Showing entry for Kinesin-1 heavy chain


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009699
Protein NameKinesin-1 heavy chain
Uniport IdP33176
GeneKIF5B
Gene Id3799
DomainKinesin
Pfam PF00225  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04144 Endocytosis
5. Organismal Systems 5.6 Nervous system hsa04728 Dopaminergic synapse
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0099641 anterograde axonal protein transport
Biological Process GO:0098971 anterograde dendritic transport of neurotransmitter receptor complex
Biological Process GO:1990048 anterograde neuronal dense core vesicle transport
Biological Process GO:0007411 axon guidance
Biological Process GO:0071346 cellular response to interferon-gamma
Biological Process GO:0051642 centrosome localization
Biological Process GO:0007028 cytoplasm organization
Biological Process GO:0030705 cytoskeleton-dependent intracellular transport
Biological Process GO:0021766 hippocampus development
Biological Process GO:0007018 microtubule-based movement
Biological Process GO:0072383 plus-end-directed vesicle transport along microtubule
Biological Process GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
Biological Process GO:0090316 positive regulation of intracellular protein transport
Biological Process GO:0043268 positive regulation of potassium ion transport
Biological Process GO:1903078 positive regulation of protein localization to plasma membrane
Biological Process GO:0032230 positive regulation of synaptic transmission, GABAergic
Biological Process GO:0031340 positive regulation of vesicle fusion
Biological Process GO:1905152 positive regulation of voltage-gated sodium channel activity
Biological Process GO:0042391 regulation of membrane potential
Biological Process GO:1990049 retrograde neuronal dense core vesicle transport
Biological Process GO:0035617 stress granule disassembly
Biological Process GO:0048489 synaptic vesicle transport
Biological Process GO:0047496 vesicle transport along microtubule
molecular function GO:0016887 ATPase activity
molecular function GO:0005524 ATP binding
molecular function GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed
molecular function GO:0045296 cadherin binding
molecular function GO:0042802 identical protein binding
molecular function GO:0008432 JUN kinase binding
molecular function GO:0008017 microtubule binding
molecular function GO:0099609 microtubule lateral binding
molecular function GO:0003777 microtubule motor activity
cellular component GO:0044295 axonal growth cone
cellular component GO:1904115 axon cytoplasm
cellular component GO:0034451 centriolar satellite
cellular component GO:0035253 ciliary rootlet
cellular component GO:0005829 cytosol
cellular component GO:0032839 dendrite cytoplasm
cellular component GO:0005871 kinesin complex
cellular component GO:0016020 membrane
cellular component GO:0005874 microtubule
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0045335 phagocytic vesicle
cellular component GO:0031982 vesicle
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-1280218 Adaptive Immune System
R-HSA-162582 Signal Transduction
R-HSA-168256 Immune System
R-HSA-194315 Signaling by Rho GTPases
R-HSA-195258 RHO GTPase Effectors
R-HSA-199991 Membrane Trafficking
R-HSA-2132295 MHC class II antigen presentation
R-HSA-264876 Insulin processing
R-HSA-2980736 Peptide hormone metabolism
R-HSA-392499 Metabolism of proteins
R-HSA-5625970 RHO GTPases activate KTN1
R-HSA-5653656 Vesicle-mediated transport
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-8856688 Golgi-to-ER retrograde transport
R-HSA-983189 Kinesins
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007120 BXGD000435 Bronchioloalveolar Adenocarcinoma Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0016057 BXGD001042 Fibrosarcoma Neoplasms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0019618 BXGD001339 Histiocytosis Hemic and Lymphatic Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0027022 BXGD001962 Myeloproliferative disease Hemic and Lymphatic Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0034152 BXGD002467 Henoch-Schoenlein Purpura Pathological Conditions, Signs and Symptoms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037773 BXGD002704 Spastic Paraplegia, Hereditary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0042341 BXGD002975 Varicocele Male Urogenital Diseases; Cardiovascular Diseases
C0080032 BXGD003105 Pleural Effusion, Malignant Neoplasms; Respiratory Tract Diseases
C0149782 BXGD003365 Squamous cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0220650 BXGD004310 Metastatic malignant neoplasm to brain Pathological Conditions, Signs and Symptoms; Neoplasms; Nervous System Diseases
C0238462 BXGD004937 Medullary carcinoma of thyroid Neoplasms; Endocrine System Diseases
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0260037 BXGD005227 Multiple tumors Neoplasms
C0278595 BXGD006545 Adult Fibrosarcoma Neoplasms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279557 BXGD006636 Adenosquamous cell lung cancer Neoplasms; Respiratory Tract Diseases
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0344482 BXGD007678 Hypoplasia of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0393555 BXGD008088 Pure hereditary spastic paraplegia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0398597 BXGD008198 Histiocytic syndrome Immune System Diseases; Hemic and Lymphatic Diseases
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0557874 BXGD009444 Global developmental delay
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1265996 BXGD011927 Large cell neuroendocrine carcinoma Neoplasms
C1266002 BXGD011929 Non-small cell carcinoma Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1334363 BXGD012699 Lung Large Cell Neuroendocrine Carcinoma
C1336518 BXGD012845 Subglottic hemangioma Neoplasms
C1511789 BXGD013183 Desmoplastic
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1858712 BXGD015821 Spastic paraplegia 10, autosomal dominant Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C2845975 BXGD017806 Malignant neuroendocrine tumor Neoplasms
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4551584 BXGD023362 Brain atrophy Nervous System Diseases
C4744444 BXGD023941 Metastatic Lung Adenocarcinoma Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002588 Magnesium 24.31
BXGC0002708 Strontium 87.62
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein