Showing entry for Vascular calcification


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD007522
Disease NameVascular calcification
Disease CUI IdC0342649
MeSH Codes C18  
Disease Class NameNutritional and Metabolic Diseases
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id HP:0000924   HP:0001626  
Human Phenotype Ontology TermAbnormality of the skeletal system; Abnormality of the cardiovascular system
Disease Ontology Id   
Disease Ontology Class Name
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O00141 BXGT003882 Serine/threonine-protein kinase Sgk1 6446 reviewed Kinase
O00206 BXGT003894 Toll-like receptor 4 7099 reviewed
O14638 BXGT004077 Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 5169 reviewed Enzyme
O14684 BXGT004082 Prostaglandin E synthase 9536 reviewed
O14788 BXGT004100 Tumor necrosis factor ligand superfamily member 11 8600 reviewed Signaling
O14920 BXGT004110 Inhibitor of nuclear factor kappa-B kinase subunit beta 3551 reviewed Kinase
O14939 BXGT004115 Phospholipase D2 5338 reviewed
O43293 BXGT004584 Death-associated protein kinase 3 1613 reviewed Kinase
O60260 BXGT004864 E3 ubiquitin-protein ligase parkin 5071 reviewed Enzyme
O60563 BXGT004883 Cyclin-T1 904 reviewed Enzyme modulator
O60603 BXGT004887 Toll-like receptor 2 7097 reviewed
O95255 BXGT005363 Multidrug resistance-associated protein 6 368 reviewed Transporter
P00734 BXGT005630 Prothrombin 2147 reviewed Enzyme
P00797 BXGT005658 Renin 5972 reviewed Enzyme
P01019 BXGT005717 Angiotensinogen 183 reviewed Enzyme modulator
P01130 BXGT005735 Low-density lipoprotein receptor 3949 reviewed
P01270 BXGT005746 Parathyroid hormone 5741 reviewed
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P02649 BXGT005909 Apolipoprotein E 348 reviewed
P02741 BXGT005936 C-reactive protein 1401 reviewed
P02765 BXGT005952 Alpha-2-HS-glycoprotein 197 reviewed Enzyme modulator
P02768 BXGT005955 Serum albumin 213 reviewed Transporter
P02818 BXGT005969 Osteocalcin 632 reviewed
P04062 BXGT006140 Lysosomal acid glucosylceramidase 2629 reviewed
P04271 BXGT006177 Protein S100-B 6285 reviewed Calcium-binding protein
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P05121 BXGT006320 Plasminogen activator inhibitor 1 5054 reviewed Enzyme modulator
P05186 BXGT006338 Alkaline phosphatase, tissue-nonspecific isozyme 249 reviewed Enzyme
P05187 BXGT006339 Alkaline phosphatase, placental type 250 reviewed Enzyme
P05231 BXGT006345 Interleukin-6 3569 reviewed
P06280 BXGT006433 Alpha-galactosidase A 2717 reviewed
P07204 BXGT006567 Thrombomodulin 7056 reviewed
P07384 BXGT006619 Calpain-1 catalytic subunit 823 reviewed Enzyme
P08069 BXGT006723 Insulin-like growth factor 1 receptor 3480 reviewed Kinase
P08133 BXGT006727 Annexin A6 309 reviewed
P08253 BXGT006757 72 kDa type IV collagenase 4313 reviewed Enzyme
P08254 BXGT006758 Stromelysin-1 4314 reviewed Enzyme
P08842 BXGT006830 Steryl-sulfatase 412 reviewed Enzyme
P09038 BXGT006851 Fibroblast growth factor 2 2247 reviewed Signaling
P09238 BXGT006875 Stromelysin-2 4319 reviewed Enzyme
P09429 BXGT006889 High mobility group protein B1 3146 reviewed Nucleic acid binding
P09874 BXGT006934 Poly [ADP-ribose] polymerase 1 142 reviewed
P0DMV8 BXGT007509 Heat shock 70 kDa protein 1A 3304 reviewed
P0DMV9 BXGT007510 Heat shock 70 kDa protein 1B 3304 reviewed
P10144 BXGT007541 Granzyme B 3002 reviewed Enzyme
P10145 BXGT007542 Interleukin-8 3576 reviewed Signaling
P10275 BXGT007552 Androgen receptor 367 reviewed Nuclear receptor
P11166 BXGT007661 Solute carrier family 2, facilitated glucose transporter member 1 6513 reviewed Transporter
P11362 BXGT007693 Fibroblast growth factor receptor 1 2260 reviewed Kinase
P11473 BXGT007709 Vitamin D3 receptor 7421 reviewed Nuclear receptor
P12004 BXGT007766 Proliferating cell nuclear antigen 5111 reviewed Nucleic acid binding
P12643 BXGT007830 Bone morphogenetic protein 2 650 reviewed Signaling
P14210 BXGT007994 Hepatocyte growth factor 3082 reviewed Enzyme
P15144 BXGT008087 Aminopeptidase N 290 reviewed Enzyme
P17252 BXGT008294 Protein kinase C alpha type 5578 reviewed Kinase
P17301 BXGT008299 Integrin alpha-2 3673 reviewed
P17931 BXGT008356 Galectin-3 3958 reviewed Signaling
P18075 BXGT008375 Bone morphogenetic protein 7 655 reviewed Signaling
P18848 BXGT008432 Cyclic AMP-dependent transcription factor ATF-4 468 reviewed
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 1131 reviewed G-protein coupled receptor
P21580 BXGT008666 Tumor necrosis factor alpha-induced protein 3 7128 reviewed Enzyme
P21589 BXGT008669 5'-nucleotidase 4907 reviewed Enzyme
P22413 BXGT008764 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 5167 reviewed Enzyme
P23219 BXGT008837 Prostaglandin G/H synthase 1 5742 reviewed Enzyme
P23297 BXGT008848 Protein S100-A1 6271 reviewed Calcium-binding protein
P24530 BXGT008975 Endothelin receptor type B 1910 reviewed G-protein coupled receptor
P25101 BXGT009018 Endothelin-1 receptor 1909 reviewed G-protein coupled receptor
P27037 BXGT009153 Activin receptor type-2A 92 reviewed Kinase
P27487 BXGT009187 Dipeptidyl peptidase 4 1803 reviewed Enzyme
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase 328 reviewed
P28300 BXGT009243 Protein-lysine 6-oxidase 4015 reviewed
P28347 BXGT009257 Transcriptional enhancer factor TEF-1 7003 reviewed Transcription factor
P28482 BXGT009263 Mitogen-activated protein kinase 1 5594 reviewed Kinase
P29474 BXGT009352 Nitric oxide synthase, endothelial 4846 reviewed
P30536 BXGT009435 Translocator protein 706 reviewed
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase 207 reviewed Kinase
P34896 BXGT009767 Serine hydroxymethyltransferase, cytosolic 6470 reviewed Enzyme
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P35354 BXGT009816 Prostaglandin G/H synthase 2 5743 reviewed Enzyme
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma 5468 reviewed Nuclear receptor
P38435 BXGT010040 Vitamin K-dependent gamma-carboxylase 2677 reviewed
P41180 BXGT010230 Extracellular calcium-sensing receptor 846 reviewed G-protein coupled receptor
P42345 BXGT010304 Serine/threonine-protein kinase mTOR 2475 reviewed Kinase
P46108 BXGT010509 Adapter molecule crk 1398 reviewed
P46531 BXGT010526 Neurogenic locus notch homolog protein 1 4851 reviewed
P46934 BXGT010553 E3 ubiquitin-protein ligase NEDD4 4734 reviewed Enzyme
P49747 BXGT010732 Cartilage oligomeric matrix protein 1311 reviewed
P49840 BXGT010749 Glycogen synthase kinase-3 alpha 2931 reviewed Kinase
P49841 BXGT010750 Glycogen synthase kinase-3 beta 2932 reviewed Kinase
P50052 BXGT010768 Type-2 angiotensin II receptor 186 reviewed G-protein coupled receptor
P50591 BXGT010814 Tumor necrosis factor ligand superfamily member 10 8743 reviewed Signaling
P50750 BXGT010818 Cyclin-dependent kinase 9 1025 reviewed Kinase
P51532 BXGT010852 Transcription activator BRG1 6597 reviewed Epigenetic regulator
P53355 BXGT010985 Death-associated protein kinase 1 1612 reviewed Kinase
P54646 BXGT011062 5'-AMP-activated protein kinase catalytic subunit alpha-2 5563 reviewed Kinase
P56524 BXGT011176 Histone deacetylase 4 9759 reviewed Epigenetic regulator
P60709 BXGT011322 Actin, cytoplasmic 1 60 reviewed Cellular structure
P60953 BXGT011342 Cell division control protein 42 homolog 998 reviewed Enzyme modulator
P78536 BXGT011847 Disintegrin and metalloproteinase domain-containing protein 17 6868 reviewed
P80511 BXGT011914 Protein S100-A12 6283 reviewed Calcium-binding protein
Q00987 BXGT012559 E3 ubiquitin-protein ligase Mdm2 4193 reviewed Nucleic acid binding
Q06187 BXGT012860 Tyrosine-protein kinase BTK 695 reviewed Kinase
Q07011 BXGT012912 Tumor necrosis factor receptor superfamily member 9 3604 reviewed
Q08345 BXGT012982 Epithelial discoidin domain-containing receptor 1 780 reviewed Kinase
Q13131 BXGT013314 5'-AMP-activated protein kinase catalytic subunit alpha-1 5562 reviewed Kinase
Q13155 BXGT013320 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 7965 reviewed
Q13393 BXGT013346 Phospholipase D1 5337 reviewed
Q13547 BXGT013373 Histone deacetylase 1 3065 reviewed Epigenetic regulator
Q13873 BXGT013398 Bone morphogenetic protein receptor type-2 659 reviewed Kinase
Q14116 BXGT013442 Interleukin-18 3606 reviewed
Q14289 BXGT013459 Protein-tyrosine kinase 2-beta 2185 reviewed Kinase
Q14393 BXGT013466 Growth arrest-specific protein 6 2621 reviewed Extracellular structure
Q14457 BXGT013472 Beclin-1 8678 reviewed Enzyme modulator
Q15109 BXGT013537 Advanced glycosylation end product-specific receptor 177 reviewed Receptor
Q15848 BXGT013609 Adiponectin 9370 reviewed
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 4780 reviewed Enzyme
Q16539 BXGT013634 Mitogen-activated protein kinase 14 1432 reviewed Kinase
Q16654 BXGT013650 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 5166 reviewed Kinase
Q6IB77 BXGT016325 Glycine N-acyltransferase 10249 reviewed
Q7L266 BXGT016993 Isoaspartyl peptidase/L-asparaginase 80150 reviewed Enzyme
Q86Z14 BXGT017639 Beta-klotho 152831 reviewed Enzyme
Q8WTS6 BXGT018986 Histone-lysine N-methyltransferase SETD7 80854 reviewed Epigenetic regulator
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 23411 reviewed Epigenetic regulator
Q99523 BXGT019929 Sortilin 6272 reviewed Transporter
Q9BPX6 BXGT020104 Calcium uptake protein 1, mitochondrial 10367 reviewed Calcium-binding protein
Q9BQB6 BXGT020108 Vitamin K epoxide reductase complex subunit 1 79001 reviewed Enzyme
Q9BQE4 BXGT020110 Selenoprotein S 55829 reviewed
Q9H0A0 BXGT020434 RNA cytidine acetyltransferase 55226 reviewed
Q9HCE5 BXGT020531 N6-adenosine-methyltransferase non-catalytic subunit 57721 reviewed Transcription factor
Q9NP58 BXGT021143 ATP-binding cassette sub-family B member 6, mitochondrial 10058 reviewed Transporter
Q9NR12 BXGT021174 PDZ and LIM domain protein 7 9260 reviewed Cellular structure
Q9UKV0 BXGT021750 Histone deacetylase 9 9734 reviewed Epigenetic regulator
Q9ULV1 BXGT021764 Frizzled-4 8322 reviewed G-protein coupled receptor
Q9Y251 BXGT022215 Heparanase 10855 reviewed Enzyme
Q9Y478 BXGT022271 5'-AMP-activated protein kinase subunit beta-1 5564 reviewed Kinase
Q01995 BXGT022678 Transgelin 6876 reviewed Cellular structure
P16284 BXGT022972 Platelet endothelial cell adhesion molecule 5175 reviewed Cell adhesion
O14793 BXGT023280 Growth/differentiation factor 8 2660 reviewed Signaling
P00395 BXGT023596 Cytochrome c oxidase subunit 1 4512 reviewed Enzyme
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease