adisease

Showing entry for Chagas Disease

General Disease Information
BXGD Id	BXGD002901
Disease Name	Chagas Disease
Disease CUI Id	C0041234
MeSH Codes	C01
Disease Class Name	Infections
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id	DOID:0050117
Disease Ontology Class Name	disease by infectious agent
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00182	BXGT003889	Galectin-9	3965	reviewed	Signaling
O00187	BXGT003890	Mannan-binding lectin serine protease 2	10747	reviewed	Enzyme
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O00408	BXGT003916	cGMP-dependent 3',5'-cyclic phosphodiesterase	5138	reviewed
O14788	BXGT004100	Tumor necrosis factor ligand superfamily member 11	8600	reviewed	Signaling
O43524	BXGT004599	Forkhead box protein O3	2309	reviewed
O60603	BXGT004887	Toll-like receptor 2	7097	reviewed
O75923	BXGT005166	Dysferlin	8291	reviewed	Transporter
P00156	BXGT005469	Cytochrome b	4519	reviewed
P00491	BXGT005555	Purine nucleoside phosphorylase	4860	reviewed	Enzyme
P00797	BXGT005658	Renin	5972	reviewed	Enzyme
P00813	BXGT005667	Adenosine deaminase	100	reviewed	Enzyme
P01019	BXGT005717	Angiotensinogen	183	reviewed	Enzyme modulator
P01024	BXGT005719	Complement C3	718	reviewed	Enzyme modulator
P01042	BXGT005722	Kininogen-1	3827	reviewed	Enzyme modulator
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01138	BXGT005738	Beta-nerve growth factor	4803	reviewed	Signaling
P01189	BXGT005742	Pro-opiomelanocortin	5443	reviewed
P01236	BXGT005744	Prolactin	5617	reviewed	Signaling
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P01589	BXGT005773	Interleukin-2 receptor subunit alpha	3559	reviewed	Receptor
P01911	BXGT005816	HLA class II histocompatibility antigen, DRB1-15 beta chain	3123	reviewed	Immune response
P02647	BXGT005908	Apolipoprotein A-I	335	reviewed
P02751	BXGT005943	Fibronectin	2335	reviewed	Signaling
P02768	BXGT005955	Serum albumin	213	reviewed	Transporter
P02775	BXGT005960	Platelet basic protein	5473	reviewed	Signaling
P04179	BXGT006163	Superoxide dismutase [Mn], mitochondrial	6648	reviewed	Enzyme
P04440	BXGT006216	HLA class II histocompatibility antigen, DP beta 1 chain	3115	reviewed	Immune response
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P04839	BXGT006273	Cytochrome b-245 heavy chain	1536	reviewed	Ion channel
P05089	BXGT006310	Arginase-1	383	reviewed	Enzyme
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05787	BXGT006385	Keratin, type II cytoskeletal 8	3856	reviewed
P06276	BXGT006430	Cholinesterase	590	reviewed
P07711	BXGT006661	Cathepsin L1	1514	reviewed	Enzyme
P07858	BXGT006689	Cathepsin B	1508	reviewed	Enzyme
P07996	BXGT006710	Thrombospondin-1	7057	reviewed
P08253	BXGT006757	72 kDa type IV collagenase	4313	reviewed	Enzyme
P08670	BXGT006810	Vimentin	7431	reviewed
P08842	BXGT006830	Steryl-sulfatase	412	reviewed	Enzyme
P08922	BXGT006843	Proto-oncogene tyrosine-protein kinase ROS	6098	reviewed	Kinase
P09466	BXGT006892	Glycodelin	5047	reviewed	Enzyme
P09874	BXGT006934	Poly [ADP-ribose] polymerase 1	142	reviewed
P09917	BXGT006941	Arachidonate 5-lipoxygenase	240	reviewed	Enzyme
P10147	BXGT007543	C-C motif chemokine 3	6348	reviewed	Signaling
P10809	BXGT007617	60 kDa heat shock protein, mitochondrial	3329	reviewed
P11226	BXGT007675	Mannose-binding protein C	4153	reviewed	Receptor
P11413	BXGT007701	Glucose-6-phosphate 1-dehydrogenase	2539	reviewed	Enzyme
P11473	BXGT007709	Vitamin D3 receptor	7421	reviewed	Nuclear receptor
P12004	BXGT007766	Proliferating cell nuclear antigen	5111	reviewed	Nucleic acid binding
P12821	BXGT007849	Angiotensin-converting enzyme	1636	reviewed	Enzyme
P13236	BXGT007891	C-C motif chemokine 4	6351	reviewed
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P14174	BXGT007991	Macrophage migration inhibitory factor	4282	reviewed
P14324	BXGT008005	Farnesyl pyrophosphate synthase	2224	reviewed	Enzyme
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P15104	BXGT008081	Glutamine synthetase	2752	reviewed	Enzyme
P16442	BXGT008227	Histo-blood group ABO system transferase	28	reviewed	Enzyme
P17405	BXGT008304	Sphingomyelin phosphodiesterase	6609	reviewed	Enzyme
P17931	BXGT008356	Galectin-3	3958	reviewed	Signaling
P19623	BXGT008503	Spermidine synthase	6723	reviewed	Enzyme
P20062	BXGT008543	Transcobalamin-2	6948	reviewed
P20813	BXGT008603	Cytochrome P450 2B6	1555	reviewed
P21589	BXGT008669	5'-nucleotidase	4907	reviewed	Enzyme
P22303	BXGT008751	Acetylcholinesterase	43	reviewed	Enzyme
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P27797	BXGT009206	Calreticulin	811	reviewed	Calcium-binding protein
P29460	BXGT009348	Interleukin-12 subunit beta	3593	reviewed	Signaling
P29597	BXGT009367	Non-receptor tyrosine-protein kinase TYK2	7297	reviewed	Kinase
P32241	BXGT009613	Vasoactive intestinal polypeptide receptor 1	7433	reviewed	G-protein coupled receptor
P33681	BXGT009739	T-lymphocyte activation antigen CD80	941	reviewed
P34932	BXGT009772	Heat shock 70 kDa protein 4	3308	reviewed
P35228	BXGT009800	Nitric oxide synthase, inducible	4843	reviewed
P35354	BXGT009816	Prostaglandin G/H synthase 2	5743	reviewed	Enzyme
P35555	BXGT009845	Fibrillin-1	2200	reviewed	Calcium-binding protein
P35557	BXGT009846	Glucokinase	2645	reviewed	Kinase
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	5468	reviewed	Nuclear receptor
P38936	BXGT010074	Cyclin-dependent kinase inhibitor 1	1026	reviewed
P40933	BXGT010209	Interleukin-15	3600	reviewed
P41597	BXGT010268	C-C chemokine receptor type 2	729230	reviewed
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P49789	BXGT010742	Bis(5'-adenosyl)-triphosphatase	2272	reviewed
P49913	BXGT010761	Cathelicidin antimicrobial peptide	820	reviewed
P51681	BXGT010878	C-C chemokine receptor type 5	1234	reviewed	G-protein coupled receptor
P54098	BXGT011030	DNA polymerase subunit gamma-1	5428	reviewed	Enzyme
P55040	BXGT011099	GTP-binding protein GEM	2669	reviewed
P55042	BXGT011100	GTP-binding protein RAD	6236	reviewed
P56817	BXGT011200	Beta-secretase 1	23621	reviewed	Enzyme
P60174	BXGT011294	Triosephosphate isomerase	7167	reviewed	Enzyme
P60568	BXGT011315	Interleukin-2	3558	reviewed
P60709	BXGT011322	Actin, cytoplasmic 1	60	reviewed	Cellular structure
Q02127	BXGT012635	Dihydroorotate dehydrogenase (quinone), mitochondrial	1723	reviewed	Enzyme
Q06609	BXGT012884	DNA repair protein RAD51 homolog 1	5888	reviewed
Q13315	BXGT013339	Serine-protein kinase ATM	472	reviewed	Kinase
Q13936	BXGT013404	Voltage-dependent L-type calcium channel subunit alpha-1C	775	reviewed	Ion channel
Q14116	BXGT013442	Interleukin-18	3606	reviewed
Q14643	BXGT013493	Inositol 1,4,5-trisphosphate receptor type 1	3708	reviewed	Ion channel
Q15485	BXGT013574	Ficolin-2	2220	reviewed	Signaling
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q16698	BXGT013659	2,4-dienoyl-CoA reductase, mitochondrial	1666	reviewed	Enzyme
Q16718	BXGT013661	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	4698	reviewed	Enzyme
Q16850	BXGT013681	Lanosterol 14-alpha demethylase	1595	reviewed	Enzyme
Q8IXJ6	BXGT018362	NAD-dependent protein deacetylase sirtuin-2	22933	reviewed	Epigenetic regulator
Q8NE86	BXGT018552	Calcium uniporter protein, mitochondrial	90550	reviewed	Ion channel
Q96AZ6	BXGT019621	Interferon-stimulated gene 20 kDa protein	3669	reviewed
Q96EB6	BXGT019646	NAD-dependent protein deacetylase sirtuin-1	23411	reviewed	Epigenetic regulator
Q96P20	BXGT019704	NACHT, LRR and PYD domains-containing protein 3	114548	reviewed
Q99572	BXGT019935	P2X purinoceptor 7	5027	reviewed	Ion channel
Q99836	BXGT019970	Myeloid differentiation primary response protein MyD88	4615	reviewed	Enzyme modulator
Q9BWP8	BXGT020153	Collectin-11	78989	reviewed	Surfactant
Q9NR96	BXGT021181	Toll-like receptor 9	54106	reviewed
Q9NZ09	BXGT021267	Ubiquitin-associated protein 1	51271	reviewed
Q9UBB5	BXGT021649	Methyl-CpG-binding domain protein 2	8932	reviewed	Epigenetic regulator
Q9UPN9	BXGT021799	E3 ubiquitin-protein ligase TRIM33	51592	reviewed
Q9Y2R2	BXGT022243	Tyrosine-protein phosphatase non-receptor type 22	26191	reviewed
P04439	BXGT022649	HLA class I histocompatibility antigen, A-3 alpha chain	3105	reviewed
P00738	BXGT022874	Haptoglobin	3240	reviewed	Enzyme
Q16552	BXGT023419	Interleukin-17A	3605	reviewed
P00395	BXGT023596	Cytochrome c oxidase subunit 1	4512	reviewed	Enzyme
P19474	BXGT025520	E3 ubiquitin-protein ligase TRIM21	6737	reviewed
Q96RD7	BXGT025890	Pannexin-1	24145	reviewed	Ion channel
P00403	BXGT026137	Cytochrome c oxidase subunit 2	4513	reviewed	Enzyme

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}