Showing entry for cGMP-dependent 3',5'-cyclic phosphodiesterase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT003916
Protein NamecGMP-dependent 3',5'-cyclic phosphodiesterase
Uniport IdO00408
GenePDE2A
Gene Id5138
DomainGAF; PDEase_I
Pfam PF01590   PF13185   PF00233  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.4 Nucleotide metabolism hsa00230 Purine metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
3. Environmental Information Processing 3.2 Signal transduction hsa04022 cGMP-PKG signaling pathway
5. Organismal Systems 5.7 Sensory system hsa04740 Olfactory transduction
5. Organismal Systems 5.2 Endocrine system hsa04925 Aldosterone synthesis and secretion
6. Human Diseases 6.5 Substance dependence hsa05032 Morphine addiction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Biological Process GO:0035904 aorta development
Biological Process GO:0019933 cAMP-mediated signaling
Biological Process GO:1904613 cellular response to 2,3,7,8-tetrachlorodibenzodioxine
Biological Process GO:0071320 cellular response to cAMP
Biological Process GO:0071321 cellular response to cGMP
Biological Process GO:0035690 cellular response to drug
Biological Process GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus
Biological Process GO:0036006 cellular response to macrophage colony-stimulating factor stimulus
Biological Process GO:0071260 cellular response to mechanical stimulus
Biological Process GO:0071560 cellular response to transforming growth factor beta stimulus
Biological Process GO:0046069 cGMP catabolic process
Biological Process GO:0019934 cGMP-mediated signaling
Biological Process GO:0061028 establishment of endothelial barrier
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0003170 heart valve development
Biological Process GO:0030224 monocyte differentiation
Biological Process GO:0043951 negative regulation of cAMP-mediated signaling
Biological Process GO:0010754 negative regulation of cGMP-mediated signaling
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0043116 negative regulation of vascular permeability
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0050729 positive regulation of inflammatory response
Biological Process GO:0043117 positive regulation of vascular permeability
Biological Process GO:0010821 regulation of mitochondrion organization
Biological Process GO:0003281 ventricular septum development
molecular function GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
molecular function GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
molecular function GO:0030552 cAMP binding
molecular function GO:0030553 cGMP binding
molecular function GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
molecular function GO:0008144 drug binding
molecular function GO:0042802 identical protein binding
molecular function GO:0000287 magnesium ion binding
molecular function GO:0042301 phosphate ion binding
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0030911 TPR domain binding
molecular function GO:0008270 zinc ion binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005794 Golgi apparatus
cellular component GO:0005743 mitochondrial inner membrane
cellular component GO:0005759 mitochondrial matrix
cellular component GO:0005741 mitochondrial outer membrane
cellular component GO:0005634 nucleus
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0005886 plasma membrane
cellular component GO:0042734 presynaptic membrane
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-162582 Signal Transduction
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-392154 Nitric oxide stimulates guanylate cyclase
R-HSA-418346 Platelet homeostasis
R-HSA-418457 cGMP effects
R-HSA-418555 G alpha (s) signalling events
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0008489 BXGD000546 Chorea Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0016667 BXGD001072 Fragile X Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0018798 BXGD001223 Congenital Heart Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0025261 BXGD001843 Memory Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0026691 BXGD001917 Mucocutaneous Lymph Node Syndrome Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0033141 BXGD002400 Cardiomyopathies, Primary Cardiovascular Diseases
C0034544 BXGD002484 Radiculitis Nervous System Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036529 BXGD002624 Myocardial Diseases, Secondary Cardiovascular Diseases
C0041234 BXGD002901 Chagas Disease Infections
C0149721 BXGD003349 Left Ventricular Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0206667 BXGD004228 Adrenal Cortical Adenoma Neoplasms; Endocrine System Diseases
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0236848 BXGD004840 Age-related cognitive decline Mental Disorders
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0265886 BXGD005585 Overriding aorta Respiratory Tract Diseases; Cardiovascular Diseases
C0281899 BXGD006788 Prolapsed lumbar disc Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0392885 BXGD008071 High density lipoprotein measurement
C0393593 BXGD008103 Dystonia Disorders Nervous System Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0428472 BXGD008630 Serum HDL cholesterol measurement
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699731 BXGD009859 Hereditary Chorea Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0700594 BXGD009894 Radiculopathy Nervous System Diseases
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C1257931 BXGD011815 Mammary Neoplasms, Human Neoplasms; Skin and Connective Tissue Diseases
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C2936719 BXGD018130 Mechanical Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4704874 BXGD023682 Mammary Carcinoma, Human Neoplasms; Skin and Connective Tissue Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000202 Papaverine 339.39
BXGC0000204 Theophylline 180.16
BXGC0000436 Glycerol 92.09
BXGC0001502 Caffeine 194.19
BXGC0002588 Magnesium 24.31
BXGC0003705 Chloride 35.45
BXGC0036634 Cgmp 345.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein