Showing entry for Pyrin


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004181
Protein NamePyrin
Uniport IdO15553
GeneMEFV
Gene Id4210
DomainPRY; PYRIN; SPRY; zf-B_box
Pfam PF13765   PF02758   PF00622   PF00643  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04621 NOD-like receptor signaling pathway
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05135 Yersinia infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006954 inflammatory response
Biological Process GO:0045087 innate immune response
Biological Process GO:1900016 negative regulation of cytokine production involved in inflammatory response
Biological Process GO:0050728 negative regulation of inflammatory response
Biological Process GO:0032695 negative regulation of interleukin-12 production
Biological Process GO:0032691 negative regulation of interleukin-1 beta production
Biological Process GO:0071641 negative regulation of macrophage inflammatory protein 1 alpha production
Biological Process GO:1900226 negative regulation of NLRP3 inflammasome complex assembly
Biological Process GO:0010508 positive regulation of autophagy
Biological Process GO:2001056 positive regulation of cysteine-type endopeptidase activity
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:0010468 regulation of gene expression
Biological Process GO:0034341 response to interferon-gamma
molecular function GO:0003779 actin binding
molecular function GO:0042802 identical protein binding
molecular function GO:0061630 ubiquitin protein ligase activity
molecular function GO:0008270 zinc ion binding
cellular component GO:0005776 autophagosome
cellular component GO:0005737 cytoplasm
cellular component GO:0031410 cytoplasmic vesicle
cellular component GO:0005829 cytosol
cellular component GO:0030027 lamellipodium
cellular component GO:0005874 microtubule
cellular component GO:0005875 microtubule associated complex
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0001726 ruffle
Reactome
Pathway Id Pathway Name
R-HSA-1643685 Disease
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
R-HSA-5663205 Infectious disease
R-HSA-622312 Inflammasomes
R-HSA-844456 The NLRP3 inflammasome
R-HSA-9658195 Leishmania infection
R-HSA-9660826 Purinergic signaling in leishmaniasis infection
R-HSA-9664424 Cell recruitment (pro-inflammatory response)
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000727 BXGD000001 Abdomen, Acute Pathological Conditions, Signs and Symptoms
C0000737 BXGD000005 Abdominal Pain Pathological Conditions, Signs and Symptoms
C0001144 BXGD000028 Acne Vulgaris Skin and Connective Tissue Diseases
C0001339 BXGD000041 Acute pancreatitis Digestive System Diseases
C0001416 BXGD000049 Adenitis Hemic and Lymphatic Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0002986 BXGD000165 Fabry Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Cardiovascular Diseases
C0003123 BXGD000178 Anorexia Pathological Conditions, Signs and Symptoms
C0003504 BXGD000202 Aortic Valve Insufficiency Cardiovascular Diseases
C0003615 BXGD000212 Appendicitis Digestive System Diseases; Infections
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003862 BXGD000230 Arthralgia Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003868 BXGD000233 Arthritis, Gouty Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0003869 BXGD000234 Arthritis, Infectious Infections; Musculoskeletal Diseases
C0003872 BXGD000235 Arthritis, Psoriatic Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0003962 BXGD000244 Ascites Pathological Conditions, Signs and Symptoms
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004943 BXGD000297 Behcet Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Skin and Connective Tissue Diseases; Stomatognathic Diseases; Cardiovascular Diseases
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006309 BXGD000392 Brucellosis Infections
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007570 BXGD000467 Celiac Disease Digestive System Diseases; Nutritional and Metabolic Diseases
C0007820 BXGD000491 Cerebrovascular Disorders Nervous System Diseases; Cardiovascular Diseases
C0008031 BXGD000511 Chest Pain Pathological Conditions, Signs and Symptoms
C0008495 BXGD000548 Chorioamnionitis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0009676 BXGD000619 Confusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0009952 BXGD000639 Febrile Convulsions Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011195 BXGD000702 Dejerine-Sottas Disease (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011633 BXGD000742 Dermatomyositis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0011884 BXGD000762 Diabetic Retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0013390 BXGD000828 Dysmenorrhea Pathological Conditions, Signs and Symptoms
C0014038 BXGD000878 Encephalitis Nervous System Diseases
C0014118 BXGD000894 Endocarditis Cardiovascular Diseases
C0014356 BXGD000910 Enterocolitis Digestive System Diseases
C0014733 BXGD000942 Erysipelas Infections; Skin and Connective Tissue Diseases
C0015230 BXGD000969 Exanthema Skin and Connective Tissue Diseases
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0015974 BXGD001031 Periodic fever
C0016053 BXGD001041 Fibromyalgia Musculoskeletal Diseases; Nervous System Diseases
C0017086 BXGD001091 Gangrene Pathological Conditions, Signs and Symptoms
C0017181 BXGD001103 Gastrointestinal Hemorrhage Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0017658 BXGD001138 Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0017661 BXGD001139 IGA Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C0018021 BXGD001162 Goiter Endocrine System Diseases
C0018681 BXGD001214 Headache Pathological Conditions, Signs and Symptoms
C0018790 BXGD001221 Cardiac Arrest Cardiovascular Diseases
C0018817 BXGD001235 Atrial Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0018989 BXGD001263 Hemiparesis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0019079 BXGD001278 Hemoptysis Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0019158 BXGD001293 Hepatitis Digestive System Diseases
C0019159 BXGD001294 Hepatitis A Digestive System Diseases; Infections
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0019829 BXGD001350 Hodgkin Disease Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0020217 BXGD001365 Hydatidiform Mole Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021368 BXGD001502 Inflammation Pathological Conditions, Signs and Symptoms
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0021843 BXGD001520 Intestinal Obstruction Digestive System Diseases
C0021933 BXGD001524 Intussusception Digestive System Diseases
C0022107 BXGD001530 Irritable Mood Behavior and Behavior Mechanisms
C0022575 BXGD001555 Keratoconjunctivitis Sicca Eye Diseases
C0022578 BXGD001557 Keratoconus Eye Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023222 BXGD001620 Pain in lower limb
C0023348 BXGD001636 Leprosy, Lepromatous Infections
C0023440 BXGD001646 Acute Erythroblastic Leukemia Neoplasms; Hemic and Lymphatic Diseases
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023480 BXGD001664 Leukemia, Myelomonocytic, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023518 BXGD001677 Leukocytosis Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0023532 BXGD001685 Leukoplakia, Oral Pathological Conditions, Signs and Symptoms; Neoplasms; Stomatognathic Diseases
C0024115 BXGD001732 Lung diseases Respiratory Tract Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024143 BXGD001741 Lupus Nephritis Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Male Urogenital Diseases; Immune System Diseases
C0024205 BXGD001744 Lymphadenitis Hemic and Lymphatic Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024523 BXGD001781 Malabsorption Syndrome Digestive System Diseases; Nutritional and Metabolic Diseases
C0024530 BXGD001783 Malaria Infections
C0025289 BXGD001851 Meningitis Nervous System Diseases
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0026266 BXGD001895 Mitral Valve Insufficiency Cardiovascular Diseases
C0026636 BXGD001911 Mouth Diseases Stomatognathic Diseases
C0026691 BXGD001917 Mucocutaneous Lymph Node Syndrome Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0026837 BXGD001937 Muscle Rigidity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0026896 BXGD001946 Myasthenia Gravis Neoplasms; Immune System Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027059 BXGD001965 Myocarditis Cardiovascular Diseases
C0027121 BXGD001973 Myositis Musculoskeletal Diseases; Nervous System Diseases
C0027149 BXGD001979 Myxoma Neoplasms
C0027341 BXGD001982 Nail-Patella Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0027498 BXGD001994 Nausea and vomiting Pathological Conditions, Signs and Symptoms
C0027543 BXGD001997 Avascular necrosis of bone Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027709 BXGD002026 Nephrocalcinosis Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027726 BXGD002030 Nephrotic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0027832 BXGD002048 Neurofibromatosis 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029191 BXGD002122 Orchitis Male Urogenital Diseases; Endocrine System Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029882 BXGD002177 Otitis Media Otorhinolaryngologic Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030305 BXGD002206 Pancreatitis Digestive System Diseases
C0030554 BXGD002239 Paresthesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0031036 BXGD002273 Polyarteritis Nodosa Skin and Connective Tissue Diseases; Cardiovascular Diseases
C0031046 BXGD002275 Pericarditis Cardiovascular Diseases
C0031048 BXGD002276 Pericarditis, Constrictive Cardiovascular Diseases
C0031069 BXGD002279 Familial Mediterranean Fever Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0031099 BXGD002282 Periodontitis Stomatognathic Diseases
C0031154 BXGD002291 Peritonitis Digestive System Diseases; Infections
C0031350 BXGD002300 Pharyngitis Infections; Respiratory Tract Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C0032227 BXGD002336 Pleural effusion disorder Respiratory Tract Diseases
C0032231 BXGD002339 Pleurisy Infections; Respiratory Tract Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0032371 BXGD002353 Poliomyelitis Infections; Nervous System Diseases
C0032805 BXGD002374 Postpericardiotomy Syndrome Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0033680 BXGD002414 Protein-Losing Enteropathies Digestive System Diseases
C0033687 BXGD002415 Proteinuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0034065 BXGD002454 Pulmonary Embolism Respiratory Tract Diseases; Cardiovascular Diseases
C0034067 BXGD002456 Pulmonary Emphysema Respiratory Tract Diseases
C0034150 BXGD002466 Purpura Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0034152 BXGD002467 Henoch-Schoenlein Purpura Pathological Conditions, Signs and Symptoms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0035021 BXGD002501 Relapsing Fever Infections
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0035335 BXGD002540 Retinoblastoma Neoplasms; Eye Diseases
C0035435 BXGD002549 Rheumatism Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0035436 BXGD002550 Rheumatic Fever Infections; Musculoskeletal Diseases
C0035439 BXGD002551 Rheumatic Heart Disease Infections; Cardiovascular Diseases
C0036202 BXGD002581 Sarcoidosis Hemic and Lymphatic Diseases
C0036323 BXGD002595 Schistosomiasis Infections
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0037054 BXGD002663 Sickle Cell Trait Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0037274 BXGD002676 Dermatologic disorders Skin and Connective Tissue Diseases
C0038002 BXGD002723 Splenomegaly Pathological Conditions, Signs and Symptoms
C0038013 BXGD002725 Ankylosing spondylitis Musculoskeletal Diseases
C0038273 BXGD002743 Stereotypic Movement Disorder Mental Disorders
C0038363 BXGD002750 Aphthous Stomatitis Stomatognathic Diseases
C0038395 BXGD002753 Streptococcal Infections Infections
C0038443 BXGD002757 Stress, Psychological Behavior and Behavior Mechanisms
C0038525 BXGD002768 Subarachnoid Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0039538 BXGD002819 Teratoma Neoplasms
C0041296 BXGD002903 Tuberculosis Infections
C0041834 BXGD002935 Erythema Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0041956 BXGD002942 Ureteral obstruction Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0042029 BXGD002951 Urinary tract infection Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0042109 BXGD002957 Urticaria Skin and Connective Tissue Diseases; Immune System Diseases
C0042341 BXGD002975 Varicocele Male Urogenital Diseases; Cardiovascular Diseases
C0042384 BXGD002979 Vasculitis Cardiovascular Diseases
C0042487 BXGD002986 Venous Thrombosis Cardiovascular Diseases
C0042571 BXGD002991 Vertigo Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0042580 BXGD002992 Vesico-Ureteral Reflux Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0043528 BXGD003050 Zoonoses Infections; Animal Diseases
C0085077 BXGD003117 Sweet Syndrome Skin and Connective Tissue Diseases
C0085078 BXGD003118 Lysosomal Storage Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0085253 BXGD003144 Adult-Onset Still Disease Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0085574 BXGD003187 Palindromic rheumatism Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0085582 BXGD003193 Retrobulbar Neuritis Eye Diseases; Nervous System Diseases
C0085636 BXGD003218 Photophobia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0085652 BXGD003224 Pyoderma Gangrenosum Skin and Connective Tissue Diseases
C0085655 BXGD003226 Polymyositis Musculoskeletal Diseases; Nervous System Diseases
C0085660 BXGD003228 Aseptic necrosis Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0149630 BXGD003334 Bicuspid aortic valve Cardiovascular Diseases
C0149642 BXGD003338 Cervical lymphadenitis Hemic and Lymphatic Diseases
C0149745 BXGD003356 Oral Ulcer Stomatognathic Diseases
C0149875 BXGD003376 Primary dysmenorrhea Pathological Conditions, Signs and Symptoms
C0149896 BXGD003382 Primary gout Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0149910 BXGD003384 Intermittent joint effusion Musculoskeletal Diseases
C0149931 BXGD003388 Migraine Disorders Nervous System Diseases
C0151311 BXGD003412 Cranial nerve palsies Nervous System Diseases
C0151632 BXGD003450 ESR raised
C0151740 BXGD003468 Intracranial Hypertension Nervous System Diseases
C0151811 BXGD003478 Subcutaneous nodule Neoplasms; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0151859 BXGD003489 Polyserositis Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151942 BXGD003507 Arterial thrombosis Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0155626 BXGD003806 Acute myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0156181 BXGD003841 Peritoneal adhesion Digestive System Diseases; Skin and Connective Tissue Diseases
C0158026 BXGD003874 Monoarthritis Musculoskeletal Diseases
C0162323 BXGD003937 Polyarthritis Musculoskeletal Diseases
C0162557 BXGD003956 Liver Failure, Acute Digestive System Diseases
C0162836 BXGD003990 Hidradenitis Suppurativa Infections; Skin and Connective Tissue Diseases
C0178664 BXGD004032 Glomerulosclerosis (disorder) Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Cardiovascular Diseases
C0206664 BXGD004226 Teratocarcinoma Neoplasms
C0220597 BXGD004292 Adult Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0220644 BXGD004306 Childhood Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0221014 BXGD004364 Reactive systemic amyloidosis Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0221056 BXGD004383 Adult type dermatomyositis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0221357 BXGD004449 Brachydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0231528 BXGD004496 Myalgia Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0234132 BXGD004623 Pyramidal sign Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235896 BXGD004785 Pulmonary Infiltrate Respiratory Tract Diseases
C0237653 BXGD004847 Immunologic hypersensitivity
C0238694 BXGD004953 Peripheral arthritis Musculoskeletal Diseases
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0242966 BXGD005201 Systemic Inflammatory Response Syndrome Pathological Conditions, Signs and Symptoms
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0262655 BXGD005264 Recurrent urinary tract infection Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0263680 BXGD005344 Chronic arthritis Musculoskeletal Diseases
C0265259 BXGD005487 Popliteal pterygium syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Eye Diseases; Musculoskeletal Diseases; Male Urogenital Diseases; Stomatognathic Diseases
C0266929 BXGD005722 Chronic Periodontitis Stomatognathic Diseases
C0267809 BXGD005779 Cirrhosis, Cryptogenic Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0268380 BXGD005921 Systemic amyloidosis Nutritional and Metabolic Diseases
C0268382 BXGD005923 Amyloid nephropathy Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0268390 BXGD005929 Muckle-Wells Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0268731 BXGD006029 Renal glomerular disease Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0275518 BXGD006375 Acute infectious disease Pathological Conditions, Signs and Symptoms; Infections
C0276447 BXGD006425 Rhinovirus infection Infections
C0276680 BXGD006443 Infection by Candida albicans Infections
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0281479 BXGD006776 Primary Systemic Amyloidosis Neoplasms; Nutritional and Metabolic Diseases; Immune System Diseases
C0332563 BXGD006894 Papule Pathological Conditions, Signs and Symptoms
C0333516 BXGD006957 Tumor necrosis Pathological Conditions, Signs and Symptoms
C0341332 BXGD007403 Indeterminate colitis Digestive System Diseases
C0342731 BXGD007535 Deficiency of mevalonate kinase Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases; Nervous System Diseases; Hemic and Lymphatic Diseases
C0343068 BXGD007596 Familial cold urticaria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0349639 BXGD007943 Juvenile Myelomonocytic Leukemia Neoplasms; Hemic and Lymphatic Diseases
C0374997 BXGD007967 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376545 BXGD008002 Hematologic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0392788 BXGD008070 Nasal Type Extranodal NK/T-Cell Lymphoma Neoplasms
C0392885 BXGD008071 High density lipoprotein measurement
C0398686 BXGD008215 Primary immune deficiency disorder Immune System Diseases
C0398691 BXGD008217 Hyperimmunoglobulinemia D Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases; Nervous System Diseases; Hemic and Lymphatic Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0409818 BXGD008396 Chronic Infantile Neurological, Cutaneous, and Articular Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0409952 BXGD008399 Idiopathic osteoarthritis Musculoskeletal Diseases
C0410000 BXGD008406 Overlap syndrome Skin and Connective Tissue Diseases; Immune System Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0424503 BXGD008532 Dysmorphic facies
C0428472 BXGD008630 Serum HDL cholesterol measurement
C0431447 BXGD008690 Synophrys Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0432072 BXGD008718 Dysmorphic features
C0456909 BXGD008883 Blindness Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0497156 BXGD009053 Lymphadenopathy Hemic and Lymphatic Diseases
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0542476 BXGD009276 Forgetful Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0557874 BXGD009444 Global developmental delay
C0566602 BXGD009489 Primary sclerosing cholangitis Digestive System Diseases
C0574002 BXGD009497 Edema of foot (finding) Pathological Conditions, Signs and Symptoms
C0574960 BXGD009507 Sacroiliitis Musculoskeletal Diseases
C0575081 BXGD009512 Gait abnormality Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0585213 BXGD009587 Minor oral aphthous ulceration Pathological Conditions, Signs and Symptoms; Stomatognathic Diseases
C0585274 BXGD009591 Periodic syndrome
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598608 BXGD009668 Hyperhomocysteinemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0677932 BXGD009736 Progressive Neoplastic Disease
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0694549 BXGD009851 Community acquired pneumonia Infections; Respiratory Tract Diseases
C0702166 BXGD009912 Acne Skin and Connective Tissue Diseases
C0740394 BXGD009989 Hyperuricemia Pathological Conditions, Signs and Symptoms
C0750901 BXGD010242 Alzheimer Disease, Early Onset Nervous System Diseases; Mental Disorders
C0751422 BXGD010438 Hereditary Autoinflammatory Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0751967 BXGD010657 Multiple Sclerosis, Relapsing-Remitting Immune System Diseases; Nervous System Diseases
C0856975 BXGD011127 Autistic behavior Behavior and Behavior Mechanisms
C0858762 BXGD011190 Neuro-Behcet disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Skin and Connective Tissue Diseases; Stomatognathic Diseases; Cardiovascular Diseases
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C0917798 BXGD011409 Cerebral Ischemia Nervous System Diseases; Cardiovascular Diseases
C0917813 BXGD011417 Spina Bifida, Open Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0947751 BXGD011494 Vascular inflammations Cardiovascular Diseases
C0948163 BXGD011511 Leukoaraiosis Pathological Conditions, Signs and Symptoms
C0949690 BXGD011584 Spondylarthritis Musculoskeletal Diseases
C1096155 BXGD011605 Macrophage Activation Syndrome Immune System Diseases
C1112734 BXGD011683 Gastric infection
C1142272 BXGD011744 Neutrophilic dermatosis
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1262477 BXGD011882 Weight decreased Pathological Conditions, Signs and Symptoms
C1269955 BXGD012005 Tumor Cell Invasion
C1275126 BXGD012062 TNF receptor-associated periodic fever syndrome (TRAPS) Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C1282952 BXGD012153 Enthesitis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Nervous System Diseases; Wounds and Injuries
C1290884 BXGD012198 Inflammatory disorder Pathological Conditions, Signs and Symptoms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1320214 BXGD012421 Invasive Streptococcus pneumoniae disease Infections
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1368898 BXGD012904 Adult Teratoma Neoplasms
C1384584 BXGD012943 Generalized osteoarthritis Musculoskeletal Diseases
C1384600 BXGD012945 Systemic onset juvenile chronic arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C1405301 BXGD013025 Poliomyelitis, paralytic
C1411966 BXGD013047 Clostridium; difficile (disorder)
C1456687 BXGD013122 Polio and Post-Polio Syndrome Infections
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1519353 BXGD013236 Skin Papule Skin and Connective Tissue Diseases
C1519670 BXGD013241 Tumor Angiogenesis Pathological Conditions, Signs and Symptoms
C1519689 BXGD013245 Tumor Promotion Pathological Conditions, Signs and Symptoms; Neoplasms
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1565489 BXGD013401 Renal Insufficiency Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1608408 BXGD013434 Malignant transformation
C1611743 BXGD013456 Familial (FPAH)
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1692886 BXGD013495 Arthritis, Bacterial Infections; Musculoskeletal Diseases
C1698626 BXGD013520 Small Intestinal Mucositis
C1836830 BXGD014165 Developmental regression Mental Disorders
C1842364 BXGD014511 Central hypotonia
C1845050 BXGD014703 PIGMENTARY DISORDER, RETICULATE, WITH SYSTEMIC MANIFESTATIONS Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C1848296 BXGD014918 DOSAGE-SENSITIVE SEX REVERSAL Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C1849265 BXGD015028 Overgrowth
C1851347 BXGD015209 Familial Mediterranean Fever, Autosomal Dominant Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1855179 BXGD015468 CATARACT, ANTERIOR POLAR Eye Diseases
C1857953 BXGD015759 Deep plantar creases
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1858361 BXGD015784 Pyogenic Arthritis, Pyoderma Gangrenosum and Acne Infections; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C1861502 BXGD016054 COLCHICINE RESISTANCE
C1862389 BXGD016126 ATRIAL SEPTAL DEFECT 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1962966 BXGD016678 Retinopathy, CTCAE
C1963165 BXGD016685 Malabsorption, CTCAE
C1963167 BXGD016686 Memory Impairment, CTCAE 3.0
C2062441 BXGD016897 Influenza A
C2132198 BXGD016930 Abnormal blistering of the skin
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2243051 BXGD017008 Large head (disorder)
C2316212 BXGD017025 Cryopyrin-Associated Periodic Syndromes Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C2347748 BXGD017041 Adult Erythroleukemia
C2347761 BXGD017049 Childhood Myelodysplastic Syndrome Hemic and Lymphatic Diseases
C2347762 BXGD017050 Childhood Teratoma Neoplasms
C2363741 BXGD017100 HIV-1 infection
C2363774 BXGD017105 Neutrophilic asthma
C2700617 BXGD017474 Irritation - emotion Behavior and Behavior Mechanisms
C2827407 BXGD017795 Infectious Otitis Media Otorhinolaryngologic Diseases
C2936904 BXGD018150 Opitz GBBB Syndrome, X-Linked Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases; Male Urogenital Diseases; Stomatognathic Diseases
C2937365 BXGD018161 Recurrent aphthous ulcer Stomatognathic Diseases
C2939461 BXGD018180 Myeloid neoplasm Neoplasms; Hemic and Lymphatic Diseases
C3152231 BXGD018463 Gastrointestinal infarctions
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
C3267073 BXGD018613 Autoinflammatory disease
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3463897 BXGD018900 HYDATIDIFORM MOLE, RECURRENT, 1
C3495559 BXGD018994 Juvenile arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3495919 BXGD019013 Enthesitis-Related Arthritis Musculoskeletal Diseases
C3536715 BXGD019070 AA amyloidosis Nutritional and Metabolic Diseases
C3539781 BXGD019086 Progressive cGVHD
C3553450 BXGD019175 Profound global developmental delay
C3714745 BXGD019427 Malabsorption Digestive System Diseases
C3714757 BXGD019430 Juvenile rheumatoid arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3714758 BXGD019431 Juvenile psoriatic arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3714772 BXGD019433 Recurrent fevers
C3805083 BXGD019459 Portal fibrosis Digestive System Diseases
C3854373 BXGD019829 Morvan syndrome Nervous System Diseases
C3860213 BXGD019844 Autoinflammatory disorder
C3887513 BXGD019887 Avascular necrosis Pathological Conditions, Signs and Symptoms
C3889136 BXGD020002 Tumor Necrosis Factor Receptor 1-Associated Periodic Syndrome
C3889979 BXGD020015 Periodic Fever Syndrome Pathological Conditions, Signs and Symptoms
C3890176 BXGD020019 Psoriatic Juvenile Idiopathic Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3890737 BXGD020025 Autoinflammatory Syndrome Pathological Conditions, Signs and Symptoms
C3891815 BXGD020034 Arthritis, Suppurative Infections; Musculoskeletal Diseases
C3900098 BXGD020106 Adult Myelodysplastic Syndrome Hemic and Lymphatic Diseases
C4020732 BXGD020474 Mitochondrial abnormalities
C4021798 BXGD020788 Impaired use of nonverbal behaviors Mental Disorders
C4025758 BXGD021779 Abnormal myocardium morphology Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C4025875 BXGD021840 Abnormality of the anterior fontanelle
C4082167 BXGD022082 Periodic Fever, Aphthous Stomatitis, Pharyngitis, Adenitis Syndrome Pathological Conditions, Signs and Symptoms; Infections; Respiratory Tract Diseases; Immune System Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C4268691 BXGD022325 Tumor necrosis factor receptor associated periodic syndrome [TRAPS]
C4268694 BXGD022326 Periodic fever, aphthous stomatitis, pharyngitis, and adenopathy syndrome [PFAPA]
C4310620 BXGD022602 Yao syndrome
C4520840 BXGD023041 Erythroleukemia (Erythroid/Myeloid) Neoplasms; Hemic and Lymphatic Diseases
C4521256 BXGD023058 Glomerulopathy Assessment
C4529962 BXGD023178 Fatty Liver Disease
C4551563 BXGD023351 Microcephaly (physical finding)
C4551915 BXGD023441 Gait Disturbance, CTCAE
C4552810 BXGD023525 Irritability, CTCAE
C4553018 BXGD023532 Avascular Necrosis, CTCAE
C4553765 BXGD023551 Memory Impairment, CTCAE 5.0
C4707791 BXGD023722 Inflammatory myopathy with abundant macrophages Musculoskeletal Diseases; Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0004275 Acetaldehyde 44.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein