Showing entry for Copper chaperone for superoxide dismutase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004076
Protein NameCopper chaperone for superoxide dismutase
Uniport IdO14618
GeneCCS
Gene Id9973
DomainHMA; Sod_Cu
Pfam PF00403   PF00080  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
6. Human Diseases 6.4 Neurodegenerative diseases hsa05014 Amyotrophic lateral sclerosis (ALS)
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0034599 cellular response to oxidative stress
Biological Process GO:0030001 metal ion transport
Biological Process GO:0051353 positive regulation of oxidoreductase activity
Biological Process GO:0015680 protein maturation by copper ion transfer
Biological Process GO:0019430 removal of superoxide radicals
Biological Process GO:0006801 superoxide metabolic process
molecular function GO:0045296 cadherin binding
molecular function GO:0005507 copper ion binding
molecular function GO:0015035 protein disulfide oxidoreductase activity
molecular function GO:0004784 superoxide dismutase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-2262752 Cellular responses to stress
R-HSA-2262752 Cellular responses to stress
R-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-8953897 Cellular responses to external stimuli
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001510 BXGD000057 Postoperative adhesion Pathological Conditions, Signs and Symptoms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0002962 BXGD000160 Angina Pectoris Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007130 BXGD000440 Mucinous Adenocarcinoma Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011265 BXGD000708 Presenile dementia Nervous System Diseases; Mental Disorders
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019189 BXGD001298 Hepatitis, Chronic Digestive System Diseases
C0019202 BXGD001302 Hepatolenticular Degeneration Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Nervous System Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0027404 BXGD001984 Narcolepsy Nervous System Diseases; Mental Disorders
C0027651 BXGD002009 Neoplasms Neoplasms
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0149519 BXGD003326 Chronic Persistent Hepatitis Digestive System Diseases
C0206062 BXGD004148 Lung Diseases, Interstitial Respiratory Tract Diseases
C0206651 BXGD004215 Clear Cell Sarcoma of Soft Tissue Neoplasms
C0206696 BXGD004247 Carcinoma, Signet Ring Cell Neoplasms
C0268070 BXGD005808 Hypocupremia
C0268237 BXGD005861 Cytochrome-c Oxidase Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0278704 BXGD006567 Malignant Childhood Neoplasm Neoplasms
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0520463 BXGD009085 Chronic active hepatitis Digestive System Diseases
C0524611 BXGD009235 Cryptogenic Chronic Hepatitis Digestive System Diseases
C0525045 BXGD009255 Mood Disorders Mental Disorders
C0549357 BXGD009371 Abdominal adhesions Digestive System Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0741923 BXGD010045 cardiac event
C0742343 BXGD010061 Acute Chest Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C0865800 BXGD011295 asthma with copd
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1136033 BXGD011703 Cutaneous Mastocytosis Neoplasms; Skin and Connective Tissue Diseases
C1261473 BXGD011855 Sarcoma Neoplasms
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1536131 BXGD013337 Heart failure NYHA class II
C1836330 BXGD014109 ERYTHROKERATODERMIA VARIABILIS 3 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C1862939 BXGD016144 AMYOTROPHIC LATERAL SCLEROSIS 1 Nutritional and Metabolic Diseases; Nervous System Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C3275069 BXGD018658 Chronic Total Occlusion Vessel
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3825201 BXGD019684 Mitochondrial pathology
C4551686 BXGD023391 Malignant neoplasm of soft tissue Neoplasms
C4551993 BXGD023469 Amyotrophic Lateral Sclerosis, Familial Nutritional and Metabolic Diseases; Nervous System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002682 Zinc 65.41
BXGC0004269 Propanoic acid 74.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein