signs and Symptoms
C0018939 BXGD001253 Hematological Disease Hemic and Lymphatic Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019189 BXGD001298 Hepatitis, Chronic Digestive System Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020458 BXGD001393 Hyperhidrosis disorder Skin and Connective Tissue Diseases
C0020532 BXGD001420 Hypersplenism Hemic and Lymphatic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023462 BXGD001654 Acute Megakaryocytic Leukemias Neoplasms
C0023465 BXGD001656 Acute monocytic leukemia Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023470 BXGD001659 Myeloid Leukemia Neoplasms
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023480 BXGD001664 Leukemia, Myelomonocytic, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023530 BXGD001683 Leukopenia Hemic and Lymphatic Diseases
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024115 BXGD001732 Lung diseases Respiratory Tract Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024282 BXGD001755 Lymphocytosis Hemic and Lymphatic Diseases
C0024790 BXGD001804 Paroxysmal nocturnal hemoglobinuria Hemic and Lymphatic Diseases
C0025295 BXGD001855 Meningitis, Pneumococcal Infections; Nervous System Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026985 BXGD001956 Myelodysplasia
C0026987 BXGD001957 Myelofibrosis Pathological Conditions, Signs and Symptoms; Neoplasms; Hemic and Lymphatic Diseases
C0027022 BXGD001962 Myeloproliferative disease Hemic and Lymphatic Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0027947 BXGD002061 Neutropenia Hemic and Lymphatic Diseases
C0030312 BXGD002207 Pancytopenia Hemic and Lymphatic Diseases
C0030554 BXGD002239 Paresthesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0032181 BXGD002332 Platelet Count measurement
C0032463 BXGD002357 Polycythemia Vera Neoplasms; Hemic and Lymphatic Diseases
C0033027 BXGD002388 Preleukemia Neoplasms; Hemic and Lymphatic Diseases
C0033141 BXGD002400 Cardiomyopathies, Primary Cardiovascular Diseases
C0033774 BXGD002419 Pruritus Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0036529 BXGD002624 Myocardial Diseases, Secondary Cardiovascular Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0038002 BXGD002723 Splenomegaly Pathological Conditions, Signs and Symptoms
C0039070 BXGD002787 Syncope Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0040028 BXGD002835 Thrombocythemia, Essential Hemic and Lymphatic Diseases
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0042487 BXGD002986 Venous Thrombosis Cardiovascular Diseases
C0042571 BXGD002991 Vertigo Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0042974 BXGD003019 von Willebrand Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0043194 BXGD003036 Wiskott-Aldrich Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C0085437 BXGD003178 Meningitis, Bacterial Infections; Nervous System Diseases
C0085605 BXGD003200 Liver Failure Digestive System Diseases
C0085669 BXGD003233 Acute leukemia Pathological Conditions, Signs and Symptoms; Neoplasms
C0151942 BXGD003507 Arterial thrombosis Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0154301 BXGD003714 Acquired thrombocytopenia Hemic and Lymphatic Diseases
C0162557 BXGD003956 Liver Failure, Acute Digestive System Diseases
C0175703 BXGD004009 Thrombocytopenia-Absent Radius Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Hemic and Lymphatic Diseases
C0200665 BXGD004045 Platelet mean volume determination (procedure)
C0206624 BXGD004190 Hepatoblastoma Neoplasms
C0206634 BXGD004199 Liposarcoma, Myxoid Neoplasms
C0220615 BXGD004298 Adult Acute Myeloblastic Leukemia Neoplasms
C0220621 BXGD004300 Childhood Acute Myeloid Leukemia Neoplasms
C0220810 BXGD004346 Congenital defects
C0221347 BXGD004442 Acrocyanosis Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Respiratory Tract Diseases; Cardiovascular Diseases
C0235604 BXGD004760 Qualitative platelet deficiency
C0242350 BXGD005154 Erectile dysfunction Male Urogenital Diseases; Mental Disorders
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242584 BXGD005179 Autoimmune thrombocytopenia Immune System Diseases; Hemic and Lymphatic Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0271907 BXGD006279 Acquired aplastic anemia Hemic and Lymphatic Diseases
C0272278 BXGD006335 Congenital thrombocytopenia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C0272286 BXGD006337 Thrombocytopenia due to platelet alloimmunization Hemic and Lymphatic Diseases
C0272296 BXGD006339 Thrombocytopenia due to sequestration Hemic and Lymphatic Diseases
C0276623 BXGD006433 Chronic viral hepatitis Digestive System Diseases
C0280449 BXGD006746 secondary acute myeloid leukemia Neoplasms
C0280962 BXGD006768 Bone Marrow Suppression Hemic and Lymphatic Diseases
C0341439 BXGD007408 Chronic liver disease Digestive System Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0349639 BXGD007943 Juvenile Myelomonocytic Leukemia Neoplasms; Hemic and Lymphatic Diseases
C0376618 BXGD008003 Endotoxemia Pathological Conditions, Signs and Symptoms; Infections
C0398650 BXGD008212 Immune thrombocytopenic purpura Pathological Conditions, Signs and Symptoms; Immune System Diseases; Hemic and Lymphatic Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0457506 BXGD008889 Reactive thrombocytosis Hemic and Lymphatic Diseases
C0494165 BXGD009022 Secondary malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0544886 BXGD009319 Somatic mutation
C0545074 BXGD009324 Myxoid/Round Cell Liposarcoma Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0685938 BXGD009829 Malignant neoplasm of gastrointestinal tract Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0740404 BXGD009991 Limb defects
C0742343 BXGD010061 Acute Chest Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C0745744 BXGD010133 End Stage Liver Disease Digestive System Diseases
C0746102 BXGD010136 Chronic lung disease Respiratory Tract Diseases
C0749393 BXGD010215 Chronic thrombocytopenia
C0796070 BXGD010792 MICROPHTHALMIA, SYNDROMIC 7 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Skin and Connective Tissue Diseases
C0836924 BXGD010864 Thrombocytosis Hemic and Lymphatic Diseases
C0854866 BXGD011041 Recurrent Non-Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0856169 BXGD011096 Endothelial dysfunction
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0948968 BXGD011565 Osteomyelofibrosis
C1175175 BXGD011797 Severe Acute Respiratory Syndrome Infections; Respiratory Tract Diseases
C1260899 BXGD011841 Anemia, Diamond-Blackfan Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C1262477 BXGD011882 Weight decreased Pathological Conditions, Signs and Symptoms
C1264031 BXGD011908 Alloimmune thrombocytopenia
C1282609 BXGD012149 Granulocytosis Hemic and Lymphatic Diseases
C1292778 BXGD012237 Chronic myeloproliferative disorder Neoplasms; Hemic and Lymphatic Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1318485 BXGD012394 Liver regeneration disorder Digestive System Diseases
C1327915 BXGD012456 Congenital amegakaryocytic thrombocytopenia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1333177 BXGD012605 Lymphoproliferative Disorder of the Skin Skin and Connective Tissue Diseases; Immune System Diseases; Hemic and Lymphatic Diseases
C1458140 BXGD013134 Bleeding tendency Hemic and Lymphatic Diseases
C1512409 BXGD013188 Hepatocarcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1608426 BXGD013436 Compensated cirrhosis
C1611743 BXGD013456 Familial (FPAH)
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C1834582 BXGD013982 MYELOPROLIFERATIVE SYNDROME, TRANSIENT Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Hemic and Lymphatic Diseases
C1839163 BXGD014360 THROMBOCYTOPENIA 1 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C1854520 BXGD015412 SEBASTIAN SYNDROME Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases; Hemic and Lymphatic Diseases
C1855853 BXGD015555 Impaired platelet aggregation
C1857276 BXGD015688 Trichohepatoenteric Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C1879691 BXGD016581 Amegakaryocytosis
C1883018 BXGD016594 Severe Aplastic Anemia Hemic and Lymphatic Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1961102 BXGD016673 Precursor Cell Lymphoblastic Leukemia Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1963099 BXGD016682 Myelodysplasia, CTCAE
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2347761 BXGD017049 Childhood Myelodysplastic Syndrome Hemic and Lymphatic Diseases
C2586012 BXGD017143 Hereditary thrombocytopenic disorder Hemic and Lymphatic Diseases
C2826321 BXGD017789 Refractory Thrombocytopenia Hemic and Lymphatic Diseases
C2931757 BXGD018057 Acquired amegakaryocytic thrombocytopenia Pathological Conditions, Signs and Symptoms; Immune System Diseases; Hemic and Lymphatic Diseases
C2936476 BXGD018123 Chronic Liver Failure Digestive System Diseases
C2973725 BXGD018205 Pulmonary arterial hypertension Respiratory Tract Diseases; Cardiovascular Diseases
C2981142 BXGD018210 Refractory anemia, without ringed sideroblasts, without excess blasts Hemic and Lymphatic Diseases
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3277671 BXGD018715 THROMBOCYTHEMIA 1
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3489628 BXGD018938 Thrombocytosis, Autosomal Dominant Hemic and Lymphatic Diseases
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C3887875 BXGD019923 Visual field defects Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3900098 BXGD020106 Adult Myelodysplastic Syndrome Hemic and Lymphatic Diseases
C4021790 BXGD020782 Abnormality of the skeletal system
C4025272 BXGD021615 Peripheral arterial stenosis
C4048329 BXGD021904 Immunosuppression
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4273671 BXGD022333 Inherited predisposition to essential thrombocythemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C4303761 BXGD022567 Familial thrombocytosis Hemic and Lymphatic Diseases
C4476767 BXGD022864 Diffuse alveolar hemorrhage
C4511035 BXGD022995 Isolated thrombocytopenia
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000099 3,4-Dihydroxyphenylacetic acid 168.15
BXGC0000194 Sanguinarine 332.33
BXGC0000202 Papaverine 339.39
BXGC0000530 Hydroquinone 110.11
BXGC0001002 1,2-Benzenediol 110.11
BXGC0001325 Progesterone 314.46
BXGC0001899 Daidzein 254.24
BXGC0001940 Daphnetin 178.14
BXGC0002018 Morin 302.24
BXGC0002071 Apigenin 270.24
BXGC0002390 Spermine 202.34
BXGC0004119 Synepherine 167.21
BXGC0004139 Sperminidine 145.25
BXGC0004548 4-(beta-Methylaminoethyl)catechol 167.21
BXGC0005624 Genistein 270.24
BXGC0005697 2,3-Butanedione 86.09
BXGC0005871 Dopamine 153.18
BXGC0005985 Piceatannol 244.25
BXGC0006057 (Z)-Resveratrol 228.25
BXGC0006306 Myricetin 318.24
BXGC0007029 Emodin 270.24
BXGC0012352 Chelerythrine 348.12
BXGC0014430 (Z)-1-(2,4-Dihydroxyphenyl)-3-(4-Hydroxyphenyl)Prop-2-En-1-One 256.07
BXGC0014695 Loratadine 382.14
BXGC0016470 Camptothecin 348.11
BXGC0016891 Nortriptyline 263.17
BXGC0018073 2-Phenylethyl (Z)-3-(3,4-Dihydroxyphenyl)Prop-2-Enoate 284.1
BXGC0018772 Pseudoephedrine 165.12
BXGC0019164 Raloxifene 473.17
BXGC0024988 Nifedipine 346.12
BXGC0027421 Paclitaxel 853.33
BXGC0028001 Beta-Lapachone 242.09
BXGC0028278 Rutaecarpine 287.11
BXGC0030138 Colchicine 399.17
BXGC0033112 Acetylcysteine 163.03
BXGC0037152 (Z)-1-[6-[(3-Acetyl-2,4,6-Trihydroxy-5-Methylphenyl)Methyl]-5,7-Dihydroxy-2,2-Dimethylchromen-8-Yl]-3-Phenylprop-2-En-1-One 516.18
BXGC0042091 Dequalinium 456.33
BXGC0044857 Sp-600125 220.06
BXGC0045252 Sc-560 352.06
BXGC0045254 Sb-202190 331.11
BXGC0045746 Diphenyleneiodonium 278.97
BXGC0045812 Trifluoperazine 407.16
BXGC0046510 Tpck 351.07
BXGC0049647 1R,9S-Hydrastine 383.14
BXGC0050471 Fluorouracil 130.02
BXGC0052374 Reserpine 608.27
BXGC0053629 Esatenolol 266.16
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein