Showing entry for Desert hedgehog protein


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004587
Protein NameDesert hedgehog protein
Uniport IdO43323
GeneDHH
Gene Id50846
DomainHH_signal; Hint
Pfam PF01085   PF01079  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04340 Hedgehog signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007267 cell-cell signaling
Biological Process GO:0001708 cell fate specification
Biological Process GO:0033327 Leydig cell differentiation
Biological Process GO:0030238 male sex determination
Biological Process GO:0042552 myelination
Biological Process GO:0001649 osteoblast differentiation
Biological Process GO:0016540 protein autoprocessing
Biological Process GO:0010468 regulation of gene expression
Biological Process GO:0050810 regulation of steroid biosynthetic process
Biological Process GO:0032355 response to estradiol
Biological Process GO:0043627 response to estrogen
Biological Process GO:0007224 smoothened signaling pathway
Biological Process GO:0007286 spermatid development
molecular function GO:0005509 calcium ion binding
molecular function GO:0005113 patched binding
molecular function GO:0008233 peptidase activity
molecular function GO:0008270 zinc ion binding
cellular component GO:0005615 extracellular space
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-372790 Signaling by GPCR
R-HSA-373080 Class B/2 (Secretin family receptors)
R-HSA-500792 GPCR ligand binding
R-HSA-5358346 Hedgehog ligand biogenesis
R-HSA-5358346 Hedgehog ligand biogenesis
R-HSA-5358351 Signaling by Hedgehog
R-HSA-5358351 Signaling by Hedgehog
R-HSA-5362798 Release of Hh-Np from the secreting cell
R-HSA-5362798 Release of Hh-Np from the secreting cell
R-HSA-5387390 Hh mutants abrogate ligand secretion
R-HSA-5632681 Ligand-receptor interactions
R-HSA-5632681 Ligand-receptor interactions
R-HSA-5632684 Hedgehog 'on' state
R-HSA-5632684 Hedgehog 'on' state
R-HSA-5635838 Activation of SMO
R-HSA-5658034 HHAT G278V abrogates palmitoylation of Hh-Np
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0018051 BXGD001167 Gonadal Dysgenesis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0018054 BXGD001168 Gonadal Dysgenesis, 46,XY Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0021359 BXGD001498 Infertility Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0031117 BXGD002285 Peripheral Neuropathy Nervous System Diseases
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0039273 BXGD002806 Talipes cavus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0151721 BXGD003465 Testicular hypogonadism Endocrine System Diseases
C0152025 BXGD003521 Polyneuropathy Nervous System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206661 BXGD004224 Gonadoblastoma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0232939 BXGD004568 Primary physiologic amenorrhea Pathological Conditions, Signs and Symptoms
C0238395 BXGD004922 Male Pseudohermaphroditism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0241011 BXGD005073 Low serum estradiol levels
C0266371 BXGD005659 Streak ovary
C0266399 BXGD005663 Infantile uterus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0271623 BXGD006222 Hypogonadotropic hypogonadism Endocrine System Diseases
C0302885 BXGD006863 Testicular dysgenesis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0427065 BXGD008604 Distal muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0427149 BXGD008608 Gait, Drop Foot Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0442874 BXGD008814 Neuropathy Nervous System Diseases
C0452148 BXGD008833 Hypospadias, perineal Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0541794 BXGD009262 Skeletal muscle atrophy
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0687149 BXGD009841 Pure gonadal dysgenesis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0948896 BXGD011563 Primary hypogonadism Endocrine System Diseases
C1112256 BXGD011655 Sensorimotor neuropathy
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1305855 BXGD012348 Body mass index
C1836527 BXGD014127 Distal sensory impairment of all modalities
C1843859 BXGD014614 Sensory ataxic neuropathy
C1856023 BXGD015565 Abnormal vagina morphology
C1856273 BXGD015590 46,XY Gonadal Dysgenesis, Complete or Partial, DHH-Related Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C1858285 BXGD015781 Decreased number of peripheral myelinated nerve fibers
C1862265 BXGD016119 Increased circulating gonadotropin level Nervous System Diseases; Endocrine System Diseases
C1866934 BXGD016427 Reduced tendon reflexes Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1968706 BXGD016729 Hypoplasia of the fallopian tube
C2751325 BXGD017713 46,Xy Gonadal Dysgenesis, Partial, With Minifascicular Neuropathy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Nervous System Diseases; Endocrine System Diseases
C2936694 BXGD018127 Swyer Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C4020690 BXGD020468 Abnormality of peripheral nerve conduction
C4021822 BXGD020807 Abnormality of female external genitalia
C4022995 BXGD021056 Sex reversal
C4024222 BXGD021310 Abnormality of the epididymis
C4024632 BXGD021353 Gonadal dysgenesis with female appearance, male Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C4025648 BXGD021709 Abnormal peripheral myelination
C4073137 BXGD022045 Decreased serum testosterone level
C4551492 BXGD023317 Micropenis
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0002588 Magnesium 24.31
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein