protein

Showing entry for Leucine-rich repeat-containing G-protein coupled receptor 5

General Target Information
BXGT Id	BXGT005129
Protein Name	Leucine-rich repeat-containing G-protein coupled receptor 5
Uniport Id	O75473
Gene	LGR5
Gene Id	8549
Domain	LRRNT; LRR_8
Pfam	PF00560 PF13855 PF01462
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
3. Environmental Information Processing	3.2 Signal transduction	hsa04310	Wnt signaling pathway

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0007190	activation of adenylate cyclase activity
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Process	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway
Biological Process	GO:0001942	hair follicle development
Biological Process	GO:0009755	hormone-mediated signaling pathway
Biological Process	GO:0048839	inner ear development
Biological Process	GO:0009994	oocyte differentiation
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway
Biological Process	GO:0042127	regulation of cell population proliferation
molecular function	GO:0008528	G protein-coupled peptide receptor activity
molecular function	GO:0004930	G protein-coupled receptor activity
molecular function	GO:0016500	protein-hormone receptor activity
molecular function	GO:0004888	transmembrane signaling receptor activity
cellular component	GO:0005887	integral component of plasma membrane
cellular component	GO:0005886	plasma membrane
cellular component	GO:0032588	trans-Golgi network membrane

Reactome

Pathway Id	Pathway Name
R-HSA-162582	Signal Transduction
R-HSA-195721	Signaling by WNT
R-HSA-201681	TCF dependent signaling in response to WNT
R-HSA-4641263	Regulation of FZD by ubiquitination

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0001418	BXGD000050	Adenocarcinoma	Neoplasms
C0001430	BXGD000054	Adenoma	Neoplasms
C0001614	BXGD000062	Adrenal Cortex Diseases	Endocrine System Diseases
C0002395	BXGD000111	Alzheimer's Disease	Nervous System Diseases; Mental Disorders
C0002736	BXGD000127	Amyotrophic Lateral Sclerosis	Nutritional and Metabolic Diseases; Nervous System Diseases
C0002793	BXGD000130	Anaplasia	Pathological Conditions, Signs and Symptoms; Neoplasms
C0004238	BXGD000262	Atrial Fibrillation	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004763	BXGD000289	Barrett Esophagus	Digestive System Diseases; Neoplasms
C0006118	BXGD000372	Brain Neoplasms	Neoplasms; Nervous System Diseases
C0006142	BXGD000374	Malignant neoplasm of breast	Neoplasms; Skin and Connective Tissue Diseases
C0006826	BXGD000408	Malignant Neoplasms	Neoplasms
C0007097	BXGD000424	Carcinoma	Neoplasms
C0007102	BXGD000425	Malignant tumor of colon	Digestive System Diseases; Neoplasms
C0007113	BXGD000430	Rectal Carcinoma	Digestive System Diseases; Neoplasms
C0007117	BXGD000433	Basal cell carcinoma	Neoplasms
C0007131	BXGD000441	Non-Small Cell Lung Carcinoma	Neoplasms; Respiratory Tract Diseases
C0007137	BXGD000445	Squamous cell carcinoma	Neoplasms
C0007847	BXGD000492	Malignant tumor of cervix	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0009375	BXGD000602	Colonic Neoplasms	Digestive System Diseases; Neoplasms
C0009402	BXGD000605	Colorectal Carcinoma	Digestive System Diseases; Neoplasms
C0009404	BXGD000606	Colorectal Neoplasms	Digestive System Diseases; Neoplasms
C0011847	BXGD000749	Diabetes	Endocrine System Diseases
C0011849	BXGD000751	Diabetes Mellitus	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860	BXGD000755	Diabetes Mellitus, Non-Insulin-Dependent	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0012546	BXGD000776	Diphtheria	Infections
C0014175	BXGD000904	Endometriosis	Female Urogenital Diseases and Pregnancy Complications
C0017152	BXGD001096	Gastritis	Digestive System Diseases
C0017185	BXGD001104	Gastrointestinal Neoplasms	Digestive System Diseases; Neoplasms
C0017636	BXGD001131	Glioblastoma	Neoplasms
C0017638	BXGD001132	Glioma	Neoplasms
C0018552	BXGD001202	Hamartoma	Neoplasms
C0019163	BXGD001295	Hepatitis B	Digestive System Diseases; Infections
C0021051	BXGD001475	Immunologic Deficiency Syndromes	Immune System Diseases
C0021841	BXGD001519	Intestinal Neoplasms	Digestive System Diseases; Neoplasms
C0023895	BXGD001717	Liver diseases	Digestive System Diseases
C0023903	BXGD001720	Liver neoplasms	Digestive System Diseases; Neoplasms
C0024623	BXGD001791	Malignant neoplasm of stomach	Digestive System Diseases; Neoplasms
C0025286	BXGD001850	Meningioma	Neoplasms; Nervous System Diseases
C0027627	BXGD002006	Neoplasm Metastasis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651	BXGD002009	Neoplasms	Neoplasms
C0027819	BXGD002043	Neuroblastoma	Neoplasms
C0028754	BXGD002082	Obesity	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029408	BXGD002137	Degenerative polyarthritis	Musculoskeletal Diseases
C0030567	BXGD002240	Parkinson Disease	Nervous System Diseases
C0032000	BXGD002318	Pituitary Adenoma	Neoplasms; Nervous System Diseases; Endocrine System Diseases
C0032580	BXGD002362	Adenomatous Polyposis Coli	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms
C0032584	BXGD002363	polyps	Pathological Conditions, Signs and Symptoms
C0033036	BXGD002389	Atrial Premature Complexes	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0036690	BXGD002632	Septicemia	Pathological Conditions, Signs and Symptoms; Infections
C0037286	BXGD002681	Skin Neoplasms	Neoplasms; Skin and Connective Tissue Diseases
C0038362	BXGD002749	Stomatitis	Stomatognathic Diseases
C0079588	BXGD003084	Ichthyosis, X-Linked	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0085110	BXGD003126	Severe Combined Immunodeficiency	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0152415	BXGD003583	Ankyloglossia	Stomatognathic Diseases
C0153633	BXGD003674	Malignant neoplasm of brain	Neoplasms; Nervous System Diseases
C0178874	BXGD004037	Tumor Progression	Pathological Conditions, Signs and Symptoms
C0205824	BXGD004128	Liposarcoma, Dedifferentiated	Neoplasms
C0206669	BXGD004229	Hepatocellular Adenoma	Digestive System Diseases; Neoplasms
C0206754	BXGD004289	Neuroendocrine Tumors	Neoplasms
C0220630	BXGD004302	Adult Liver Carcinoma	Digestive System Diseases; Neoplasms
C0236053	BXGD004808	Mucosal ulcer	Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0238339	BXGD004914	Hereditary pancreatitis	Digestive System Diseases
C0238463	BXGD004938	Papillary thyroid carcinoma	Neoplasms; Endocrine System Diseases
C0243026	BXGD005210	Sepsis	Pathological Conditions, Signs and Symptoms; Infections
C0267187	BXGD005736	Intestinal metaplasia of gastric mucosa	Digestive System Diseases; Neoplasms
C0278601	BXGD006547	Inflammatory Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases
C0278701	BXGD006566	Gastric Adenocarcinoma	Digestive System Diseases; Neoplasms
C0278877	BXGD006608	Adult Meningioma	Neoplasms; Nervous System Diseases
C0278878	BXGD006609	Adult Glioblastoma	Neoplasms
C0279000	BXGD006622	Liver and Intrahepatic Biliary Tract Carcinoma	Digestive System Diseases; Neoplasms
C0279626	BXGD006657	Squamous cell carcinoma of esophagus	Digestive System Diseases; Neoplasms
C0280474	BXGD006748	Childhood Glioblastoma	Neoplasms
C0302592	BXGD006851	Cervix carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0333983	BXGD006975	Hyperplastic Polyp	Pathological Conditions, Signs and Symptoms
C0334037	BXGD006980	Intestinal metaplasia
C0338106	BXGD007167	Adenocarcinoma of colon	Digestive System Diseases; Neoplasms
C0345904	BXGD007745	Malignant neoplasm of liver	Digestive System Diseases; Neoplasms
C0346627	BXGD007830	Intestinal Cancer	Digestive System Diseases; Neoplasms
C0349658	BXGD007947	Trichoepithelioma	Neoplasms
C0374997	BXGD007967	Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
C0520459	BXGD009084	Necrotizing Enterocolitis	Digestive System Diseases
C0553723	BXGD009416	Squamous cell carcinoma of skin	Neoplasms; Skin and Connective Tissue Diseases
C0555198	BXGD009432	Malignant Glioma	Neoplasms
C0595905	BXGD009625	cortex bone disorders	Musculoskeletal Diseases
C0596263	BXGD009639	Carcinogenesis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0598935	BXGD009674	Tumor Initiation	Pathological Conditions, Signs and Symptoms; Neoplasms
C0677886	BXGD009734	Epithelial ovarian cancer	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0678222	BXGD009749	Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases
C0685938	BXGD009829	Malignant neoplasm of gastrointestinal tract	Digestive System Diseases; Neoplasms
C0686619	BXGD009835	Secondary malignant neoplasm of lymph node	Pathological Conditions, Signs and Symptoms; Neoplasms
C0699753	BXGD009864	Cancer Relapse
C0699790	BXGD009866	Colon Carcinoma	Digestive System Diseases; Neoplasms
C0699791	BXGD009867	Stomach Carcinoma	Digestive System Diseases; Neoplasms
C0700095	BXGD009875	Central neuroblastoma	Neoplasms; Nervous System Diseases
C0730328	BXGD009959	Central Serous Chorioretinopathy	Eye Diseases
C0853879	BXGD010982	Invasive carcinoma of breast	Neoplasms; Skin and Connective Tissue Diseases
C0919267	BXGD011426	ovarian neoplasm	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0940937	BXGD011490	precancerous lesions
C1112474	BXGD011672	Small cell carcinoma of esophagus
C1140680	BXGD011718	Malignant neoplasm of ovary	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1142339	BXGD011750	Intestinal adenoma
C1261473	BXGD011855	Sarcoma	Neoplasms
C1269955	BXGD012005	Tumor Cell Invasion
C1270972	BXGD012006	Mild cognitive disorder	Mental Disorders
C1302401	BXGD012303	Adenoma of large intestine	Digestive System Diseases; Neoplasms
C1306459	BXGD012361	Primary malignant neoplasm	Neoplasms
C1318485	BXGD012394	Liver regeneration disorder	Digestive System Diseases
C1319315	BXGD012415	Adenocarcinoma of large intestine	Digestive System Diseases; Neoplasms
C1334274	BXGD012695	Invasive Carcinoma	Neoplasms
C1335302	BXGD012775	Pancreatic Ductal Adenocarcinoma	Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1519346	BXGD013235	Skin Carcinogenesis	Pathological Conditions, Signs and Symptoms; Neoplasms
C1519670	BXGD013241	Tumor Angiogenesis	Pathological Conditions, Signs and Symptoms
C1568868	BXGD013423	Oral Mucositis	Stomatognathic Diseases
C1621958	BXGD013468	Glioblastoma Multiforme	Neoplasms
C1762616	BXGD013753	Meningioma, benign, no ICD-O subtype	Neoplasms; Nervous System Diseases
C1832661	BXGD013866	ANOPHTHALMIA AND PULMONARY HYPOPLASIA	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C2239176	BXGD016965	Liver carcinoma	Digestive System Diseases; Neoplasms
C2717836	BXGD017510	Steroid Sulfatase Deficiency Disease	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C2939419	BXGD018178	Secondary Neoplasm	Pathological Conditions, Signs and Symptoms; Neoplasms
C3539878	BXGD019087	Triple Negative Breast Neoplasms	Neoplasms; Skin and Connective Tissue Diseases
C3811653	BXGD019662	Experimental Organism Basal Cell Carcinoma	Neoplasms
C4048328	BXGD021903	cervical cancer	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4049272	BXGD021918	Tumour budding
C4082937	BXGD022095	Necrotizing enterocolitis in fetus OR newborn	Digestive System Diseases
C4086165	BXGD022126	Childhood Neuroblastoma	Neoplasms
C4551686	BXGD023391	Malignant neoplasm of soft tissue	Neoplasms
C4551687	BXGD023392	Sarcoma of soft tissue	Neoplasms
C4721610	BXGD023760	Carcinoma, Ovarian Epithelial	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4721806	BXGD023772	Carcinoma, Basal Cell	Neoplasms
C4722085	BXGD023788	Malignant neoplasm of colon and/or rectum
C4722518	BXGD023806	Triple-Negative Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0003705	Chloride		35.45
BXGC0018397	beta-1,4-mannan		180.06

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}