adisease

Showing entry for Varicocele

General Disease Information
BXGD Id	BXGD002975
Disease Name	Varicocele
Disease CUI Id	C0042341
MeSH Codes	C12 C14
Disease Class Name	Male Urogenital Diseases; Cardiovascular Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0000119
Human Phenotype Ontology Term	Abnormality of the genitourinary system
Disease Ontology Id	DOID:7
Disease Ontology Class Name	disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O15527	BXGT004176	N-glycosylase/DNA lyase	4968	reviewed
O15553	BXGT004181	Pyrin	4210	reviewed
O60603	BXGT004887	Toll-like receptor 2	7097	reviewed
O60760	BXGT004899	Hematopoietic prostaglandin D synthase	27306	reviewed
P00441	BXGT005540	Superoxide dismutase [Cu-Zn]	6647	reviewed	Enzyme
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01583	BXGT005771	Interleukin-1 alpha	3552	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P02647	BXGT005908	Apolipoprotein A-I	335	reviewed
P02751	BXGT005943	Fibronectin	2335	reviewed	Signaling
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P04040	BXGT006132	Catalase	847	reviewed	Enzyme
P05231	BXGT006345	Interleukin-6	3569	reviewed
P07355	BXGT006609	Annexin A2	302	reviewed
P07900	BXGT006696	Heat shock protein HSP 90-alpha	3320	reviewed	Chaperone
P09488	BXGT006899	Glutathione S-transferase Mu 1	2944	reviewed
P09601	BXGT006909	Heme oxygenase 1	3162	reviewed
P10275	BXGT007552	Androgen receptor	367	reviewed	Nuclear receptor
P10276	BXGT007553	Retinoic acid receptor alpha	5914	reviewed	Nuclear receptor
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10809	BXGT007617	60 kDa heat shock protein, mitochondrial	3329	reviewed
P11802	BXGT007750	Cyclin-dependent kinase 4	1019	reviewed	Kinase
P15309	BXGT008105	Prostatic acid phosphatase	55	reviewed	Enzyme
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P22749	BXGT008803	Granulysin	10578	reviewed
P24385	BXGT008965	G1/S-specific cyclin-D1	595	reviewed	Enzyme modulator
P24666	BXGT008986	Low molecular weight phosphotyrosine protein phosphatase	52	reviewed
P24855	BXGT008998	Deoxyribonuclease-1	1773	reviewed
P25440	BXGT009044	Bromodomain-containing protein 2	6046	reviewed	Epigenetic regulator
P28161	BXGT009234	Glutathione S-transferase Mu 2	2946	reviewed
P29474	BXGT009352	Nitric oxide synthase, endothelial	4846	reviewed
P30044	BXGT009395	Peroxiredoxin-5, mitochondrial	25824	reviewed
P30711	BXGT009460	Glutathione S-transferase theta-1	2952	reviewed
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P32929	BXGT009682	Cystathionine gamma-lyase	1491	reviewed	Enzyme
P33176	BXGT009699	Kinesin-1 heavy chain	3799	reviewed	Cellular structure
P34932	BXGT009772	Heat shock 70 kDa protein 4	3308	reviewed
P42224	BXGT010286	Signal transducer and activator of transcription 1-alpha/beta	6772	reviewed	Nucleic acid binding
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P42574	BXGT010317	Caspase-3	836	reviewed	Enzyme
P42898	BXGT010344	Methylenetetrahydrofolate reductase	4524	reviewed
P48023	BXGT010604	Tumor necrosis factor ligand superfamily member 6	356	reviewed	Signaling
P48357	BXGT010627	Leptin receptor	3953	reviewed	Signaling
P49327	BXGT010694	Fatty acid synthase	2194	reviewed	Enzyme
P54652	BXGT011064	Heat shock-related 70 kDa protein 2	3306	reviewed
P55211	BXGT011111	Caspase-9	842	reviewed	Enzyme
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
P60709	BXGT011322	Actin, cytoplasmic 1	60	reviewed	Cellular structure
Q07812	BXGT012940	Apoptosis regulator BAX	581	reviewed	Signaling
Q14116	BXGT013442	Interleukin-18	3606	reviewed
Q14457	BXGT013472	Beclin-1	8678	reviewed	Enzyme modulator
Q15465	BXGT013573	Sonic hedgehog protein	6469	reviewed
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	3091	reviewed	Transcription factor
Q8NER1	BXGT018556	Transient receptor potential cation channel subfamily V member 1	7442	reviewed	Ion channel
Q96EB6	BXGT019646	NAD-dependent protein deacetylase sirtuin-1	23411	reviewed	Epigenetic regulator
Q96P20	BXGT019704	NACHT, LRR and PYD domains-containing protein 3	114548	reviewed
Q99685	BXGT019948	Monoglyceride lipase	11343	reviewed	Enzyme
Q9H492	BXGT020472	Microtubule-associated proteins 1A/1B light chain 3A	84557	reviewed	Cellular structure
Q9H4Y5	BXGT020479	Glutathione S-transferase omega-2	119391	reviewed
Q9Y2Q3	BXGT022242	Glutathione S-transferase kappa 1	373156	reviewed
Q13330	BXGT023103	Metastasis-associated protein MTA1	9112	reviewed	Nucleic acid binding
Q86SQ9	BXGT025875	Dehydrodolichyl diphosphate synthase complex subunit DHDDS	79947	reviewed	Enzyme
P00403	BXGT026137	Cytochrome c oxidase subunit 2	4513	reviewed	Enzyme

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}