Showing entry for Amyotrophic Lateral Sclerosis, Sporadic


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD016145
Disease NameAmyotrophic Lateral Sclerosis, Sporadic
Disease CUI IdC1862941
MeSH Codes C18   C10  
Disease Class NameNutritional and Metabolic Diseases; Nervous System Diseases
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id DOID:630   DOID:7  
Disease Ontology Class Namegenetic disease; disease of anatomical entity
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O00755 BXGT003945 Protein Wnt-7a 7476 reviewed Signaling
O14782 BXGT004098 Kinesin-like protein KIF3C 3797 reviewed Cellular structure
O75746 BXGT005148 Calcium-binding mitochondrial carrier protein Aralar1 8604 reviewed Transporter
P00390 BXGT005526 Glutathione reductase, mitochondrial 2936 reviewed Enzyme
P00441 BXGT005540 Superoxide dismutase [Cu-Zn] 6647 reviewed Enzyme
P01011 BXGT005715 Alpha-1-antichymotrypsin 12 reviewed Enzyme modulator
P01034 BXGT005721 Cystatin-C 1471 reviewed
P01100 BXGT005727 Proto-oncogene c-Fos 2353 reviewed Transcription factor
P01130 BXGT005735 Low-density lipoprotein receptor 3949 reviewed
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P02649 BXGT005909 Apolipoprotein E 348 reviewed
P02746 BXGT005938 Complement C1q subcomponent subunit B 713 reviewed
P03950 BXGT006116 Angiogenin 283 reviewed
P04040 BXGT006132 Catalase 847 reviewed Enzyme
P04179 BXGT006163 Superoxide dismutase [Mn], mitochondrial 6648 reviewed Enzyme
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P04731 BXGT006251 Metallothionein-1A 4489 reviewed
P04732 BXGT006252 Metallothionein-1E 4493 reviewed
P05231 BXGT006345 Interleukin-6 3569 reviewed
P07237 BXGT006576 Protein disulfide-isomerase 5034 reviewed
P07339 BXGT006604 Cathepsin D 1509 reviewed Enzyme
P07510 BXGT006631 Acetylcholine receptor subunit gamma 1146 reviewed Ion channel
P07737 BXGT006663 Profilin-1 5216 reviewed
P08670 BXGT006810 Vimentin 7431 reviewed
P10636 BXGT007596 Microtubule-associated protein tau 4137 reviewed
P10909 BXGT007630 Clusterin 1191 reviewed
P14210 BXGT007994 Hepatocyte growth factor 3082 reviewed Enzyme
P14735 BXGT008042 Insulin-degrading enzyme 3416 reviewed Enzyme
P14780 BXGT008053 Matrix metalloproteinase-9 4318 reviewed Enzyme
P14867 BXGT008061 Gamma-aminobutyric acid receptor subunit alpha-1 2554 reviewed Ion channel
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P18887 BXGT008437 DNA repair protein XRCC1 7515 reviewed
P19793 BXGT008515 Retinoic acid receptor RXR-alpha 6256 reviewed Nuclear receptor
P23560 BXGT008883 Brain-derived neurotrophic factor 627 reviewed Signaling
P27169 BXGT009161 Serum paraoxonase/arylesterase 1 5444 reviewed
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase 328 reviewed
P29320 BXGT009332 Ephrin type-A receptor 3 2042 reviewed Kinase
P29466 BXGT009349 Caspase-1 834 reviewed Enzyme
P35613 BXGT009856 Basigin 682 reviewed
P35858 BXGT009876 Insulin-like growth factor-binding protein complex acid labile subunit 3483 reviewed Receptor
P36222 BXGT009914 Chitinase-3-like protein 1 1116 reviewed
P42262 BXGT010294 Glutamate receptor 2 2891 reviewed Ion channel
P42263 BXGT010295 Glutamate receptor 3 2892 reviewed Ion channel
P42658 BXGT010327 Dipeptidyl aminopeptidase-like protein 6 1804 reviewed Enzyme
P42898 BXGT010344 Methylenetetrahydrofolate reductase 4524 reviewed
P43004 BXGT010348 Excitatory amino acid transporter 2 6506 reviewed Transporter
P43681 BXGT010407 Neuronal acetylcholine receptor subunit alpha-4 1137 reviewed Ion channel
P48740 BXGT010659 Mannan-binding lectin serine protease 1 5648 reviewed Enzyme
P49674 BXGT010725 Casein kinase I isoform epsilon 1454 reviewed
P52333 BXGT010928 Tyrosine-protein kinase JAK3 3718 reviewed Kinase
P55072 BXGT011103 Transitional endoplasmic reticulum ATPase 7415 reviewed
P78563 BXGT011850 Double-stranded RNA-specific editase 1 104 reviewed Enzyme
P98170 BXGT012231 E3 ubiquitin-protein ligase XIAP 331 reviewed Enzyme modulator
Q00613 BXGT012540 Heat shock factor protein 1 3297 reviewed Transcription factor
Q05940 BXGT012846 Synaptic vesicular amine transporter 6571 reviewed Transporter
Q07817 BXGT012941 Bcl-2-like protein 1 598 reviewed Signaling
Q13009 BXGT013305 T-lymphoma invasion and metastasis-inducing protein 1 7074 reviewed
Q13148 BXGT013318 TAR DNA-binding protein 43 23435 reviewed
Q13501 BXGT013365 Sequestosome-1 8878 reviewed
Q13907 BXGT013403 Isopentenyl-diphosphate Delta-isomerase 1 3422 reviewed Enzyme
Q14203 BXGT013455 Dynactin subunit 1 1639 reviewed Chaperone
Q14204 BXGT013456 Cytoplasmic dynein 1 heavy chain 1 1778 reviewed Enzyme
Q14416 BXGT013468 Metabotropic glutamate receptor 2 2912 reviewed G-protein coupled receptor
Q14571 BXGT013485 Inositol 1,4,5-trisphosphate receptor type 2 3709 reviewed Ion channel
Q14974 BXGT013516 Importin subunit beta-1 3837 reviewed Transporter
Q14982 BXGT013518 Opioid-binding protein/cell adhesion molecule 4978 reviewed
Q15303 BXGT013557 Receptor tyrosine-protein kinase erbB-4 2066 reviewed Kinase
Q16637 BXGT013646 Survival motor neuron protein 6607 reviewed Epigenetic regulator
Q30201 BXGT014297 Hereditary hemochromatosis protein 3077 reviewed
Q92793 BXGT019374 CREB-binding protein 1387 reviewed
Q99700 BXGT019949 Ataxin-2 6311 reviewed Nucleic acid binding
Q9BXS1 BXGT020174 Isopentenyl-diphosphate delta-isomerase 2 91734 reviewed Enzyme
Q9BZR6 BXGT020202 Reticulon-4 receptor 65078 reviewed
Q9C0B1 BXGT020209 Alpha-ketoglutarate-dependent dioxygenase FTO 79068 reviewed
Q9UHD2 BXGT021697 Serine/threonine-protein kinase TBK1 29110 reviewed Kinase
Q9UN36 BXGT021780 Protein NDRG2 57447 reviewed Enzyme
Q16552 BXGT023419 Interleukin-17A 3605 reviewed
P17535 BXGT023437 Transcription factor jun-D 3727 reviewed Transcription factor
Q6SZW1 BXGT025034 NAD(+) hydrolase SARM1 23098 reviewed
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease