Showing entry for Malignant Peripheral Nerve Sheath Tumor


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD010553
Disease NameMalignant Peripheral Nerve Sheath Tumor
Disease CUI IdC0751690
MeSH Codes C04   C10  
Disease Class NameNeoplasms; Nervous System Diseases
Semantic TypeNeoplastic Process
Human Phenotype Ontology Id HP:0002664  
Human Phenotype Ontology TermNeoplasm
Disease Ontology Id DOID:7   DOID:14566  
Disease Ontology Class Namedisease of anatomical entity; disease of cellular proliferation
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
A0A024RAV5 BXGT000013 V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b 3845 unreviewed
O00329 BXGT003909 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 5293 reviewed Kinase
O14733 BXGT004087 Dual specificity mitogen-activated protein kinase kinase 7 5609 reviewed Kinase
O14746 BXGT004091 Telomerase reverse transcriptase 7015 reviewed Enzyme
O14965 BXGT004117 Aurora kinase A 6790 reviewed Kinase
O15392 BXGT004162 Baculoviral IAP repeat-containing protein 5 332 reviewed Enzyme modulator
O15438 BXGT004168 Canalicular multispecific organic anion transporter 2 8714 reviewed Transporter
O15540 BXGT004178 Fatty acid-binding protein, brain 2173 reviewed
O60566 BXGT004884 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta 701 reviewed Kinase
O60885 BXGT004906 Bromodomain-containing protein 4 23476 reviewed Epigenetic regulator
O75530 BXGT005135 Polycomb protein EED 8726 reviewed
O95835 BXGT005400 Serine/threonine-protein kinase LATS1 9113 reviewed Kinase
P00533 BXGT005575 Epidermal growth factor receptor 1956 reviewed Kinase
P00813 BXGT005667 Adenosine deaminase 100 reviewed Enzyme
P01111 BXGT005731 GTPase NRas 4893 reviewed Enzyme modulator
P01112 BXGT005732 GTPase HRas 3265 reviewed Enzyme modulator
P01116 BXGT005733 GTPase KRas 3845 reviewed Enzyme modulator
P01133 BXGT005736 Pro-epidermal growth factor 1950 reviewed
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P02751 BXGT005943 Fibronectin 2335 reviewed Signaling
P03372 BXGT006059 Estrogen receptor 2099 reviewed Nuclear receptor
P04049 BXGT006133 RAF proto-oncogene serine/threonine-protein kinase 5894 reviewed Kinase
P04271 BXGT006177 Protein S100-B 6285 reviewed Calcium-binding protein
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 2064 reviewed Kinase
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P06730 BXGT006487 Eukaryotic translation initiation factor 4E 1977 reviewed Nucleic acid binding
P06731 BXGT006488 Carcinoembryonic antigen-related cell adhesion molecule 5 1048 reviewed
P07333 BXGT006602 Macrophage colony-stimulating factor 1 receptor 1436 reviewed Kinase
P08069 BXGT006723 Insulin-like growth factor 1 receptor 3480 reviewed Kinase
P08138 BXGT006729 Tumor necrosis factor receptor superfamily member 16 4804 reviewed Receptor
P08183 BXGT006741 ATP-dependent translocase ABCB1 5243 reviewed Transporter
P08581 BXGT006794 Hepatocyte growth factor receptor 4233 reviewed Kinase
P09382 BXGT006882 Galectin-1 3956 reviewed Signaling
P09619 BXGT006911 Platelet-derived growth factor receptor beta 5159 reviewed Kinase
P09874 BXGT006934 Poly [ADP-ribose] polymerase 1 142 reviewed
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P10644 BXGT007597 cAMP-dependent protein kinase type I-alpha regulatory subunit 5573 reviewed
P10721 BXGT007605 Mast/stem cell growth factor receptor Kit 3815 reviewed Kinase
P11387 BXGT007696 DNA topoisomerase 1 7150 reviewed Enzyme
P11388 BXGT007697 DNA topoisomerase 2-alpha 7153 reviewed
P11413 BXGT007701 Glucose-6-phosphate 1-dehydrogenase 2539 reviewed Enzyme
P11802 BXGT007750 Cyclin-dependent kinase 4 1019 reviewed Kinase
P12004 BXGT007766 Proliferating cell nuclear antigen 5111 reviewed Nucleic acid binding
P12643 BXGT007830 Bone morphogenetic protein 2 650 reviewed Signaling
P14210 BXGT007994 Hepatocyte growth factor 3082 reviewed Enzyme
P14616 BXGT008026 Insulin receptor-related protein 3645 reviewed Kinase
P15056 BXGT008075 Serine/threonine-protein kinase B-raf 673 reviewed Kinase
P15529 BXGT008134 Membrane cofactor protein 4179 reviewed
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P16070 BXGT008186 CD44 antigen 960 reviewed
P16144 BXGT008200 Integrin beta-4 3691 reviewed Receptor
P16234 BXGT008209 Platelet-derived growth factor receptor alpha 5156 reviewed Kinase
P16410 BXGT008224 Cytotoxic T-lymphocyte protein 4 1493 reviewed
P17844 BXGT008346 Probable ATP-dependent RNA helicase DDX5 1655 reviewed
P19544 BXGT008494 Wilms tumor protein 7490 reviewed Nucleic acid binding
P20936 BXGT008619 Ras GTPase-activating protein 1 5921 reviewed Enzyme modulator
P21359 BXGT008640 Neurofibromin 4763 reviewed Enzyme modulator
P21579 BXGT008665 Synaptotagmin-1 6857 reviewed Transporter
P23297 BXGT008848 Protein S100-A1 6271 reviewed Calcium-binding protein
P24385 BXGT008965 G1/S-specific cyclin-D1 595 reviewed Enzyme modulator
P26012 BXGT009083 Integrin beta-8 3696 reviewed Receptor
P27361 BXGT009176 Mitogen-activated protein kinase 3 5595 reviewed Kinase
P28482 BXGT009263 Mitogen-activated protein kinase 1 5594 reviewed Kinase
P28562 BXGT009270 Dual specificity protein phosphatase 1 1843 reviewed
P28907 BXGT009301 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 952 reviewed Enzyme
P29323 BXGT009334 Ephrin type-B receptor 2 2048 reviewed Kinase
P29373 BXGT009337 Cellular retinoic acid-binding protein 2 1382 reviewed
P29597 BXGT009367 Non-receptor tyrosine-protein kinase TYK2 7297 reviewed Kinase
P31350 BXGT009526 Ribonucleoside-diphosphate reductase subunit M2 6241 reviewed Enzyme
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase 207 reviewed Kinase
P33527 BXGT009728 Multidrug resistance-associated protein 1 4363 reviewed Transporter
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P35610 BXGT009855 Sterol O-acyltransferase 1 6646 reviewed Enzyme
P35869 BXGT009877 Aryl hydrocarbon receptor 196 reviewed Transcription factor
P35968 BXGT009887 Vascular endothelial growth factor receptor 2 3791 reviewed Kinase
P36955 BXGT009946 Pigment epithelium-derived factor 5176 reviewed Enzyme modulator
P37023 BXGT009953 Serine/threonine-protein kinase receptor R3 94 reviewed Kinase
P38398 BXGT010037 Breast cancer type 1 susceptibility protein 672 reviewed Enzyme
P39900 BXGT010148 Macrophage metalloelastase 4321 reviewed Enzyme
P40763 BXGT010202 Signal transducer and activator of transcription 3 6774 reviewed Nucleic acid binding
P41182 BXGT010231 B-cell lymphoma 6 protein 604 reviewed
P42224 BXGT010286 Signal transducer and activator of transcription 1-alpha/beta 6772 reviewed Nucleic acid binding
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42338 BXGT010303 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 5291 reviewed Kinase
P42345 BXGT010304 Serine/threonine-protein kinase mTOR 2475 reviewed Kinase
P45452 BXGT010462 Collagenase 3 4322 reviewed Enzyme
P45983 BXGT010494 Mitogen-activated protein kinase 8 5599 reviewed Kinase
P46100 BXGT010508 Transcriptional regulator ATRX 546 reviewed
P46527 BXGT010525 Cyclin-dependent kinase inhibitor 1B 1027 reviewed
P46531 BXGT010526 Neurogenic locus notch homolog protein 1 4851 reviewed
P46937 BXGT010554 Transcriptional coactivator YAP1 10413 reviewed Enzyme modulator
P48061 BXGT010616 Stromal cell-derived factor 1 6387 reviewed
P48736 BXGT010658 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 5294 reviewed Kinase
P51858 BXGT010900 Hepatoma-derived growth factor 3068 reviewed Signaling
P53350 BXGT010984 Serine/threonine-protein kinase PLK1 5347 reviewed Kinase
P53667 BXGT011008 LIM domain kinase 1 3984 reviewed Kinase
P54687 BXGT011067 Branched-chain-amino-acid aminotransferase, cytosolic 586 reviewed Enzyme
P60484 BXGT011307 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5728 reviewed Enzyme
P60842 BXGT011330 Eukaryotic initiation factor 4A-I 1973 reviewed
P61073 BXGT011352 C-X-C chemokine receptor type 4 7852 reviewed G-protein coupled receptor
P62753 BXGT011454 40S ribosomal protein S6 6194 reviewed Nucleic acid binding
P63000 BXGT011481 Ras-related C3 botulinum toxin substrate 1 5879 reviewed Enzyme modulator
P78358 BXGT011838 Cancer/testis antigen 1 246100 reviewed
Q00613 BXGT012540 Heat shock factor protein 1 3297 reviewed Transcription factor
Q00987 BXGT012559 E3 ubiquitin-protein ligase Mdm2 4193 reviewed Nucleic acid binding
Q01453 BXGT012588 Peripheral myelin protein 22 5376 reviewed Cellular structure
Q02750 BXGT012662 Dual specificity mitogen-activated protein kinase kinase 1 5604 reviewed Kinase
Q04637 BXGT012771 Eukaryotic translation initiation factor 4 gamma 1 1981 reviewed Nucleic acid binding
Q04724 BXGT012778 Transducin-like enhancer protein 1 7088 reviewed Transcription factor
Q06710 BXGT012887 Paired box protein Pax-8 7849 reviewed
Q07820 BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 4170 reviewed Signaling
Q08050 BXGT012958 Forkhead box protein M1 2305 reviewed
Q13153 BXGT013319 Serine/threonine-protein kinase PAK 1 5058 reviewed Kinase
Q13616 BXGT013381 Cullin-1 8454 reviewed Enzyme
Q14240 BXGT013458 Eukaryotic initiation factor 4A-II 1974 reviewed
Q14457 BXGT013472 Beclin-1 8678 reviewed Enzyme modulator
Q14627 BXGT013492 Interleukin-13 receptor subunit alpha-2 3598 reviewed Signaling
Q14839 BXGT013509 Chromodomain-helicase-DNA-binding protein 4 1108 reviewed
Q14974 BXGT013516 Importin subunit beta-1 3837 reviewed Transporter
Q15022 BXGT013523 Polycomb protein SUZ12 23512 reviewed Nucleic acid binding
Q15257 BXGT013554 Serine/threonine-protein phosphatase 2A activator 5524 reviewed Enzyme modulator
Q15303 BXGT013557 Receptor tyrosine-protein kinase erbB-4 2066 reviewed Kinase
Q15910 BXGT013612 Histone-lysine N-methyltransferase EZH2 2146 reviewed Epigenetic regulator
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha 3091 reviewed Transcription factor
Q16769 BXGT013665 Glutaminyl-peptide cyclotransferase 25797 reviewed Enzyme
Q16828 BXGT013676 Dual specificity protein phosphatase 6 1848 reviewed
Q53EL6 BXGT015008 Programmed cell death protein 4 27250 reviewed Nucleic acid binding
Q8TAF3 BXGT018786 WD repeat-containing protein 48 57599 reviewed
Q8TDQ0 BXGT018810 Hepatitis A virus cellular receptor 2 84868 reviewed
Q92731 BXGT019366 Estrogen receptor beta 2100 reviewed Nuclear receptor
Q92743 BXGT019368 Serine protease HTRA1 5654 reviewed Enzyme
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 79915 reviewed
Q99828 BXGT019967 Calcium and integrin-binding protein 1 10519 reviewed
Q9BR01 BXGT020115 Sulfotransferase 4A1 25830 reviewed
Q9BY41 BXGT020180 Histone deacetylase 8 55869 reviewed Epigenetic regulator
Q9NZQ7 BXGT021281 Programmed cell death 1 ligand 1 29126 reviewed Receptor
Q9UGN5 BXGT021688 Poly [ADP-ribose] polymerase 2 10038 reviewed
Q9UKV0 BXGT021750 Histone deacetylase 9 9734 reviewed Epigenetic regulator
Q9UKV8 BXGT021752 Protein argonaute-2 27161 reviewed
Q9UNQ0 BXGT021792 ATP-binding cassette sub-family G member 2 9429 reviewed Transporter
Q92911 BXGT022650 Sodium/iodide cotransporter 6528 reviewed Transporter
Q01995 BXGT022678 Transgelin 6876 reviewed Cellular structure
Q14678 BXGT023543 KN motif and ankyrin repeat domain-containing protein 1 23189 reviewed
O60232 BXGT024169 Protein ZNRD2 10534 reviewed
Q9NRR4 BXGT025788 Ribonuclease 3 29102 reviewed Enzyme
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease