Showing entry for Sonic hedgehog protein


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013573
Protein NameSonic hedgehog protein
Uniport IdQ15465
GeneSHH
Gene Id6469
DomainHH_signal; Hint
Pfam PF01085   PF01079  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04340 Hedgehog signaling pathway
5. Organismal Systems 5.8 Development hsa04360 Axon guidance
6. Human Diseases 6.1 Cancers: Overview hsa05200 Pathways in cancer
6. Human Diseases 6.1 Cancers: Overview hsa05205 Proteoglycans in cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05217 Basal cell carcinoma
6. Human Diseases 6.2 Cancers: Specific types hsa05226 Gastric cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0008209 androgen metabolic process
Biological Process GO:0048645 animal organ formation
Biological Process GO:0097190 apoptotic signaling pathway
Biological Process GO:0060840 artery development
Biological Process GO:0007411 axon guidance
Biological Process GO:0060020 Bergmann glial cell differentiation
Biological Process GO:0007596 blood coagulation
Biological Process GO:0001569 branching involved in blood vessel morphogenesis
Biological Process GO:0060445 branching involved in salivary gland morphogenesis
Biological Process GO:0001658 branching involved in ureteric bud morphogenesis
Biological Process GO:0048754 branching morphogenesis of an epithelial tube
Biological Process GO:0060447 bud outgrowth involved in lung branching
Biological Process GO:0043010 camera-type eye development
Biological Process GO:0060070 canonical Wnt signaling pathway
Biological Process GO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
Biological Process GO:0007267 cell-cell signaling
Biological Process GO:0048468 cell development
Biological Process GO:0001708 cell fate specification
Biological Process GO:0071285 cellular response to lithium ion
Biological Process GO:0007417 central nervous system development
Biological Process GO:0021930 cerebellar granule cell precursor proliferation
Biological Process GO:0003140 determination of left/right asymmetry in lateral mesoderm
Biological Process GO:0071542 dopaminergic neuron differentiation
Biological Process GO:0021904 dorsal/ventral neural tube patterning
Biological Process GO:0009953 dorsal/ventral pattern formation
Biological Process GO:0007398 ectoderm development
Biological Process GO:0048557 embryonic digestive tract morphogenesis
Biological Process GO:0042733 embryonic digit morphogenesis
Biological Process GO:0048617 embryonic foregut morphogenesis
Biological Process GO:0035115 embryonic forelimb morphogenesis
Biological Process GO:0035116 embryonic hindlimb morphogenesis
Biological Process GO:0030326 embryonic limb morphogenesis
Biological Process GO:0009880 embryonic pattern specification
Biological Process GO:0048706 embryonic skeletal system development
Biological Process GO:0006897 endocytosis
Biological Process GO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis
Biological Process GO:0060738 epithelial-mesenchymal signaling involved in prostate gland development
Biological Process GO:0030010 establishment of cell polarity
Biological Process GO:0030900 forebrain development
Biological Process GO:0048859 formation of anatomical boundary
Biological Process GO:0031069 hair follicle morphogenesis
Biological Process GO:0007507 heart development
Biological Process GO:0001947 heart looping
Biological Process GO:0030902 hindbrain development
Biological Process GO:0007442 hindgut morphogenesis
Biological Process GO:0048839 inner ear development
Biological Process GO:0016539 intein-mediated protein splicing
Biological Process GO:0045109 intermediate filament organization
Biological Process GO:0060459 left lung development
Biological Process GO:0060174 limb bud formation
Biological Process GO:0060484 lung-associated mesenchyme development
Biological Process GO:0030324 lung development
Biological Process GO:0060428 lung epithelium development
Biological Process GO:0060463 lung lobe morphogenesis
Biological Process GO:0002320 lymphoid progenitor cell differentiation
Biological Process GO:0030539 male genitalia development
Biological Process GO:0060916 mesenchymal cell proliferation involved in lung development
Biological Process GO:0060783 mesenchymal smoothened signaling pathway involved in prostate gland development
Biological Process GO:0072205 metanephric collecting duct development
Biological Process GO:0072136 metanephric mesenchymal cell proliferation involved in metanephros development
Biological Process GO:0001656 metanephros development
Biological Process GO:0030901 midbrain development
Biological Process GO:0045445 myoblast differentiation
Biological Process GO:0014902 myotube differentiation
Biological Process GO:0046639 negative regulation of alpha-beta T cell differentiation
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0090090 negative regulation of canonical Wnt signaling pathway
Biological Process GO:0045596 negative regulation of cell differentiation
Biological Process GO:0030336 negative regulation of cell migration
Biological Process GO:0090370 negative regulation of cholesterol efflux
Biological Process GO:1904339 negative regulation of dopaminergic neuron differentiation
Biological Process GO:2000357 negative regulation of kidney smooth muscle cell differentiation
Biological Process GO:2001054 negative regulation of mesenchymal cell apoptotic process
Biological Process GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Process GO:0042130 negative regulation of T cell proliferation
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter
Biological Process GO:2000062 negative regulation of ureter smooth muscle cell differentiation
Biological Process GO:0045060 negative thymic T cell selection
Biological Process GO:0001755 neural crest cell migration
Biological Process GO:0007405 neuroblast proliferation
Biological Process GO:0048663 neuron fate commitment
Biological Process GO:0042475 odontogenesis of dentin-containing tooth
Biological Process GO:0014003 oligodendrocyte development
Biological Process GO:0048709 oligodendrocyte differentiation
Biological Process GO:0002076 osteoblast development
Biological Process GO:0031016 pancreas development
Biological Process GO:0007389 pattern specification process
Biological Process GO:0009949 polarity specification of anterior/posterior axis
Biological Process GO:0046638 positive regulation of alpha-beta T cell differentiation
Biological Process GO:0051781 positive regulation of cell division
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0060769 positive regulation of epithelial cell proliferation involved in prostate gland development
Biological Process GO:0007228 positive regulation of hh target transcription factor activity
Biological Process GO:0033092 positive regulation of immature T cell proliferation in thymus
Biological Process GO:2000358 positive regulation of kidney smooth muscle cell differentiation
Biological Process GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development
Biological Process GO:0002052 positive regulation of neuroblast proliferation
Biological Process GO:0048714 positive regulation of oligodendrocyte differentiation
Biological Process GO:0042307 positive regulation of protein import into nucleus
Biological Process GO:0061189 positive regulation of sclerotome development
Biological Process GO:0014858 positive regulation of skeletal muscle cell proliferation
Biological Process GO:0048643 positive regulation of skeletal muscle tissue development
Biological Process GO:0045880 positive regulation of smoothened signaling pathway
Biological Process GO:0051155 positive regulation of striated muscle cell differentiation
Biological Process GO:0033089 positive regulation of T cell differentiation in thymus
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:2000063 positive regulation of ureter smooth muscle cell differentiation
Biological Process GO:0030177 positive regulation of Wnt signaling pathway
Biological Process GO:0045059 positive thymic T cell selection
Biological Process GO:0060516 primary prostatic bud elongation
Biological Process GO:0060523 prostate epithelial cord elongation
Biological Process GO:0030850 prostate gland development
Biological Process GO:0016540 protein autoprocessing
Biological Process GO:0034504 protein localization to nucleus
Biological Process GO:0042127 regulation of cell population proliferation
Biological Process GO:0010468 regulation of gene expression
Biological Process GO:0060782 regulation of mesenchymal cell proliferation involved in prostate gland development
Biological Process GO:1900175 regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
Biological Process GO:0042481 regulation of odontogenesis
Biological Process GO:0060685 regulation of prostatic bud formation
Biological Process GO:1900180 regulation of protein localization to nucleus
Biological Process GO:0030162 regulation of proteolysis
Biological Process GO:0060458 right lung development
Biological Process GO:0060021 roof of mouth development
Biological Process GO:0060662 salivary gland cavitation
Biological Process GO:0007224 smoothened signaling pathway
Biological Process GO:0021938 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
Biological Process GO:0048745 smooth muscle tissue development
Biological Process GO:0061053 somite development
Biological Process GO:0021513 spinal cord dorsal/ventral patterning
Biological Process GO:0021522 spinal cord motor neuron differentiation
Biological Process GO:0048864 stem cell development
Biological Process GO:0014706 striated muscle tissue development
Biological Process GO:0033077 T cell differentiation in thymus
Biological Process GO:0021978 telencephalon regionalization
Biological Process GO:0021794 thalamus development
Biological Process GO:0048538 thymus development
Biological Process GO:0030878 thyroid gland development
Biological Process GO:0060439 trachea morphogenesis
Biological Process GO:1905327 tracheoesophageal septum formation
Biological Process GO:0001570 vasculogenesis
Biological Process GO:0007418 ventral midline development
molecular function GO:0005509 calcium ion binding
molecular function GO:0005539 glycosaminoglycan binding
molecular function GO:0043237 laminin-1 binding
molecular function GO:0016015 morphogen activity
molecular function GO:0005113 patched binding
molecular function GO:0008233 peptidase activity
molecular function GO:0008270 zinc ion binding
cellular component GO:0009986 cell surface
cellular component GO:0062023 collagen-containing extracellular matrix
cellular component GO:0005829 cytosol
cellular component GO:0005788 endoplasmic reticulum lumen
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0045121 membrane raft
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-372790 Signaling by GPCR
R-HSA-373080 Class B/2 (Secretin family receptors)
R-HSA-500792 GPCR ligand binding
R-HSA-5358346 Hedgehog ligand biogenesis
R-HSA-5358346 Hedgehog ligand biogenesis
R-HSA-5358351 Signaling by Hedgehog
R-HSA-5358351 Signaling by Hedgehog
R-HSA-5362768 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
R-HSA-5362798 Release of Hh-Np from the secreting cell
R-HSA-5362798 Release of Hh-Np from the secreting cell
R-HSA-5387390 Hh mutants abrogate ligand secretion
R-HSA-5632681 Ligand-receptor interactions
R-HSA-5632681 Ligand-receptor interactions
R-HSA-5632684 Hedgehog 'on' state
R-HSA-5632684 Hedgehog 'on' state
R-HSA-5635838 Activation of SMO
R-HSA-5658034 HHAT G278V abrogates palmitoylation of Hh-Np
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001430 BXGD000054 Adenoma Neoplasms
C0002448 BXGD000115 Ameloblastoma Neoplasms
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0002893 BXGD000150 Refractory anemias Hemic and Lymphatic Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004610 BXGD000281 Bacteremia Pathological Conditions, Signs and Symptoms; Infections
C0004779 BXGD000291 Basal Cell Nevus Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Musculoskeletal Diseases; Stomatognathic Diseases
C0005411 BXGD000313 Biliary Atresia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007115 BXGD000432 Malignant neoplasm of thyroid Neoplasms; Endocrine System Diseases
C0007129 BXGD000439 Merkel cell carcinoma Neoplasms; Infections
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007138 BXGD000446 Carcinoma, Transitional Cell Neoplasms
C0008073 BXGD000518 Developmental Disabilities Mental Disorders
C0008297 BXGD000522 Choanal Atresia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0008350 BXGD000531 Cholelithiasis Digestive System Diseases
C0008626 BXGD000559 Congenital chromosomal disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0008924 BXGD000574 Cleft upper lip Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0008925 BXGD000575 Cleft Palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010036 BXGD000642 Corneal dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010276 BXGD000659 Craniopharyngioma Neoplasms
C0011649 BXGD000746 Dermoid Cyst Neoplasms
C0011882 BXGD000761 Diabetic Neuropathies Nervous System Diseases; Endocrine System Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0014013 BXGD000877 Empyema, Pleural Pathological Conditions, Signs and Symptoms; Infections; Respiratory Tract Diseases
C0014072 BXGD000888 Experimental Autoimmune Encephalomyelitis Immune System Diseases; Nervous System Diseases
C0014474 BXGD000917 Ependymoma Neoplasms
C0014556 BXGD000932 Epilepsy, Temporal Lobe Nervous System Diseases
C0014850 BXGD000957 Esophageal Atresia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0015300 BXGD000973 Exophthalmos Eye Diseases
C0015393 BXGD000981 Eye Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0016325 BXGD001053 Fluoride Poisoning Chemically-Induced Disorders
C0017152 BXGD001096 Gastritis Digestive System Diseases
C0017154 BXGD001097 Gastritis, Atrophic Digestive System Diseases
C0017185 BXGD001104 Gastrointestinal Neoplasms Digestive System Diseases; Neoplasms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0018552 BXGD001202 Hamartoma Neoplasms
C0018916 BXGD001245 Hemangioma Neoplasms
C0019284 BXGD001312 Diaphragmatic Hernia Pathological Conditions, Signs and Symptoms
C0020295 BXGD001372 Hydronephrosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0020476 BXGD001398 Hyperlipoproteinemias Nutritional and Metabolic Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023015 BXGD001601 Language Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0023267 BXGD001626 Fibroid Tumor Neoplasms
C0023418 BXGD001642 leukemia Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0025500 BXGD001874 Mesothelioma Neoplasms
C0025568 BXGD001877 Metaplasia Pathological Conditions, Signs and Symptoms
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026010 BXGD001886 Microphthalmos Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0026267 BXGD001896 Mitral Valve Prolapse Syndrome Cardiovascular Diseases
C0026499 BXGD001905 Monosomy Pathological Conditions, Signs and Symptoms
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027055 BXGD001964 Myocardial Reperfusion Injury Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027794 BXGD002036 Neural Tube Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0028840 BXGD002089 Ocular Hypertension Eye Diseases
C0028860 BXGD002093 Oculocerebrorenal Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Nervous System Diseases
C0028880 BXGD002097 Odontogenic Tumors Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0030297 BXGD002204 Pancreatic Neoplasm Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0030305 BXGD002206 Pancreatitis Digestive System Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0030569 BXGD002242 Secondary Parkinson Disease Nervous System Diseases
C0032019 BXGD002321 Pituitary Neoplasms Neoplasms; Nervous System Diseases; Endocrine System Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0032584 BXGD002363 polyps Pathological Conditions, Signs and Symptoms
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0035412 BXGD002548 Rhabdomyosarcoma Neoplasms
C0035934 BXGD002572 Rubinstein-Taybi Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037221 BXGD002673 Situs Inversus Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0038356 BXGD002747 Stomach Neoplasms Digestive System Diseases; Neoplasms
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0038525 BXGD002768 Subarachnoid Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0039685 BXGD002825 Tetralogy of Fallot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0040588 BXGD002879 Tracheoesophageal Fistula Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Respiratory Tract Diseases
C0042341 BXGD002975 Varicocele Male Urogenital Diseases; Cardiovascular Diseases
C0078982 BXGD003060 Arhinencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0079541 BXGD003081 Holoprosencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0085078 BXGD003118 Lysosomal Storage Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0085207 BXGD003140 Gestational Diabetes Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0085390 BXGD003160 Li-Fraumeni Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nutritional and Metabolic Diseases
C0149782 BXGD003365 Squamous cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0149925 BXGD003387 Small cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0151526 BXGD003432 Premature Birth Female Urogenital Diseases and Pregnancy Complications
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0152021 BXGD003520 Congenital heart disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0152427 BXGD003590 Polydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0153452 BXGD003647 Malignant neoplasm of gallbladder Digestive System Diseases; Neoplasms
C0153633 BXGD003674 Malignant neoplasm of brain Neoplasms; Nervous System Diseases
C0158733 BXGD003903 Hand polydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0158734 BXGD003904 Polydactyly of toes Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0175694 BXGD004002 Smith-Lemli-Opitz Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0175754 BXGD004015 Agenesis of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206180 BXGD004170 Ki-1+ Anaplastic Large Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0206624 BXGD004190 Hepatoblastoma Neoplasms
C0206663 BXGD004225 Neuroectodermal Tumor, Primitive Neoplasms
C0206695 BXGD004246 Carcinoma, Neuroendocrine Neoplasms
C0220603 BXGD004293 Childhood Brain Neoplasm Neoplasms; Nervous System Diseases
C0220611 BXGD004295 Childhood Rhabdomyosarcoma Neoplasms
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0220708 BXGD004328 VATER Association Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Cardiovascular Diseases
C0221023 BXGD004369 Cyclic neutropenia Hemic and Lymphatic Diseases
C0221170 BXGD004400 Muscular stiffness Nervous System Diseases
C0221352 BXGD004444 Syndactyly of fingers Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases
C0235782 BXGD004769 Gallbladder Carcinoma Digestive System Diseases; Neoplasms
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238198 BXGD004893 Gastrointestinal Stromal Tumors Digestive System Diseases; Neoplasms
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0240063 BXGD005015 Coloboma of iris Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0240896 BXGD005059 Fundus coloboma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0241397 BXGD005095 Triphalangeal thumb Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0242343 BXGD005153 Panhypopituitarism Nervous System Diseases; Endocrine System Diseases
C0242350 BXGD005154 Erectile dysfunction Male Urogenital Diseases; Mental Disorders
C0242422 BXGD005163 Parkinsonian Disorders Nervous System Diseases
C0265581 BXGD005551 Longitudinal deficiency of radius Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0265633 BXGD005556 Congenital absence of tibia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0265660 BXGD005561 Syndactyly of the toes Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0265677 BXGD005564 Congenital hemivertebra Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0266174 BXGD005626 Duodenal atresia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0266362 BXGD005657 Ambiguous Genitalia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0266435 BXGD005668 Congenital hypoplasia of penis Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0266449 BXGD005670 Congenital anomaly of brain Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Nervous System Diseases
C0266484 BXGD005681 Schizencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0266551 BXGD005693 Congenital coloboma of iris Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0266642 BXGD005705 Situs ambiguus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0266667 BXGD005707 Cyclocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0266981 BXGD005724 Torus palatinus Musculoskeletal Diseases; Stomatognathic Diseases
C0271561 BXGD006213 Somatotropin deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Endocrine System Diseases
C0278510 BXGD006526 Childhood Medulloblastoma Neoplasms
C0278652 BXGD006554 Childhood Craniopharyngioma Neoplasms
C0278704 BXGD006567 Malignant Childhood Neoplasm Neoplasms
C0278874 BXGD006605 Adult Ependymoma Neoplasms
C0278875 BXGD006606 Adult Craniopharyngioma Neoplasms
C0278876 BXGD006607 Adult Medulloblastoma Neoplasms
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0279550 BXGD006635 Adult Rhabdomyosarcoma Neoplasms
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0280313 BXGD006737 Squamous cell carcinoma of oropharynx Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C0281361 BXGD006774 Adenocarcinoma of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0300948 BXGD006828 Caudal Regression Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0333641 BXGD006961 Atrophic Pathological Conditions, Signs and Symptoms
C0333983 BXGD006975 Hyperplastic Polyp Pathological Conditions, Signs and Symptoms
C0334634 BXGD007144 Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0341154 BXGD007391 Esophageal atresia with tracheoesophageal fistula (disorder) Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0344490 BXGD007680 Sacral agenesis Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0345354 BXGD007728 Radial polydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0349588 BXGD007933 Short stature
C0374997 BXGD007967 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376634 BXGD008006 Craniofacial Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0392514 BXGD008051 Hereditary hemochromatosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0399440 BXGD008244 Hereditary gingival fibromatosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0409348 BXGD008384 Flexion contracture of proximal interphalangeal joint
C0424711 BXGD008541 Orbital separation diminished
C0431362 BXGD008670 Lobar Holoprosencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0431363 BXGD008671 Alobar Holoprosencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0431414 BXGD008687 Sacral dysgenesis
C0431904 BXGD008713 Ulnar polydactyly of fingers Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0432215 BXGD008739 Progressive pseudorheumatoid dysplasia Musculoskeletal Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0549306 BXGD009368 Mesomelia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0557874 BXGD009444 Global developmental delay
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677898 BXGD009735 invasive cancer Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0685682 BXGD009812 Single naris Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases
C0685869 BXGD009822 Monophthalmos Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0687140 BXGD009840 Hemangioma of skin Neoplasms; Skin and Connective Tissue Diseases; Cardiovascular Diseases
C0687720 BXGD009844 Central Diabetes Insipidus Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0751291 BXGD010379 Desmoplastic Medulloblastoma Neoplasms
C0751297 BXGD010384 Leptomeningeal Neoplasms Neoplasms; Nervous System Diseases
C0751414 BXGD010434 Parkinson Disease, Secondary Vascular Nervous System Diseases
C0751415 BXGD010435 Atherosclerotic Parkinsonism Nervous System Diseases
C0751617 BXGD010525 Semilobar Holoprosencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0795803 BXGD010734 Chromosome 2, trisomy 2p Pathological Conditions, Signs and Symptoms
C0795839 BXGD010745 Chromosome 10, monosomy 10q Pathological Conditions, Signs and Symptoms
C0796611 BXGD010835 Newly Diagnosed Childhood Ependymoma Neoplasms
C0848558 BXGD010882 Hypospadias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0850666 BXGD010901 Infection caused by Helicobacter pylori Infections
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1266184 BXGD011991 Atypical Teratoid Rhabdoid Tumor Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1302401 BXGD012303 Adenoma of large intestine Digestive System Diseases; Neoplasms
C1304508 BXGD012341 Spindle cell hemangioma Neoplasms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1367420 BXGD012882 Kaposiform Hemangioendothelioma Neoplasms; Infections; Hemic and Lymphatic Diseases
C1395852 BXGD012991 Polydactyly preaxial type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1531647 BXGD013301 Cerebral ventriculomegaly Nervous System Diseases
C1609433 BXGD013438 Congenital absence of kidneys syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1691215 BXGD013491 Penile hypospadias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1704436 BXGD013564 Peripheral Arterial Diseases Cardiovascular Diseases
C1707400 BXGD013582 Classic medulloblastoma Neoplasms
C1735591 BXGD013712 VACTERL Association Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Cardiovascular Diseases
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1836542 BXGD014129 Depressed nasal bridge
C1838610 BXGD014326 Aplasia of the 1st metacarpal
C1839767 BXGD014404 Tented upper lip vermilion
C1840077 BXGD014434 Anteverted nostril
C1840235 BXGD014436 SOLITARY MEDIAN MAXILLARY CENTRAL INCISOR Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C1840238 BXGD014437 Midnasal stenosis
C1840529 BXGD014474 HOLOPROSENCEPHALY 3 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C1843496 BXGD014588 Bilateral microphthalmos Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1845108 BXGD014710 Prominent median palatal raphe
C1850049 BXGD015101 Clinodactyly of the 5th finger
C1850259 BXGD015125 Short tibia
C1851584 BXGD015221 Childhood Ependymoma Neoplasms
C1853242 BXGD015322 Midface retrusion
C1854114 BXGD015383 Short nose
C1855340 BXGD015490 Bowing of the long bones
C1856892 BXGD015652 Facial Dysmorphism with Multiple Malformations Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C1857108 BXGD015677 Limitation of joint mobility
C1857479 BXGD015705 Short columella
C1858085 BXGD015770 Malar flattening
C1859717 BXGD015924 Depressed nasal tip
C1861028 BXGD016010 Esophageal atresia with or without tracheoesophageal fistula Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C1861324 BXGD016029 Short philtrum
C1861355 BXGD016038 Syndactyly, Type IV Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1861360 BXGD016039 6 metacarpals
C1861403 BXGD016045 Variable expressivity
C1862151 BXGD016110 BRACHYDACTYLY, TYPE A1 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1868114 BXGD016489 POLYDACTYLY, PREAXIAL II (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Musculoskeletal Diseases
C1961102 BXGD016673 Precursor Cell Lymphoblastic Leukemia Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1968843 BXGD016739 MICROPHTHALMIA, ISOLATED, WITH COLOBOMA 5 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2347613 BXGD017039 Childhood Atypical Teratoid/Rhabdoid Tumor
C2363741 BXGD017100 HIV-1 infection
C2698045 BXGD017445 Merkel Cell Polyomavirus Infection Infections
C2699510 BXGD017460 Split-Hand/Foot Malformation Pathological Conditions, Signs and Symptoms
C2749463 BXGD017620 Aplasia/Hypoplasia of the radius
C2919142 BXGD017867 Short Stature, CTCAE
C2931501 BXGD018031 Microphthalmia associated with colobomatous cyst Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Eye Diseases
C2931870 BXGD018086 Familial schizencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3179455 BXGD018552 Niemann-Pick Disease, Type C1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Hemic and Lymphatic Diseases
C3179508 BXGD018554 Aplasia/Hypoplasia of the thumb Musculoskeletal Diseases
C3241937 BXGD018578 Nonalcoholic Steatohepatitis Digestive System Diseases
C3276742 BXGD018695 Fibular duplication
C3278923 BXGD018748 Dilated ventricles (finding)
C3495676 BXGD019000 Anorectal Malformations Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C3540764 BXGD019092 Coloboma of the Retina Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3714796 BXGD019434 Isolated somatotropin deficiency
C3811653 BXGD019662 Experimental Organism Basal Cell Carcinoma Neoplasms
C3828416 BXGD019740 Radiation Damage Wounds and Injuries
C3839990 BXGD019791 Congenital stenosis of nasal pyriform aperture Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C4021100 BXGD020554 Increased fibular diameter
C4021726 BXGD020735 EMG: myopathic abnormalities Musculoskeletal Diseases; Nervous System Diseases
C4023728 BXGD021254 1-5 finger syndactyly
C4024338 BXGD021320 Deviation of the hand or of fingers of the hand Musculoskeletal Diseases
C4025390 BXGD021656 Abnormality of the trapezium
C4025397 BXGD021657 Abnormality of the scaphoid
C4025846 BXGD021826 Abnormality of vision
C4082761 BXGD022092 Abnormality of limb bone morphology
C4330667 BXGD022804 Medulloblastoma, Non-WNT/Non-SHH
C4520983 BXGD023052 Congenital atresia of extrahepatic bile duct Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C4525297 BXGD023131 Stage 0 Gallbladder Cancer AJCC v8
C4525300 BXGD023132 Stage IIA Gallbladder Cancer AJCC v8
C4525301 BXGD023133 Stage IIB Gallbladder Cancer AJCC v8
C4525302 BXGD023134 Stage III Gallbladder Cancer AJCC v8
C4525305 BXGD023135 Stage IV Gallbladder Cancer AJCC v8
C4529962 BXGD023178 Fatty Liver Disease
C4551488 BXGD023314 Bifid uvula
C4551564 BXGD023352 Narrow nasal bridge
C4551583 BXGD023361 Cerebral cortical atrophy
C4721806 BXGD023772 Carcinoma, Basal Cell Neoplasms
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0002586 Calcium 40.08
BXGC0002588 Magnesium 24.31
BXGC0003705 Chloride 35.45
BXGC0005513 Hexadecanoic acid 256.42
BXGC0028981 Serine 105.04
BXGC0037795 Cyclopamine 411.31
BXGC0038316 Cholesterol 386.35
BXGC0053358 Jervine 425.29
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein