Showing entry for Calcium-binding mitochondrial carrier protein Aralar1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005148
Protein NameCalcium-binding mitochondrial carrier protein Aralar1
Uniport IdO75746
GeneSLC25A12
Gene Id8604
DomainMito_carr
Pfam PF00153  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0015810 aspartate transmembrane transport
Biological Process GO:0006094 gluconeogenesis
Biological Process GO:0006537 glutamate biosynthetic process
Biological Process GO:0015813 L-glutamate transmembrane transport
Biological Process GO:0043490 malate-aspartate shuttle
Biological Process GO:1904024 negative regulation of glucose catabolic process to lactate via pyruvate
Biological Process GO:2001171 positive regulation of ATP biosynthetic process
Biological Process GO:0010907 positive regulation of glucose metabolic process
Biological Process GO:0031643 positive regulation of myelination
Biological Process GO:0051592 response to calcium ion
molecular function GO:0005347 ATP transmembrane transporter activity
molecular function GO:0005509 calcium ion binding
molecular function GO:0042802 identical protein binding
molecular function GO:0015183 L-aspartate transmembrane transporter activity
molecular function GO:0005313 L-glutamate transmembrane transporter activity
cellular component GO:0016021 integral component of membrane
cellular component GO:0005743 mitochondrial inner membrane
cellular component GO:0005739 mitochondrion
Reactome
Pathway Id Pathway Name
R-HSA-1268020 Mitochondrial protein import
R-HSA-1430728 Metabolism
R-HSA-70263 Gluconeogenesis
R-HSA-70326 Glucose metabolism
R-HSA-71291 Metabolism of amino acids and derivatives
R-HSA-71387 Metabolism of carbohydrates
R-HSA-8963693 Aspartate and asparagine metabolism
R-HSA-9609507 Protein localization
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0008495 BXGD000548 Chorioamnionitis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0021704 BXGD001510 Intelligence Behavior and Behavior Mechanisms
C0025362 BXGD001866 Mental Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027092 BXGD001971 Myopia Eye Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0158266 BXGD003878 Intervertebral Disc Degeneration Musculoskeletal Diseases
C0239337 BXGD004978 Deformity of limb
C0524528 BXGD009229 Pervasive Development Disorder Mental Disorders
C0543888 BXGD009300 Epileptic encephalopathy Nervous System Diseases
C0557874 BXGD009444 Global developmental delay
C0596887 BXGD009648 mathematical ability
C1445953 BXGD013080 Poor eye contact Mental Disorders
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1611743 BXGD013456 Familial (FPAH)
C1839630 BXGD014391 Severe muscular hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1842675 BXGD014528 AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)
C1854882 BXGD015439 Absent speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1862939 BXGD016144 AMYOTROPHIC LATERAL SCLEROSIS 1 Nutritional and Metabolic Diseases; Nervous System Diseases
C1862941 BXGD016145 Amyotrophic Lateral Sclerosis, Sporadic Nutritional and Metabolic Diseases; Nervous System Diseases
C1863844 BXGD016200 Adult-onset citrullinemia type 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2677328 BXGD017371 Cerebral hypomyelination
C2751855 BXGD017748 Hypomyelination, Global Cerebral Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Behavior and Behavior Mechanisms
C3542025 BXGD019103 AMYOTROPHIC LATERAL SCLEROSIS 1, AUTOSOMAL RECESSIVE
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4512050 BXGD023011 Epileptic encephalopathy with global cerebral demyelination Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Eye Diseases; Musculoskeletal Diseases; Nervous System Diseases; Cardiovascular Diseases
C4553743 BXGD023548 Spasticity, CTCAE
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0006186 L-Aspartic acid 133.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein