adisease

Showing entry for Childhood asthma

General Disease Information
BXGD Id	BXGD005387
Disease Name	Childhood asthma
Disease CUI Id	C0264408
MeSH Codes	C08 C20
Disease Class Name	Respiratory Tract Diseases; Immune System Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id	DOID:7
Disease Ontology Class Name	disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O15439	BXGT004169	Multidrug resistance-associated protein 4	10257	reviewed	Transporter
O43557	BXGT004600	Tumor necrosis factor ligand superfamily member 14	8740	reviewed	Signaling
O60603	BXGT004887	Toll-like receptor 2	7097	reviewed
O60760	BXGT004899	Hematopoietic prostaglandin D synthase	27306	reviewed
O75762	BXGT005151	Transient receptor potential cation channel subfamily A member 1	8989	reviewed	Ion channel
P01042	BXGT005722	Kininogen-1	3827	reviewed	Enzyme modulator
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01589	BXGT005773	Interleukin-2 receptor subunit alpha	3559	reviewed	Receptor
P01889	BXGT005809	HLA class I histocompatibility antigen, B-7 alpha chain	3106	reviewed
P01909	BXGT005815	HLA class II histocompatibility antigen, DQ alpha 1 chain	3117	reviewed	Immune response
P01911	BXGT005816	HLA class II histocompatibility antigen, DRB1-15 beta chain	3123	reviewed	Immune response
P02763	BXGT005951	Alpha-1-acid glycoprotein 1	5004	reviewed
P02774	BXGT005959	Vitamin D-binding protein	2638	reviewed	Transporter
P05089	BXGT006310	Arginase-1	383	reviewed	Enzyme
P05108	BXGT006317	Cholesterol side-chain cleavage enzyme, mitochondrial	1583	reviewed
P05121	BXGT006320	Plasminogen activator inhibitor 1	5054	reviewed	Enzyme modulator
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05362	BXGT006350	Intercellular adhesion molecule 1	3383	reviewed
P06734	BXGT006491	Low affinity immunoglobulin epsilon Fc receptor	2208	reviewed	Receptor
P07093	BXGT006544	Glia-derived nexin	5270	reviewed	Enzyme modulator
P07099	BXGT006546	Epoxide hydrolase 1	2052	reviewed
P07355	BXGT006609	Annexin A2	302	reviewed
P07550	BXGT006636	Beta-2 adrenergic receptor	154	reviewed	G-protein coupled receptor
P07602	BXGT006646	Prosaposin	5660	reviewed
P08842	BXGT006830	Steryl-sulfatase	412	reviewed	Enzyme
P09211	BXGT006869	Glutathione S-transferase P	2950	reviewed
P09429	BXGT006889	High mobility group protein B1	3146	reviewed	Nucleic acid binding
P09488	BXGT006899	Glutathione S-transferase Mu 1	2944	reviewed
P09917	BXGT006941	Arachidonate 5-lipoxygenase	240	reviewed	Enzyme
P09960	BXGT006952	Leukotriene A-4 hydrolase	4048	reviewed
P10144	BXGT007541	Granzyme B	3002	reviewed	Enzyme
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10909	BXGT007630	Clusterin	1191	reviewed
P11226	BXGT007675	Mannose-binding protein C	4153	reviewed	Receptor
P11473	BXGT007709	Vitamin D3 receptor	7421	reviewed	Nuclear receptor
P11498	BXGT007714	Pyruvate carboxylase, mitochondrial	5091	reviewed	Enzyme
P12004	BXGT007766	Proliferating cell nuclear antigen	5111	reviewed	Nucleic acid binding
P12821	BXGT007849	Angiotensin-converting enzyme	1636	reviewed	Enzyme
P12830	BXGT007852	Cadherin-1	999	reviewed
P13501	BXGT007917	C-C motif chemokine 5	6352	reviewed	Signaling
P13569	BXGT007923	Cystic fibrosis transmembrane conductance regulator	1080	reviewed	Ion channel
P13612	BXGT007928	Integrin alpha-4	3676	reviewed
P14174	BXGT007991	Macrophage migration inhibitory factor	4282	reviewed
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P15121	BXGT008083	Aldo-keto reductase family 1 member B1	231	reviewed	Enzyme
P15559	BXGT008139	NAD(P)H dehydrogenase [quinone] 1	1728	reviewed
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P16234	BXGT008209	Platelet-derived growth factor receptor alpha	5156	reviewed	Kinase
P16278	BXGT008213	Beta-galactosidase	2720	reviewed	Enzyme
P16410	BXGT008224	Cytotoxic T-lymphocyte protein 4	1493	reviewed
P16442	BXGT008227	Histo-blood group ABO system transferase	28	reviewed	Enzyme
P18440	BXGT008404	Arylamine N-acetyltransferase 1	9	reviewed	Enzyme
P19440	BXGT008481	Glutathione hydrolase 1 proenzyme	2678	reviewed	Enzyme
P19838	BXGT008526	Nuclear factor NF-kappa-B p105 subunit	4790	reviewed	Transcription factor
P20309	BXGT008562	Muscarinic acetylcholine receptor M3	1131	reviewed	G-protein coupled receptor
P20930	BXGT008616	Filaggrin	2312	reviewed	Cellular structure
P21580	BXGT008666	Tumor necrosis factor alpha-induced protein 3	7128	reviewed	Enzyme
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P23946	BXGT008932	Chymase	1215	reviewed	Enzyme
P25705	BXGT009060	ATP synthase subunit alpha, mitochondrial	498	reviewed	Transporter
P25791	BXGT009072	Rhombotin-2	4005	reviewed
P25963	BXGT009080	NF-kappa-B inhibitor alpha	4792	reviewed
P26012	BXGT009083	Integrin beta-8	3696	reviewed	Receptor
P28161	BXGT009234	Glutathione S-transferase Mu 2	2946	reviewed
P29460	BXGT009348	Interleukin-12 subunit beta	3593	reviewed	Signaling
P29475	BXGT009353	Nitric oxide synthase, brain	4842	reviewed
P30530	BXGT009431	Tyrosine-protein kinase receptor UFO	558	reviewed	Kinase
P30542	BXGT009436	Adenosine receptor A1	134	reviewed	G-protein coupled receptor
P30711	BXGT009460	Glutathione S-transferase theta-1	2952	reviewed
P32302	BXGT009619	C-X-C chemokine receptor type 5	643	reviewed	G-protein coupled receptor
P34998	BXGT009781	Corticotropin-releasing factor receptor 1	1394	reviewed
P35221	BXGT009798	Catenin alpha-1	1495	reviewed	Cellular structure
P35247	BXGT009804	Pulmonary surfactant-associated protein D	6441	reviewed	Surfactant
P35398	BXGT009825	Nuclear receptor ROR-alpha	6095	reviewed	Nuclear receptor
P36222	BXGT009914	Chitinase-3-like protein 1	1116	reviewed
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	5468	reviewed	Nuclear receptor
P39900	BXGT010148	Macrophage metalloelastase	4321	reviewed	Enzyme
P42226	BXGT010288	Signal transducer and activator of transcription 6	6778	reviewed	Nucleic acid binding
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P42898	BXGT010344	Methylenetetrahydrofolate reductase	4524	reviewed
P48357	BXGT010627	Leptin receptor	3953	reviewed	Signaling
P49913	BXGT010761	Cathelicidin antimicrobial peptide	820	reviewed
P50135	BXGT010776	Histamine N-methyltransferase	3176	reviewed
P51692	BXGT010885	Signal transducer and activator of transcription 5B	6777	reviewed	Nucleic acid binding
P52732	BXGT010948	Kinesin-like protein KIF11	3832	reviewed	Cellular structure
P57772	BXGT011220	Selenocysteine-specific elongation factor	60678	reviewed	Enzyme
P60022	BXGT011285	Beta-defensin 1	1672	reviewed
P60568	BXGT011315	Interleukin-2	3558	reviewed
P68371	BXGT011597	Tubulin beta-4B chain	10383	reviewed	Cellular structure
P78540	BXGT011848	Arginase-2, mitochondrial	384	reviewed	Enzyme
P78556	BXGT011849	C-C motif chemokine 20	6364	reviewed	Signaling
P84022	BXGT012027	Mothers against decapentaplegic homolog 3	4088	reviewed	Transcription factor
Q01196	BXGT012575	Runt-related transcription factor 1	861	reviewed	Transcription factor
Q04759	BXGT012781	Protein kinase C theta type	5588	reviewed	Kinase
Q08174	BXGT012963	Protocadherin-1	5097	reviewed
Q08257	BXGT012975	Quinone oxidoreductase	1429	reviewed
Q13231	BXGT013329	Chitotriosidase-1	1118	reviewed
Q13324	BXGT013340	Corticotropin-releasing factor receptor 2	1395	reviewed	G-protein coupled receptor
Q13478	BXGT013362	Interleukin-18 receptor 1	8809	reviewed	Receptor
Q13489	BXGT013364	Baculoviral IAP repeat-containing protein 3	330	reviewed	Enzyme modulator
Q13547	BXGT013373	Histone deacetylase 1	3065	reviewed	Epigenetic regulator
Q14392	BXGT013465	Transforming growth factor beta activator LRRC32	2615	reviewed	Receptor
Q15063	BXGT013531	Periostin	10631	reviewed	Signaling
Q15262	BXGT013555	Receptor-type tyrosine-protein phosphatase kappa	5796	reviewed	Enzyme
Q15848	BXGT013609	Adiponectin	9370	reviewed
Q29980	BXGT013981	MHC class I polypeptide-related sequence B	4277	reviewed
Q53EL6	BXGT015008	Programmed cell death protein 4	27250	reviewed	Nucleic acid binding
Q6P589	BXGT016452	Tumor necrosis factor alpha-induced protein 8-like protein 2	79626	reviewed
Q6VVX0	BXGT016585	Vitamin D 25-hydroxylase	120227	reviewed
Q6W5P4	BXGT016588	Neuropeptide S receptor	387129	reviewed
Q8N608	BXGT018522	Inactive dipeptidyl peptidase 10	57628	reviewed	Enzyme
Q8NER1	BXGT018556	Transient receptor potential cation channel subfamily V member 1	7442	reviewed	Ion channel
Q8TAX9	BXGT018788	Gasdermin-B	55876	reviewed
Q8TDQ0	BXGT018810	Hepatitis A virus cellular receptor 2	84868	reviewed
Q92736	BXGT019367	Ryanodine receptor 2	6262	reviewed	Ion channel
Q96D42	BXGT019636	Hepatitis A virus cellular receptor 1	26762	reviewed
Q96H15	BXGT019669	T-cell immunoglobulin and mucin domain-containing protein 4	91937	reviewed
Q96PD4	BXGT019705	Interleukin-17F	112744	reviewed
Q99581	BXGT019937	Protein FEV	54738	reviewed	Transcription factor
Q99700	BXGT019949	Ataxin-2	6311	reviewed	Nucleic acid binding
Q9BZ11	BXGT020193	Disintegrin and metalloproteinase domain-containing protein 33	80332	reviewed	Enzyme
Q9BZP6	BXGT020201	Acidic mammalian chitinase	27159	reviewed
Q9H227	BXGT020447	Cytosolic beta-glucosidase	57733	reviewed	Enzyme
Q9H6X2	BXGT020486	Anthrax toxin receptor 1	84168	reviewed	Receptor
Q9HBA0	BXGT020516	Transient receptor potential cation channel subfamily V member 4	59341	reviewed	Ion channel
Q9HC29	BXGT020526	Nucleotide-binding oligomerization domain-containing protein 2	64127	reviewed	Enzyme
Q9NP56	BXGT021142	cAMP-specific 3',5'-cyclic phosphodiesterase 7B	27115	reviewed
Q9UNA4	BXGT021785	DNA polymerase iota	11201	reviewed
Q9Y239	BXGT022213	Nucleotide-binding oligomerization domain-containing protein 1	10392	reviewed	Enzyme
Q9Y2Q3	BXGT022242	Glutathione S-transferase kappa 1	373156	reviewed
Q9Y2R2	BXGT022243	Tyrosine-protein phosphatase non-receptor type 22	26191	reviewed
Q9Y5S1	BXGT022300	Transient receptor potential cation channel subfamily V member 2	51393	reviewed	Ion channel
P20036	BXGT022764	HLA class II histocompatibility antigen, DP alpha 1 chain	3113	reviewed	Immune response
Q9UNS1	BXGT022882	Protein timeless homolog	8914	reviewed
Q92878	BXGT023071	DNA repair protein RAD50	10111	reviewed
Q16552	BXGT023419	Interleukin-17A	3605	reviewed
Q6ZTQ4	BXGT025244	Cadherin-related family member 3	222256	reviewed
Q92599	BXGT025758	Septin-8	23176	reviewed	Enzyme modulator
Q8N573	BXGT026157	Oxidation resistance protein 1	55074	reviewed
P21731	BXGT026174	Thromboxane A2 receptor	6915	reviewed	G-protein coupled receptor

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}