adisease

Showing entry for Uveitis

General Disease Information
BXGD Id	BXGD002965
Disease Name	Uveitis
Disease CUI Id	C0042164
MeSH Codes	C11
Disease Class Name	Eye Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0002715 HP:0000478
Human Phenotype Ontology Term	Abnormality of the immune system; Abnormality of the eye
Disease Ontology Id	DOID:7
Disease Ontology Class Name	disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O14733	BXGT004087	Dual specificity mitogen-activated protein kinase kinase 7	5609	reviewed	Kinase
O60603	BXGT004887	Toll-like receptor 2	7097	reviewed
O95267	BXGT005368	RAS guanyl-releasing protein 1	10125	reviewed	Enzyme modulator
P00966	BXGT005707	Argininosuccinate synthase	445	reviewed	Enzyme
P01009	BXGT005714	Alpha-1-antitrypsin	5265	reviewed	Enzyme modulator
P01133	BXGT005736	Pro-epidermal growth factor	1950	reviewed
P01189	BXGT005742	Pro-opiomelanocortin	5443	reviewed
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01574	BXGT005768	Interferon beta	3456	reviewed
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01583	BXGT005771	Interleukin-1 alpha	3552	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P01889	BXGT005809	HLA class I histocompatibility antigen, B-7 alpha chain	3106	reviewed
P01909	BXGT005815	HLA class II histocompatibility antigen, DQ alpha 1 chain	3117	reviewed	Immune response
P01911	BXGT005816	HLA class II histocompatibility antigen, DRB1-15 beta chain	3123	reviewed	Immune response
P01920	BXGT005817	HLA class II histocompatibility antigen, DQ beta 1 chain	3119	reviewed	Immune response
P02741	BXGT005936	C-reactive protein	1401	reviewed
P02743	BXGT005937	Serum amyloid P-component	325	reviewed
P02768	BXGT005955	Serum albumin	213	reviewed	Transporter
P02774	BXGT005959	Vitamin D-binding protein	2638	reviewed	Transporter
P03905	BXGT006113	NADH-ubiquinone oxidoreductase chain 4	4538	reviewed	Enzyme
P04083	BXGT006147	Annexin A1	301	reviewed
P04150	BXGT006154	Glucocorticoid receptor	2908	reviewed	Nuclear receptor
P04179	BXGT006163	Superoxide dismutase [Mn], mitochondrial	6648	reviewed	Enzyme
P04271	BXGT006177	Protein S100-B	6285	reviewed	Calcium-binding protein
P05089	BXGT006310	Arginase-1	383	reviewed	Enzyme
P05109	BXGT006318	Protein S100-A8	6279	reviewed	Calcium-binding protein
P05156	BXGT006329	Complement factor I	3426	reviewed
P05164	BXGT006333	Myeloperoxidase	4353	reviewed	Enzyme
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05362	BXGT006350	Intercellular adhesion molecule 1	3383	reviewed
P07204	BXGT006567	Thrombomodulin	7056	reviewed
P07814	BXGT006680	Bifunctional glutamate/proline--tRNA ligase	2058	reviewed	Enzyme
P08235	BXGT006751	Mineralocorticoid receptor	4306	reviewed	Nuclear receptor
P08603	BXGT006798	Complement factor H	3075	reviewed
P09429	BXGT006889	High mobility group protein B1	3146	reviewed	Nucleic acid binding
P09601	BXGT006909	Heme oxygenase 1	3162	reviewed
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10586	BXGT007581	Receptor-type tyrosine-protein phosphatase F	5792	reviewed	Enzyme
P10745	BXGT007608	Retinol-binding protein 3	5949	reviewed
P10768	BXGT007611	S-formylglutathione hydrolase	2098	reviewed	Enzyme
P11226	BXGT007675	Mannose-binding protein C	4153	reviewed	Receptor
P12271	BXGT007786	Retinaldehyde-binding protein 1	6017	reviewed	Transporter
P12277	BXGT007789	Creatine kinase B-type	1152	reviewed	Kinase
P12821	BXGT007849	Angiotensin-converting enzyme	1636	reviewed	Enzyme
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P13501	BXGT007917	C-C motif chemokine 5	6352	reviewed	Signaling
P14921	BXGT008068	Protein C-ets-1	2113	reviewed	Transcription factor
P15056	BXGT008075	Serine/threonine-protein kinase B-raf	673	reviewed	Kinase
P15121	BXGT008083	Aldo-keto reductase family 1 member B1	231	reviewed	Enzyme
P15529	BXGT008134	Membrane cofactor protein	4179	reviewed
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P15884	BXGT008166	Transcription factor 4	6925	reviewed	Transcription factor
P16410	BXGT008224	Cytotoxic T-lymphocyte protein 4	1493	reviewed
P17706	BXGT008330	Tyrosine-protein phosphatase non-receptor type 2	5771	reviewed
P17707	BXGT008331	S-adenosylmethionine decarboxylase proenzyme	262	reviewed	Enzyme
P19438	BXGT008480	Tumor necrosis factor receptor superfamily member 1A	7132	reviewed
P23297	BXGT008848	Protein S100-A1	6271	reviewed	Calcium-binding protein
P25942	BXGT009079	Tumor necrosis factor receptor superfamily member 5	958	reviewed
P27361	BXGT009176	Mitogen-activated protein kinase 3	5595	reviewed	Kinase
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P33032	BXGT009689	Melanocortin receptor 5	4161	reviewed	G-protein coupled receptor
P34931	BXGT009771	Heat shock 70 kDa protein 1-like	3305	reviewed
P35228	BXGT009800	Nitric oxide synthase, inducible	4843	reviewed
P35869	BXGT009877	Aryl hydrocarbon receptor	196	reviewed	Transcription factor
P36955	BXGT009946	Pigment epithelium-derived factor	5176	reviewed	Enzyme modulator
P40189	BXGT010164	Interleukin-6 receptor subunit beta	3572	reviewed	Signaling
P40933	BXGT010209	Interleukin-15	3600	reviewed
P42224	BXGT010286	Signal transducer and activator of transcription 1-alpha/beta	6772	reviewed	Nucleic acid binding
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P46108	BXGT010509	Adapter molecule crk	1398	reviewed
P48023	BXGT010604	Tumor necrosis factor ligand superfamily member 6	356	reviewed	Signaling
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P51681	BXGT010878	C-C chemokine receptor type 5	1234	reviewed	G-protein coupled receptor
P55040	BXGT011099	GTP-binding protein GEM	2669	reviewed
P55087	BXGT011105	Aquaporin-4	361	reviewed	Ion channel
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
P60568	BXGT011315	Interleukin-2	3558	reviewed
P61073	BXGT011352	C-X-C chemokine receptor type 4	7852	reviewed	G-protein coupled receptor
P62937	BXGT011471	Peptidyl-prolyl cis-trans isomerase A	5478	reviewed
P78508	BXGT011845	ATP-sensitive inward rectifier potassium channel 10	3766	reviewed	Ion channel
P78556	BXGT011849	C-C motif chemokine 20	6364	reviewed	Signaling
P80075	BXGT011876	C-C motif chemokine 8	6355	reviewed	Signaling
P80188	BXGT011882	Neutrophil gelatinase-associated lipocalin	3934	reviewed	Enzyme
P80511	BXGT011914	Protein S100-A12	6283	reviewed	Calcium-binding protein
P98170	BXGT012231	E3 ubiquitin-protein ligase XIAP	331	reviewed	Enzyme modulator
Q04206	BXGT012754	Transcription factor p65	5970	reviewed	Transcription factor
Q05655	BXGT012832	Protein kinase C delta type	5580	reviewed	Kinase
Q07157	BXGT012920	Tight junction protein ZO-1	7082	reviewed	Cell-cell junction
Q07973	BXGT012952	1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	1591	reviewed	Enzyme
Q13155	BXGT013320	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2	7965	reviewed
Q14116	BXGT013442	Interleukin-18	3606	reviewed
Q15116	BXGT013539	Programmed cell death protein 1	5133	reviewed
Q15389	BXGT013564	Angiopoietin-1	284	reviewed	Signaling
Q15599	BXGT013583	Na(+)/H(+) exchange regulatory cofactor NHE-RF2	9351	reviewed
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q16539	BXGT013634	Mitogen-activated protein kinase 14	1432	reviewed	Kinase
Q16698	BXGT013659	2,4-dienoyl-CoA reductase, mitochondrial	1666	reviewed	Enzyme
Q16853	BXGT013683	Membrane primary amine oxidase	8639	reviewed
Q5T6L4	BXGT015848	Argininosuccinate synthase 1 isoform 1	445	unreviewed
Q5VWK5	BXGT015891	Interleukin-23 receptor	149233	reviewed	Signaling
Q5Y7D3	BXGT015912	HLA class II histocompatibility antigen DQ beta chain	3119	unreviewed
Q6P179	BXGT016440	Endoplasmic reticulum aminopeptidase 2	64167	reviewed	Enzyme
Q7Z7D3	BXGT017262	V-set domain-containing T-cell activation inhibitor 1	79679	reviewed	Enzyme modulator
Q8NCC3	BXGT018546	Group XV phospholipase A2	23659	reviewed	Enzyme
Q96AT9	BXGT019619	Ribulose-phosphate 3-epimerase	6120	reviewed
Q96EB6	BXGT019646	NAD-dependent protein deacetylase sirtuin-1	23411	reviewed	Epigenetic regulator
Q96P20	BXGT019704	NACHT, LRR and PYD domains-containing protein 3	114548	reviewed
Q99572	BXGT019935	P2X purinoceptor 7	5027	reviewed	Ion channel
Q99836	BXGT019970	Myeloid differentiation primary response protein MyD88	4615	reviewed	Enzyme modulator
Q9BZR6	BXGT020202	Reticulon-4 receptor	65078	reviewed
Q9BZS1	BXGT020203	Forkhead box protein P3	50943	reviewed
Q9C000	BXGT020206	NACHT, LRR and PYD domains-containing protein 1	22861	reviewed
Q9GZX6	BXGT020428	Interleukin-22	50616	reviewed
Q9HC29	BXGT020526	Nucleotide-binding oligomerization domain-containing protein 2	64127	reviewed	Enzyme
Q9HC97	BXGT020527	G-protein coupled receptor 35	2859	reviewed	G-protein coupled receptor
Q9NZ08	BXGT021266	Endoplasmic reticulum aminopeptidase 1	51752	reviewed	Enzyme
Q9NZQ7	BXGT021281	Programmed cell death 1 ligand 1	29126	reviewed	Receptor
Q9UKU7	BXGT021749	Isobutyryl-CoA dehydrogenase, mitochondrial	27034	reviewed	Enzyme
Q9Y5S1	BXGT022300	Transient receptor potential cation channel subfamily V member 2	51393	reviewed	Ion channel
Q9Y6K9	BXGT022333	NF-kappa-B essential modulator	8517	reviewed	Kinase
P04439	BXGT022649	HLA class I histocompatibility antigen, A-3 alpha chain	3105	reviewed
Q16552	BXGT023419	Interleukin-17A	3605	reviewed
Q96QC4	BXGT023878	MHC class I polypeptide-related sequence A	100507436	unreviewed
P38646	BXGT024954	Stress-70 protein, mitochondrial	3313	reviewed
Q92729	BXGT025605	Receptor-type tyrosine-protein phosphatase U	10076	reviewed	Enzyme
Q969H8	BXGT025606	Myeloid-derived growth factor	56005	reviewed
P43320	BXGT026151	Beta-crystallin B2	1415	reviewed
P02489	BXGT026168	Alpha-crystallin A chain	1409	reviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}