Showing entry for Apolipoprotein A-IV


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006485
Protein NameApolipoprotein A-IV
Uniport IdP06727
GeneAPOA4
Gene Id337
DomainApolipoprotein
Pfam PF01442  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0044267 cellular protein metabolic process
Biological Process GO:0006695 cholesterol biosynthetic process
Biological Process GO:0033344 cholesterol efflux
Biological Process GO:0042632 cholesterol homeostasis
Biological Process GO:0008203 cholesterol metabolic process
Biological Process GO:0034378 chylomicron assembly
Biological Process GO:0034371 chylomicron remodeling
Biological Process GO:0034380 high-density lipoprotein particle assembly
Biological Process GO:0034375 high-density lipoprotein particle remodeling
Biological Process GO:0042744 hydrogen peroxide catabolic process
Biological Process GO:0002227 innate immune response in mucosa
Biological Process GO:0007159 leukocyte cell-cell adhesion
Biological Process GO:0016042 lipid catabolic process
Biological Process GO:0055088 lipid homeostasis
Biological Process GO:0006869 lipid transport
Biological Process GO:0042157 lipoprotein metabolic process
Biological Process GO:0034445 negative regulation of plasma lipoprotein oxidation
Biological Process GO:0046470 phosphatidylcholine metabolic process
Biological Process GO:0033700 phospholipid efflux
Biological Process GO:0010873 positive regulation of cholesterol esterification
Biological Process GO:0045723 positive regulation of fatty acid biosynthetic process
Biological Process GO:0046889 positive regulation of lipid biosynthetic process
Biological Process GO:0051006 positive regulation of lipoprotein lipase activity
Biological Process GO:0010898 positive regulation of triglyceride catabolic process
Biological Process GO:0065005 protein-lipid complex assembly
Biological Process GO:0032374 regulation of cholesterol transport
Biological Process GO:0030300 regulation of intestinal cholesterol absorption
Biological Process GO:0019430 removal of superoxide radicals
Biological Process GO:0006982 response to lipid hydroperoxide
Biological Process GO:0035634 response to stilbenoid
Biological Process GO:0001523 retinoid metabolic process
Biological Process GO:0043691 reverse cholesterol transport
Biological Process GO:0070328 triglyceride homeostasis
Biological Process GO:0034372 very-low-density lipoprotein particle remodeling
molecular function GO:0016209 antioxidant activity
molecular function GO:0015485 cholesterol binding
molecular function GO:0120020 cholesterol transfer activity
molecular function GO:0005507 copper ion binding
molecular function GO:0042802 identical protein binding
molecular function GO:0008289 lipid binding
molecular function GO:0005319 lipid transporter activity
molecular function GO:0031210 phosphatidylcholine binding
molecular function GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity
molecular function GO:0005543 phospholipid binding
molecular function GO:0042803 protein homodimerization activity
cellular component GO:0072562 blood microparticle
cellular component GO:0042627 chylomicron
cellular component GO:0062023 collagen-containing extracellular matrix
cellular component GO:0005829 cytosol
cellular component GO:0005769 early endosome
cellular component GO:0005788 endoplasmic reticulum lumen
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0034364 high-density lipoprotein particle
cellular component GO:0034361 very-low-density lipoprotein particle
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1430728 Metabolism
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance
R-HSA-196854 Metabolism of vitamins and cofactors
R-HSA-196854 Metabolism of vitamins and cofactors
R-HSA-2187338 Visual phototransduction
R-HSA-2187338 Visual phototransduction
R-HSA-372790 Signaling by GPCR
R-HSA-372790 Signaling by GPCR
R-HSA-382551 Transport of small molecules
R-HSA-382551 Transport of small molecules
R-HSA-388396 GPCR downstream signalling
R-HSA-388396 GPCR downstream signalling
R-HSA-392499 Metabolism of proteins
R-HSA-418594 G alpha (i) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-6806667 Metabolism of fat-soluble vitamins
R-HSA-6806667 Metabolism of fat-soluble vitamins
R-HSA-8963888 Chylomicron assembly
R-HSA-8963889 Assembly of active LPL and LIPC lipase complexes
R-HSA-8963898 Plasma lipoprotein assembly
R-HSA-8963899 Plasma lipoprotein remodeling
R-HSA-8963899 Plasma lipoprotein remodeling
R-HSA-8963901 Chylomicron remodeling
R-HSA-975634 Retinoid metabolism and transport
R-HSA-975634 Retinoid metabolism and transport
R-HSA-977225 Amyloid fiber formation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007820 BXGD000491 Cerebrovascular Disorders Nervous System Diseases; Cardiovascular Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0017168 BXGD001101 Gastroesophageal reflux disease Digestive System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017920 BXGD001151 Glycogen Storage Disease Type I Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0019159 BXGD001294 Hepatitis A Digestive System Diseases; Infections
C0019207 BXGD001303 Hepatoma, Morris Digestive System Diseases; Neoplasms
C0019208 BXGD001304 Hepatoma, Novikoff Digestive System Diseases; Neoplasms
C0020443 BXGD001385 Hypercholesterolemia Nutritional and Metabolic Diseases
C0020445 BXGD001386 Hypercholesterolemia, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020473 BXGD001396 Hyperlipidemia Nutritional and Metabolic Diseases
C0020474 BXGD001397 Hyperlipidemia, Familial Combined Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020557 BXGD001432 Hypertriglyceridemia Nutritional and Metabolic Diseases
C0021368 BXGD001502 Inflammation Pathological Conditions, Signs and Symptoms
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023904 BXGD001721 Liver Neoplasms, Experimental Digestive System Diseases; Neoplasms
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024517 BXGD001780 Major depression, single episode Mental Disorders
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027726 BXGD002030 Nephrotic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030305 BXGD002206 Pancreatitis Digestive System Diseases
C0035078 BXGD002505 Kidney Failure Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0039292 BXGD002807 Tangier Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0085271 BXGD003148 Self-Injurious Behavior Behavior and Behavior Mechanisms
C0085293 BXGD003154 Hepatitis E Digestive System Diseases; Infections
C0086404 BXGD003278 Experimental Hepatoma Digestive System Diseases; Neoplasms
C0151718 BXGD003464 Hypocholesterolemia Nutritional and Metabolic Diseases
C0154409 BXGD003717 Recurrent major depressive episodes Mental Disorders
C0202236 BXGD004086 Triglycerides measurement
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0242339 BXGD005150 Dyslipidemias Nutritional and Metabolic Diseases
C0268380 BXGD005921 Systemic amyloidosis Nutritional and Metabolic Diseases
C0281479 BXGD006776 Primary Systemic Amyloidosis Neoplasms; Nutritional and Metabolic Diseases; Immune System Diseases
C0342883 BXGD007574 Cholesteryl Ester Transfer Protein Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0494463 BXGD009029 Alzheimer Disease, Late Onset Nervous System Diseases; Mental Disorders
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0745103 BXGD010114 Hyperlipoproteinemia Type IIa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0867389 BXGD011300 Chronic graft-versus-host disease Immune System Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1563937 BXGD013397 Atherogenesis Cardiovascular Diseases
C1565489 BXGD013401 Renal Insufficiency Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1608408 BXGD013434 Malignant transformation
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1704417 BXGD013557 Hyperlipoproteinemia Type IIb Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C1867743 BXGD016470 Premature coronary artery atherosclerosis Cardiovascular Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C3149462 BXGD018280 HYPERALPHALIPOPROTEINEMIA 1
C3714619 BXGD019418 Insulin resistance syndrome Nutritional and Metabolic Diseases
C4015844 BXGD020235 APOLIPOPROTEIN A-IV POLYMORPHISM, APOA4*1/APOA4*2 PHENOTYPE
C4529962 BXGD023178 Fatty Liver Disease
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002616 Copper 63.55
BXGC0002682 Zinc 65.41
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein