Showing entry for Heat shock 70 kDa protein 1-like


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009771
Protein NameHeat shock 70 kDa protein 1-like
Uniport IdP34931
GeneHSPA1L
Gene Id3305
DomainHSP70
Pfam PF00012  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.1 Transcription hsa03040 Spliceosome
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa04141 Protein processing in endoplasmic reticulum
4. Cellular Processes 4.1 Transport and catabolism hsa04144 Endocytosis
5. Organismal Systems 5.9 Aging hsa04213 Longevity regulating pathway - multiple species
5. Organismal Systems 5.1 Immune system hsa04612 Antigen processing and presentation
5. Organismal Systems 5.2 Endocrine system hsa04915 Estrogen signaling pathway
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05134 Legionellosis
6. Human Diseases 6.10 Infectious diseases: Parasitic hsa05145 Toxoplasmosis
6. Human Diseases 6.9 Infectious diseases: Viral hsa05162 Measles
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007339 binding of sperm to zona pellucida
Biological Process GO:0034620 cellular response to unfolded protein
Biological Process GO:0051085 chaperone cofactor-dependent protein refolding
Biological Process GO:1903955 positive regulation of protein targeting to mitochondrion
Biological Process GO:0042026 protein refolding
Biological Process GO:1900034 regulation of cellular response to heat
Biological Process GO:0006986 response to unfolded protein
Biological Process GO:0016192 vesicle-mediated transport
molecular function GO:0016887 ATPase activity
molecular function GO:0005524 ATP binding
molecular function GO:0031072 heat shock protein binding
molecular function GO:0051787 misfolded protein binding
molecular function GO:0044183 protein folding chaperone
molecular function GO:0031625 ubiquitin protein ligase binding
molecular function GO:0051082 unfolded protein binding
cellular component GO:0072562 blood microparticle
cellular component GO:0044297 cell body
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005759 mitochondrial matrix
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
cellular component GO:0002199 zona pellucida receptor complex
Reactome
Pathway Id Pathway Name
R-HSA-2262752 Cellular responses to stress
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-3371556 Cellular response to heat stress
R-HSA-3371568 Attenuation phase
R-HSA-3371571 HSF1-dependent transactivation
R-HSA-8953897 Cellular responses to external stimuli
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003165 BXGD000186 Anthracosis Respiratory Tract Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0013182 BXGD000803 Drug Allergy Immune System Diseases; Chemically-Induced Disorders
C0018133 BXGD001176 Graft-vs-Host Disease Immune System Diseases
C0019189 BXGD001298 Hepatitis, Chronic Digestive System Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024305 BXGD001763 Lymphoma, Non-Hodgkin Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024517 BXGD001780 Major depression, single episode Mental Disorders
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0036202 BXGD002581 Sarcoidosis Hemic and Lymphatic Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036349 BXGD002604 Paranoid Schizophrenia Mental Disorders
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0038013 BXGD002725 Ankylosing spondylitis Musculoskeletal Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0041696 BXGD002932 Unipolar Depression Mental Disorders
C0042164 BXGD002965 Uveitis Eye Diseases
C0085435 BXGD003176 Arthritis, Reactive Infections; Musculoskeletal Diseases
C0085605 BXGD003200 Liver Failure Digestive System Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0151517 BXGD003431 Complete atrioventricular block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0220605 BXGD004294 Adult Non-Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0220612 BXGD004296 Childhood Non-Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0263313 BXGD005285 Pemphigus Foliaceus Skin and Connective Tissue Diseases; Immune System Diseases
C0333523 BXGD006959 Deep caries Pathological Conditions, Signs and Symptoms; Stomatognathic Diseases
C0340100 BXGD007304 High altitude pulmonary edema Respiratory Tract Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0524909 BXGD009247 Hepatitis B, Chronic Digestive System Diseases; Infections
C0577608 BXGD009532 C4 complement assay (procedure)
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678202 BXGD009747 Regional enteritis Digestive System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0740391 BXGD009987 Middle Cerebral Artery Occlusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0856825 BXGD011118 Acute GVH disease Immune System Diseases
C0867389 BXGD011300 Chronic graft-versus-host disease Immune System Diseases
C0949691 BXGD011585 Spondylarthropathies Musculoskeletal Diseases
C1262760 BXGD011886 Hepatitis, Drug-Induced Digestive System Diseases; Chemically-Induced Disorders
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1719672 BXGD013659 Severe Sepsis Pathological Conditions, Signs and Symptoms; Infections
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C4039764 BXGD021864 Undifferentiated spondyloarthropathy Musculoskeletal Diseases
C4721532 BXGD023752 Lymphoma, Non-Hodgkin, Familial Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein