Showing entry for Complement component C6


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT007941
Protein NameComplement component C6
Uniport IdP13671
GeneC6
Gene Id729
DomainLdl_recept_a; MACPF; Sushi; TSP_1
Pfam PF00057   PF01823   PF00084   PF00090  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04610 Complement and coagulation cascades
6. Human Diseases 6.4 Neurodegenerative diseases hsa05020 Prion diseases
6. Human Diseases 6.3 Immune diseases hsa05322 Systemic lupus erythematosus
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006956 complement activation
Biological Process GO:0006958 complement activation, classical pathway
Biological Process GO:0019835 cytolysis
Biological Process GO:0045087 innate immune response
Biological Process GO:0001701 in utero embryonic development
Biological Process GO:0001970 positive regulation of activation of membrane attack complex
Biological Process GO:0045766 positive regulation of angiogenesis
Biological Process GO:0030449 regulation of complement activation
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0005579 membrane attack complex
Reactome
Pathway Id Pathway Name
R-HSA-166658 Complement cascade
R-HSA-166665 Terminal pathway of complement
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-977606 Regulation of Complement cascade
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0006663 BXGD000403 Calcinosis Nutritional and Metabolic Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0014072 BXGD000888 Experimental Autoimmune Encephalomyelitis Immune System Diseases; Nervous System Diseases
C0017658 BXGD001138 Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0018824 BXGD001237 Heart valve disease Cardiovascular Diseases
C0019069 BXGD001277 Hemophilia A Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0020550 BXGD001429 Hyperthyroidism Endocrine System Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024790 BXGD001804 Paroxysmal nocturnal hemoglobinuria Hemic and Lymphatic Diseases
C0025294 BXGD001854 Meningococcal meningitis Infections; Nervous System Diseases
C0027430 BXGD001988 Nasal Polyps Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0033687 BXGD002415 Proteinuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0152451 BXGD003597 Chronic glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0263628 BXGD005334 Tumoral calcinosis Nutritional and Metabolic Diseases
C0272242 BXGD006330 Complement deficiency disease Immune System Diseases; Hemic and Lymphatic Diseases
C0521174 BXGD009133 Microcalcification Nutritional and Metabolic Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1864694 BXGD016243 Complement Component 7 Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases
C1970263 BXGD016827 Recurrent meningococcal disease
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2316810 BXGD017030 Chronic kidney disease stage 5 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2676232 BXGD017328 Complement Component 6 Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases
C3494187 BXGD018958 Factor VIII Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C3714514 BXGD019409 Infection Infections
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0005620 beta-D-Glucopyranose 180.16
BXGC0018397 beta-1,4-mannan 180.06
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein