Showing entry for Ectonucleotide pyrophosphatase/phosphodiesterase family member 3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004077
Protein NameEctonucleotide pyrophosphatase/phosphodiesterase family member 3
Uniport IdO14638
GeneENPP3
Gene Id5169
DomainEndonuclease_NS; Phosphodiest; Somatomedin_B
Pfam PF01223   PF01663   PF01033  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.4 Nucleotide metabolism hsa00230 Purine metabolism
1. Metabolism 1.4 Nucleotide metabolism hsa00240 Pyrimidine metabolism
1. Metabolism 1.1 Carbohydrate metabolism hsa00500 Starch and sucrose metabolism
1. Metabolism 1.8 Metabolism of cofactors and vitamins hsa00740 Riboflavin metabolism
1. Metabolism 1.8 Metabolism of cofactors and vitamins hsa00760 Nicotinate and nicotinamide metabolism
1. Metabolism 1.8 Metabolism of cofactors and vitamins hsa00770 Pantothenate and CoA biosynthesis
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0046034 ATP metabolic process
Biological Process GO:0002276 basophil activation involved in immune response
Biological Process GO:0050728 negative regulation of inflammatory response
Biological Process GO:0033007 negative regulation of mast cell activation involved in immune response
Biological Process GO:0070667 negative regulation of mast cell proliferation
Biological Process GO:0009143 nucleoside triphosphate catabolic process
Biological Process GO:0006796 phosphate-containing compound metabolic process
Biological Process GO:0006220 pyrimidine nucleotide metabolic process
molecular function GO:0005509 calcium ion binding
molecular function GO:0036218 dTTP diphosphatase activity
molecular function GO:0035529 NADH pyrophosphatase activity
molecular function GO:0003676 nucleic acid binding
molecular function GO:0047429 nucleoside-triphosphate diphosphatase activity
molecular function GO:0004528 phosphodiesterase I activity
molecular function GO:0008270 zinc ion binding
cellular component GO:0016324 apical plasma membrane
cellular component GO:0009897 external side of plasma membrane
cellular component GO:0070062 extracellular exosome
cellular component GO:0016021 integral component of membrane
cellular component GO:0048471 perinuclear region of cytoplasm
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors
R-HSA-196854 Metabolism of vitamins and cofactors
R-HSA-199220 Vitamin B5 (pantothenate) metabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0005395 BXGD000309 Bile Duct Diseases Digestive System Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007124 BXGD000437 Noninfiltrating Intraductal Carcinoma Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0008497 BXGD000549 Choriocarcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0012546 BXGD000776 Diphtheria Infections
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0018621 BXGD001210 Hay fever Respiratory Tract Diseases; Immune System Diseases; Otorhinolaryngologic Diseases
C0023461 BXGD001653 Leukemia, Mast-Cell Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024899 BXGD001812 Mastocytosis Neoplasms; Skin and Connective Tissue Diseases; Immune System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0202178 BXGD004080 Phosphorus measurement
C0206686 BXGD004241 Adrenocortical carcinoma Neoplasms; Endocrine System Diseases
C0221013 BXGD004363 Mastocytosis, Systemic Neoplasms; Immune System Diseases
C0269102 BXGD006053 Endometrioma Female Urogenital Diseases and Pregnancy Complications
C0278678 BXGD006556 Metastatic Renal Cell Cancer
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0342649 BXGD007522 Vascular calcification Nutritional and Metabolic Diseases
C0410702 BXGD008447 Adolescent idiopathic scoliosis Musculoskeletal Diseases
C0523827 BXGD009220 Inorganic phosphate measurement
C0578870 BXGD009553 Chronic idiopathic urticaria Skin and Connective Tissue Diseases; Immune System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0740277 BXGD009972 Bile duct carcinoma Digestive System Diseases; Neoplasms
C0949570 BXGD011579 Wheat Hypersensitivity Immune System Diseases
C1266044 BXGD011940 Collecting Duct Carcinoma of the Kidney Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1739388 BXGD013737 Birch pollen allergy
C1837461 BXGD014234 SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
C1862103 BXGD016103 Brachydactyly type C Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C2607914 BXGD017148 Allergic rhinitis (disorder) Respiratory Tract Diseases; Immune System Diseases; Otorhinolaryngologic Diseases
C3662483 BXGD019270 Allergic sensitization
C3853540 BXGD019820 Aspirin exacerbated respiratory disease Pathological Conditions, Signs and Symptoms; Infections; Respiratory Tract Diseases; Immune System Diseases; Chemically-Induced Disorders; Otorhinolaryngologic Diseases
C4524092 BXGD023092 Chronic rhinosinusitis with nasal polyps
C4721698 BXGD023763 Metastatic Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0003705 Chloride 35.45
BXGC0003993 Uridine diphosphate 404.16
BXGC0018397 beta-1,4-mannan 180.06
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein