Showing entry for Paroxysmal nocturnal hemoglobinuria


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD001804
Disease NameParoxysmal nocturnal hemoglobinuria
Disease CUI IdC0024790
MeSH Codes C15  
Disease Class NameHemic and Lymphatic Diseases
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id HP:0001939   HP:0000119  
Human Phenotype Ontology TermAbnormality of metabolism/homeostasis; Abnormality of the genitourinary system
Disease Ontology Id DOID:7  
Disease Ontology Class Namedisease of anatomical entity
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
F7VJQ1 BXGT003310 Alternative prion protein 5621 reviewed
O60260 BXGT004864 E3 ubiquitin-protein ligase parkin 5071 reviewed Enzyme
O60674 BXGT004892 Tyrosine-protein kinase JAK2 3717 reviewed Kinase
O60885 BXGT004906 Bromodomain-containing protein 4 23476 reviewed Epigenetic regulator
O75015 BXGT005095 Low affinity immunoglobulin gamma Fc region receptor III-B 2215 reviewed Cell adhesion
O75521 BXGT005134 Enoyl-CoA delta isomerase 2, mitochondrial 10455 reviewed Enzyme modulator
O75874 BXGT005157 Isocitrate dehydrogenase [NADP] cytoplasmic 3417 reviewed
P00492 BXGT005556 Hypoxanthine-guanine phosphoribosyltransferase 3251 reviewed Enzyme
P00734 BXGT005630 Prothrombin 2147 reviewed Enzyme
P00746 BXGT005638 Complement factor D 1675 reviewed Enzyme
P00747 BXGT005639 Plasminogen 5340 reviewed Enzyme
P00749 BXGT005641 Urokinase-type plasminogen activator 5328 reviewed Enzyme
P01008 BXGT005713 Antithrombin-III 462 reviewed Enzyme modulator
P01024 BXGT005719 Complement C3 718 reviewed Enzyme modulator
P01031 BXGT005720 Complement C5 727 reviewed Enzyme modulator
P01111 BXGT005731 GTPase NRas 4893 reviewed Enzyme modulator
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01579 BXGT005770 Interferon gamma 3458 reviewed
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P01909 BXGT005815 HLA class II histocompatibility antigen, DQ alpha 1 chain 3117 reviewed Immune response
P01911 BXGT005816 HLA class II histocompatibility antigen, DRB1-15 beta chain 3123 reviewed Immune response
P02724 BXGT005934 Glycophorin-A 2993 reviewed
P02786 BXGT005961 Transferrin receptor protein 1 7037 reviewed Enzyme
P04156 BXGT006156 Major prion protein 5621 reviewed
P05107 BXGT006316 Integrin beta-2 3689 reviewed Receptor
P05164 BXGT006333 Myeloperoxidase 4353 reviewed Enzyme
P05231 BXGT006345 Interleukin-6 3569 reviewed
P06744 BXGT006494 Glucose-6-phosphate isomerase 2821 reviewed Enzyme
P07204 BXGT006567 Thrombomodulin 7056 reviewed
P07332 BXGT006601 Tyrosine-protein kinase Fes/Fps 2242 reviewed Kinase
P08174 BXGT006739 Complement decay-accelerating factor 1604 reviewed
P08473 BXGT006773 Neprilysin 4311 reviewed Enzyme
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C 5788 reviewed Enzyme
P08603 BXGT006798 Complement factor H 3075 reviewed
P08637 BXGT006802 Low affinity immunoglobulin gamma Fc region receptor III-A 2214 reviewed Cell adhesion
P10646 BXGT007598 Tissue factor pathway inhibitor 7035 reviewed Enzyme modulator
P11413 BXGT007701 Glucose-6-phosphate 1-dehydrogenase 2539 reviewed Enzyme
P12314 BXGT007798 High affinity immunoglobulin gamma Fc receptor I 2209 reviewed Cell adhesion
P13500 BXGT007916 C-C motif chemokine 2 6347 reviewed Signaling
P13671 BXGT007941 Complement component C6 729 reviewed
P14151 BXGT007990 L-selectin 6402 reviewed
P15336 BXGT008109 Cyclic AMP-dependent transcription factor ATF-2 1386 reviewed Transcription factor
P15813 BXGT008158 Antigen-presenting glycoprotein CD1d 912 reviewed
P16671 BXGT008255 Platelet glycoprotein 4 948 reviewed Receptor
P18146 BXGT008384 Early growth response protein 1 1958 reviewed Nucleic acid binding
P19544 BXGT008494 Wilms tumor protein 7490 reviewed Nucleic acid binding
P21333 BXGT008638 Filamin-A 2316 reviewed
P22083 BXGT008727 Alpha-(1,3)-fucosyltransferase 4 2526 reviewed Enzyme
P24158 BXGT008951 Myeloblastin 5657 reviewed Enzyme
P25025 BXGT009006 C-X-C chemokine receptor type 2 3579 reviewed G-protein coupled receptor
P25942 BXGT009079 Tumor necrosis factor receptor superfamily member 5 958 reviewed
P27352 BXGT009174 Cobalamin binding intrinsic factor 2694 reviewed
P28907 BXGT009301 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 952 reviewed Enzyme
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase 207 reviewed Kinase
P31997 BXGT009593 Carcinoembryonic antigen-related cell adhesion molecule 8 1088 reviewed
P40225 BXGT010168 Thrombopoietin 7066 reviewed
P41597 BXGT010268 C-C chemokine receptor type 2 729230 reviewed
P51812 BXGT010893 Ribosomal protein S6 kinase alpha-3 6197 reviewed Kinase
P55040 BXGT011099 GTP-binding protein GEM 2669 reviewed
P60568 BXGT011315 Interleukin-2 3558 reviewed
P60709 BXGT011322 Actin, cytoplasmic 1 60 reviewed Cellular structure
P61073 BXGT011352 C-X-C chemokine receptor type 4 7852 reviewed G-protein coupled receptor
Q03405 BXGT012713 Urokinase plasminogen activator surface receptor 5329 reviewed
Q10588 BXGT013202 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 683 reviewed Enzyme
Q13873 BXGT013398 Bone morphogenetic protein receptor type-2 659 reviewed Kinase
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 4780 reviewed Enzyme
Q76LX8 BXGT016870 A disintegrin and metalloproteinase with thrombospondin motifs 13 11093 reviewed Enzyme
Q8N0X4 BXGT018493 Citramalyl-CoA lyase, mitochondrial 171425 reviewed
Q96PU5 BXGT019711 E3 ubiquitin-protein ligase NEDD4-like 23327 reviewed Enzyme
Q96RI1 BXGT019727 Bile acid receptor 9971 reviewed Nuclear receptor
Q9BX66 BXGT020158 Sorbin and SH3 domain-containing protein 1 10580 reviewed
Q9UIQ6 BXGT021721 Leucyl-cystinyl aminopeptidase 4012 reviewed Enzyme
P04439 BXGT022649 HLA class I histocompatibility antigen, A-3 alpha chain 3105 reviewed
O60936 BXGT022857 Nucleolar protein 3 8996 reviewed
P00738 BXGT022874 Haptoglobin 3240 reviewed Enzyme
P31358 BXGT025061 CAMPATH-1 antigen 1043 reviewed
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease