Showing entry for Chloride intracellular channel protein 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004142
Protein NameChloride intracellular channel protein 2
Uniport IdO15247
GeneCLIC2
Gene Id1193
DomainGST_N_2
Pfam PF13409  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity
Biological Process GO:0051099 positive regulation of binding
Biological Process GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
Biological Process GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
Biological Process GO:0007165 signal transduction
molecular function GO:0005254 chloride channel activity
molecular function GO:0004602 glutathione peroxidase activity
molecular function GO:0005244 voltage-gated ion channel activity
cellular component GO:0034707 chloride channel complex
cellular component GO:0005737 cytoplasm
cellular component GO:0005622 intracellular
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-2672351 Stimuli-sensing channels
R-HSA-382551 Transport of small molecules
R-HSA-397014 Muscle contraction
R-HSA-5576891 Cardiac conduction
R-HSA-5578775 Ion homeostasis
R-HSA-983712 Ion channel transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003507 BXGD000203 Aortic Valve Stenosis Cardiovascular Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004239 BXGD000263 Atrial Flutter Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0008073 BXGD000518 Developmental Disabilities Mental Disorders
C0018800 BXGD001225 Cardiomegaly Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0026266 BXGD001895 Mitral Valve Insufficiency Cardiovascular Diseases
C0026267 BXGD001896 Mitral Valve Prolapse Syndrome Cardiovascular Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0040961 BXGD002891 Tricuspid Valve Insufficiency Cardiovascular Diseases
C0152421 BXGD003586 Macrotia
C0205969 BXGD004143 Thymic Carcinoma Neoplasms; Hemic and Lymphatic Diseases
C0240543 BXGD005042 Bulbous nose
C0241442 BXGD005099 Protrusion of tongue
C0345392 BXGD007732 Congenital kyphoscoliosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0399526 BXGD008251 Class III malocclusion Stomatognathic Diseases
C0426970 BXGD008598 Spastic Quadriplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0427149 BXGD008608 Gait, Drop Foot Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0557874 BXGD009444 Global developmental delay
C0575158 BXGD009515 Kyphoscoliosis deformity of spine Musculoskeletal Diseases
C0600033 BXGD009682 Acquired Kyphoscoliosis Musculoskeletal Diseases
C1142533 BXGD011758 Smooth philtrum
C1263023 BXGD011888 Macroorchidism
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C1720983 BXGD013698 Channelopathies Pathological Conditions, Signs and Symptoms
C1836542 BXGD014129 Depressed nasal bridge
C1837731 BXGD014260 Overfolded helix
C1845847 BXGD014760 Coarse facial features Pathological Conditions, Signs and Symptoms
C1845977 BXGD014769 X- linked recessive
C1848207 BXGD014916 Poor speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1853246 BXGD015323 Eversion of lower lip
C1854113 BXGD015382 Prominent nasal bridge
C1854882 BXGD015439 Absent speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1859698 BXGD015923 Contractures of the large joints
C3161330 BXGD018511 Profound intellectual disabilities Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3550913 BXGD019142 MENTAL RETARDATION, X-LINKED, SYNDROMIC 32
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000989 Glutathione 307.32
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein