Showing entry for Integrin beta-8


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009083
Protein NameIntegrin beta-8
Uniport IdP26012
GeneITGB8
Gene Id3696
DomainEGF_2; Integrin_beta; PSI_integrin
Pfam PF07974   PF00362   PF17205  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04151 PI3K-Akt signaling pathway
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04510 Focal adhesion
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04512 ECM-receptor interaction
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04514 Cell adhesion molecules (CAMs)
4. Cellular Processes 4.5 Cell motility hsa04810 Regulation of actin cytoskeleton
6. Human Diseases 6.9 Infectious diseases: Viral hsa05165 Human papillomavirus infection
6. Human Diseases 6.6 Cardiovascular diseases hsa05410 Hypertrophic cardiomyopathy (HCM)
6. Human Diseases 6.6 Cardiovascular diseases hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
6. Human Diseases 6.6 Cardiovascular diseases hsa05414 Dilated cardiomyopathy (DCM)
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0051216 cartilage development
Biological Process GO:0007155 cell adhesion
Biological Process GO:0033627 cell adhesion mediated by integrin
Biological Process GO:0016477 cell migration
Biological Process GO:0030198 extracellular matrix organization
Biological Process GO:0001573 ganglioside metabolic process
Biological Process GO:0007229 integrin-mediated signaling pathway
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0060674 placenta blood vessel development
Biological Process GO:0045766 positive regulation of angiogenesis
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:1901388 regulation of transforming growth factor beta activation
Biological Process GO:0001570 vasculogenesis
molecular function GO:1990430 extracellular matrix protein binding
molecular function GO:0005178 integrin binding
molecular function GO:0038023 signaling receptor activity
cellular component GO:0009986 cell surface
cellular component GO:0070062 extracellular exosome
cellular component GO:0005925 focal adhesion
cellular component GO:0034686 integrin alphav-beta8 complex
cellular component GO:0008305 integrin complex
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1474244 Extracellular matrix organization
R-HSA-1566948 Elastic fibre formation
R-HSA-2129379 Molecules associated with elastic fibres
R-HSA-216083 Integrin cell surface interactions
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003857 BXGD000228 Congenital arteriovenous malformation Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0005411 BXGD000313 Biliary Atresia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0005890 BXGD000345 Body Height
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0037369 BXGD002691 Smoking Behavior and Behavior Mechanisms
C0042834 BXGD003004 Vital capacity
C0205682 BXGD004105 Waist-Hip Ratio
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0264408 BXGD005387 Childhood asthma Respiratory Tract Diseases; Immune System Diseases
C0269102 BXGD006053 Endometrioma Female Urogenital Diseases and Pregnancy Complications
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0410702 BXGD008447 Adolescent idiopathic scoliosis Musculoskeletal Diseases
C0424621 BXGD008536 Body Fat Distribution
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0751690 BXGD010553 Malignant Peripheral Nerve Sheath Tumor Neoplasms; Nervous System Diseases
C0917804 BXGD011413 Arteriovenous Malformations, Cerebral Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Cardiovascular Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1519383 BXGD013237 Smoking Behaviors Behavior and Behavior Mechanisms
C1527304 BXGD013266 Allergic Reaction Immune System Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C1837461 BXGD014234 SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
C2931456 BXGD018024 Prostate cancer, familial Neoplasms; Male Urogenital Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C4049938 BXGD021956 Physical Activity Measurement
C4520983 BXGD023052 Congenital atresia of extrahepatic bile duct Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722327 BXGD023799 PROSTATE CANCER, HEREDITARY, 1 Neoplasms; Male Urogenital Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0002588 Magnesium 24.31
BXGC0018397 beta-1,4-mannan 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein