Showing entry for Monoglyceride lipase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT019948
Protein NameMonoglyceride lipase
Uniport IdQ99685
GeneMGLL
Gene Id11343
DomainHydrolase_4
Pfam PF12146  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00561 Glycerolipid metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
5. Organismal Systems 5.10 Environmental adaptation hsa04714 Thermogenesis
5. Organismal Systems 5.6 Nervous system hsa04723 Retrograde endocannabinoid signaling
5. Organismal Systems 5.2 Endocrine system hsa04923 Regulation of lipolysis in adipocytes
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0036155 acylglycerol acyl-chain remodeling
Biological Process GO:0046464 acylglycerol catabolic process
Biological Process GO:0019369 arachidonic acid metabolic process
Biological Process GO:0006633 fatty acid biosynthetic process
Biological Process GO:0006954 inflammatory response
Biological Process GO:0006629 lipid metabolic process
Biological Process GO:0052651 monoacylglycerol catabolic process
Biological Process GO:2000124 regulation of endocannabinoid signaling pathway
Biological Process GO:0050727 regulation of inflammatory response
Biological Process GO:0051930 regulation of sensory perception of pain
Biological Process GO:0009966 regulation of signal transduction
Biological Process GO:0019433 triglyceride catabolic process
molecular function GO:0047372 acylglycerol lipase activity
molecular function GO:0016298 lipase activity
molecular function GO:0004622 lysophospholipase activity
molecular function GO:0042803 protein homodimerization activity
cellular component GO:0005829 cytosol
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0019898 extrinsic component of membrane
cellular component GO:0016020 membrane
cellular component GO:0005654 nucleoplasm
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-114508 Effects of PIP2 hydrolysis
R-HSA-1430728 Metabolism
R-HSA-1430728 Metabolism
R-HSA-1482883 Acyl chain remodeling of DAG and TAG
R-HSA-1483206 Glycerophospholipid biosynthesis
R-HSA-1483257 Phospholipid metabolism
R-HSA-162582 Signal Transduction
R-HSA-163560 Triglyceride catabolism
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-416476 G alpha (q) signalling events
R-HSA-426048 Arachidonate production from DAG
R-HSA-556833 Metabolism of lipids
R-HSA-556833 Metabolism of lipids
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-8979227 Triglyceride metabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001430 BXGD000054 Adenoma Neoplasms
C0001787 BXGD000076 Osteoporosis, Age-Related Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0005940 BXGD000352 Bone Diseases Musculoskeletal Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0006870 BXGD000416 Cannabis Dependence Chemically-Induced Disorders; Mental Disorders
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007682 BXGD000471 CNS disorder Nervous System Diseases
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0008313 BXGD000528 Cholangitis, Sclerosing Digestive System Diseases
C0008373 BXGD000536 Cholesteatoma Skin and Connective Tissue Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011615 BXGD000738 Dermatitis, Atopic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013170 BXGD000802 Drug habituation Chemically-Induced Disorders; Mental Disorders
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0016529 BXGD001068 Forced expiratory volume function
C0017601 BXGD001125 Glaucoma Eye Diseases
C0018790 BXGD001221 Cardiac Arrest Cardiovascular Diseases
C0019158 BXGD001293 Hepatitis Digestive System Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024523 BXGD001781 Malabsorption Syndrome Digestive System Diseases; Nutritional and Metabolic Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029459 BXGD002159 Osteoporosis, Senile Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030201 BXGD002194 Pain, Postoperative Pathological Conditions, Signs and Symptoms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0032927 BXGD002381 Precancerous Conditions Neoplasms
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038358 BXGD002748 Gastric ulcer Digestive System Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0038586 BXGD002772 Substance Use Disorders Chemically-Induced Disorders; Mental Disorders
C0042341 BXGD002975 Varicocele Male Urogenital Diseases; Cardiovascular Diseases
C0085207 BXGD003140 Gestational Diabetes Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0149931 BXGD003388 Migraine Disorders Nervous System Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0152230 BXGD003564 Cholinergic urticaria Skin and Connective Tissue Diseases; Immune System Diseases
C0153690 BXGD003684 Secondary malignant neoplasm of bone Pathological Conditions, Signs and Symptoms; Neoplasms; Musculoskeletal Diseases
C0178782 BXGD004034 Orofacial Pain Pathological Conditions, Signs and Symptoms
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0200638 BXGD004043 Eosinophil count procedure
C0206623 BXGD004189 Adenosquamous carcinoma Neoplasms
C0234251 BXGD004645 Inflammatory pain Pathological Conditions, Signs and Symptoms
C0238198 BXGD004893 Gastrointestinal Stromal Tumors Digestive System Diseases; Neoplasms
C0242339 BXGD005150 Dyslipidemias Nutritional and Metabolic Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0279530 BXGD006628 Malignant Bone Neoplasm Neoplasms; Musculoskeletal Diseases
C0282488 BXGD006804 Interstitial Cystitis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0344395 BXGD007668 Bilirubin measurement
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0392885 BXGD008071 High density lipoprotein measurement
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0428472 BXGD008630 Serum HDL cholesterol measurement
C0442874 BXGD008814 Neuropathy Nervous System Diseases
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0563625 BXGD009484 Agnosia for Pain Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0566602 BXGD009489 Primary sclerosing cholangitis Digestive System Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596240 BXGD009638 Cancer Pain Pathological Conditions, Signs and Symptoms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600040 BXGD009684 Chronic interstitial cystitis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0740391 BXGD009987 Middle Cerebral Artery Occlusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0742034 BXGD010052 cerebellar function
C0751406 BXGD010428 Post-Traumatic Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0860580 BXGD011232 Medullary carcinoma of breast
C0877008 BXGD011325 Enzyme inhibition disorder
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1445957 BXGD013081 Serum total cholesterol measurement
C1510472 BXGD013170 Drug Dependence Chemically-Induced Disorders; Mental Disorders
C1527349 BXGD013277 Ductal Breast Carcinoma Neoplasms
C1853195 BXGD015313 Prostate Cancer, Hereditary, 7 Neoplasms; Male Urogenital Diseases
C1861172 BXGD016016 Venous Thromboembolism Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2936719 BXGD018130 Mechanical Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2985290 BXGD018224 Fetal Alcohol Spectrum Disorders Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Chemically-Induced Disorders
C3160814 BXGD018477 Cannabis use
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4285693 BXGD022446 HIV-associated neurocognitive disorder Infections; Immune System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000663 Papain 206.28
BXGC0003705 Chloride 35.45
BXGC0006466 Oleanolic acid 456.71
BXGC0009122 Zein 174.19
BXGC0012243 Ukonan D 151.16
BXGC0014695 Loratadine 382.14
BXGC0015760 Puerarin 416.11
BXGC0030612 tetraethylene glycol 194.12
BXGC0035075 Obacunone 454.2
BXGC0037599 Tanshinone Iia 294.13
BXGC0037687 (4S)-2-methylpentane-2,4-diol 118.1
BXGC0041560 Thiram 239.99
BXGC0052948 Tanshinone I 276.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein